Stauffer Chemical Research Articles

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OPINION Reactions ShareShare onFacebookTwitterWechatLinked InRedditEmail C&EN, 2021, 99 (31), p 3August 30, 2021Cite this:C&EN 99, 31, 3Letters to the editorHydrogen fluorideIn the Aug. 24, 2020, issue of C&EN, a two-page feature article by Michael McCoy was published on “a new route to hydrogen fluoride” with the subheadline “In a first for the US, the fluorochemical raw material will be made from a fertilizer industry by-product” (page 24). While I agree that this is a very worthwhile undertaking to utilize an environmental pollutant for supplying an important raw material for fluorochemical makers, the article omitted important information on the history of this process. The concept of using the SiF4 by-product from fertilizer plants as a source of HF and using it as a starting material for the synthesis of fluorocarbons is neither new nor a first for the US. It was developed 60 years ago in the US at Stauffer Chemical in Richmond, California, by Albert Mohr. The Mohr process was utilized to prepare either concentrated HF or SiF4 and was reduced to practice on the pilot-plant scale. It is described in detail in US patent 3,257,167, issued on June 21, 1966.Furthermore, the use of SiF4 to produce fluorochemicals was extensively studied in the early ’60s at Stauffer and is described in US patent 3,287,426 by Attila Pavlath and me, issued on Nov. 22, 1966, and in the publication “Silicon Tetrafluoride, a New Fluorinating Agent” (J. Org. Chem. 1964, DOI: 10.1021/jo01033a052). The use of SiF4 for producing hydrohalocarbon and halocarbon compounds has also been patented by Bamidele Omotowa in 2009 in the world patent WO 2009/032849 A1.Karl O. ChristeCalabasas, CaliforniaFrank DavisAs a former graduate student of Frank Davis in the biochemistry department at Rutgers University, I appreciated your commemorating his invention of attaching polyethylene glycol to proteins to escape the body’s immune response (May 31, 2021, page 13).Before this work he was a nucleic acid chemist who discovered pseudouridine, the most abundant modification in RNA (J. Biol. Chem.1957, 227, 907).Philip BarnettNew York CityTitanium dioxide in foodThis letter is in response to the article on titanium dioxide in foodpublished in C&EN’s May 17, 2021, issue (page 13).I cannot think of any cogent reason for permitting any purely cosmetic additive in food unless it is a natural constituent of some other foodstuff generally recognized as safe. In my opinion, all artificial food colorings should be banned and the public should be educated to recognize, accept and—ultimately—prefer foods with their natural appearance.Alexander MoreLondon CorrectionAug. 16/23, 2021, page 38: The Talented 12 profile of Chern-Hooi Lim incorrectly says he raised $7 million for his company, New Iridium. The company has raised $2.5 million in nondilutive funding.

Joseph S. Chirtel

Joseph S. Chirtel, 94, died on Jan. 11 in Osprey, Florida. “Joseph served as a corporal in the 20th Weather Squadron and was honorably discharged in February of 1946. He was director of manufacturing for Stauffer Chemical and retired in 1983 after 35 distinguished years in the industry. After retiring, he continued to work as a part-time consultant to various government agencies involved in the chemical treaty ban. He was honored when asked to travel to Iraq in 1996 on a UN inspections mission. He had many professional affiliations, held four patents, and was a part-time consultant until his final day.”—Priscilla Adams, daughter Most recent title: Director of manufacturing, Stauffer Chemical Education: BS, chemical engineering, University of Illinois at Urbana-Champaign, 1948; MS, chemical engineering, University of Delaware, 1949 Survivors: Daughter, Priscilla Adams; stepdaughter, Phyllis Irwin; one granddaughter. Predeceased by his wife, Elaine. To recognize your late loved one or colleague,

Reminiscences of Leon A. Heppel

Reminiscences of Leon A. Heppel

Monsanto, ICI agree on glyphosate patents

Monsanto and ICI have reached a settlement that protects Monsanto's patents on glyphosate, the active ingredient in its premier herbicide, Roundup, but gives a license to ICI to sell its own version of a glyphosate herbicide in the U.S. beginning in the 1990s. The settlement stems from a patent infringement suit filed by Monsanto in 1983 against Stauffer Chemical, which had begun marketing an herbicide called Touchdown. Stauffer's agricultural chemicals unit and its Touchdown business were acquired by ICI last year. The case was important to Monsanto because its crop chemicals unit, although supplying just 15% of corporate sales in 1987, contributed almost 49% of operating income. Roundup sales and income are major factors in these numbers. As part of the settlement agreement, the Federal District Court in St. Louis has entered a final judgment decreeing that Monsanto patents involved in the suit are valid, enforceable, and were infringed on by Stauffer's Touchdown herbicide. However, ...

4689121 Recovery of phosphorus from sludge : George J Morgan assigned to Stauffer Chemical Company

4689121 Recovery of phosphorus from sludge : George J Morgan assigned to Stauffer Chemical Company

An Evaluation of Tricalcium Phosphate Excipients Particularly Using Instrumented Rotary and Single Station Tablet Presses

AbstractTwo direct compression grades of tricalcium phosphate, Tri-CompressR (Edward Mendell Co., Inc.) and Tri-TabR (Stauffer Chemical Co.), and a product containing tricalcium phosphate, D locust bean gum and citric acid, Loco-TabR (Ingredient Technology Corp.), were studied. Loco-Tab is composed of smaller particles having more irregularly shaped surfaces than the others. It is also less dense and somewhat less flowable than the other materials. None of these excipients lost weight at elevated temperature and none can be considered to be hygroscopic. Compressibility in formulations was studied using instrumented rotary and single station tablet presses. In all cases, the single station press yielded harder tablets at a given compression force. Dissolution of an insoluble drug was affected to a degree by the press used. Drug dissolution from Loco-Tab formulations was excellent at all tablet hardnesses, a highly desirable property for tablets to be coated using fluidized bed equipment. Loco-Tab would see...

4670399 Hybrid plasmid with marker: Patricia A Okubara, Dorothy Pierce, Robert Nutter assigned to Stauffer Chemical Co

4670399 Hybrid plasmid with marker: Patricia A Okubara, Dorothy Pierce, Robert Nutter assigned to Stauffer Chemical Co

4676987 Production of fermented whey containing calcium propionate: William P Ahern, Dale F Andrist, Lawrence E Skogerson assigned to Stauffer Chemical Co

4676987 Production of fermented whey containing calcium propionate: William P Ahern, Dale F Andrist, Lawrence E Skogerson assigned to Stauffer Chemical Co

4681849 Sunflower induction, maintenance and regeneration media, methods of use and plants regenerated therefrom: Karol E Paterson, Nicholas P Everett assigned to Stauffer Chemical Company

4681849 Sunflower induction, maintenance and regeneration media, methods of use and plants regenerated therefrom: Karol E Paterson, Nicholas P Everett assigned to Stauffer Chemical Company

4552844 Plant growth medium: Nicholas P Everett assigned to Stauffer Chemical Company

4552844 Plant growth medium: Nicholas P Everett assigned to Stauffer Chemical Company

4559308 Corynebacterium plasmid and vector: Robert C Nutter, Lucy C Panganiban assigned to Stauffer Chemical Co

4559308 Corynebacterium plasmid and vector: Robert C Nutter, Lucy C Panganiban assigned to Stauffer Chemical Co

4506010 Method for testing microbial degradation of cellulose: Nelson Goodman, Brian C Cunningham assigned to Stauffer Chemical Company

4506010 Method for testing microbial degradation of cellulose: Nelson Goodman, Brian C Cunningham assigned to Stauffer Chemical Company

Stauffer Chemical settles SEC fraud suit

Stauffer Chemical settles SEC fraud suit

4466216 Method for propagating plants from tissue cultures: John A Howard assigned to Stauffer Chemical Company

4466216 Method for propagating plants from tissue cultures: John A Howard assigned to Stauffer Chemical Company

4362750 Production of fermented type sausage: William E. Swartz, assigned to Stauffer Chemical Company

4362750 Production of fermented type sausage: William E. Swartz, assigned to Stauffer Chemical Company

Comparative Toxicity of Three Formulations of Phosmet to Western Spruce Budworm, 1980

Abstract The Imidan 1E formulation of phosmet has been field tested against the western spruce budworm with mixed results. In an attempt to increase the amount of phosmet in the Imidan formulation so that less carrier need be applied, Stauffer Chemical Co. developed two experimental formulations of Imidan, 2E and 3E. For laboratory tests, insects were placed on fresh Douglas-fir foliage 24 hours before spraying and were held in Randall cages. Insecticide sprays were applied to 6th-stage larvae on foliage in a spray chamber. Formulations were diluted in water (12 or 32 mg ai/ml) with a delivery volume of 0.25 ml (equivalent to 9.4 l/ha). Two doses were selected from a dose response curve established for Imidan 1E; one was estimated to cause 50 percent mortality, the other 90 percent. The two doses of each formulation were applied in increasing concentration; the order of application of each formulation was randomized. After spraying, insects and foliage were replaced in the Randall cage. Mortality was evaluated at 7 days post-spray. Differences in mortality between the three formulations for each dose were evaluated with a 3 x 2 contingency table at the = 0.05 level.

Davis named president at Stauffer Chemical

Davis named president at Stauffer Chemical

Rigid plastic admixed with crosslinked acrylate/vinyl chloride interpolymer : Gallagher, R.E. (Stauffer Chemical Company) US Pat 3 988 393 (26 October 1976)

Rigid plastic admixed with crosslinked acrylate/vinyl chloride interpolymer : Gallagher, R.E. (Stauffer Chemical Company) US Pat 3 988 393 (26 October 1976)

Control of Grasshoppers on Rangeland, 1977

Abstract An undiluted formulation containing 92% technical fenitrothion (supplied by Stauffer Chemical Company) was applied at rates of 4 and 6 fluid oz/acre to 4 square 10-acre plots per dosage near Laurel, Montana on July 12, 1977. Applications were made at 45 psi pressure with a Piper Pawnee aircraft equipped with 2 or 4 Tee-jet flat fan No. 8001 nozzles. Flight speed was 90 mph, flight height was 20 ft, and swath width was 75 ft. These treatments were compared with a standard application of 8 fluid oz of ULV malathion/acre applied under the same conditions except that 8 nozzles were used. All nozzles were directed 45 degrees down and back to prevent atomization of droplets. Results were assessed by counting grasshoppers in 50 estimated 1-yd2 subsamples in each treated plot and also in 4 contiguous untreated plots located outside of the experimental area. Counts were made on ‘ July 11, 15, 19, and 26. The species listed above comprised 49, 25, 6, and 11% of the pretreatment infestation, respectively.

Effect of insect growth regulators and fertilizers applied as foliar sprays during the egg stage of the sawfly Neodiprionsertifer

Two insect growth regulators, a mixture containing about 25% Cecropia juvenile hormone with its geometrical isomers (AY-22342-3: Ayerst Research Laboratories, Saint-Laurent, Quebec) and a preparation containing 75% of the aromatic terpenoid ether, 4-ethylphenyl-6,7-epoxygeranyl ether (R-20458-B: Stauffer Chemical Co., Mountain View, California), were tested under field conditions for ovicidal activity against eggs of Neodiprionsertifer (Geoff.). Single egg clusters on Scots pine (Pinussylvestris L.) and whole red pine (P. resinosa Ait.) trees were sprayed to the drip point with formulations containing 0.1, 1, or 10 g/litre of insect growth regulator. AY-22342-3 reduced egg hatch at 10 g/litre on both tree species but was more effective in the red pine trial. R-20458-B did not reduce egg hatch significantly. Results with AY-22342-3 in the laboratory were about twice as effective as field trials. The application of fertilizers (urea, KNO3, or NH4NO3) accompanying a spray of AY-22342-3 on whole red pine trees does not enhance larval mortality. For trees receiving relatively intensive care, notably ornamentals and Christmas trees, the ovicidal activity of insect growth regulators might be useful as a means of preventing sawfly defoliation.