Summary The objective of this study is to evaluate facies heterogeneity, including both lateral and vertical distributions within the mixed carbonate and siliciclastic reservoirs of the Mississippian System (Lower Carboniferous). This research and statistical approach will aid in future investigations related to determining optimal landing zones, enhancing completion designs, and providing geologic insight into fracture driven well interference studies to increase production efficiency. This study integrates well log, petrographic, sedimentologic, and conventional core analyses along a set of transects across the Anadarko Basin and includes the development of core-based facies logs. Statistical analysis indicates that the Mississippian System in the STACK play of the Anadarko Basin is fundamentally a highly layered rhythmic succession in which a variety of carbonate rock types, siliciclastic rock types, and chert tend to form couplets with siltstone. Thickness-frequency distributions and Markov chain analysis indicate that sediment thickness and lithologic transitions were stochastically regulated and that lithologic cyclicity is not apparent. Overall lithologic trends indicate a transition from carbonate to sandstone in the midramp and from carbonate to mudstone and siltstone in the outer ramp. Stratal geometry defines a series of south-prograding clinoforms, and detailed analysis of vertical trends in the distribution of mudstone, siltstone, sandstone, chert, and carbonate facilitates identification of shoaling-upward parasequences that can be correlated regionally.