This study aims to determine whether there is an influence of the level of knowledge of JKN-KIS participants, the attitude of health workers and the accessibility of health facilities simultaneously on the utilization of health services for JKN-KIS participants at Community Health Centers and their networks.The method used in this study is a quantitative method. Minimum of 99 samples from JKN-KIS participants in the work area of Pematang Panggang III.b Health Center, Mesuji Makmur District, Ogan Komering Ilir Regency. In this study, there were two hypothesis tests, namely the Partial Significance Test (T-Test) and the Simultaneous Test (F-Test). The data analysis technique used descriptive statistical analysis techniques; multiple linear regression analysis. The results showed that the level of knowledge of JKN-KIS participants did not have a significant effect on the utilization of health services at the Pematang Panggang III.b Health Center, Mesuji Makmur District and its network. The accessibility of health facilities had a positive and significant effect on the utilization of health services for JKN-KIS participants at the Pematang Panggang III.b Health Center, Mesuji Makmur District. The level of knowledge of JKN-KIS participants, the attitude of health workers and the accessibility of health facilities simultaneously had a positive and significant effect on the utilization of health services for JKN-KIS participants at the Pematang Panggang III.b Health Center, Mesuji Makmur District, Prosperous Mesuji.