In this article, the extraordinary life of the astronomer Dorothea Klumpke (1861–1942) is described in detail for the first time, focussing on the four phases of her career, in which she researched various astronomical questions both as an amateur and as an employee of an observatory and as one half of a couple in science. For this reason, Klumpke's biography provides insights into the cornucopia of research approaches in astronomy at the time, in which professional and amateur astronomers explored the heavens in observatories, on field trips to exotic countries, in their own backyards, or aboard hot air balloons, using telescopes, gazing through the lenses of cameras and spectroscopes, or based on mathematical reasoning. By comparing her life to biographies of other contemporary women, including Klumpke's sisters, among them the famous neurologist Augusta Klumpke-Déjerine, the criteria that women had to fulfill in order to pursue an academic career in the long nineteenth century will be discussed at the same time. In this, particular attention will be paid to factors over which women themselves had no influence, also to show that before the middle of the twentieth century, many stars had to align in order to have such an unusual career as Dorothea Klumpke.