This research, titled “Low-carbon transformation and ecological safeguarding in the Yellow River Basin: Integrating biomechanical and biological insights” explores the interplay between economic activities, land use changes, and environmental impact. Through regression analyses and assessments of land use alterations, the study identifies significant provincial variations in factors influencing carbon emissions. In addition to the socio-economic factors, the research incorporates insights from biomechanics and biology, drawing parallels between the ecological systems of the Yellow River Basin and biological processes such as energy efficiency and resource allocation in living organisms. For instance, just as organisms optimize energy usage and adapt to external stressors, the proposed low-carbon strategies aim to optimize resource use and improve the resilience of the basin’s ecosystem. Proposed strategies for low-carbon transformation provide a practical roadmap for sustainable development, informed by biological principles like ecological balance, regeneration, and the importance of maintaining biodiversity. These principles reflect how biomechanical systems, such as musculoskeletal structures, balance energy expenditure and repair to maintain functionality under strain, similar to how ecosystems must manage resource cycles to withstand environmental stressors. The integration of socio-economic indicators, alongside biological and biomechanical insights, underscores the need for region-specific policies that consider not only economic factors but also the natural regenerative capacities of the ecosystem. The study suggests that, like biological systems that repair and adapt to maintain homeostasis, the Yellow River Basin’s ecological processes can be guided by sustainable management practices to ensure long-term resilience and stability. In conclusion, the research contributes valuable insights to the global discourse on balancing economic growth with ecological preservation in the ecologically vital Yellow River Basin, highlighting how the integration of biomechanical and biological principles can enhance both ecological safeguarding and low-carbon transformation strategies.