The hybrid cable-stayed and suspension (HCSS) bridge is known for its stability and cost-effectiveness, with significant application potential. This study examined the static performance of an HCSS bridge with a 1440 m main span. A finite element model (FEM) was developed to assess key parameters, such as the span-to-rise ratio, cable-to-hanger ratio, pylon stiffness, steel–concrete interface, and cable stiffness. Through FEM analysis and parameter optimization using the zero-order and first-order optimization methods in an ANSYS module, key design variables were optimized. The results show that an inappropriate span-to-rise ratio negatively impacts mid-span girder forces, while increasing the cable-stayed area enhances the overall stiffness. Main cable stiffness plays a crucial role in load-bearing and deformation control. Significant force differences were observed between stay and hanger cables, with axial force in the main girder increasing from the side span to the pylon under dead load. Bending moments in the transition region varied widely under combined loads. Optimizing parameters, such as the span-to-rise and cable-to-hanger ratios, significantly improved the mechanical performance of HCSS bridges, offering valuable insights for future designs.