CO emission has been widely used as a tracer of molecular gas mass. However, it is a long-standing issue to accurately constrain the CO-to-H2 conversion factor (α CO) that converts CO luminosity to molecular gas mass, especially in starburst galaxies. We present the first resolved α CO modeling results with multiple Atacama Large Millimeter/submillimeter Array CO and 13CO transition observations at both giant molecular cloud (GMC) scale at 150 pc and kiloparsec scale for one of the closest starburst mergers, the Antennae. By combining our CO modeling results and measurements of 350 GHz dust continuum, we find that most GMCs in the Antennae have α CO values approximately four times smaller than the commonly adopted Milky Way value (4.3). We find that α CO at GMC scales shows a strong dependence on CO intensity, 13CO/CO ratio, and GMC velocity dispersion, which is consistent with various theoretical and simulation predictions. Specifically, we suggest that the 13CO/CO line ratio and the velocity dispersion can be used to infer α CO in starburst regions. By applying our modeled α CO in GMC analyses, we find that GMCs in the Antennae are less gravitationally bound than in normal spiral galaxies, which is more consistent with what is predicted by merger simulations. At kiloparsec scale, we find that our modeled α CO values are smaller than the modeled α CO at GMC scale by 40%, which can be due to inclusion of a diffuse gas component with lower α CO values. We find a similar correlation of α CO and CO intensity at kiloparsec scales to that at GMC scales.