ABSTRACT State wildlife agencies (SWAs) rely on hunter harvest submissions to help monitor and manage chronic wasting disease (CWD). Thus, effective CWD management is contingent upon SWAs’ understanding of hunters’ attitudes about, concerns with, and management preferences used to address CWD. We examined these and other human dimensions constructs, including trust and behavioral intentions, by surveying a random sample of resident and nonresident deer hunters who had purchased licenses in areas of Colorado where CWD had been detected. Our results suggest that regardless of residency, hunters are concerned about CWD. However, we detected substantive differences across the groups’ hunting motivations, management acceptability, and behavioral intentions. These data can help agencies develop communication strategies based on specific stakeholder motivations, concerns, and management preferences. Additionally, findings can help SWAs understand how hunting behavior may change if CWD prevalence increases, allowing them to adjust course as needed.