Cold metal transfer (CMT) welding process was used to join the AL6XN super-austenitic stainless steel to a nickel-based super alloy IN718. Microhardness, tensile and low cycle fatigue tests were carried out to determine the mechanical properties of the welded joint. The heat used to perform the weld decreases the microhardness in the heat affected zone (HAZ) of the IN718 material. A decrement of about 50% with respect to the base material (∼410 HV0.2) was observed, which is attributed to the microstructural transformation produced by the weld thermal cycles, inducing the partial dissolution of the γ'′ phase in the nickel matrix. In contrast, the HAZ on the AL6XN side, the microhardness tends to be similar with respect to the base material (∼203 HV0.2). In terms of the fracture energy, determined from the stress-strain plot, the welded joint decreases about 60–65% with respect to the base materials. This tendency was also observed in the case of the Charpy impact test behavior. From the low cycle fatigue test, it was observed that AL6XN material and AL6XN-IN718, performed better than the IN718 alloy, i.e. more tolerance to the strain cyclic, increasing the number of cycles to failure. A 3-D transient thermal conduction finite element model was developed to correlate the thermal history with the microstructural transformation on the HAZ and mechanical properties. The weld thermal cycles are in good agreement with the experimental measurements obtained by K-type thermocouples.