State University Medical Center Research Articles

Abstract PO-230: Improved clinical outcomes with shorter intervals between concurrent chemoradiation and brachytherapy in FIGO IB2-IVA cervical cancer patients among a predominantly African-American population

Abstract Purpose: To assess if the time interval between concurrent chemo radiotherapy [conc ChemoRT] followed by brachytherapy [B] determines the clinical outcomes in cervical cancer patients (FIGO stage IB2 – IVA) among a predominantly African- American population in a state university medical center. Methods: A retrospective analysis of 147 cervical cancer patients diagnosed with stage IB2- IVA treated with conc ChemoRT followed by B at various time intervals between 2005 and 2018 was performed. Survival analysis with several treatment [TX] duration interval parameters (pre 2010 and post 2010 to evaluate the significant organizational advancements); conc ChemoRT and B completed ≤ 60 days and > 60 days per American College of Surgeons cervical cancer surveillance measure; and TX intervals 6 to 10 weeks were evaluated. The overall survival [OS], local control [LC] and distant control [DC] were estimated by using Kaplan- Meier method. Uni, bi and multi- variable Cox hazard regression analyses were used to compare the risk of death among cervical cancer patients with different TX intervals. The SPSS v.24.0 was used for statistical analyses. Results: The 147 cervical cancer patients (median age, 55 y; range 28-83 y) had a median follow-up of 32 months (range 0 to 164 months). Our patient cohort included 34% patients treated pre 2010 and 66% post 2010; 42.2% ≤60 days and 57.8% > 60 days; 53.1% ≤ 6 to 8 weeks, 12.2% ≤ 8 to 10 weeks and 34.7% d>10 weeks. The patients diagnosed and treated post 2010 had better 5-year OS rates (65% vs. 32%) compared to pre 2010; p=0.000; patients treated ≤ 60 days had better 5-year OS rates (59.3% vs. 40.3%) to > 60 days; p=0.094; patients treated ≤ 6 to 8 weeks had better 5-year OS rates (56.1% vs. 53.1% and 34.3%) compared to ≤ 8 to 10 weeks and > 10 weeks; p=0.188 respectively. The 5-y OS rates for FIGO stages were IB2 (65.8%); IIA (62.5%); IIB (40.4%); IIIA (50%); IIIB (42.4%); and IVA (25.2%); p=0.508. There was no trend for improved LC (p=0.331; p=0.962; p=0.616) and DC (p= 0.284; p=0.596; p=0.606) observed among patients with different TX intervals. In the bi-variate analysis for TX year group, after adjusting for age, race, insurance, income level, distance travelled, tobacco exposure, alcohol history, and tumor stage, BMI-lower had twice the risk of death (hazard ratio [HR], 2.74; 95% CI, 1.34-5.59; p= 0.005). For patients treated ≤ 60 days, their insurance-private had a 63% reduction (HR, 0.37; 95% CI, 0.15-0.90; p=0.029), and for the weekly TX group by the multivariate analysis, insurance-private showed a 76% reduction in the risk of death (HR, 0.35; 95% CI, 0.14-0.87; p=0.024). Conclusion: Our analysis suggests better OS among patients diagnosed and treated post 2010; ≤ 60 days duration; and ≤ 6 to 8 weeks with a shorter interval between conc ChemoRT and B to be superior to that of the patients undergoing longer TX’s. Citation Format: Mary R. Nittala, Satyaseelan Packianathan, Eswar K. Mundra, Maurice L. King, Shivanthidevi Gandhi, Robert M. Albright, Maria L. Smith, William C. Woods, Toms V. Thomas, Mildred Ridgway, Srinivasan Vijayakumar. Improved clinical outcomes with shorter intervals between concurrent chemoradiation and brachytherapy in FIGO IB2-IVA cervical cancer patients among a predominantly African-American population [abstract]. In: Proceedings of the AACR Virtual Conference: Thirteenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2020 Oct 2-4. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(12 Suppl):Abstract nr PO-230.

Introduction of Steven A. Nadler, Recipient of the Henry Baldwin Ward Medal for 2013

Introduction of Steven A. Nadler, Recipient of the Henry Baldwin Ward Medal for 2013

Abstract B27: The Ohio Patient Navigation Research Program (OPNRP): Does the ACS-patient navigation model improve time to resolution among patients with abnormal screening tests?

Abstract Objectives: To test the Ohio American Cancer Society (ACS) model of patient navigation (PN) as it relates to reducing time to diagnostic resolution among persons with abnormal breast, cervical, or colorectal cancer screening tests or symptoms. Methods: 862 patients from 18 primary care and specialty clinics within the Ohio State University (OSU) Medical Center and Columbus Neighborhood Health Centers with one of these abnormal findings were eligible to participate in this group-randomized study. Clinics were paired and randomized within pairs to either usual care or PN. Patients were informed about the study, consented, and completed a baseline survey. The navigators were not clinic-based, but followed the Ohio ACS-PN model where navigators mainly used phone contact from a non-clinic location. Chart review was done to capture medical information on the abnormality as well as the date of resolution and follow-up tests received. The primary analysis focused on time to resolution using shared gamma frailty models used to test for effect of navigation on time to resolution. Crude Hazard Ratios (HR) were used, as adjustment for OSU and national variables did not significantly change the hazard ratios. Assessment of effect modification was also conducted. Results: Crude HR's deviated starting at 6 months, so that by 15 months, participants in the PN arm were 61% more likely to have their abnormality resolved (p=0.004 for difference in risks across arms; p=0.005 for increase in relative risk over time). Effect modifier analysis showed a trend for income (<$50K vs. $50K+; p=0.07) in that lower income participants benefited earlier from PN. Participants in the navigation arm (N=475) were further assessed in terms of reported barriers and navigator actions documented in the navigation encounters. Almost half reported no barriers (n=226; 46.6%), while the remainder reported one barrier (n=113; 23.8%), or 2+ barriers (n=136; 28.6%). The most frequently reported barriers were perception/beliefs about tests or treatment (n=89), communication with providers (n=84), scheduling problems (n=65), insurance/co-pay problems (n=49), and medical/mental health co-morbidities (n=44). Most frequent action taken by navigators were providing support (n=175), referrals (n=125), and education (n=74). On average, navigated participants with barriers received 3 encounters with a PN, and 90.9% of the encounters lasted <15 minutes. The most frequent actions taken by a PN included: support (n=175); referrals (n=125); and education (n=74). Conclusions: The OPNRP demonstrated that patients with abnormal cancer screening tests or symptoms are more likely to resolve their abnormality, if assigned to a PN program compared to those not assigned to a PN program, even when navigators are not embedded in the clinic. Citation Information: Cancer Epidemiol Biomarkers Prev 2011;20(10 Suppl):B27.

Training Older Adults to Work as Psychiatric Case Management Aides

Adults who were age 55 and over were trained to work as case management aides for individuals with serious and persistent mental illness. The training program was a cooperative effort of several state, academic, and private agencies in the New Orleans area, including the department of psychiatry at a state university medical center, the State Office of Mental Health, a consortium of colleges and universities providing educational opportunities for older adults, and the American Association of Retired Persons. The program curriculum included ten weeks of classroom instruction and a four-month field practicum. Of the 14 participants in the initial group of trainees, 13 sought and received employment as case aides. At follow-up three months after employment, supervisors of the case aides rated their job performance as excellent.

Political Interference With Research?

To the Editor. — Regarding JAMA's recent story on Dr Carey's work in shooting cats to analyze brain injuries, 1 allow me to make a few comments: In 1988, I requested a General Accounting Office (GAO) investigation because there were serious questions about the validity of Dr Carey's research. I had already been in extended conversations with Louisiana State University (LSU) Medical Center representatives, the army, and local residents (not national animal rights groups). Since I had received a great deal of incomplete information from all sides and since Dr Carey had not published a single article on his work, which the taxpayers had been funding since 1983, some answers clearly were in order. Contrary to Dr Carey's belief, it is entirely appropriate and customary for members of Congress to turn to the GAO for specialized investigations. While other agencies, such as the National Institutes of Health (NIH) and the

PATHOLOGY OF PREGNANCY

Department of Environmental Medicine and Community Health, State University Medical Center at New York, the Department of Pathology, Harvard University Medical School and the Pathology Laboratory, Boston Lying-in Hospital, Boston, Massachusetts, and Department of Epidemiology, Harvard University School of Public Health, Boston, Mass.

Therapy of traumatic shock.

Article1 October 1951THERAPY OF TRAUMATIC SHOCKBENJAMIN BURBANK, M.D., F.A.C.P.BENJAMIN BURBANK, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-35-4-857 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe experiences of the past war have shown how very difficult it is to define by exact criteria just what constitutes the condition of shock. The end stage, in which the patient has no perceptible blood pressure or pulse, is pale with a gray cyanosis and cold with clammy perspiration, represents a medical defeat in diagnosis. Attempts to delineate a definite blood pressure level, such as 70 mm. Hg, have serious drawbacks because the end stage as described above may take place within a matter of minutes after such a reading. The same objections hold true for determining the...Bibliography1. Blalock A: Principles of surgical care; shock and other problems, 1940, C. V. Mosby Co., St. Louis. Google Scholar2. Moon VH: Shock and related capillary phenomena, 1938, Oxford University Press, New York. Google Scholar3. BurfordBurbank THB: Traumatic wet lung, J. Thoracic Surg. 14: 6 (Dec.) 1945. CrossrefGoogle Scholar4. BrewerBurbankSamsonSchiff LABPCCA: The wet lung in war casualties, Ann. Surg. 123: 343 (March), 1946. CrossrefGoogle Scholar5. JawetzSpeck ERS: Joint action of penicillin and chloramphenicol on an experimental streptococcic infection of mice, Proc. Soc. Exper. Biol. and Med. 74: 93-96, 1950. CrossrefMedlineGoogle Scholar6. Beecher HK: Morphine poisoning in battle casualties, Medical Bulletin, NATOUSA 1: 22 (Feb.) 1944. Google Scholar7. Dry J: Personal communication. Google Scholar8. FitzpatrickAdamsBurbank LJAJB: Nerve block in the treatment of thoracic injuries, Medical Bulletin, NATOUSA 2: 51-53 (Sept.) 1944. Google Scholar9. SamsonBrewerBurbank PCLAB: Tracheobronchial catheter aspiration, Bull. U. S. Army M. Dept. 5: 227 (Feb.) 1946. MedlineGoogle Scholar10. Hadfield G: Differential diagnosis of lung injuries, Lancet 2: 197-199 (Aug. 16) 1941. Google Scholar11. Zuckerman S: Discussion on problems of blast injuries, Proc. Roy. Soc. Med. 34: 171-192 (Jan. 6) 1941. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Brooklyn, New York*Received for publication February 7, 1951.From the Department of Medicine, State University Medical Center at New York, College of Medicine, and the Long Island College Hospital, Brooklyn, New York. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1951Volume 35, Issue 4Page: 857-871KeywordsBlood pressureHeart rateHospital medicineShockSweat ePublished: 1 December 2008 Issue Published: 1 October 1951 PDF downloadLoading ...

Patterned loss of hair in man; types and incidence.

Annals of the New York Academy of SciencesVolume 53, Issue 3 p. 708-728 PATTERNED LOSS OF HAIR IN MAN: TYPES AND INCIDENCE James B. Hamilton, James B. Hamilton Department of Anatomy, State University Medical Center at New York City, Brooklyn, New YorkSearch for more papers by this author James B. Hamilton, James B. Hamilton Department of Anatomy, State University Medical Center at New York City, Brooklyn, New YorkSearch for more papers by this author First published: March 1951 https://doi.org/10.1111/j.1749-6632.1951.tb31971.xCitations: 629 This study was supported in part by research grants RG 1036 and H 397 b the U. S. Public Health Service. It is also a pleasure to express appreciation of the technical aid of Gordon Mestler, and of the cooperation and helpfulness of the subjects and staffs of the institutions in which this work was carried out. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume53, Issue3The Growth, Replacement, and Types of HairMarch 1951Pages 708-728 RelatedInformation

Doctor Means Teacher

Clinical Assistant in Preventive Medicine and Community Health, State University Medical Center at New York City; Director, Health Education Division, Health Insurance Plan of Greater New York New York, N. Y.

Excitability of the mammalian ventricle throughout the cardiac cycle.

ArticleEXCITABILITY OF THE MAMMALIAN VENTRICLE THROUGHOUT THE CARDIAC CYCLEOscar Orias, Chandler McC. Brooks, Eustace E. Suckling, Jerome L. Gilbert, and Arthur A. SiebensOscar OriasFrom the Department of Physiology and Pharmacology, State University of New York, State University Medical Center at New York, Chandler McC. BrooksFrom the Department of Physiology and Pharmacology, State University of New York, State University Medical Center at New York, Eustace E. SucklingFrom the Department of Physiology and Pharmacology, State University of New York, State University Medical Center at New York, Jerome L. GilbertFrom the Department of Physiology and Pharmacology, State University of New York, State University Medical Center at New York, and Arthur A. SiebensFrom the Department of Physiology and Pharmacology, State University of New York, State University Medical Center at New YorkPublished Online:31 Oct 1950https://doi.org/10.1152/ajplegacy.1950.163.2.272MoreSectionsPDF (1 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation Cited ByExamination of stimulation mechanism and strength-interval curve in cardiac tissueVeniamin Y. Sidorov, Marcella C. Woods, Petra Baudenbacher, and Franz Baudenbacher1 December 2005 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 289, No. 6 More from this issue > Volume 163Issue 2October 1950Pages 272-282 Copyright & PermissionsCopyright © 1950 by American Physiological Societyhttps://doi.org/10.1152/ajplegacy.1950.163.2.272PubMed14789994History Received 22 May 1950 Published online 31 October 1950 Published in print 31 October 1950 Metrics

The use of dental acrylic in the preparation of pressure injection casts of the auditory apparatus and paranasal sinuses.

The Anatomical RecordVolume 107, Issue 2 p. 181-186 Article The use of dental acrylic in the preparation of pressure injection casts of the auditory apparatus and paranasal sinuses C. A. Swinyard, C. A. Swinyard Department of Anatomy, Department of Surgery (Otolaryngology), University of Utah Visiting Professor of Anatomy, State University Medical Center, New York, 1949–50.Search for more papers by this authorDavid A. Dolowitz, David A. Dolowitz Department of Anatomy, Department of Surgery (Otolaryngology), University of UtahSearch for more papers by this authorW. Seliger, W. Seliger Department of Anatomy, Department of Surgery (Otolaryngology), University of UtahSearch for more papers by this authorBenjamin B. Kamrin, Benjamin B. Kamrin Department of Anatomy, State University Medical Center, New YorkSearch for more papers by this author C. A. Swinyard, C. A. Swinyard Department of Anatomy, Department of Surgery (Otolaryngology), University of Utah Visiting Professor of Anatomy, State University Medical Center, New York, 1949–50.Search for more papers by this authorDavid A. Dolowitz, David A. Dolowitz Department of Anatomy, Department of Surgery (Otolaryngology), University of UtahSearch for more papers by this authorW. Seliger, W. Seliger Department of Anatomy, Department of Surgery (Otolaryngology), University of UtahSearch for more papers by this authorBenjamin B. Kamrin, Benjamin B. Kamrin Department of Anatomy, State University Medical Center, New YorkSearch for more papers by this author First published: June 1950 https://doi.org/10.1002/ar.1091070208Citations: 5 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Citing Literature Volume107, Issue2June 1950Pages 181-186 RelatedInformation