Central obesity is one of the causes of metabolic syndrome and other degenerative diseases. This study aimed to analyze the relationship between age, gender, physical activity, genetics, stress, and diet with the incidence of central obesity in academic staff at Universitas Negeri Gorontalo. The research method used was an analytical observational method with a cross-sectional study design with the number of research subjects 248 samples consisting of employees or education personnel at Universitas Negeri Gorontalo. Data were collected using a questionnaire and analyzed using binary logistic regression analysis. The results showed that physical activity, genetics, stress, and calorie requirement had a significant relationship with central obesity, while age and gender did not. The calorie requirement variable had a p-value of 0.000 and an odds ratio of 10.75. The physical activity variable had a p-value of 0.009 with an odds ratio of 0.59. The stress variable has a p-value of 0.015 with an odds ratio of 2.09. The results of the data analysis test obtained an R-square value of 0.359. This indicates that the independent variable can explain or influence the dependent variable by 35.9%. The remaining 64.1% is explained by other variables not included in this study.