The isolation technology is widely used to protect structures against strong earthquake. For the inter-story isolated tall building located in strong wind-prone area, the soft isolation layer prolongs the structural period, which can make the wind effects significant. This study presents an analytical framework for assessing three-dimensional coupled wind-induced response of inter-story isolated eccentric tall buildings employing friction-pendulum bearings. The framework utilizes a biaxial Bouc-Wen hysteresis model and a velocity-dependent friction coefficient to describe the coupled frictional forces at each bearing. To enhance the computational efficiency, a simplified model with reduced degrees of freedom is proposed to represent the building. This study investigates eighty combinations of stiffness and mass eccentricities of lower and upper structures relative to isolation layer to analyze their impact on building acceleration. A spherical and two aspheric sliding surfaces of the bearing are examined to understand their effects on building response. The findings suggest that the stiffness eccentricity of either lower or upper building solely affects its own response without influencing other part of the structure. Conversely, the mass eccentricity of upper building induces significant mode coupling, resulting in noticeable impact on the accelerations of both upper and lower buildings. Moreover, the acceleration of the story conner farther from the mass eccentric position experiences significantly amplification. The proposed aspherical bearing demonstrates the capability to substantially reduce the bearing displacement, although with a limited increase in other building responses not exceeding 20 %.