This study aims to assess the global reliability of coupled transmission tower-insulator-line systems considering soil-structure interaction (CTTILSs-SSI) subjected to multi-hazard of wind and ice. Firstly, two simplified models of CTTILSs-SSI under stochastic wind and ice loads are established, and their governing equations are derived through the Lagrange equation. On this basis, a global reliability assessment framework of CTTILSs-SSI is proposed based on the improved maximum entropy method, in which the global performance function of CTTILSs-SSI is defined via the state variable description method. Finally, a practical ultra-high voltage overhead transmission line located on the icing zone is chosen to illustrate the proposed framework. Moreover, to investigate the influence of soil-structure interaction (SSI) and soil types on the global reliability of transmission tower-insulator-line systems (TTILSs), the global reliability of CTTILSs-SSI with various soil types is compared with that of a fixed base system. The results indicate that under the in-plane wind and ice loads, the global failure probability of TTILSs is almost zero, and it is essentially not affected by the SSI effect and soil types. However, under the out-of-plane wind and ice loads, the global failure probability of CTTILSs-SSI is higher than that of the fixed base system, and the global failure probability of CTTILSs-SSI increases as the soil stiffness decreases. Accordingly, it may be more reasonable to consider the SSI effect into the global reliability analysis of TTILSs subjected to ice and out-of-plane wind loads, particularly when the soil is soft.