The paper describes the results of an experimental campaign conducted on full-scale steel frames equipped with dissipative components within the European Research Fund for Coal and Steel (RFCS) pilot project DISSIPABLE. Dissipative Replaceable Link Frame (DRLF), whose characteristic is the large energy dissipation combined with ease of replacement, were installed on the frame and coupled through high-strength steel (HSS) beams characterised by an elastic response to increase the overall frame stiffness and to improve the re-centring capability after a major seismic event. The seismic performance of the steel frame was investigated by means of Hybrid Simulation (HS) at three different limit states, i.e., damage limitation (DL), significant damage (SD) and near collapse (NC). In particular, the first floor of the frame was physically built, whilst the response of the remaining five floors was numerically simulated. The results of the tests highlighted the large dissipation capabilities of the DRLF system. In addition, the high-strength steel coupling beams remained elastic even at the NC limit state and provided excellent behaviour in increasing stiffness and re-centring capabilities. Finally, the repairability of the DRLF components was demonstrated.