State Of Hypnosis Research Articles

The Utility of Electroencephalograhy in Guiding General Anesthesia in Children.

Traditional pediatric anesthetic dosing using pharmacokinetic estimates based on age and weight is often imprecise, frequently leading to oversedation. Intraoperative electroencephalography (EEG) allows visualization of the brain's response to anesthetic agents in real time, facilitating precise titration of anesthetic drug doses optimized for the individual child. The goal of EEG-guided anesthesia management is to maintain an optimal state of hypnosis during various stages of the procedure while minimizing hemodynamic instability and other adverse effects of anesthesia. This is especially important in children with less predictable anesthetic requirements, such as children with atypical neurodevelopment, altered levels of consciousness before anesthesia, or those receiving total intravenous anesthesia, neuromuscular blockers, or a combination of anesthetic agents with different mechanisms of actions. Children with limited cardiorespiratory reserves and those undergoing high-risk procedures such as cardiopulmonary bypass also benefit from EEG guidance as they have a narrower therapeutic window for optimal anesthetic dosing. Various processed EEG (pEEG) monitors are available for intraoperative monitoring in children. These monitors display a pEEG index based on the manufacturer's algorithm, purportedly indicating the patient's hypnotic state. Due to differences in developmental neurophysiology and EEG dynamics in children, pEEG indices may not always reliably indicate the hypnotic state, especially in neonates and infants. Learning to interpret nonproprietary EEG parameters including the raw EEG, spectral-edge frequency 95% (SEF95), and density spectral array can prevent overreliance on pEEG indices. This review provides an overview of the advantages of EEG guidance during clinical anesthesia, including potential reduction in anesthetic dosage, prevention of EEG suppression, and reduction in peri-operative adverse events. We describe the use of nonproprietary EEG parameters in guiding anesthesia in children for various clinical end points including laryngoscopy, surgical incision, and maintenance of anesthesia, as well as sedation. We illustrate these principles with various case examples commonly encountered during pediatric anesthesia. Lastly, we discuss strategies to expand intraoperative EEG monitoring in children through education and training programs, as well as advocate for further research to assess clinical outcomes associated with EEG guidance to support its routine use in clinical care.

The use of temporary familys in the preparation of honey bees for the period of hypobiosis

The survival of bee families during hypobiosis is considered the most critical period of their life. It correlates with the number of workers in the nest, that is, the strength of the family. The article presents one of the possible implementations of the potential of bee families to increase their strength before the period of hypobiosis. The proposed technology involves using auxiliary queens in temporary families formed before wintering from their maternal families. The work aimed to study the effectiveness of using this retention technology. For research, two groups of families created by analogs were formed. There were 5 bee families in each group. In the research group, on July 30, one litter was made from each maternal research family. Thus, before the beginning of the period of hypobiosis in experimental families, the number of offspring was obtained from two queens. A characteristic feature of the control group was the presence in the nest of brood obtained from only one queen. The conducted studies indicate that using temporary families during the preparation of bees for the state of hypnosis ensured a significant increase in the strength of bee colonies. As a result of the proposed technology, the strength of the families of the experimental group exceeded the control group by 22.2 % (Р < 0.001). The proposed technology made it possible to completely replace the queens of maternal families with young queens from temporary families.

Investigating functional brain connectivity patterns associated with two hypnotic states.

While there's been clinical success and growing research interest in hypnosis, neurobiological underpinnings induced by hypnosis remain unclear. In this fMRI study (which is part of a larger hypnosis project) with 50 hypnosis-experienced participants, we analyzed neural and physiological responses during two hypnosis states, comparing them to non-hypnotic control conditions and to each other. An unbiased whole-brain analysis (multi-voxel- pattern analysis, MVPA), pinpointed key neural hubs in parieto-occipital-temporal areas, cuneal/precuneal and occipital cortices, lingual gyri, and the occipital pole. Comparing directly both hypnotic states revealed depth-dependent connectivity changes, notably in left superior temporal/supramarginal gyri, cuneus, planum temporale, and lingual gyri. Multi-voxel- pattern analysis (MVPA) based seeds were implemented in a seed-to-voxel analysis unveiling region-specific increases and decreases in functional connectivity patterns. Physiologically, the respiration rate significantly slowed during hypnosis. Summarized, these findings foster fresh insights into hypnosis-induced functional connectivity changes and illuminate further knowledge related with the neurobiology of altered consciousness.

Multivariable discrete MPC with exponential cost function on the automation of the anesthesia process

AbstractThe automation of the delivery of anesthesia infusion rate in a general medical procedure consists of calculating the adequate infusion to regulate a patient's hypnosis state. In this procedure, the patient model has been considered as a Single‐Input Single‐Output system. However, the anesthesiologist introduces other medications, such as analgesics. Therefore, this contribution considers a closed‐loop formulation with two drugs as input control variables: propofol as an anesthetic, and remifentanil as an analgesic. Then, through the mathematical model description, this paper introduces a multiple‐input and multiple‐output (MIMO) model predictive control (MPC) to regulate the deep of hypnosis (DOH) based on the co‐administration of propofol and remifentanil. Since the control variables must be positive during the procedure, the MPC is formulated as a constrained optimization problem. Quadratic programming solves the optimization problem by designing and developing an exponential cost function, which allows the rapid convergence of the MPC optimization algorithm. Finally, the proposed MPC formulation is tested on 12 patients in silico, simulating a 60‐min general surgery. The simulated results verify the performance of the proposed MPC.

Emotional and Synesthetic Test of Hypnosis Induction with Video to relieve the patient from psycho-physical pain

Introduction: Emotions consist of patterns of physiological changes associated with behaviors. The urgency of putting them into action accompanied by emotional sensations that determine behavior and adaptive functions have guided the evolution of our brain. Emotions are also called "response frames" and their neuronal and hormonal control affects moral judgments and social behaviors. Historically, their expressions and recognitions have also been addressed to examine the nature of the sensations that accompany the different emotions [1]. With Multidisciplinary Team ABA, we have done two Tests on Emotions and Synesthesia in Google Tool and Video-EBT-CVS test to induce in a gradual state of hypnosis, patients properly evaluated and in the management of emotions during the Covid and post-pandemic Covid. With the aim of teaching him to recognize and manage emotions with a gradual induction to a pseudo-hypnopompic state to tell us spontaneous story of their memories that, with a meditative music, lets flow and induce first an initial induction of emotions and final recognition of their emotions and others. Clinical study: The dissemination of the Tool Emotional/Synesthesia Battery Test among adults and students at Italian schools is in an early stage, but the partial data received until now, with informed consensus, are only 19 in total and among these only 5 patients have, for health reasons that we specify in detail below, have agreed to perform the preliminary evaluation tests after the EBT/CVS Tool of 90 minutes maximum with the aim to complete the Video induction EBT-CVS with hypnosis and training to management/ treatment emotions for a total time of 1 hour 14 minutes and 40 seconds. Materials and Methods: The sample was taken after a presentation of the research made in collaboration between Private Medical Study and ASST Bergamo West/East with a total of patients who performed Tool Test on Emotions and Synesthesia. The study sample that performed Tool Test remotely with Quilgo, 19 patients performed the Tool in Google, among them 5 also performed the Test of emotions and hypnotic induction in video EBT-CVS program. Only the Video-Emotional induction/synesthetic test with evaluation of the 5 subjects, already known for years, evaluate their neuro-endocrinal and psychological pathology conditions, as described above, with 3 preliminary tests for stable their psycho-intellectual state of departure in sufficient well-being, the respective tests are: Mini Mental state examination (Italian) by MF Folstein, Raven’s standard Matrices, Test to evaluate the Hypnosis Induction Profile or Hypnotic Induction Profile of Spiegel (HIP), the Program with Tool Emotional/ Synesthesia Battery Test (EBT-CVS) and Video Test with Emotion Induction Test/Synesthesia Colombo-Vassallo-Shore or EBT-video CVS. Data analysis: The Google Test Tool EBT-CVS was sent to 44 patients in charge, of which 19 completed and sent within the 90 minutes required as the maximum time of performance. Of the 19 patients who performed it correctly. The data of the 19 tests performed have for age a range of 10-84 years, average 41,78 of years old and an average score of EQ (Emotional Quotient) of 56%, median of 54,02% and a range of 38,98%-91,10% at the EBT or Emotional Battery Test standard in Google Tool. 5 out of 19 patients tested by means of preliminary assessments, inherent our Video-Test of induction of emotions up to hypnosis, induced by the same associated video, and music in the final part of the test of recognition related also to facial expressions own and others. We analyzed the data with Anova-Mongomery 2001 to perform a variance analysis of the Tool Emotional Battery Test attended by 19 patients (Attachment 1-2, tables and graphics). Conclusions: Considering the data collected, I think it is appropriate to reflect on the tests available to us to evaluate the Emotional Quotient (Emotional/Synesthetic) of 19 persons to better understand the conscious and unconscious behavior of our patients. They can do this test in Google Tool and/or Video-Test of the Emotional Battery Test. The aim of EBT-CVS is to induce emotions with 5 senses

Хипноза, вменяемост и наказателна (не)отговорност в българското наказателно право

Since the beginning of time, hypnosis has been largely utilized in the field of medicine and psychiatry. However, recently, hypnosis has found its practical use in a few legal systems proposing a rather intriguing approach in numerous legal aspects. The importance of hypnosis has increased tremendously in the past few years in the subject area of criminal law, putting forward a fairly important question whether a person should be held criminally responsible for committing a crime in a state of hypnosis.

Starea de hipnoză în dreptul penal substanțial al Republicii Moldova

This article presents the analysis of the state of hypnosis from the aspect of criminal law. At the same time, it is approached the hypnosis as the special psychological state and its tangency with the institutions of criminal law. In this study, the state of hypnosis will be analyzed under two aspects. First, we will analyze the issues related to the qualification of the crime committed against a hypnotized person. In this case, hypnosis will be seen as a method of committing the crime. Secondly, we aimed to analyze the legal-criminal classification of the state of hypnosis in case of committing the crime by a hypnotized person. Since the current criminal law lacks a precise classification of the state of hypnosis, under this aspect, there are two different opinions regarding their legal classification: the state of irresponsibility or a form of mental coercion. This issue requires an in-depth approach, for the reason that in practice, such cases are encountered more and more often, and legislative gaps, in this sense, create difficulties.

Intraoperative Awareness during General Anesthesia: Experience in 200 Patients in “185’s Hospital for Emergency Surgeries and Burn”. (An Observational Questionnaire-based Study)

BACKGROUND: General anesthesia (GA) is a complex state of hypnosis, amnesia, and suppression of stress response to stimuli and production of a quiet surgical field. Awareness under GA considered as unexpected and undesirable complication which can be source of pain and torture for many individuals after surgery. 
 AIM: The aim of the study was to evaluate the incidence of intraoperative awareness during general anesthesia in emergency operations using Brice questionnaire. 
 METHODS: Two hundred patients were included and undergone emergency operations under GA at Cairo University’s Hospitals. Intravenous induction then inhalational maintenance of anesthesia with muscle relaxant was commenced, basic vital signs were monitored and kept within normal range. Depth of anesthesia was manipulated and kept adequate intraoperatively according to patient’s clinical status. At the end of surgery, patients were fully reversed and extubated fully awake then transferred to the recovery room, then data were collected. 
 RESULTS: Data analysis showed 110 (55%) men and 90 (45%) women. Two hours postoperatively, one patient (0.5%) reported intraoperative awareness, while 199 patients (99.5%) remembered nothing intraoperatively. 
 CONCLUSION: The incidence of intraoperative awareness in our emergency hospital is relatively fair and clinical evaluation of anesthesia depth is an effective measure to detect and prevents intraoperative awareness.

The Problem of Committing a Crime in a State of Hypnosis

The Problem of Committing a Crime in a State of Hypnosis

Potential Effect of Repetitive Hypnotic Inductions on Subjectively Rated Hypnotizability: A Brief Report

ABSTRACT This study aimed to describe the potential influence of repetitive hypnotic inductions on hypnotizability, presentation of change dynamics, and comparison of 2 types of assessment. Six subjects underwent 5 subsequent hypnotic procedures. Ratings of response to hypnotic suggestions included self ratings by subjects and ratings by observers. The suggestion effects were evaluated using a 0-to-3 rating scale. Five out of 6 subjects were susceptible to suggestions; 1 was not responsive. Increase or stability, not decrease, were observed within subsequent procedures. The hypnotizability ratings increased significantly in subjects’ assessment. However, there was an insignificant change in observers’ assessment. Repetitive hypnotic inductions may modulate subjectively rated hypnotizability. Behavioral responses do not precisely reflect subjective experiences in the state of hypnosis.

Coupled Temporal Fluctuation and Global Signal Synchronization of Spontaneous Brain Activity in Hypnosis for Respiration Control: An fMRI Study

Hypnosis is a psychological technology proved to be effective in respiratory motion control, which is essential to reduce radiation dose during radiotherapy. This study explored the neural mechanisms and cognitive neuroscience of hypnosis for respiration control by functional magnetic resonance imaging with a within-subject design of 15 healthy volunteers in rest state (RS) and hypnosis state (HS). Temporal fluctuation and signal synchronization of brain activity were employed to investigate the altered physiological performance in hypnosis. The altered correlations between temporal fluctuation and signal synchronization were examined within large scale of intrinsic networks which were identified by seed-wise functional connectivity. As a result, hypnosis was observed with increased activity in the right calcarine, bilateral fusiform gyrus and left middle temporal gyrus, and with decreased activity in the left cerebellum posterior lobe (inferior semilunar lobule part). Compared to RS, enhanced positive correlations were observed between temporal fluctuation and signal synchronization in HS. Most importantly, coupled correlation was observed between temporal fluctuation and global signal synchronization within the identified intrinsic networks (R = 0.3843, p > 0.05 in RS; R = 0.6212, p < 0.005 in HS). The findings provide implications for the neural basis of hypnosis for respiratory motion control and suggest the involvement of emotional processing and regulation of perceptual consciousness in hypnosis.

Falsely high patient state index during cardiopulmonary bypass with intra-aortic balloon pumping: a case report

BackgroundThe patient state index (PSI) is a parameter of a four-channel electroencephalography (EEG)-derived variable used to assess the depth of anesthesia. A PSI value of 25–50 indicates adequate state of hypnosis, and a value of 100 indicates a fully awake state. Due to reduced interference from electronic devices like electrocautery, falsely high intraoperative PSI values are rarely reported. However, this case report cautions about falsely high PSI during cardiopulmonary bypass (CPB) with intra-aortic balloon pumping (IABP).Case presentationA 68-year-old man was scheduled for coronary artery bypass graft surgery with IABP. General anesthesia was maintained using sevoflurane. Initial PSI was between 30 and 50 before CPB. Propofol was administered during CPB, and IABP provided pulsatile flow. IABP was stopped soon after the initiation of CPB, and the ascending aorta was partially clamped to anastomose the saphenous vein graft to the ascending aorta. The PSI value decreased drastically, but with resumption of IABP, the value increased to approximately 80, despite increasing the dose of anesthetics. Meanwhile, the EEG waveform was nearly flat. After discontinuing CPB, the PSI value returned to being extremely low. There was no evidence of intraoperative awareness or instrument trouble.After reviewing the anesthesia record, the high PSI value was almost consistent with ongoing IABP during CPB. We suspect that the oscillation noise created by IABP during CPB erroneously influences the PSI algorithm, resulting in a falsely high PSI.ConclusionsAnesthesiologists should note that adherence to pEEG-derived values without discretion may cause errors when monitoring the depth of anesthesia.

Hypnotic State Modulates Sensorimotor Beta Rhythms During Real Movement and Motor Imagery.

Hypnosis techniques are currently used in the medical field and directly influences the patient's state of relaxation, perception of the body, and its visual imagination. There is evidence to suggest that a hypnotic state may help patients to better achieve tasks of motor imagination, which is central in the rehabilitation protocols after a stroke. However, the hypnosis techniques could also alter activity in the motor cortex. To the best of our knowledge, the impact of hypnosis on the EEG signal during a movement or an imagined movement is poorly investigated. In particular, how event-related desynchronization (ERD) and event-related synchronization (ERS) patterns would be modulated for different motor tasks may provide a better understanding of the potential benefits of hypnosis for stroke rehabilitation. To investigate this purpose, we recorded EEG signals from 23 healthy volunteers who performed real movements and motor imageries in a closed eye condition. Our results suggest that the state of hypnosis changes the sensorimotor beta rhythm during the ERD phase but maintains the ERS phase in the mu and beta frequency band, suggesting a different activation of the motor cortex in a hypnotized state.

Investigation on the Neural Mechanism of Hypnosis-Based Respiratory Control Using Functional MRI.

Respiratory control is essential for treatment effect of radiotherapy due to the high dose, especially for thoracic-abdomen tumor, such as lung and liver tumors. As a noninvasive and comfortable way of respiratory control, hypnosis has been proven effective as a psychological technology in clinical therapy. In this study, the neural control mechanism of hypnosis for respiration was investigated by using functional magnetic resonance imaging (fMRI). Altered spontaneous brain activity as well as neural correlation of respiratory motion was detected for eight healthy subjects in normal state (NS) and hypnosis state (HS) guided by a hypnotist. Reduced respiratory amplitude was observed in HS (mean ± SD: 14.23 ± 3.40 mm in NS, 12.79 ± 2.49 mm in HS, p=0.0350), with mean amplitude deduction of 9.2%. Interstate difference of neural activity showed activations in the visual cortex and cerebellum, while deactivations in the prefrontal cortex and precuneus/posterior cingulate cortex (PCu/PCC) in HS. Within these regions, negative correlations of neural activity and respiratory motion were observed in visual cortex in HS. Moreover, in HS, voxel-wise neural correlations of respiratory amplitude demonstrated positive correlations in cerebellum anterior lobe and insula, while negative correlations were shown in the prefrontal cortex and sensorimotor area. These findings reveal the involvement of cognitive, executive control, and sensorimotor processing in the control mechanisms of hypnosis for respiration, and shed new light on hypnosis performance in interaction of psychology, physiology, and cognitive neuroscience.

Hypnosis is More Effective than Clinical Interviews

To determine whether hypnosis is more effective than conventional interviewing to find traumatic life events in patients with fibromyalgia, we carried out a within-subject experimental design with complete intragroup counterbalancing. Thirty-two women under care in a public primary care center gave 2 identical interviews, with an interval of 3 months, in which the occurrence of traumatic life events was explored, once in a state of wakefulness and once in a state of hypnosis. The state of consciousness was evaluated using 3 measures: bispectral index, skin conductance level, and pain intensity. In the hypnotic state, the patients expressed 9.8 times more traumatic life events than in the waking state, a statistically significant difference with a large effect size.

Broadband electroencephalographic parameters in healthy young subjects during hypnosis state

Broadband electroencephalographic parameters in healthy young subjects during hypnosis state

SU-F-J-139: Amplitude of Low Frequency Fluctuation(ALFF) and Regional Homogeneity (ReHo) Study of the Respiration Motion Control Byhypnosis

Purpose: Respiration control by hypnosis is a method in reducing the detriment to the healthy organs or organizations for patients during radiotherapy, especially for lung and abdomen cancer (Fig.1). It's hypothesized that there exists alterations neurological brain activity during the hypnosis state of respiratory motion control in comparison with resting state. Methods: Thirteen healthy volunteers were organized to participate in a hypnosis experiment that consisted of two sectional scans of functional magnetic resonance imaging (fMRI), rest state condition (RSC) scanning and hypnosis state condition (HSC) scanning. In addition, the coronal section of the lung was scanned during both conditions. During the hypnosis scan, the volunteers were under the hypnotists’ guidance to keep peace and stable respiration. To evaluate the altered physiological performance of hypnosis in the respiratory control, three conventional indicators ALFF/fALFF (0.01–0.08Hz) and ReHo, were applied to identify the difference. Results: Compared with RSC, HSC showed significant (p<0.05) higher ReHo in superior temporal gyrus, middle temporal gyrus, frontal lobe, middle occipital gyrus, parietal lobe, cerebellum anterior Lobe and lingual gyrus, and left brainstem (Fig.2). While significant lower ReHo in middle frontal gyrus, superior frontal gyrus, inferior semi-lunar lobule, sub-lobar and limbic lobe (Fig.2). As for the ALFF results, significant higher value of HSC was observed in superior temporal gyrus, middle temporal gyrus, middle occipital gyrus, middle occipital gyrus, cerebellum anterior lobe, lingual gyrus, sub-lobar, limbic lobe, and lower in cerebellum posterior lobe, inferior semi-lunar lobule, inferior parietal lobule right middle frontal gyrus, cerebellar tonsil (Fig.3). The results of fALFF were similar to ALFF (Fig.4). The above results demonstrated that most significant regions of brain were uniform between ReHo and ALFF/fALFF. Conclusion: Hypnosis is a new psychological and helpful technology for respiration control. This study provides new insights of neurological brain activity during hypnosis of respiration control. This work is supported by grants from Guangdong Innovative Research Team Program of China (Grant No. 2011S013), National 863 Programs of China (Grant Nos. 2012AA02A604 and 2015AA043203), the National High-tech R&D Program for Young Scientists by the Ministry of Science and Technology of China (Grant No. 2015AA020917)

Hipnose, imobilidade tônica e eletroencefalograma

OBJETIVO: Apresentar uma revisão sobre as características da atividade elétrica cerebral que acompanha a hipnose animal, estado induzido em laboratório em mamíferos por manipulações experimentais, bem como sobre as alterações encontradas no EEG durante o estado de hipnose, visando à discussão dos resultados encontrados na busca de evidências dos fundamentos filogenéticos que possam conduzir ao entendimento dos rudimentos neurais da hipnose humana. MÉTODO: Livros e bases eletrônicas de dados foram consultados. Critério de inclusão: artigos originais publicados entre 1966-2012. Critério de exclusão: artigos que se afastavam da visão eletroneurofisiológica da hipnose. RESULTADOS: Foram encontradas 662 referências, tendo sido selecionados os artigos e livros referenciados. Além desses artigos, foi incluído no estudo o artigo de Hoagland, publicado em 1928, que é um clássico na área de imobilidade tônica em vertebrados. CONCLUSÕES: O estado de hipnose humano resulta de processamentos em inúmeros circuitos paralelos distribuídos em uma complexa rede neuronal, envolvendo, dessa forma, uma ampla área do encéfalo. Na trajetória evolutiva, a grande ampliação dos recursos corticais pode ter tornado as respostas de imobilidade tônica passíveis de modulação consciente, respostas essas ainda presentes nos humanos e que se manifestam involuntariamente em situações de grande ameaça. Vários estudos têm evidenciado mecanismos neurofisiológicos capazes de reforçar a visão da hipnose não só como um eficiente recurso para procedimentos médicos e odontológicos, funcionando como auxiliar na analgesia e sedação, mas também como excelente ferramenta psicoterapêutica.

SU‐E‐J‐144: Control of Respiratory Motion by Hypnosis Intervention During Radiotherapy of Lung Cancer

Purpose: To effectively control respiratory motion during radiotherapy of lung cancer without any side effects. Methods: A novel motion control scheme, hypnosis, has been introduced in lung cancer treatment. As we know, the uncertain position of lung tumor compromises the treatment effect. However, during hypnosis the respiration becomes uniform and stability compared to normal respiration. Therefore, hypnosis can be a helpful technique for respiratory control. Six volunteers are selected with a wide range of distribution of height, weight, and vital capacity. A set of experiments have been conducted for each volunteer, which is guided by a professional hypnotist. The amplitude of respiration has been recorded in the normal state and hypnosis state, respectively. Statistics approaches are used to analysis the data after experiments. All the experiments are repeated twice in the same condition. Results: The mean and root‐mean‐square (RMS) of the breathing amplitude are calculated for each experiment. The stability of the peaks and the similarity of the adjacent wave are also analyzed. The mean and the RMS of the amplitude are 16.2mm and 8.6mm during hypnosis state, while they are 37.4mm and 23.9mm during normal state. It can be seen that the mean and the RMS during hypnosis state are 56.6% and 64.2% smaller than during normal state, respectively. Moreover, the passing ratio of γ index between one of the 13 adjacent cycles and the others during hypnosis state is 16.4% higher than during normal state. Conclusion: The hypnosis intervention can be an alternative way for respiratory control, which can effectively reduce the respiratory amplitude and increase the stability of respiratory cycle. It will find useful application in image guided radiotherapy. This work is supported in part by grants from National Natural Science Foundation of China (NSFC: 81171402), NSFC Joint Research Fund for Overseas Research Chinese, Hong Kong and Macao Young Scholars (30928030), National Basic Research Program 973 (2010CB732606) from Ministry of Science and Technology of China, and Guangdong Innovative Research Team Program (No. 2011S013) of China.

Fractal dimension of electroencephalogram for assessment of hypnosis state of patient during anaesthesia

Depth of Anaesthesia (DoA) measurement and control is a demanding task that must be done to avoid intraoperative awareness and explicit recall of pain during surgery. Conventional methods of assessing DoA involve monitoring of physiological parameters, which are not found reliable, as patient awareness during surgery with anaesthetic agents has been reported. Electroencephalogram (EEG) is found to be a reliable means to determine the real anaesthetic state of a patient during surgery. Balanced anaesthesia is the fusion of four different components: hypnosis, analgesia, amnesia and neuromuscular blockade. The accurate control of anaesthesia is possible only with the accurate assessment of the different components of anaesthesia. The major component of balanced anaesthesia is hypnosis, which gives the level of unconsciousness of the patient during surgery. In the present study, efforts were made to calculate and validate an EEG-based parameter which is able to predict the awake and anaesthetic sleep state of the patient. In the present study, the EEG of 60 patients were recorded during normal awake state and while under anaesthesia. Analysis of the EEG signals was performed by non-linear quantifiers. Higuchi’s Fractal Dimension (HFD) has been calculated for this recorded EEG waveform for all patients in both states. It was found that HFD is able to predict the awake/sleep state of the patient quite accurately. Validation of the study was done by monitoring BIS in parallel and concluded that the HFD of the EEG goes down as the patient moves into deep hypnosis state.