This research investigates the comprehensive acceptance of artificial intelligence (AI) in business management, finance, and e-commerce, focusing on the factors driving its adoption, the obstacles encountered, and strategies for enhancing integration. AI technologies have transformed these sectors, delivering exceptional efficiencies, predictive analytics, and personalized customer experiences. However, their acceptance is influenced by various factors, including technological readiness, organizational culture, and perceived benefits. In business management, AI improves decision-making processes, optimizes operations, and fosters innovation. Financial institutions utilize AI for risk management, fraud detection, and personalized banking services, while the e-commerce sector gains from AI through enhanced customer service, dynamic pricing, and inventory management. Despite these benefits, challenges such as data privacy concerns, high implementation costs, and resistance to change impede widespread adoption. Additionally, ethical considerations and the need for regulatory compliance add layers of complexity. This paper identifies key strategies to address these challenges, such as promoting a culture of innovation, investing in AI education and training, and developing robust data governance frameworks. Strategic partnerships and collaborations with AI experts and tech firms are also essential for navigating the AI landscape. By comprehensively addressing these factors and challenges, businesses can unlock AI's full potential, driving sustainable growth and competitive advantage. This study contributes to understanding AI acceptance in critical sectors, providing a roadmap for successful AI implementation and emphasizing the importance of strategic planning and stakeholder engagement.