The Open-hole compressive (OHC) strength of a fiber reinforced laminate is one of the most critical allowables for design of aerostructures. In this paper, results for predicting the OHC strength using the semi-discrete damage modeling framework are presented. The predictions are seen to capture experimentally observed failure mechanisms and measured failure loads. The constitutive model includes local axial compressive failure (and subsequent load bearing at a reduced plateau stress) while maintaining numerical robustness. Standard stacking sequences (quasi-isotropic, “hard” and “soft”) have been analyzed and compared to publicly available databases. Additionally, the model is challenged to predict delamination-dominated failure due to ply-scaling. Overall, the model is able to capture relevant failure mechanisms, while the ultimate loads are predicted with good accuracy. Therefore, this framework can be used with confidence in predicting OHC strengths of laminates.