The present paper gives a method to directly estimate the dynamic failure peak ground acceleration of single-layer reticulated domes according to the Chinese earthquake response spectrum. A method given by the Japanese code for seismic design of buildings is presented first, which can be used to estimate the dynamic failure peak ground acceleration of a single-layer dome. However, the existing method cannot be used to calculate the dynamic failure load for a structure in China because of the different codes and methods used for the seismic design of single-layer reticulated domes. Meanwhile, the existing method needs to repeat the finite element method (FEM) elasto-plastic static analysis and FEM nonlinear time–history response analysis to calculate the FEM plasticity adjustment factor and the dynamic ductility index of different domes. Secondly, on this basis, 28 Kiewitt-8 (K8) single-layer reticulated domes with different key structural design parameters are designed using the relevant Chinese specifications, they will be used for the parameter revision of the peak ground acceleration and the dome’s design spectral acceleration, the fitting of the formula to calculate the FEM plasticity adjustment factor, and the statistical analysis of the dynamic ductility index respectively. Thirdly, the peak ground acceleration and the dome’s design spectral acceleration in the existing method are revised according to the Chinese code for the seismic design of buildings. Fourthly, the FEM elasto-plastic static analysis is carried out to get a fitting formula to directly calculate the FEM plasticity adjustment factor with the static safety factor K of the dome. The calculation results of this formula are smaller than that of FEM analysis, which can ensure the safety of the dome. Fifthly, the failure criteria with clear physical meaning are selected from the existing dynamic failure criteria to predict the dynamic failure load of the domes. Then, a FEM nonlinear time–history response analysis is carried out using the FE package ANSYS for the 28 typical domes subjected to 30 different ground motions, and the dynamic failure loads are calculated by the selected failure criteria. It is found that the dynamic failure loads correspond to two different failure modes, one is the local failure caused by the sudden increase of the displacement of the dome’s local node, the other is the global failure caused by the sudden increase of the overall energy of the single-layer reticulated dome. After this, the lower bound failure accelerations with a certain guaranteed rate of those dynamic failure loads are determined using a lognormal distribution. The dynamic ductility index is then revised by the lower bound failure accelerations and the statistical analysis of the dynamic ductility index of the 28 typical domes is conducted to get a lower bound value for it. Finally, a method directly estimating the dynamic failure load of a dome is constructed and verified. The research will provide a new method under a certain degree of reliability to directly estimate the dynamic failure loads of single-layer reticulated shells in the earthquake area of China and contribute to the structural design with more overall confidence.