Stratified Case Research Articles

A Comparison Between Conventional and MILD Combustion Processes of Turbulent Stratified Mixtures

ABSTRACT The relative enhancements of volume-integrated burning rate and flame surface area under turbulence and heat release rate contributions due to different combustion and flame propagation modes have been compared between conventional and Moderate or Intense Low Oxygen Dilution (MILD) combustion of stratified mixtures (for a global mean equivalence ratio of 0.8) for the first time using three-dimensional Direct Numerical Simulation (DNS) data. The burning rate enhancement under turbulence is found to be comparable to the enhancement of flame surface area for the conventional stratified flames considered here, whereas the burning rate enhancement is found to be considerably greater than flame area augmentation in the MILD cases analyzed here. It has been found that almost all the heat release rate arises due to the lean-premixed mode of combustion for the conventional stratified flame cases considered here. In contrast, the lean premixed mode of combustion accounts for about 50% of the total heat release rate for the MILD cases where rich-premixed and non-premixed modes of combustion contribute significantly to the overall heat release rate. Under the conditions analyzed here, more than 75% of heat release rate arises from the propagation-dominated regions for both MILD combustion and stratified flame cases, but the trend is stronger in the conventional stratified mixture combustion. More than 80% of heat release rate in the globally lean conventional stratified flame cases considered here originates from back-supported flame propagation, whereas both front and back-supported flame propagation modes have comparable contributions to heat release in the MILD combustion cases. The non-premixed mode of combustion has been found to play a more important role in the MILD combustion cases than in the case of conventional stratified flames. This implies that the closures, which work reasonably well for MILD combustion of homogeneous mixtures, may not be sufficient for modeling of MILD combustion of stratified/inhomogeneous mixtures.

Mixing of a cylindrical gravity current in a stratified ambient

Simulation results from direct numerical simulations (DNSs) of cylindrical gravity currents propagating into a linearly stratified ambient with stratification strengths ranging from 0 to 0.8, at a moderate Reynolds number of Re=3450 are presented. The simulations are based on the incompressible Navier–Stokes equations, assuming small density differences such that the Boussinesq approximation is valid. The density of the ambient fluid increases linearly from the top (ρ0) to the bottom (ρb) of the domain. A comparative analysis is conducted between the stratified cases and the unstratified case to investigate the impact of ambient stratification strength on the mixing behaviour of cylindrical gravity currents. The energy conversion processes are analysed using the mechanical framework proposed by Winters et al. (1995). The energy budget is formulated by considering gravitational available potential energy, and the evolution of potential energy due to reversible stirring and irreversible diapycnal mixing in the system. The findings reveal a decrease in available potential energy and kinetic energy with increasing stratification strength, indicating lower energy exchange for gravity currents propagating in the stratified environment. Instantaneous and cumulative mixing efficiency calculations during the slumping phase indicate that Kelvin–Helmholtz billow play an important role in stirring the heavy fluid and causing irreversible mixing with the ambient fluid.

Effect of stratification on the propagation of a cylindrical gravity current

Direct numerical simulations (DNSs) of three-dimensional cylindrical release gravity currents in a linearly stratified ambient are presented. The simulations cover a range of stratification strengths $0< S\leq 0.8$ (where $S=(\rho _b^*-\rho _0^*)/(\rho _c^*-\rho _0^*), \rho _b^*, \rho _0^*$ and $\rho _c^*$ are the dimensional density at the bottom of the domain, top of the domain and the dense fluid, respectively) at two different Reynolds numbers. A comparison between the stratified and unstratified cases illustrates the influence of stratification strength on the dynamics of cylindrical gravity currents. Specifically, the front velocity in the slumping phase decreases with increasing stratification strength whereas the duration of the slumping phase increases with increments of $S$ . The Froude number calculated in this phase shows a good agreement with models proposed by Ungarish & Huppert (J. Fluid Mech., vol. 458, 2002, pp. 283–301) and Ungarish (J. Fluid Mech., vol. 548, 2006, pp. 49–68), originally developed for planar gravity currents in a stratified ambient. In the inertial phase, the front velocity across cases with different stratification strengths adheres to a power-law scaling with an exponent of $-$ 1/2. Higher Reynolds numbers led to more frequent lobe splitting and merging, with lobe size diminishing as stratification strength increased. Strong interactions among inner vortex rings occurred during the slumping phase, leading to the early formation of hairpin vortices in weakly stratified cases, while strongly stratified cases exhibited delayed vortex formation and less turbulence.

Turbulent spot formation in stably stratified three-dimensional Yukawa liquids

A plane-Couette flow (PCF) is considered in a stably stratified three-dimensional (3D) Yukawa liquid, perturbed initially with a finite amplitude 3D perturbation. Stable stratification in density is achieved by subjecting the medium to external gravity. We demonstrate turbulent spot formation in a stably stratified PCF. The dynamics of the system is shown to depend upon the value of κ, which is associated with the range of interaction. We have performed “first principles” classical 3D molecular dynamics (MD) simulations for “hypergravity” (1.3g0, g0 is Earth's gravitational force for unit mass in our normalized unit) and “milligravity” (9×10−3g0) cases for κ, 1.0 and 4.0, respectively. We extract relevant fluid quantities from MD data. For the hypergravity case, when the system is evolved in time under stable stratification, the kinetic energy is observed to deposit in the lower wave vectors (Kx, Kz), leading to “inverse cascade” in the plane perpendicular to the direction of stratification. As a result, we observe large-scale structure formation in velocity and streamwise vorticity fields. Nucleation of velocity streak is observed for the first time in the stably stratified case in our simulation. The coherent structures in the velocity and streamwise vorticity fields are found to sustain for longer period of time for the stably stratified cases as compared to the unstratified case. For the milligravity case, the large-scale dynamics is observed to enhance. Unlike unstratified PCF, a background flow in Y-averaged streamwise fluid velocity field is observed for the stably stratified case. We believe that our results using “first principles” classical MD simulations on subcritical turbulence in stably stratified Yukawa liquid, may have ramifications to wider class turbulence problems. Published by the American Physical Society 2024

Twin forces: similarity between rotation and stratification effects on wall turbulence

Can the similarity between rotation and stratification provide quantitative predictions for complex turbulence? In this work, we focus on plane Couette turbulence as the background flow, which allows us to eliminate the key differences between Rayleigh–Bénard and Taylor–Couette turbulence, and facilitates a quantitative mapping across many complex turbulent systems involving rotation, stratification and curvature effects. To characterize the separated or coupled effects of rotation and stratification, we introduce an overall Richardson number ${Ri}_\chi$ which is the sum of the Coriolis Richardson number $Ri_\theta$ and the buoyancy Richardson number $Ri_T$ . When the Prandtl number $Pr=1$ , the heat and inertial-frame momentum transport almost coincide and mainly depend on ${Ri}_\chi$ and the Reynolds number, regardless of the specific ratio between $Ri_\theta$ and $Ri_T$ . When $Pr$ varies, the weighted average ${Nu}_\chi$ of the transport coefficients can still remain approximately invariant in most cases. Furthermore, the large-scale structures in purely rotating and purely stratified cases exhibit strikingly similar features. These findings not only indicate a more reasonable analogy for the ultimate Taylor–Couette turbulence but also pave the way for developing new predictive models for natural and industrial processes.

Green space and stroke: A scoping review of the evidence

BackgroundGlobal industrialisation and urbanisation has led to an increased interest in the link between the environment and health. Stroke is a major cause of morbidity and mortality, and there is increased evidence that environmental factors may affect both the incidence and severity of stroke. This review summarises the evidence for relationship between green space exposure and stroke incidence and outcomes. MethodsWe conducted a literature search in Medline and Scopus until 1 August 2023, and screened references of relevant articles. Selected articles were appraised for their relevance, and critically reviewed. The findings were thematically categorised. ResultsOf the 1342 papers identified, 27 were included. These involved a mix of study designs (cohort, cross-sectional, quasi-experimental, time stratified case crossover and ecological). There was consistent evidence indicating a protective association between green space exposure and disability and stroke-related death with mortality hazard ratios between 0.66 and 0.95. Most studies also showed that green space was inversely associated with stroke risk, with risk estimates from studies showing a protective effect ranging between 0.4 and 0.98; however, results were more mixed and some did not reach statistical significance. The moderating effects of green spaces on ambient temperatures, noise and air pollution, and psychosocial health plus greater enjoyment and opportunity for exercise and enrichment of the human microbiome may underly these associations. ConclusionThere is likely some protective effect of green space on stroke, with the benefits most convincingly shown for post-stroke outcomes. More research is recommended to confirm the protective association between green space exposure and reduced stroke risk.

Mediation analysis with case-control sampling: Identification and estimation in the presence of a binary mediator.

With reference to a stratified case-control (CC) procedure based on a binary variable of primary interest, we derive the expression of the distortion induced by the sampling design on the parameters of the logistic model of a secondary variable. This is particularly relevant when performing mediation analysis (possibly in a causal framework) with stratified case-control (SCC) data in settings where both the outcome and the mediator are binary. Despite being designed for parametric identification, our strategy is general and can be used also in a nonparametric context. With reference to parametric estimation, we derive the maximum likelihood (ML) estimator and the M-estimator of the joint outcome-mediator parameter vector. We then conduct a simulation study focusing on the main causal mediation quantities (i.e., natural effects) and comparing M- and ML estimation to existing methods, based on weighting. As an illustrative example, we reanalyze a German CC data set in order to investigate whether the effect of reduced immunocompetency on listeriosis onset is mediated by the intake of gastric acidsuppressors.

Large eddy simulation of thermal stratification effects on tracer gas dispersion in a cavity

This paper assesses the effect of thermal stratification on the prediction of inert tracer gas dispersion within a cavity of height (H) 1.0 m, and unity aspect ratio, using large eddy simulation. The Reynolds number of the cavity flow, was 67 000. Thermal stratification was achieved through the heating or cooling of one or more of the walls within the cavity. When compared to an isothermal (neutral) case, unstable stratification from surface heating generally has a weak influence on the primary recirculating cavity vortex, except in the case where the windward wall is heated. For windward wall heating, a large secondary vortex appears at the corner of the windward wall and cavity floor. Unstable stratification has no significant influence on the removal of pollutant mass from the cavity. Stable stratification through surface cooling drastically alters the flow pattern within the cavity, pushing the cavity vortex towards the upper quadrant of the cavity. As a result, large regions of stagnant fluid are present within the cavity, reducing the effectiveness of the shear layer at removing pollutant concentration from the cavity. Some stable stratification configurations can increase the pollutant mass within the cavity by over a factor of five, when compared to the neutral case. Pollutant concentration flux maps show that, in stably stratified cases, the majority of pollutant transport from the cavity is the result of entrainment into the primary cavity vortex. The results show that pollutant concentrations in urban street canyon-type flows are substantially altered by diurnal heating and cooling, which may influence pedestrian management strategies in urban environments.

Investigation of strong isothermal stratification effects on multi-mode compressible Rayleigh–Taylor instability

Rayleigh–Taylor instability, RTI, occurs at the interface separating two fluids subjected to acceleration when the density gradient and the acceleration are in opposite directions. Previous scientific research primarily considered RTI under the incompressible assumption, which may not be valid in many high-energy-density engineering applications and astrophysical phenomena. In this study, the compressibility effects of the background isothermal stratification strength on multi-mode two-dimensional RTI are explored using fully compressible multi-species direct numerical simulations. Cases under three different isothermal Mach numbers – Ma=0.15, 0.3, and 0.45 – are investigated to explore weakly, moderately, and strongly stratified compressible RTI, respectively, at an Atwood number of 0.04. Unlike incompressible RTI, an increase in the flow compressibility through the strength of the background stratification can suppress the RTI growth and can lead to a termination of the RTI mixing layer growth with a highly molecularly mixed state. Our findings suggest that even at the chosen relatively low Atwood number, the variable-density effects can be significantly enhanced due to an increase in the background stratification for the compressible RTI as different spatial profiles become noticeably asymmetric across the mixing layer for the strongly stratified case. In addition, this study compares the chaotic behavior of the cases by studying the transport of the turbulent kinetic energy as well as the vortex dynamics. The Reynolds number dependence of the results is also examined with three different Reynolds numbers, and the findings for the large-scale mixing and flow quantities of interest are shown to be universal in the range of the Reynolds numbers studied.

Modification of low temperature-related hospital admissions for cardiovascular diseases by multiple green space indicators at multiple spatial scales: Evidence from Guangzhou, China

Extreme temperatures have an adverse effect on the occurrence of cardiovascular diseases (CVDs). Previous literatures tend to discuss the modification of CVDs occurrence by green space under high temperature. Relatively less attention is paid to the modification under low temperature. The variation of different attributes and spatial scales of green space in affecting CVDs occurrence are also overlooked. This study collected a total of 4364 first-time admission cases due to CVDs in a tertiary hospital in Guangzhou from 2012 to 2018, measured the scale of green space by greening rate (GR) and percentage of landscape (PLAND), the distribution of green space by patch density (PD), mean nearest neighbor distance (ENN_MN) and largest patch index (LPI), and the accessibility of green space by green patch accessibility index (GPAI). Using the time stratified case crossover design method, the modification of low temperature-related CVDs occurrence by the above green space indicators is evaluated in an area with a radius of 100-1000m which is further divided at an interval of 100m. We found high GR, high PLAND, high PD, low ENN_MN, high LPI, and low GPAI corresponds to low risk of CVDs occurrence, the optimal modification scale of each green space indicator, which is radius corresponding to the maximum risk difference between high and low indicator subgroups, is around 800m (GR), 600m (PLAND and PD), 500m (GPAI), and 300m (LPI and ENN_MN), respectively. As the temperature decreases further, the health benefit from low GPAI at the optimal scale is weakened, whereas the benefits from the others are strengthened. Low temperature related CVDs occurrence risk can be modified by multiple green space indicators, and these modifications have spatial scale effect. Our findings have important theoretical and practical significance for the formulation and implementation of local green space policies.

Association of embolization with long-term outcomes in brain arteriovenous malformations: a propensity score-matched analysis using nationwide multicenter prospective registry data.

Brain arteriovenous malformations (AVMs) account for 25% of hemorrhagic strokes in young adults. Although embolization has been widely performed as a stand-alone procedure to cure brain AVM, it is undermined whether patients benefit from this treatment. This study aimed to compare the long-term outcome of hemorrhagic stroke or death in patients with either conservative management or stand-alone embolization for AVM. The study population was derived from a nationwide multicenter prospective collaboration registry (the *BLINDED* registry) between 2011.08 and 2021.08. The propensity score-matched survival analysis was performed in the overall and stratified AVM cases (unruptured and ruptured) respectively, to compare the long-term outcome of hemorrhagic stroke or death, and neurological status. The efficacy of distinct embolization strategies was also evaluated. Hazard ratios (HRs) with 95% confidence intervals were calculated using Fine-Gray competing risk models. Of the 3,682 consecutive AVMs, 906 underwent either conservative management or embolization as the stand-alone management strategy. After propensity score matching, a total of 622 (311 pairs) patients constituted an overall cohort. The unruptured and ruptured subgroups were composed of 288 cases (144 pairs) and 252 cases (126 pairs), respectively. In the overall cohort, embolization did not prevent long-term hemorrhagic stroke or death compared with conservative management (2.07 vs. 1.57 per 100 patient-years; HR, 1.28 [95%CI, 0.81-2.04]). Similar results maintained in both unruptured AVMs (1.97 vs. 0.93 per 100 patient-years; HR, 2.09 [95%CI, 0.99-4.41]) and ruptured AVMs (2.36 vs. 2.57 per 100 patient-years; HR, 0.76 [95%CI, 0.39-1.48]). Stratified analysis showed that the target embolization might be beneficial for unruptured AVMs (HR, 0.42 [95%CI, 0.08-2.29]), while the curative embolization improved the outcome of ruptured AVMs (HR, 0.29 [95%CI, 0.10-0.87]). The long-term neurological status was similar between these two strategies. This prospective cohort study did not support a substantial superiority of embolization over conservative management for AVMs in preventing long-term hemorrhagic stroke or death.

The r-modes of slowly rotating, stratified neutron stars

ABSTRACT The only r-modes that exist in a globally barotropic, rotating, Newtonian star are the fundamental l = |m| solutions, where l and m are the indices of the spherical harmonic $Y_l^m$ that describe the mode’s angular dependence. This is in stark contrast to a stellar model that is non-barotropic throughout its interior, which hosts all the l ≥ |m| perturbations including radial overtones. In reality, neutron stars are stratified with locally barotropic regions. Therefore, we explore how stratification alters a star’s ability to support r-modes. We consider the globally stratified case and examine the behaviour of the modes as the star gets close to barotropicity. In this limit, we find that all but the fundamental l = |m| perturbations change character and become generic inertial modes. Restricting the analysis to l = |m| perturbations, we develop the r-mode equations in order to consider stellar models that exhibit local barotropicity. Our results for such models show that the r-mode overtones diverge and join the inertial modes. In order to see which r-modes persist and retain their character in realistic neutron stars, these calculations will need to be brought into full general relativity.

Thermal efficiency improvement of a spark ignition engine by stratified water distribution

The stratified water distribution was introduced on a single cylinder direct injection spark ignition engine by changing the direct Water Injection Timing (WIT) and Water Fuel Ratio (WFR) to control the water distribution states before ignition. Experiments were conducted to fundamentally understand the stratified water effects on combustion process control. The results show that different water injection timing could result in wall wetting state, homogeneous state, and stratified state. Stratified water distribution has more obvious suppression effects on knock combustion than other states. Furthermore, optimized combustion process of stratified water distribution case by advancing spark timing is with higher thermal efficiency than homogeneous case.Finally, with the experiment of increasing water injection amounts at stratified state, thermal efficiency increasing was realized by 2.1 %. The high correlation between ignition delay and knocking combustion was demonstrated, which substantiate that water stratified injection has much talent on knock combustion suppressing and thermal efficiency increasing. In further research, the stratified water effects by split injection strategy is hopeful to reduce the water amounts and avoiding oil dilution.

A general comparison principle for Hamilton Jacobi Bellman equations on stratified domains

This manuscript aims to study finite horizon, first order Hamilton Jacobi Bellman equations on stratified domains. This problem is related to optimal control problems with discontinuous dynamics. We use nonsmooth analysis techniques to derive a strong comparison principle as in the classical theory and deduce that the value function is the unique viscosity solution. Furthermore, we prove some stability results of the Hamilton Jacobi Bellman equation. Finally, we establish a general convergence result for monotone numerical schemes in the stratified case.

Numerical study on pile group efficiency for piles embedded in cohesive and cohesionless soils

This paper aims to study the efficiency of pile groups with various numbers of piles and pile spacing. Axial loading tests on pile groups and also single piles were simulated using a three-dimensional finite element program to obtain the load-settlement curve and the ultimate bearing capacity of the piles which was later used to estimate the pile group efficiency. In this study, the piles were embedded in cohesive and cohesionless soils. The stress-strain responses of the soils and the concrete pile and pile cap were simulated using the Mohr-Coulomb and the linear elastic models, respectively. The numerical-based pile group efficiencies were then compared to those computed using the published formulas. To verify the findings, a series of parametric studies on pile groups embedded in stratified soil was performed where the parameters of the soils were derived based on a back analysis on a case study of a single pile axial loading test in South Jakarta. The results show that the axial pile group efficiency in cohesive soil would be less than or equal to one, whereas in cohesionless soil would be more than or equal to one, especially at pile spacing more than three times the pile diameter. Meanwhile, similar results as found in cohesionless soil were obtained for the stratified soil case.

The effect of hydrogen addition on methane-air flame in a stratified swirl burner

This numerical study has focused on assessing the influence of adding 20% and 40% hydrogen (on the volume of fuel basis) in different slots of a turbulent methane-air flame. The injection configurations are as follows: in the (i) inner slot, (ii) outer slot, (iii) and both slots. RANS numerical results has been obtained using OpenFOAM code. The impact of enrichment configuration and level on various flow fields have been investigated in the stratified and premixed cases. The results showed that adding hydrogen in the outer slot does not change the flow characteristics significantly, and adding H2 in both slots showed a slight difference compared to adding hydrogen in the inner slot. Hydrogen addition in the inner slot and both slots increased the combustion intensity near the burner exit and resulted in a robust flame attachment which is mainly the result of the enhancement of reaction rates of OH+H2=H+H2O and OH+CH4=CH3+H2O in the premixed case. In the stratified case, in addition to the pathways mentioned above, the reaction rate of H+O2=O+OH also enhanced, which resulted in better flame attachment. Regarding pollutant emissions, H2 addition, decreased CO and increased NOx emission in all configurations of the premixed and stratified cases.

OpenFOAM-Hybrid: A Morphology Adaptive Multifield Two-Fluid Model

Industrial multiphase flows are typically characterized by coexisting morphologies. Modern simulation methods are well established for dispersed [e.g., Euler-Euler (E-E)] or resolved [e.g., volume-of-fluid (VOF)] interfacial structures. Hence, a morphology adaptive multifield two-fluid model is proposed that is able to handle dispersed and resolved interfacial structures coexisting in the computational domain with the same set of equations. An interfacial drag formulation for large interfacial structures is used to describe them in a VOF-like manner. For the dispersed structures, the baseline model developed at Helmholtz-Zentrum Dresden-Rossendorf is applied. The functionality of the framework is demonstrated by investigating a single rising gas bubble in a stagnant water column, a two-dimensional stagnant stratification of water and oil sharing a large-scale interface that is penetrated by micro gas bubbles, and an isothermal countercurrent stratified flow case. Recent developments focus on the transition region, where bubbles are overresolved or underresolved either for E-E or for VOF. Furthermore, a concept is presented for the transition of oversized dispersed bubbles into the resolved phase.

Exploring stratification effects in stable Ekman boundary layers using a stochastic one-dimensional turbulence model

Abstract. Small-scale processes in atmospheric boundary layers are typically not resolved due to cost constraints but modeled based on physical relations with the resolved scales, neglecting expensive backscatter. This lack in modeling is addressed in the present study with the aid of the one-dimensional turbulence (ODT) model. ODT is applied as stand-alone column model to numerically investigate stratification effects in long-lived transient Ekman flows as canonical example of polar boundary layers by resolving turbulent winds and fluctuating temperature profiles on all relevant scales of the flow. We first calibrate the adjustable model parameters for neutral cases based on the surface drag law which yields slightly different optimal model set-ups for finite low and moderate Reynolds numbers. For the stably stratified cases, previously calibrated parameters are kept fixed and the model predictions are compared with various reference numerical simulations and also observations by an exploitation of boundary layer similarity. ODT reasonably captures the temporally developing flow for various prescribed stratification profiles, but fails to fully capture the near-surface laminarization by remaining longer in a fully developed turbulent state, which suggests preferential applicability to high-Reynolds-number flow regimes. Nevertheless, the model suggests that large near-surface turbulence scales are primarily affected by the developing stratification due to scale-selective buoyancy damping which agrees with the literature. The variability of the wind-turning angle represented by the ensemble of stratified cases simulated covers a wider range than reference reanalysis data. The present study suggests that the vertical-column ODT formulation that is highly resolved in space and time can help to accurately represent multi-physics boundary-layer and subgrid-scale processes, offering new opportunities for analysis of very stable polar boundary layer and atmospheric chemistry applications.

Dual-fuel, dual-swirl burner for the mitigation of thermoacoustic instabilities in turbulent ammonia-hydrogen flames

In this paper, a novel dual-fuel, dual-swirl burner is presented and its potential to mitigate thermoacoustic coupling for ammonia-hydrogen-air flames is explored. The key feature of this burner is that the extent of mixing between ammonia and hydrogen before injection into the combustion chamber can be tuned by recessing an inner dividing tube. Non-reacting, 1-D Raman measurements confirm that recessing the dividing tube changes the radial profile of fuel composition at the injector's outlet. Time-averaged flame imaging shows that this modifies, in turn, the flame morphology. Specifically, the more stratified is the fuel, the least compact is the flame. In the most stratified case, a “blue” flame, predominantly burning hydrogen, pilots another “orange” flame, predominantly burning ammonia, further downstream. Acoustic measurements show that the least stratified (most compact) flame exhibits intrinsic thermoacoustic modes (ITA), while these modes are not featured for the most stratified (least compact) flame. Consequently, this study demonstrates that the thermoacoustic behavior of this carbon-free burner can be altered by tailoring the injection of ammonia and hydrogen while keeping the thermal power (7.4 kW), global equivalence ratio (0.64), and fuel flow rates strictly constant. This lays the foundation for the development of future practical burners in which the extent of mixing between ammonia and hydrogen upstream of the flame would be actively controlled to mitigate thermoacoustic coupling.

The utility of a genetic progression risk test for Barrett esophagus.

This study sought to characterize the utility of a gene methylation-based biomarker test that has been validated to predict progression towards esophageal adenocarcinoma. Barrett esophagus (BE) is a precursor condition for esophageal adenocarcinoma (EAC) with somewhat variable approaches among gastroenterologists toward managing neoplastic progression risk. Capsulomics has developed a validated multigene DNA methylation-based biomarker assay performed on BE biopsies designed to address this variability by classifying BE patients into progression risk groups. In the current study, a survey was administered to practicing gastroenterologists in order to assess the potential impact of this assay on clinical practice. In this context, 89% (95% Cl: 85.4-92.6%) of surveyed physicians felt strongly that the multigene Barrett Esophagus test helped resolve uncertainties and optimize care of patients with BE by impacting their decisions on surveillance intervals and use of active treatments, such as ablation. The assay significantly impacted surveillance intervals for both high-risk (22.0 no assay vs 12.3 months with assay; P = 1.7E-8) and low-risk (7.9 no assay vs 11.4 months with assay, P = 8.8E-4) stratified case results. Finally, the assay also significantly impacted decisions to pursue active ablation treatments in both high-risk (5% recommending ablation without assay vs 42% with assay; P = 3.7E-11) and low-risk (42% recommending ablation without assay vs 29% with assay; P = .049) stratified case results. Results demonstrated a strong effect of the assay on clinical decision making, even in conjunction with established clinical guidelines.