In the first two decades of the 21st century, the Indo-Pacific region has emerged as the epicenter of power competition in the global geopolitical landscape, influencing adjustments in national security strategies of regional and global powers. Amidst the complex fluctuations of the modern world political situation, the EU is actively intensifying strategic competition in the Indo-Pacific region for the benefit of its alliance. Among these efforts, ASEAN stands as one of the most crucial leading partners in the policies and strategies that the EU has been implementing in this region. The research findings are significant in elucidating the influencing factors and providing assessing ASEAN - EU relations in the first two decades of the 21st century and the impact of this relationship on Vietnam.