Introduction. The coronavirus disease (COVID-19) recognized as a pandemic caused by the rapid spread of the SARS-CoV-2 coronavirus has become a serious challenge for the health care system around the world. Consequences of psychological health during recovery from COVID-19 can contribute to social alienation, social isolation, and economic losses. In particular, it remains to be investigated how the reproductive system can be directly or indirectly affected by SARS-CoV-2, in the long-term, precisely against the background of psycho-emotional changes. Aim. To study the psycho-emotional state of women and the impact on the reproductive system due to the impact of SARS-CoV-2. Materials and methods. In order to determine the impact of changes in the psycho-emotional state after suffering from the COVID-19 disease on the reproductive function of women with infertility, we included 80 patients who applied to the Carpathian Center for Human Reproduction in Ivano-Frankivsk in the period 2020–2022 for infertility treatment in a comprehensive examination, aged 18–40. Results. Vegetative dysfunction syndrome (VD), which was previously called vegetovascular dystonia (VDD), is attracting the attention of researchers again, in particular in association with "long-Covid-19", an increase in stressogenic loads. Currently, in world medicine, the term somatoform autonomic dysfunction is used, which most often refers to symptoms that are a consequence of another disease. Personal psycho-emotional characteristics of patients play a certain role in the occurrence and course of diseases, especially psychosomatic ones, which include the long-COVID-19 syndrome. A strong correlation of the severity of SVD with three main scales of the FPI personality test was established: with neuroticism (the strongest direct relationship, ρ = 0.72), depression (strong direct relationship, ρ = 0.64) and equanimity (strong inverse relationship, ρ = -0.61). Thus, the vast majority of women with long-Covid-19 were in an anxious state (91.2% vs. 30.0% of women in the control group, p<0.05), 22.5% had an anxiety level of 11 or higher and corresponded to clinically expressed, only 5.5% patients with clinically expressed anxiety were found in the group without COVID-19 (p<0.05). Clinically expressed depression in the main group was diagnosed 5 times more often than in the control group (13.8% vs. 2.5%, respectively, p<0.05). Conclusions. Disturbance of the psycho-emotional state in women with impaired fertility of reproductive age after suffering from Covid-19 has an impact on the effectiveness of infertility treatment. Understanding the mechanisms of the impact of the SARS-CoV-2 virus on the psycho-emotional state of women with infertility will contribute to the search for ways to prevent reproductive losses and pregnancy complications in women who have experienced COVID-19.
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