To evaluate the stone clearance rate and limitations of a novel integrated suction capability within a single-use flexible ureteroscope according to stone particle size. Varying sized stone particles were created using a stone phantom (Begostone Plus, Bego ©, Lincoln, RI, USA). Particle size ranged as follows: 63-125µm, 125-250µm, 250-500µm, 500µm- 1mm and 1-2mm. These were mixed with Normal saline (0.9%) to mimic in vivo conditions. The suction enabled single-use flexible ureteroscope (Pusen, Zhuhai, China) was used to aspirate stone fragments in three trials. Firstly, aspiration of 5g of each dust range was attempted. Secondly, a direct comparison of the integrated suction to a manual syringe technique was applied to 1g of each size range. Finally, aspiration was applied to 5g of a heterogenous 1:1:1:1:1 mixture. Endoscopic clearance rate (g/min) and number of blockages were recorded. Each challenge was repeated three times. The integrated suction cleared 100% of dust < 250µm. Endoscopic clearance rates were significantly faster than manual aspiration (3.01g/min versus 0.41g/min) for dust between 125 and 250µm (p = 0.008). Complete endoscopic clearance by 180s (without encountering test limiting blockages) was unsuccessful for particles > 250µm. Clearance rates were greatly limited by stone particle size heterogeneity above 250µm, to 0.09g/min. This technology works better in vitro than previously DISS evaluated methods when challenged by stone dust < 250µm. However, this adaptation is significantly challenged in the presence of stone dust particles > 250µm.