Statistical Hypothesis Research Articles

Comparison of efficacy and safety of regorafenib and anti-EGFR targeted therapy in metastatic colorectal cancer: A retrospective study

Aim. To compare the efficacy of regorafenib and the combination of chemotherapy (CT) with anti-EGFR (cetuximab/panitumumab) in the third-line treatment of metastatic colorectal cancer (mCRC). Materials and methods. A retrospective analysis of a prospective database of patients with mCRC from two clinics in the Russian Federation was conducted. Overall survival was considered the primary efficacy criterion. Additional criteria were progression-free survival (PFS), objective effect (OE), and incidence of toxicity. No statistical hypothesis was assumed. Statistical analysis was performed using SPSS (IBM SPPS Statistics v. 20). Results. The database identified 51 patients with morphologically confirmed left-sided mCRC with wild-type RAS and BRAF genes who received more than two lines of antitumor drug therapy from 2010 to 2021, one of which included anti-EGFR antibodies in the third and subsequent lines of treatment. Thirty patients who received regorafenib in the third line and 21 patients who received CT in combination with anti-EGFR in the third line were selected, of which 7 patients had a history of anti-EGFR use, and 14 patients received anti-EGFR for the first time. The median overall survival from the third line initiation date in the CT group in combination with anti-EGFR was numerically higher (21 months, CI 9.0–32.9 months) than in the regorafenib group (10 months, CI 2.4–17.5 months); p=0.1 by log-rank test (Mantel–Cox test); p=0.2 by Breslow–Wilcoxon test; p=0.3 (Tarone–Ware test). PFS was also higher in the anti-EGFR CT group (6 months, CI 3.8–8.2 months) than in the regorafenib group (3 months, CI 1.2–4.7 months); p=0.05 according to Breslow–Wilcoxon test. OE of third-line therapy was reported in 57.1% (n=12) of patients in the CT with anti-EGFR group and significantly less often in the regorafenib group – 10.3% (n=3) of patients (p=0.001). The toxicity of drug therapy of all grades in the regorafenib group was reported in 86.2% (n=25) of patients, while in the CT anti-EGFR group, it was significantly less common – in 52.4% (n=11) of patients (p=0.01). Conclusion. Compared with regorafenib, combining CT with anti-EGFR agents in the third-line treatment of patients with left-sided mCRC with wild-type RAS and BRAF genes is associated with better PFS and the frequency of OE with significantly less toxicity.

Structural equations modeling for the entry into becoming a sport sponsorship of the halal product in Thailand

This research study aims 1) to create a structural equation model for sports sponsorship of halal products in Thailand and 2) to examine the direct and indirect influence of variables that are components of the structural equation model for halal products, specifically in the context of becoming a sports sponsorship for halal products in Thailand. The study focused on a sample group of Thai Muslims interested in watching and following the news and participating in Thai sporting events. The researcher chose a sample size of 400 participants from this population, excluding backup data gathering and data analysis, to ensure the questionnaire’s quality and dependability. The results of the data analysis from the structural equation model created show that it is consistent with empirical data. The results of the statistical hypothesis test reveal that the level of religious adherence and the level of awareness of entering into sponsorship have both direct and indirect influences on consumer attitudes and purchase intentions with statistical significance at 0.01. It can also be identified that if a sponsor increases awareness among Muslim viewers through branding or product presentations in events that feature halal symbols or indicate compliance with religious standards, it will lead to a more positive attitude and higher purchase intentions. This insight can be applied to marketing promotion in administrative regions or countries where the majority of the population is Muslim.

Organizational Commitment of Officers in Nakhon Si Thammarat Provincial Governor's Office

Background and Aim: As a result of the reform of Thailand's civil service system, officers of the Nakhon Si Thammarat Provincial Office must act efficiently and effectively according to both agency and individual indicators. This causes some officers to perform their duties under stressful conditions. As a result, the agency's officers are frequently changed in and out. This research, therefore, aims to (1) study the level of the work environment of organizational commitment of officers in the Nakhon Si Thammarat Provincial Office. And (2) compare factors of organizational commitment among officers. Nakhon Si Thammarat Provincial Office is classified by operating environment, Quality of life at work, corporate culture, Motivation for work, and job satisfaction. Materials and Methods: This research used quantitative research methods to study. The tool used to collect data is a questionnaire. Data analysis, according to objective 1, uses statistics on frequency distribution, percentage, mean, and standard deviation to analyze data. As for data analysis according to objective 2, one-way ANOVA test statistics were used to test statistical hypotheses. At the statistical significance level of .05 Results: The study results found that the officers 's organizational commitment in the Nakhon Si Thammarat Provincial Office is at the highest level overall. To consider each aspect, it was found that organizational culture at a high level is first, followed by job satisfaction. At a high level, organizational commitment, a high level of quality of life at work at a high level, and motivation in practice are the last. The results of comparing organizational commitment factors of officers in the Nakhon Si Thammarat Provincial Office found that officers with a quality of life at work Motivation for work, and job satisfaction are different and Have ties to different organizations at the significance at 0.05 level. Conclusion: The study emphasizes that a strong organizational culture and job satisfaction are the main factors driving the high organizational commitment among officers in the Nakhon Si Thammarat Provincial Office. Additionally, there is a strong correlation between variations in officers' organizational commitment and differences in job satisfaction, motivation, and quality of life at work.

Evidential Analysis: An Alternative to Hypothesis Testing in Normal Linear Models

Statistical hypothesis testing, as formalized by 20th century statisticians and taught in college statistics courses, has been a cornerstone of 100 years of scientific progress. Nevertheless, the methodology is increasingly questioned in many scientific disciplines. We demonstrate in this paper how many of the worrisome aspects of statistical hypothesis testing can be ameliorated with concepts and methods from evidential analysis. The model family we treat is the familiar normal linear model with fixed effects, embracing multiple regression and analysis of variance, a warhorse of everyday science in labs and field stations. Questions about study design, the applicability of the null hypothesis, the effect size, error probabilities, evidence strength, and model misspecification become more naturally housed in an evidential setting. We provide a completely worked example featuring a two-way analysis of variance.

Science and Innovation Management: Sustainable Development Goals 8 and 9 as Challenges for Poland

This manuscript continues the series of research publications on Sustainable Development Goals 8 and 9 (SDGs 8 and 9). Innovations play an essential role in the global and national economies, as they contribute to the growth of economic productivity, the creation of new products, services, and jobs, and improve the quality of life. In the context of innovation, economy and artificial intelligence (AI) are the ideological and technological components of the innovation process. The authors hypothesized that the Polish system for assessing the importance of scientific economic journals is ineffective for social development and for creating an innovation-based economy. The research methods are a scientometric analysis of 795,070 scientific sources by the keywords “Economy” and “Artificial Intelligence”, a bibliometric analysis of 219,739 sources by the keywords “Economy”, “Economic productivity”, and “Innovation”, correlation analysis, and testing statistical hypotheses. The study led to the adoption of an alternative statistical hypothesis, which is a strong confirmation of the basic hypothesis. A new model for assessing the weight of scientific journals was created based on the existing system. Two management recommendations were formulated in the rules for determining the weight of journals. The high R2 value indicates that the new model effectively predicts the result. The correlation coefficient of the weight of journals in the new model is more than 98%. When verifying statistical hypotheses, a high significance level of 99.0 was used. The study’s practical significance is in the movement of Polish science to a leading place in the world market of scientific products.

Development of IBL STEM Model-Based Teaching Materials Using Wordwall to Improve Students' Critical Thinking Skills

This study aims to develop teaching materials based on the IBL STEM model using the Wordwall application to improve students' critical thinking skills. The development model used refers to the ADDIE model with 30 students of the Chemistry Education Study Program, UNIMED as research subjects. The research instrument used an expert validation sheet and a test of students' critical thinking skills on stoichiometry material as many as 25 questions in the form of multiple choices. The results of the study indicate that teaching materials based on the IBL STEM model using the Wordwall application are feasible and effective in improving students' critical thinking skills in Stoichiometry learning. The feasibility is met qualitatively based on the assessment of material expert validators with an average total score of 4.36 (valid) and the assessment of media expert validators with an average total score of 4.32 (valid). Effectiveness is met based on the results of product implementation and evaluation results and is proven by statistical hypothesis testing (p < 0.05) with an average achievement of increasing students' critical thinking skills of 40.067 ± 9.318.

The Gods as Latent Causes: A Statistical Inference Theory of Religion

ABSTRACT The statistical brain hypothesis posits that the brain constructs probabilistic models of the environment. Here we examine whether this perspective can provide any insight on religion. We propose that religious ideas represent an attempt to explain away residuals, that is, to explain discrepancies between observations and predictions. The framework postulates probabilistic generative models where gods are described by latent variables whose possible states correspond to the actions available to the gods. As examined in the paper, our proposal offers a plausible interpretation of typical religious phenomena such as miracles, omens, and divination. Moreover, it captures important characteristics of religious beliefs including the notion that gods control multiple spheres of reality, are organized hierarchically, and control aspects that are salient for believers. Besides offering an intriguing new perspective on religion, the paper corroborates the possibility that the statistical brain hypothesis represents a unifying theory of the mind.

Probabilistic reliability model of electrical motors in submersible well pumping units used in the uranium mining by in-situ leaching

Relevance. A submersible electric motor is the most vulnerable component of an electric centrifugal pumping unit used in in-situ leaching uranium mining. The accuracy of calculating the need for new electric motors directly affects the profitability of the uranium production. Aim. Development of a probabilistic reliability model for a submersible electric motor that provides the calculation of its failure probability for the upcoming period of time and allows estimating with sufficient accuracy the number of motors required to replace the failed ones. Methods. Statistical methods, survival analysis, statistical hypothesis testing. Results and conclusions. The authors conducted a study of three probabilistic reliability models for electric motors of submersible well pumping units used in in-situ leaching uranium mining. As a result of the study, the maximum likelihood estimates of model parameters were determined for each model; the adequacy of the models under study was checked based on nonparametric goodness-of-fit tests. Despite the fact that the test results did not allow excluding any of the considered models, a model based on a mixture of two Weibull distributions was selected as a probabilistic reliability model demonstrating higher consistency with real data, compared to the other models. At the same time, the analysis of the components of the mixture distribution indicated the presence of a group of electric motors with an uncharacteristically low time-to-failure value compared to the average value calculated for the entire set of equipment under study, and made it possible to estimate the share of such motors, which amounted to 8% of the total population. Possible reasons explaining such heterogeneity of data, according to the authors, are hidden manufacturing defects or more severe operating conditions in which some submersible electric motors operate.

The Development of a Blended Instructional Model Using the Inquiry Process with Digital Games to Enhance Analytical Thinking Skills for Primary Students

Analytical thinking skills were an essential learning process for primary students. The research objectives were to 1) study the current condition, problems, and good practices regarding teaching and learning. 2) develop a blended instructional model using the inquiry process with digital games to enhance analytical thinking skills for elementary school. 3) study the results of using the instructional model. The research and development process was divided into 3 phases. Phase 1; study the current conditions, problems, and good practices regarding teaching and learning, the sample group included 377 teachers and 11 teachers. Phase 2; develop a blended instructional model, the sample consisted of 7 and 7 experts. Phase 3; study the results of using the instructional model the sample consisted of 34 grade 6 students. The data were analyzed by basic statistics and hypothesis testing statistics. The research found that 1) The current condition and overall problems were moderate level. The good practices included blended learning methods, the inquiry process, and instructional media with digital games. 2) The blended instructional model using an inquiry process along with a digital game included 4 core components: principles, objectives, management of teaching-learning processes, and measurement and evaluation. Seven experts evaluated and certified this instructional model that was appropriate in all aspects at a high level. 3) The results of using the instructional model found that (1) the analytical thinking skills of students who studied using the instructional model overall post-test were significantly higher than pre-test at the .05. (2) Measuring students’ learning achievement overall score post-test was significantly higher than pre-test at the .05. (3) Students’ post-test scores of the experimental were significantly higher than the control group at the .05. (4) Students’ post-test scores of the experimental were significantly higher than the control group at the .05.

Crossmodal correspondence of elevation/pitch and size/pitch is driven by real-world features.

Crossmodal correspondences are consistent associations between sensory features from different modalities, with some theories suggesting they may either reflect environmental correlations or stem from innate neural structures. This study investigates this question by examining whether retinotopic or representational features of stimuli induce crossmodal congruency effects. Participants completed an auditory pitch discrimination task paired with visual stimuli varying in their sensory (retinotopic) or representational (scene integrated) nature, for both the elevation/pitch and size/pitch correspondences. Results show that only representational visual stimuli produced crossmodal congruency effects on pitch discrimination. These results support an environmental statistics hypothesis, suggesting crossmodal correspondences rely on real-world features rather than on sensory representations.

The Effect of Using Open the Box Type Wordwall Educational Game on Students' IPAS Cognitive Learning Outcomes

The purpose of this study was to determine whether there is an effect of using the open the box type wordwall educational game on the cognitive learning outcomes of IPAS students at SDN Palumbonsari 1, East Karawang District. This study used a quantitative method of pre-experiment type with a one group pretest posttest design. The population in this study were all fourth grade students of SDN Palumbonsari 1, totaling 135 people. The sampling technique used purposive sampling technique, so the sample in this study was class IV A with a total of 46 people. Data collection techniques using multiple choice tests as many as 30 items before and after treatment. Then carried out feasibility testing with validity test obtained 20 valid items, reliability test obtained r11 0.73, differentiator test and difficulty level. Data analysis techniques using descriptive statistical analysis and inferential statistics. Then the statistical hypothesis test was carried out with the paired sample t-test test obtained a Sig (2-tailed) value of 0.001 < 0.05, meaning that H0 was rejected and H1 was accepted. So it can be concluded that there is an effect of using the open the box type wordwall educational game on the cognitive learning outcomes of IPAS students at SDN Palumbonsari 1.

Prediction of physical activity and nutritional behaviors based on social cognitive theory in middle-aged population at risk of coronary artery disease in Bandar Abbas

AbstractCoronary artery disease (CAD) is the most common cardiovascular disease and the main cause of mortality in developing countries. Since physical activity and nutritional behaviors are modifiable risk factors in people at risk of CAD, the present study aims to explore the effect of an intervention based on the social cognitive theory (SCT) on physical activity and nutritional behaviors in middle-aged population at risk of CAD in the city of Bandar Abbas. The present cross-sectional study was conducted on 519 middle-aged subjects who visited the healthcare centers in Bandar Abbas, southern Iran, in 2023. The sampling was simple randomization. The data were collected using the general physical activity questionnaire, nutritional behavior questionnaire and a questionnaire based on the social cognitive theory (SCT). Descriptive statistics were used to describe the demographic features of the sample. Pearson correlation coefficient was used to test the relationship between the variables of study. Multiple linear regression was used to test the effect of the SCT constructs on physical activity and nutrition behaviors. All statistical analyses and hypothesis testing were done in SPSS 21, at a significance level of 0.05. A total number of 519 subjects participated in this study, whose average age was 44.23 ± 7.14 years. The results of Pearson correlation test showed a statistically significant positive correlation between nutritional behaviors and the constructs of self-efficacy, collective efficacy, outcome expectations, observational learning, normative beliefs, barriers and opportunities, reinforcement and punishment, and behavioral intention. There was also a significant positive correlation between physical activity and self-efficacy, normative beliefs, social support and behavioral intention. Social support, self-efficacy, normative beliefs, observational learning, behavioral skills and knowledge were found to be the predictors of physical activity. Reinforcement and punishment, normative beliefs, collective efficacy, social support and barriers and opportunities were the predictors of nutritional behaviors in the middle-aged population. As the results of the study showed, it is suggested to increase physical activity in the middle-aged population at risk of CAD using appropriate strategies to strengthen social support through family and friends, improve self-efficacy, identify positive and negative normative beliefs. Plans should be made to improve observational learning, increase behavioral skills, and increase knowledge to improve nutritional behaviors, use appropriate strategies to provide timely and appropriate rewards and punishments, identify and strengthen positive normative beliefs, improve collective efficacy, and increase social support. To this aim, families and other individuals around the middle-aged population can help remove barriers and create opportunities.

The Impact of Ownership Authority on Cash Conversion Cycle in Public Hospitals: A Comparative Analysis of Provincial and County Hospitals

(1) Background: The aim of the paper is to identify and assess if there are differences concerning the cash conversion cycle (CCC) according to different types of ownership authority of hospitals. The main research hypothesis developed for the purpose of this study assumes that the ownership authority is of great importance for the short-term financial management analyzed through the prism of the cash conversion cycle in hospitals. (2) Methods: A statistical hypothesis testing method is employed in the empirical part of the study, analyzing differences both in the values of the cash conversion cycle itself as well as in the values of its components, i.e., inventory conversion period, receivables conversion period, and payables conversion period. The research sample consists of public hospitals subordinated to different types of ownership authorities, i.e., provinces and counties. (3) Results: It turns out that there are indeed statistically significant differences between the provincial and county hospitals as far as the cash conversion cycle and its components are analyzed, which supports the research hypothesis. (4) Conclusions: The county hospitals are characterized by a better financial situation as compared to their provincial counterparts concerning CCC management.

Refining software defect prediction through attentive neural models for code understanding

Identifying defects through manual software testing is a resource-intensive task in software development. To alleviate this, software defect prediction identifies code segments likely to contain faults using data-driven methods. Traditional techniques rely on static code metrics, which often fail to reflect the deeper syntactic and semantic features of the code. This paper introduces a novel framework that utilizes transformer-based networks with attention mechanisms to predict software defects. The framework encodes input vectors to develop meaningful representations of software modules. A bidirectional transformer encoder is employed to model programming languages, followed by fine-tuning with labeled data to detect defects. The performance of the framework is assessed through experiments across various software projects and compared against baseline techniques. Additionally, statistical hypothesis testing and an ablation study are performed to assess the impact of different parameter choices. The empirical findings indicate that the proposed approach can increase classification accuracy by an average of 15.93% and improve the F1 score by up to 44.26% compared to traditional methods.

Analisis Pengaruh Komposisi Pegawai Dan Tarif Gaji Terhadap Belanja Pegawai

The amount of employee expenditure burden in the State Budget (APBN) increases from year to year, the increase needs to be observed whether it is due to the rapid growth in the number of Civil Servants (PNS) or other causes such as recent government policies in terms of improving PNS income and welfare by adjusting PNS salary rates. This study aims to determine whether the increase in employee expenditure is more due to the increase in the number of PNS or PNS salary rates. The purpose of this study is to explain whether there is a significant influence between employee composition and salary rates on employee expenditure. This study is a quantitative study with statistical analysis. The data collection method used is through document and literature review methods, based on the source, the document is included in the secondary data category. The data testing method uses a normality test with the One-Sample Kolmogorov-Smirnov Test method. The data analysis method uses descriptive statistical analysis and hypothesis testing uses Multiple Linear Regression. Based on the results of the study with a significance level of 5%, the following conclusions were obtained: (1) There is a positive but insignificant influence between the number of PNS group I on employee expenditure; (2) There is a positive but insignificant influence between the number of PNS group II on employee expenditure; (3) There is a positive but not significant influence between the number of class III civil servants on employee expenditure; (4) There is a positive and significant influence between the number of class IV civil servants on employee expenditure; (5) There is a positive and significant influence between class I salary rates on employee expenditure; (6) There is a positive and significant influence between class II salary rates on employee expenditure; (7) There is a positive and significant influence between class III salary rates on employee expenditure; (8) There is a positive and significant influence between class IV salary rates on employee expenditure; (9) There is a positive but not significant influence between employee composition and salary rates; (10) There is a positive and significant influence on the number of class I civil servants, the number of class II civil servants, the number of class III civil servants, the number of class IV civil servants, class I salary rates, class II salary rates, class III salary rates and class IV salary rates together on employee expenditure.

Generation Z Satisfaction with Smart Homestays: ASCI and Web Crawler Insights from China

In the digital context, smart homestays have developed rapidly in the post-epidemic era and have become a new form of accommodation. Homestays are favored by many young people in China, such as those belonging to Generation Z. According to data concerning China’s national tourism and related reports, the demand for homestays has increased dramatically in recent years. Thus, we need to consider how to improve the smart homestay user experience. Based on the American Customer Satisfaction Index (ACSI) model, this study explores the factors that affect the user experience of smart homestays. An online survey of 370 respondents of Generation Z in China was conducted, followed by descriptive statistical analysis and hypothesis model validation using SPSS 26.0. The data show that among the five service variables (reservation, check-in, living, check-out, and information sharing), perceived value has a positive and positive impact on service variables in all aspects. Finally, machine learning is used for emotion text analysis, and the results show that users are biased towards smart homestays in the sentiment analysis of the comments. Although smart homestays have a certain amount of attention, there is still a lot of room for progress in technology and services. The purpose of this study is to improve and perfect the rules for making smart homestay service standards based on understanding the satisfaction of Generation Z when using smart homestays while also providing a theoretical basis and practical manuals for the industry to promote the development of the industry and improve user experience. Based on the research results of the above literature, it is imperative to carry out research on Generation Z, the main force of future consumption, especially in the field of artificial intelligence.

Experimental investigation and numerical analysis of material removal efficiency using abrasive microaggregates in grinding processes of Ti6Al4V

Reducing plastic interactions between abrasive grains and the material being processed improves grinding efficiency and lowers energy consumption. Widening the cutting zone with abrasive grains enhances chip formation and reduces lateral material displacement. This can be achieved by using abrasive microaggregates.The paper presents an experimental analysis of grinding with modified wheels containing abrasive microaggregates. It examines how these microaggregates impact the grinding wheel's surface microgeometry and material removal efficiency. The study measured changes in the number, surface area, volume, and spacing of active contact areas on the grinding wheel active surface. A comparative analysis using the Shos indicator showed that abrasive microaggregates promote the formation of active areas with wide cutting edges perpendicular to the cutting direction.Finite element method simulations confirmed that abrasive microaggregates enhance material removal by widening the micro-cutting zone and increasing lateral resistance, which reduces the formation of flashes along the cutting path. The study also assessed how these surface features impact the roughness of the ground surface. A comparative analysis of roughness parameters showed a statistically significant reduction in surface, volume, hybrid, and functional parameters when using grinding wheels with abrasive microaggregates. This analysis was conducted using bootstrap statistical hypothesis tests.

МОДЕЛЮВАННЯ ТА ОПТИМІЗАЦІЯ РЕЖИМУ ТЕРМООБРОБКИ ТРУБЧАСТИХ ЕЛЕМЕНТІВ ФЕРМЕННИХ КОНСТРУКЦІЙ ЛІТАЛЬНИХ АПАРАТІВ З ВУГЛЕПЛАСТИКУ

The article analyzes the current state of development of dimensionally stable tubular elements (TE) and technological problems arising during their production. It is shown that along with empirical methods of studying the influence of various technological schemes on the dimensional stability of tubular elements, it is useful to use the optimal temperature-time mode for heat treatment and, based on it, select the optimal technological scheme. Modeling and determination of the optimal mode of heat treatment of tubular elements were performed. The study of the TE heat treatment mode was carried out in two stages, first by methods of mathematical modeling and optimization, and then by empirical enumeration of various technological schemes. At the first stage, the material properties, which are parameters of the mathematical model, were studied, and the optimal curing modes were calculated. At the second stage, the calculated optimal curing modes were supplemented with various technological methods that cannot be mathematically modeled, and a study was carried out on the influence of the resulting combined heat treatment mode on the geometric characteristics and dimensional stability of carbon fiber TE. The mathematical model of the process of heat treatment and curing of TE in a heat chamber, when heated by a heating air flow, is a system of differential equations: thermal conductivity and curing kinetics. A mathematical model of the process of heat treatment of tubular elements manufactured by the winding method is proposed, the ways of optimizing the curing mode of carbon fiber TE are shown. A numerical calculation of temperature-conversion fields during curing and calculation of optimal curing modes of tubular elements are performed taking into account various process schemes. The values of heat capacity C and thermal conductivity l are calculated depending on the temperature T, the degree of curing b and the filling coefficient g, Безфітингова ферма з вуглепластику Безфітингова ферма з вуглепластику Безфітингова ферма з вуглепластику the power of heat release W and the thermal effect of the curing reaction Q of carbon fiber. Optimum curing modes for a plate made of composite polymer material are obtained, calculated from the data obtained as a result of studying material samples. Temperature-time curing modes are obtained, which are optimized for different thicknesses of the studied material. The statistical hypothesis about the significance of the influence of the process flow chart and reinforcement pattern on the wall thickness of a tubular element and its compressive strength was proved by the dispersion analysis method. The influence of process flow charts and heat treatment modes on the geometric and mechanical characteristics of carbon fiber tubular elements of aircraft truss structures was studied. The statistical hypothesis about the significance of the influence of the process flow chart and reinforcement pattern on the deviation of the wall thickness of tubular elements and their strength characteristics was tested. The significance of the influence of process flow charts with different heat treatment modes on the average wall thickness of a carbon fiber tubular element was statistically proven.

Examining the Relationship between Helplessness in Change and the Expectation of Approval from others with the Gender of Tehran students

Irrational beliefs are any thought, emotion or behavior that leads to self-destruction and self-destruction and its important consequences are impaired survival, happiness and joy. The purpose of this study was to investigate the relationship between helplessness in change and expectation of approval from others with gender in students of Tehran Azad University. The present study was an applied correlation study. The study population was students of Tehran Azad University.95 of whom were randomly selected. The research method was to collect field information with a questionnaire. The research instrument included the Jones irrational beliefs questionnaire and data analysis was performed using descriptive and inferential statistics in SPSS software. With0.95confidence the statistical hypothesis of zero equality of the mean of irrational beliefs and its subscales, i.e. helplessness in changing and expecting from others, is confirmed by the two groups of men and women so we can say that there is no significant difference between the means of the groups. Based on the results of the study, it can be said that each of the subscales of irrational beliefs have the same effect on both men and women and there is no significant difference between them.

12275 Effect Of Osilodrostat On Cardiovascular And Metabolic Manifestations Of Hypercortisolism In Patients With Non-Pituitary Cushing’s Syndrome: Findings From A Retrospective Observational Study (LINC 7)

Abstract Disclosure: N. Scheyer: Other; Self; Recordati Rare Diseases. J. Bertherat: Consulting Fee; Self; Novartis, HRA Pharma, Recordati Rare Diseases. B. Decoudier: Consulting Fee; Self; Recordati Rare Diseases. H. Lasolle: Speaker; Self; Recordati Rare Diseases. H. Lefebvre: Speaker; Self; Recordati Rare Diseases. D. Drui: None. C. Vaillant: None. J. Morera: None. F. Castinetti: Consulting Fee; Self; HRA Pharma Rare Diseases, Recordati Rare Diseases. Grant Recipient; Self; HRA Pharma Rare Diseases, Recordati Rare Diseases. J. Cristante: Grant Recipient; Self; HRA Pharma, Pfizer, Inc.. N. Chevalier: None. S. Fodil-Cherif: None. A. Antonellini: Employee; Self; Recordati Rare Diseases. W. Agbotounou: Employee; Self; Recordati Rare Diseases. A. Mueller: Employee; Self; Recordati Rare Diseases. A. Tabarin: Consulting Fee; Self; H Lundbeck A/S, Crinetics Pharmaceuticals, HRA Pharma, Recordati Rare Diseases. Introduction: Endogenous Cushing’s syndrome (CS) is associated with increased cardiovascular morbidity and mortality because of hypercortisolism. Osilodrostat, a potent oral 11β-hydroxylase inhibitor, is approved for patients (pts) with endogenous CS (EMA) and Cushing’s disease (CD; for whom pituitary surgery is not an option or has not been curative; FDA). The long-term safety and efficacy of osilodrostat has been demonstrated in Phase II (LINC 2, NCT01331239) and Phase III (LINC 3, NCT02180217; LINC 4, NCT02697734) studies of CD pts. Here, we investigated the effect of osilodrostat on clinical manifestations of hypercortisolism in a real-world, retrospective, observational study conducted in a heterogeneous patient population with non-pituitary CS (LINC 7; NCT05633953). Methods: Adult pts with non-pituitary CS who initiated osilodrostat prior to EU approval under the French Autorisation Temporaire d’Utilisation scheme and/or, once approved, in routine clinical practice were followed up retrospectively for up to 36 months. The primary endpoint was proportion of pts with mean urinary free cortisol (mUFC) ≤upper limit of normal (ULN) at week (W) 12, based on the modified intention-to-treat (mITT) population (pts with any cortisol measurement at W12 or not collected because of safety reasons). Secondary endpoints included cardiovascular and metabolic parameters, recorded every 4 or 12W, depending on clinical practice. No formal statistical hypothesis testing was performed; all analyses are descriptive. Results: 103 pts were enrolled (mean [SD] age: 59.3 years [15.5]; female 61.2% [n=63]; adrenal adenoma [16.5%, n=17/103; mITT: 9.6%, n=5/52], adrenocortical carcinoma [18.4%, n=19/103; mITT: 11.5%, n=6/52], macronodular adrenal hyperplasia [13.6%, n=14/103; mITT: 17.3%, n=9/52], ectopic adrenocorticotropic hormone secretion [51.5%, n=53/103; mITT: 61.5%, n=32/52]). Median (min-max) osilodrostat exposure and dose at baseline was 164.0 days (1-1178) and 5.0 mg/day (1-60), respectively. Median (min-max) osilodrostat dose at W12 and W36 was 6.0 mg/day (0-60) and 10.0 mg/day (0-120), respectively. 23/52 pts (44.2%; 95% CI 30.5-58.7) had mUFC ≤ULN at W12. Mean (95% CI) changes in cardiovascular and metabolic-related parameters from baseline to W12 and W36, respectively, were: systolic blood pressure (−5.7 [−17.9, −6.6] mmHg, n=29 and −6.3 [−19.0, −6.5] mmHg, n=11); diastolic blood pressure (−4.7 [−10.6, −1.1] mmHg, n=29 and −8.2 [−20.7, −4.3] mmHg, n=11); weight (−2.3 [−4.2, −0.4] kg, n=27 and −3.6 [−9.6, −2.5] kg, n=12); body mass index (−0.8 [−1.5, −0.2] kg/m2, n=27 and −1.2 [−3.2, −0.8] kg/m2, n=12). No new safety signals were identified. Conclusions: Findings from this real-world setting show that osilodrostat provides cortisol control alongside improvements in clinical manifestations of hypercortisolism in non-pituitary CS pts, alleviating the disease burden. Presentation: 6/1/2024