After presentation of data from our previous study' of this subject, we continued to encounter terminology during IRB sessions whose meanings we questioned whether or not research study participants understood. Our board members had lengthy discussions on the meanings of many terms used in participant consent forms and on participant comprehension. Of special note is the fact that the lay press has presented articles on difficulty patients have in understanding patient consent forms. Because of these continuing problems of understanding, we compiled and researched a new list of terms used in clinical research consent forms. This study was conducted in the spring of 1995 using the controlled methods reported in our prior publication. However, subjects were not screened to separate those with medical training. As in the first study, participants were given the two-page (front and back) questionnaire and monitored during their completing the form. A total of 302 individuals, all who were over eighteen years of age, were interviewed. This consisted of a main group of 291 participants (118 males and 173 females) and a subgroup of 11 nonresearch nurses (10 females and 1 male). This latter group of nurses was also included in the survey, but their results were not included in the overall analysis of the lay data. In the main group there were 104 individuals who had 12 years of schooling or less and 187 individuals who had college training. For the analyses of the lay data we drew a line between those who had up to a high school education and those whose education went beyond high school. Interviews were conducted in New Jersey, Pennsylvania, and California in churches, fire houses, offices, homes, airports, and beauty salons. Among interviewees’ occupations were probation officer, marketing coordinator, paralegal, salesperson, civil engineer, computer programmer, housewife, tax collector, scientist, teacher, interior designer, retiree, dietitian, insurance agent, chemist, business manager, writer, mailman, secretary, controller, grocery clerk, bookkeeper, realtor, neuropsychologist, policeman, builder, fireman, bank teller, clergyman, postal clerk, social worker, church organist, student, dental assistant, painter, stock broker, electrician, artist, and plumber. Questions and resulting answers follow (key words are highlighted) in Table 1.