Stria Research Articles

Combined Fractional CO 2 Laser With Intradermal Platelet-Rich Plasma versus Fractional CO 2 Laser Alone in the Treatment of Striae Distensae.

Striae distensae (SD) or stretch marks are common cutaneous conditions that occur because of the stretching of the dermis.OBJECTIVE To evaluate and compare the efficacy of fractional carbon dioxide (CO 2 ) laser alone versus combined fractional CO 2 laser with platelet-rich plasma (PRP) in SD treatment. Thirty adult female patients with SD (SR and SA) were enrolled. In each patient, a split-lesion design was conducted as follows: pairs of SD on both sides of the midline were selected and allocated to groups A and B. Group A: was treated with combined fractional CO 2 laser with intradermal PRP. Group B: was treated with fractional CO 2 laser alone. Skin biopsies were taken from the lesions before and after treatment for histopathologic evaluation. In group A, a significant excellent improvement of the SD was achieved more than in group B ( p = .007) and the mean of improvement was significantly higher (60.33 ± 26.49) than that in group B (43.80 ± 27.43) ( p -value = .001). Group A was also associated with a more significant dermal deposition of collagen and elastic fibers. Combined fractional CO 2 laser with PRP was more effective than fractional CO 2 laser alone for the treatment of SD.

Semiotic Interpretation of ”Imperfect: Karir, Cinta dan Timbangan” Film by Using Roland Barthes Theory

This study about the semiotic interpretation of “Imperfect: Karir, Cinta dan Timbangan” film with Roland Barthes Theory. This study aims to (a) find out the signs that found in “Imperfect: Karir, Cinta dan Timbangan” film and (b) describe how the signs interpreted in “Imperfect: Karir, Cinta dan Timbangan” film. This reasearch uses descriptive qualitative method. The data were taken from words and phrases which are collected from ‘Imperfect: Karir, Cinta dan Timbangan’ film script. The results shows that there were 15 signs found in Imperfect: Karir, Cinta dan Timbangan film. Timbangan (balance) as the most frequent signs was about 8 data such as: stranded whale; stairs vibration; power head waste; eating tissue; broccoli hair; remember your thigh; you are so fat ya, but it’s OK it’s fresh; and both of you are so different, even you are sisterhood, followed by Cinta (love) with 4 data namely: moles; stretch mark, reduce the rice; and use sunblock, and 3 data for Karir (career) such as pregnant; round face; and she is so old school. The signs includes in Karir (career) when it relates to the development, growth, and progress of someone’s job/profession. The signs that associate to Cinta (love) connects to the deepest someone’s emotional and interpersonal affection. The signs Timbangan (balance) that have a correlation with someone’s weight and physical condition or appearance. Timbangan (balance) were realized by the utterance that refers to physical condition and closely to mock. Cinta (love) associate to the word, gesture, or utterances that express a love or deepest personal affection. Karir (career) was described by a simple word to mock that closely sounds sarcastic and exaggerating.

EVALUATE THE EFFECTS OF MICRONEEDLING IN THE TREATMENT OF STRETCH MARKS

Introduction: Stretch marks are classified as linear lesions that appear on the skin due to the external mechanism that triggers tissue stretching and internal mechanism, which occurs due to genetic markers, accelerated growth and muscle mass gain. In the internal mechanism, it occurs due to genetic markers, accelerated growth and muscle mass gain, with an incidence in specific regions such as buttocks, abdomen and breasts. Microneedling is an innovative technique, which aims at the production of collagen through the mechanical stimulus generated by the rolling of the dermaroller, equipment used for the treatment of integument disorders such as stretch marks. Objective: This study aims to carry out a literature review of the regulated microneedling procedure for the use of physical therapists in the treatment of stretch marks. Materials and methods: The present study used an integrative literature review through the analysis of articles published in national and international scientific journals. A critical search of the scientific literature focused on studies that demonstrated positive results in the use of microneedling in patients with stretch marks, using the following indexed databases: Lilacs, Medline, DECs (Descriptors in Health Sciences) and Coleciona SUS (Brazil) . Results: After an initial survey, reading titles and abstracts, 11 articles were found, later, after reading all the articles critically, paying attention to the inclusion and exclusion criteria, 05 articles were selected to compose the results and discussion of this article. Conclusion: Through this study, it can be concluded that microneedling is a great option for the treatment of stretch marks, significantly improving their appearance. In addition to its remarkable effects, it must be taken into account that it is a low-cost procedure when compared to others. It was noticed that there are few studies and research that deal with the topic addressed. However, it is suggested that further studies can be carried out with a larger sample and with the isolated use of microneedling in the treatment of stretch marks.

A CLINICAL STUDY ON EFFECT OF CHANDANADI SHATADHAUT GHRITA IN THE MANAGEMENT OF KIKKISA W.S.R. TO STRAIE GRAVIDARUM

Twak is a link between internal and external environment and is also the seat of complexion, which maintains beauty and personal identity in the society. About more than 90% of total woman populations are affected by stretch marks on the body particularly on the abdomen, groin and on the chest region during and after pregnancy, which remains rest of life. Kikkisa is a type of skin ailment that occurs during pregnancy and mentioned in the disorders of pregnancy by the various Acharyas. An attempt is made to evaluate clinical efficacy of Chandanadi Shatadhaut Ghrita in 30 patients of Kikkisa. Though Kandu is a symptom of Kapha but here in Kikkis Kandu is due to dryness of skin. So Kandughna action of Tikta Rasa and Snehana effect of Snigdha Guna protect and give relief from Kandu. Tikta Rasa and Katu Vipaka have Kandughna property that helps to reduce Kandu and also Chandana and Karanaj area Kandughna drugs. Tikta and Kashaya Rasa have Daha Shamak property whereas chandan and ushira also have Pittashamak property, which reduce the Vidaha. Tikta Rasa and Katu Vipaka have Kushthaghna property and ushira and chandan have Varnya action. Kandu, Vidaha and Vaivarnyata were reduced markedly after the treatment of Kikkisa with chandanadi shatadhaut ghrita. There was no effect was seen of the chandanadi shatadhaut ghrita on reduction of the area of Kikkisa lesion. No any untoward effect was noticed during follow up study.

Clinical Patterns and Frequency of Dermatological Manifestations Associated with Pregnancy

Introduction: Pregnancy is a physiological state of women which is associated with intricate endocrinological, immunological, metabolic & vascular changes. So pregnancy makes a woman susceptible to various changes in skin & appendages. Alteration to the immune state of the pregnant women is necessary to allow mother to tolerate genetically different tissue during pregnancy. Decrease in cell mediated immunity in normal pregnancy is mainly responsible for the higher frequency and severity of certain infectious diseases. Some of which can also be transmitted to the baby during child birth. Moreover there are marked changes in the levels of sex hormones particularly oestrogen & progesterone and this can lead to profound changes in skin. Objective: To find the prevalence of dermatological manifestations in pregnant patients presenting in a tertiary care hospital Study Design: Descriptive/Cross-sectional Study Setting: The study was done in the Dermatology unit DHQ Hospital Faisalabad. Duration of Study: The study was carried out from 1st October 2016 to 10th March 2017 Subjects and methods: 185 pregnant women presenting at any gestational age in dermatology department and patients referred from Gynae department with dermatological complaints were included in the study. Patients with pre-existing medical conditions such as hypertension and diabetes were excluded. Complete history and clinical features of the patients were accessed and relevant investigations were done to support the diagnosis. Final diagnosis was made on basis of history, clinical examination and laboratory confirmation of disease as per operational definition. LFT’s for intrahepatic cholestasis of pregnancy was done from DHQ laboratory and sample for skin biopsy for pemphigoid gestationis were sent to pathology laboratory FMU. All the data was recorded in a well-structured questionnaire. Results: Age range in this study was from 18 to 40 years with mean age of 30.129±3.26 years and mean duration of disease was 5.864±1.79 week. Majority of the women were with 2nd trimester of pregnancy (67%). 60% of women had no occupation. Striae Gravidarum was seen in 48.1%, Linea Nigra 45.9%, Melasma 25.4%, Hirsutism 16.2%, Palmer Erythema 8.1%, Atopic eruption of Pregnancy 11.9%, Polymorphic eruption of Pregnancy 3.2%, Intrahepatic Cholestasis of Pregnancy 1.6%, Pemphigoid gestationis 1.1%, Acne Vulgaris 9.7%, Vulvovaginal candidosis 8.1%, Urticaria 6.5% and Scabies was 5.4%. Practical Implication: We set out to investigate the prevalence of dermatological manifestations during pregnancy, as well as other clinical characteristics affecting pregnant women in Pakistan. Conclusion: If infections during pregnancy are diagnosed at the earliest stage it may prevent morbidity during and after antenatal period. Keywords: Pregnancy; Dermatological manifestations; Frequency, Clinical Patterns, Pemphigoid Gestationis, Acne Vulgaris, Vulvovaginal Candidosis,

Lésions dermatologiques et parcours de soins chez la femme enceinte

ObjectiveMake an inventory of skin lesions during pregnancy and obtain visibility on healthcare pathway among these women in order to identify more precisely the role of the general practitioner (GP). MethodsProspective, observational study, using a self-administered questionnaire among all women in immediate postpartum period between April 2021 and August 2021, relating to pre-existing skin lesions or rashes that appeared during pregnancy, and the description of the healthcare pathway among these women. ResultsThe questionnaire was collected in 377 women with a mean age of 30.6±3.7 years, 88.6% had fair skin and 14.6% were smokers. Among them, 35 (9.3%) declared skin diseases prior to pregnancy, of which 22 had a history of atopic eczema. During pregnancy, 136 women (36.1%) declared having skin lesions, the most frequent of which were stretch marks (63.2%) and hyperpigmentation (26.5%), and mainly during the 2nd trimester (47.0%). Among these 136 women, only 59 (43.4%) referred it to a health care professional who was in 47.4% of cases (28/59) their GP and in 76.3% (45/59) of cases during a pregnancy follow-up appointment. ConclusionThis study showed that skin lesions during pregnancy were frequent and that the majority of these women consulted their GP.

Stretch Mark Treatment by Tattooing and Microneedling.

Stretch marks (striae distensae) are common dermal scarring associated with weight gain, overweight, and pregnancy. Scarring is caused by overstretching of the skin's dermis with permanent structural alteration of the collagen network fibers. Some individuals have naturally weak connective tissue and may develop major stretch marks without being overweight. Stretch marks can develop during puberty and after physical exercise with rapid muscle growth. Cortisone treatment and anabolic steroids often cause stretch marks. Stretch marks are of major cosmetic concern to many. They are red and swollen in the early sate and white and irregular in texture in the later stage. Many men and women suffer from poor self-esteem caused by stretch marks. Medical tattooing of stretch marks, also known as microneedling, can correct the skin pigmentation color in the normal direction, but not the actual textural change. However, abnormal texture may be modified by microneedling, by nonablative laser treatment, or by microdermabrasion. Treatments can also be combined, e.g., initial use of a method to flatten the skin, followed by tattooing to correct the color. Treatment options and strategies are reviewed.

A clinical and histopathological study comparing the efficacy and safety of carboxytherapy, platelet-rich plasma, and fractional carbon dioxide laser in the treatment of striae distensae

Background Striae distensae (SD) are linear scars that develop in the areas of dermal damage owing to overstretching of the skin. No gold standard line of treatment has been determined. Objectives To compare the efficacy and safety of carboxytherapy, platelet-rich plasma (PRP), and fractional carbon dioxide (CO2) laser in the treatment of SD clinically and histopathologically. Patients and methods The study included 37 female patients with SD, aged 18–50 years. Complete history taking and general and dermatological examinations were performed. The study population was randomly divided into three groups: group A was treated with carboxytherapy, group B was treated with PRP, and group C was treated with fractional CO2 laser. The groups were treated each for six sessions with 3-week intervals and followed up after a month from the last treatment session. The session showing the beginning of improvement and the overall improvement were recorded in each group. Adverse effects, as well as the satisfaction of patient and dermatologist, were also evaluated and graded. The pretreatment and posttreatment histopathological changes in each group were evaluated and recorded according to a modified scoring system. Masson’s Trichrome staining was performed to evaluate the collagen content. Results In the present study, the highest ratio of the overall improvement was observed in group C followed by group B and group A. Histopathological improvement was observed in the three groups with different mechanisms according to the applied treatment. Fractional CO2 laser showed more histopathological improvement than the other treatment modalities. Conclusions The present study concluded that carboxytherapy, PRP, and fractional CO2 laser were clinically and histopathologically effective and safe treatment options for mild to severe SD. Fractional CO2 laser was more effective especially in cases of moderate to severe striae albae. Although it is an expensive treatment method, it resulted in a higher satisfaction rate between the patient and dermatologist with a good safety profile and tolerability.

A CLINICAL OBSERVATIONAL STUDY OF SKIN CHANGES SEEN IN PREGNANCY.

Pregnancy is a state of signicant metabolic, endocrinological, immunological and vascular changes which lead to varied cutaneous changes. The cutaneous manifestations could be physiological changes, pregnancy specic dermatoses and skin conditions that are affected by pregnancy. The aim of this study was to nd the incidence of pregnancy dermatoses and characterize the various cutaneous manifestations seen in pregnant women. Methods: It was a cross-sectional descriptive study done over 2-year period from September 2016 to September 2018. All pregnant women presenting to the dermatology outpatient with complaints of skin disorders were recruited for the study. Informed consent was taken and the detailed examination ndings recorded. A total of 200 pregnant women were included i Results: n the study. Mean age was 25.5 years. Majority of participants were primigravida 130(65%). Most common presenting complaint (126 cases, 63%) was itching. Majority of participants (113) presented in the third trimester. Physiological skin changes pertaining to pregnancy was noted in 91(45.5%) participants, 156(78%) had pregnancy non-specic dermatoses and 39(19.5%) had pregnancy specic dermatoses. Hyperpigmentation and striae gravidarum were seen in 24% pregnant women. Among the pregnancy-nonspecic dermatoses infections was the most common condition (76 cases, 38%). Fungal infections constituted the majority, followed by viral and bacterial infections. STI were seen in 5 patients. Polymorphic eruption of pregnancy was the most common pregnancy specic dermatoses seen in 38 (19%) women. Thirty-three of these patients were primi in their 3rd trimester, 5 were in 2nd trimester. Atopic eruption of pregnancy was seen only in 1(0.5%) participant. Hyperpigmentation and stria Conclusion: e gravidarum are the most common physiological changes seen in pregnancy. Pregnancy predisposes to a wide variety of infections of which fungal infections are most common, followed by viral. Polymorphic eruption of pregnancy is the most common pregnancy specic dermatoses.

The effectiveness of preoperative diagnostic methods in predicting intra-abdominal adhesions before repeat cesarean section delivery

This study aimed to evaluate the effectiveness of skin appearance, striae gravidarum severity, and ultrasonographic "sliding sign" in predicting preoperative adhesions before repeat cesarean section delivery on the same patient and find the most useful one. This was a prospective cohort study conducted on pregnant women with a history of cesarean section delivery. Davey's scoring system was used for stria evaluation. The scar was assessed using their visual appearance, and transabdominal ultrasonography was applied to detect sliding sign existence. Surgeons blinded to preoperative assessment graded the severity of intra-abdominal adhesions intraoperatively using Nair's scoring system. Of the 164 pregnant women with at least one previous cesarean section delivery, 73 (44.5%) had filmy or dense intra-abdominal adhesions. Statistically significant association was found between three groups regarding parity, previous cesarean number, scar appearance, total stria score, and sliding sign existence. Negative sliding sign had a likelihood ratio of 4.198 (95%CI 1.178-14.964) for the detection of intra-abdominal adhesions. Stria score and scar appearance were also valuable for detection adhesions with likelihood ratios of 1.518 (95%CI 1.045-2.205) and 2.405 (95%CI 0.851-6.796), respectively. After receiver operator characteristics curve analysis, striae score cutoff value in adhesion prediction was determined as 3.5. Stria score, scar appearance, and sliding sign are all significant predictors for intraperitoneal adhesions, and sliding sign, as an easy-to-apply, inexpensive, useful sonographic marker, is the most effective adhesion predictor before repeat cesarean section delivery compared to other known adhesion markers.

A Narrative Review of Current Striae Treatments.

Striae (striae cutis distensae) are a common disfiguring skin condition, characterised by the appearance of linear bands on the skin, with an atrophic look. The striae development is still unknown, being more common in women than in men. The prevalence of this condition ranges from 50% to 90%. Regarding treatment, there are various treatment strategies currently available for stretch marks, including topical preparations such as tretinoin and glycolic acid, and also laser. The goal of this work is to discover the main treatments available for striae management. For that, a search was performed based on the definition of specific scientific keywords, by exploring PubMed, ScienceDirect and Biblioteca Virtual em Saúde (BVS). MeSH thesaurus (Medical Subject Headings) descriptors were used. The results indicate that, to date, no treatment is fully effective. More clinical trials are needed to validate the efficacy of these therapies and their long-term use in this type of skin lesion.

A Two-Flap Combination for Auricular Elevation in Microtia Reconstruction.

The aims of this study were to describe and evaluate the effectiveness of combined flaps, a modification of the Nagata technique, for providing a reasonable projection for reconstructed auricles. The authors modified the Nagata method for covering the cartilage block by introducing a new combined flap technique, including the temporoparietal skin flap and retroauricular flap. The authors compared the shape, size, and position of the reconstructed ear to the opposite ear, and we evaluated postoperative complications and patient satisfaction levels. They verified the effectiveness of the combined flap by assessing flap necrosis, skin color, thickness, hair in the auricular area, and scars. A total of 38 consecutive patients (39 ears) with microtia, aged 6 to 34 years, underwent reconstruction using the modified method and were followed up for 33.6 months on average. The reconstructed auricle's shape was well defined, with 41.0% having good and 15.4% having excellent results. Most cases achieved good and acceptable levels in size, position, medial longitudinal axis angle, and auriculocephalic angles, and 79.9% of patients/their families were satisfied. The authors observed no cases of flap necrosis or hypertrophic scarring, and there were low rates of flap complications, such as unmatched skin color (7.7%), unacceptable thickness (5.1%), or hair and stretch marks (10.3%). The modified method's reconstructed ear achieved stable projection, symmetric appearance, and obvious anatomical landmarks with high patient satisfaction. The combined flap method showed certain advantages: high survival rate, less skin contrast, no hypertrophic scars, and fewer complications. Therapeutic, IV.

Efficacy of Combined Treatment with Intense Pulsed Light and Erbium Fractional Laser in Striae Gravidarum.

Laser and intense pulsed light (IPL) treatments are preferred over invasive procedures due to less pain. This study looked at the efficacy and safety of IPL and Erbium fractional laser for patients with striae gravidarum (SG). All 60 patients with SG were successfully enrolled in the study. IPL treatment was followed by Erbium fractional laser (wavelength 2940 nm) treatment at 4-week intervals for a total of three treatments. SG elasticity was assessed with a SEM575 custom instrument and patients were scored for SG span with an Antera 3D multifunctional skin imaging analyzer. A 3D skin impact system was used to assess patients' epidermal thickness. A visual analog scale (VAS) was used to assess patients' pain scores during the treatment period. Improvement in stretch marks was assessed with the Global Aesthetic Improvement Scale (GAIS). The occurrence of adverse events was recorded at a follow-up of 3 months. Patient satisfaction with the outcome of the treatment was also recorded. Area of stretch marks decreased from 7.89 ± 0.49 cm2 pre-treatment to 4.94 ± 1.16 cm2 post-treatment (P < 0.001). The grayness values and atrophy of stretch marks were reduced after treatment. Furthermore, skin elasticity and thickness at the lesions of patients increased significantly after the treatment (P < 0.001), while the width of the stretch marks significantly decreased (P < 0.001). The VAS score was 5.45 ± 1.31, the incidence of adverse events was 25%, and patient satisfaction with the efficacy was 96.67%. IPL combined with Erbium fractional laser improves the area and atrophy of SG, lightens the color, and increases the elasticity and thickness of the skin, with high treatment safety and remarkable clinical results.

The Efficacy and Safety of The Innovative Cold Atmospheric-Pressure Plasma Technology in The Treatment of Striae Distensae: A Randomized Controlled Trial.

Available current therapeutics modalities for striae distensae (SD) provide inconsistently effective outcomes. There is ongoing research on innovative treatment modalities to find better treatment solutions. To evaluate the efficacy and safety of innovative cold atmospheric plasma (CAP) technology in the treatment of striae distensae METHODS: This study includes twenty-three patients with striae distensae. The body was divided into two halves. One side was randomly treated with CAP biweekly on the same treated side for five sessions with 30 days follow-up after the last session. Another half was left untreated. Efficacy assessment was done using POSAS, patient satisfaction scales, and Antera 3D® skin imaging system. Safety assessment was evaluated using the visual analog scale (VAS) and adverse effects monitoring. POSAS, patient and observer overall opinion score, and patient and observer total score in a summary of all rated characteristics, comparing treated and untreated areas, showed a statistically significant reduction in all parameters after one treatment (*P-value < 0.05). Patients rated satisfaction as a great improvement in 52.3%, moderate improvement in 39.1%, extreme improvement in 4.3%, and slight improvement in 4.3%. Adverse effects included small scabs, shallow wounds, and rash. CAP is a safe and effective, innovative treatment modality for striae distensae with minimal side effects.

Fractional CO2 Laser versus Fractional Radiofrequency for Skin Striae Treatment: Study Protocol for a Randomized Controlled Trial.

Striae are common dermal lesions associated with physiological and psychological alterations, affecting the quality of life. This proposed randomized controlled trial protocol will evaluate the clinical efficacy and treatment safety of fractional CO2 laser versus fractional radiofrequency (FRF) in clinical trials. We will randomly allocate 60 subjects who present abdominal striae into two different groups for the treatment, which will be performed once a month for a 3-month period. The results will be assessed by quartile scoring criteria; by comparing digital photos taken before and after each treatment; and also, by the measurement of cutaneous temperature, skin pH, and elasticity before and after the treatment. This paper describes the rationale and the design of the randomized controlled trial, which may provide evidence for clinical application of the methodology and the quality related to the efficacy and safety of fractional CO2 laser versus the FRF protocol for striae treatment.

SEMIOTIC INTERPRETATION OF “IMPERFECT : KARIR,CINTA DAN TIMBANGAN” FILM BY USING ROLAND BARTHES THEORY

This study about the semiotic interpretation of Imperfect: Karir, Cinta dan Timbangan” film with Roland Barthes Theory. This study aims to (a) find out the signs that found in “Imperfect: Karir, Cinta dan Timbangan” film and (b) describe how the signs interpreted in “Imperfect: Karir, Cinta dan Timbangan” film. This reasearch uses descriptive qualitative method. The data were taken from words and phrases which are collected from ‘Imperfect: Karir, Cinta dan Timbangan’ film script. The results shows that there were 15 signs found in Imperfect: Karir, Cinta dan Timbangan film. Timbangan (balance) as the most frequent signs was about 8 data such as: stranded whale; stairs vibration; power head waste; eating tissue; broccoli hair; remember your thigh; you are so fat ya, but it’s OK it’s fresh; and both of you are so different, even you are sisterhood, followed by Cinta (love) with 4 data namely: moles; stretch mark, reduce the rice; and use sunblock, and 3 data for Karir (career) such as pregnant; round face; and she is so old school. The signs includes in Karir (career) when it relates to the development, growth, and progress of someone’s job/profession. The signs that associate to Cinta (love) connects to the deepest someone’s emotional and interpersonal affection. The signs Timbangan (balance) that have a correlation with someone’s weight and physical condition or appearance. Timbangan (balance) were realized by the utterance that refers to physical condition and closely to mock. Cinta (love) associate to the word, gesture, or utterances that express a love or deepest personal affection. Karir (career) was described by a simple word to mock that closely sounds sarcastic and exaggerating. Keywords: Semiotic, Film, Imperfect: Karir, Cinta dan Timbangan

619 Preventive effect of a dermocosmetic product containing an active ingredient complex, Cicahyalumide® and Rhealba® Oat plantlets extract, on stretch mark appearance

Stretch marks are common lesions of the skin appearing under mechanical overstressed, observed during rapid weight, growth variations or pregnancy. Stretch marks are caused by molecular, cellular and fibrillar damages to the skin, affecting its overall organization. There is a characteristic maturation of stretch marks, which begins as striae rubrae, reversible inflammatory lesions but shift to striae albae, irreversible scars. Thus, it is important to specifically act on the prevention of stretch mark emergence.

Linear focal elastosis

Linear focal elastosis (LFE) is an uncommon, benign, acquired elastotic condition with uncertain pathogenesis. It is characterized clinically by asymptomatic, multiple, yellowish, elevated, irregularly indurated, striae-like lines or bands distributed horizontally across the lower and middle part of the posterior trunk. The histopathological hallmark of LFE is a focal increase of elastic fibres in the dermis. The differential diagnosis is varied, and striae distensae is the closest mimic of LFE. Response of LFE to treatment is often poor. The focus of this article is to provide insights into this condition for dermatologists.

The Objective Stretch Marks Photonumeric Assessment Scale: A New and Complete Method to Assess Striae Distensae.

Striae distensae evaluation criteria have been recently described, but none is focused on objective striae assessment. With the purpose of better and objectively estimating the severity of striae distensae, the Objective Stretch Marks Assessment Scale has been developed by the authors' team. Seven hundred White patients were included in the study and assessed. To assess the severity of striae distensae, abdomen, breasts, hips, gluteal area, back area, thighs, calves, and upper limbs photonumeric grading scales were developed. The Rasch model was used as part of the validation process. A score was attributed to each patient, based on the scales we developed. The interrater reliability and test-retest reliability were analyzed. Eight photonumeric scales for striae distensae treatment outcomes assessment were developed. All scales exceeded criteria for acceptability, reliability and validity. The interrater and intrarater reliabilities were good, with a substantial or virtually perfect interrater reliability for the total score (P = 0.16). The authors' results allowed them to validate the Objective Stretch Marks Assessment Scale as a reliable and reproducible tool to assess striae distensae treatment outcomes. This scale could be also considered as an important new metric that can be used in clinical research.

Gel Formulation Test of Gotu Kola Leaf Extract (Centella Asiatica) 15% For Handling Striae Gravidarum

Hormonal changes during pregnancy will impact the skin so that the skin of pregnant women will be vulnerable and at significant risk for striae gravidarum in several areas of the body, including the abdomen, breasts, calves, and thighs. This will impact the quality of life, the incidence of pelvic organ prolapses, and rupture of the perineum due to a lack of collagen in the body. Techniques for treating striae gravidarum have been developed in several methods, including micro-needling and fractional CO2 laser, vitamin C, the use of 0.1% tretinoin cream to the use of frequency radio microneedle (FMR). This treatment aims to help increase, maintain and stabilize collagen in the skin. Gotu kola leaf (Centella Asiatica) is one of the plants that can stimulate the production of collagen I and moisturize the skin because it contains compounds such as saponins, asiaticoside, Asiatic acid, madecassoside, and triterpenes. This plant is also anti-infectious, anti-leprosy, anti-syphilis, and skin cell revitalization. This study aimed to test the effectiveness of a gel based on Gotu kola leaf with a concentration of 15% for treating striae gravidarum. This research method is quasi-experimental with a one-group pre-test post-test design. The population and research sample consisted of 3 respondents; each respondent was assessed in 4 areas: the breast, abdomen, thigh, and calf. The results show that because the significance level is more significant than α (0.130 &gt; 0.05), there is not enough reason to accept H0, and we also get the difference between the average value before and after being given a 15% concentration, which is 1.5, which means the average decreases. Conclusion Gel preparations of Gotu kola leaf extract (Centella Asiatica) with a concentration of 15% are effective in treating striae gravidarum degrees 1,2, and 3.