The majority of high-rise structures in the northern part of India are designed to be earthquake resistant. Due to an increase in accidental and intentional explosions these structures are exposed to blast pressures so it is necessary to consider the blast load with the same importance as earthquake load. Blast loading and seismic excitations are the most destructive events a structure can experience during its life and hence, need a significant exploration. In the present study the global response of the structure subjected to blast loading is studied. The impact of different assumptions in the application of blast load to the building and loading area of the frames are studied. Then comparison is made between the response of building subjected to blast and earthquake forces. The study was performed on a 10 storey RC frame and dynamic analysis is carried out using ETABS according to IS 875–1987 & IS 1893 (part 1): 2016. The blast pressures that are, reflected blast pressure and over pressure are determined using IS 4991–1968.According to the source of the explosion, the weight of the explosive and the reaction of the safe distance of the building were found. According to the source of the explosion, the weight of the explosive and the reaction of the safe distance of the building were found to study the structural response. Depending upon the source of blast, weight of charge explosive and response of the building safe stand-off distance is found. The results presented lateral storey drifts generated by the explosive load are significantly larger than those of the seismic drifts. The study concludes that it is important to consider the overall response of the building to explosive loads and that response parameters such as lateral drift should be considered in the building evaluation and design process.