This study examines inflation targeting in Nigeria and South Africa, using fully modified least square to estimate a modified Taylor rule for the period 1970 to 2016. The study unravels evidence of a significant response of inflation and squared inflation to policy interest rates in South Africa, but not in Nigeria. Overall, South Africa�s central bank places much emphasis on inflation targeting in setting interest rates which Nigeria does not. Further, for South Africa, output gap is significant, while it is not significant for Nigeria. The study also reveals that exchange rate, openness to trade and international reserves play significant roles in central bank policy in both countries. In other words, there is need for central banks to adopt an eclectic approach, setting the monetary policy rule to adjust to any observed disequilibrium between output gap, inflation, exchange rate, foreign reserves and openness to trade. However, strict inflation targeting may not serve as an appropriate framework to address the crucial macroeconomic problems challenging these African economies. However, developing countries� central banks, such as in Nigeria and South Africa, often have weak financial, fiscal and monetary institutions, thus rendering the application of inflation targeting considerably difficult. In this regard, the degree of the triumph of inflation targeting significantly depends on executive capacity, and the political will and commitment on the part of the central banks. The central banks should therefore be flexible about inflation objectives/targets when confronted with more pressing macroeconomic problems that could be remedied using existing policy instruments. From the findings of this study, it can be seen that there is a need to adopt an eclectic approach to setting the monetary policy rule. It is important to set the interest rate to adjust to any observed disequilibrium between output gap, inflation, exchange rate, foreign reserves and openness to trade. In fact, strict inflation targeting may not be an appropriate framework to solve the key macroeconomic problems challenging these African economies, such as price instability, exchange rate stability and inclusive economic growth. Still, inflation targeting remains a relevant policy approach but may not be adequate in its capacity to deal with economic and financial crisis if deployed only.