Standard Concepts Research Articles

Accuracy enhancement of metabolic index-based blood glucose estimation with a screening process for low-quality data.

Many researchers have proposed various non-invasive glucose monitoring (NIGM) approaches using wearable or portable devices. However, due to the limited capacity of detectors for such compact devices and the movement of the body during measurement, the precision of the acquired data frequently diminishes, which can cause problems during actual use in daily life. In addition, intensive smoothing is often used in post-processing to mitigate the effects of erroneous values. However, this requires a considerable amount of data and results in a delay in the response to the actual blood glucose level (BGL). Instead of just applying data smoothing in the post-process of the data acquisition, we propose an active low-quality data screening method in the pre-process. In the proposal phase of the screening process, we employ an analytical approach to examine and formulate factors that might affect the BGL estimation accuracy. A signal quality index inspired by the standard deviation concept is introduced to detect visually apparent noise on signals. Furthermore, the total estimation error in the metabolic index (MI) is calculated based on potential perturbations defined by the signal-to-noise ratio (SNR) and the uncertainty due to discrete sampling. Thereafter, the acquired data were screened by these quality indices. By applying the proposed data screening process to the data obtained from a commercially available smartwatch device in the pre-process, the estimation accuracy of the MI-based BGL was improved significantly. Adopting the proposed screen process improves BGL estimation accuracy in the smartwatch-based prototype. Applying the proposed screen process will facilitate the integration of wearable and continuous BGL monitoring into size- and SNR-limited devices such as smartwatches and smart rings.

Economic Analysis of kharif Vegetable Cultivation in Palghar District of Maharashtra State, India

The study was undertaken with the specific objective to workout costs, returns and profitability in vegetables production of a sample of 90 vegetable cultivators of three tahsil of Palghar viz. Vasai, Palghar and Dahanu during 2023.Simple statistical tools such as arithmetic mean, average, percentage, ratios and frequency distribution were worked out. For working out cost of production, standard cost concepts viz., cost-A1, cost-A2 cost-B1, cost-B2, cost-C1, cost-C2, cost-C3 were used. The cost of cultivation of kharif brinjal, okra, cowpea, tomato, cucumber, bottle gourd and bitter gourd was Rs.130880, Rs.172317, Rs.74835, Rs.145956, Rs.166815, Rs.220387and Rs.209361for respectively. The gross returns obtained from kharif brinjal, okra, cowpea, tomato, cucumber, bottle gourd and bitter gourd was Rs.141240, Rs.271560, Rs.77532, Rs.280280, Rs.227850, Rs.337506 and Rs.345345 respectively. The benefit-cost ratio for kharif brinjal, okra, cowpea, tomato, cucumber, bottle gourd and bitter gourd was 1.08, 1.58, 1.04, 1.92, 1.37, 1.53 and 1.65 respectively. The promising benefit-cost ratios indicate a favorable environment for vegetable farming in Palghar, suggesting that with strategic crop selection and enhanced agricultural practices, the future of vegetable cultivation in the region is likely to be both profitable and sustainable.

Coconut Cultivation in South Konkan Region of Maharashtra: A Study of Economic Well-being

A study on economic well-being was conducted in the South Konkan region with 144 sample coconut growers. The objective behind this study was to estimate cost, returns, profitability and financial feasibility of coconut production. The study was conducted by means of adoption index, standard cost concept and financial feasibility measures. Numerous technologies have been suggested by the Regional Coconut Research Station, Bhatye, Dr. Balasaheb Sawant Konkan Krishi Vidyapeeth, to enhance the quality of coconut production after extensive research in the field. The extent up to which the technologies were adopted was 45.51 per cent overall. This suggested a wide scope for raising the adoption rate. The economic analysis of coconut production in the research area showed that growing coconuts through the use of recommended technology was profitable. It was observed that farmers are saving more on each expense due to the high adoption rate. In coconut cultivation, the net present value was positive (Rs. 230665). The B: C ratio is greater than one (1.41) and the internal rate of return (IRR) is higher than the going interest rate (23.01%). This demonstrated the economic viability of coconut production. The policy should be made to spread the recommendations to the farmers and training should be provided to farmers on larger scale for more profitable production.

Legal Terminology: The Meaning of Unification and the Relationship Between the Concept of Harmonization

The scientific article is devoted to the author's discussion of regulatory terminology: the meaning of unification and interrelation of the concepts of "harmonization" in a scientific context. The article also substantiates the need to unify scientific approaches to defining the concepts of harmonization, unification and standardization. The conclusion is made about the key importance of these processes in the context of the integration of the national legal system and international legal norms. The features of the processes of harmonization and unification at the stages of legal education and law enforcement are determined. Currently, there is no unified terminological apparatus in the field of improving terminology in general, including regulatory and legal ones. In the scientific literature, various terms are used to denote terms, including those related to the need to streamline regulatory legal acts, such as: unification, standardization, harmonization, etc.

Controller switching with the anti-bump adapter

Switching on a new or retuned controller while keeping the control loop engaged tends to generate transient “bumps” in the commands and plant outputs. For a linear time-invariant (LTI) controller in state–space form, these bumps can be mitigated or even suppressed by resetting the controller state to an appropriate non-zero value adapted to the pre-switching trajectories of the feedback loop signals. This paper proposes a simple way to compute this adapted controller state by minimizing the difference between the commands actually applied immediately before switching and the virtual command trajectory which the new controller would have generated if it had been activated in parallel. This adapted state can be recursively computed as the output of an LTI system in standard state–space form, the anti-bump adapter. Computing the anti-bump adapter involves only standard matrix algebra and control concepts (e.g., observability and controllability matrices/Gramians). Calculations are very simple and can be translated into compact computer code. This bump suppression procedure is applicable to any discrete-time or continuous-time LTI SISO or MIMO controller, without any assumption on or knowledge of either the previously active controller or the plant. Illustrative applications to continuous-time and discrete-time switching problems and a Matlab® code for computing the anti-bump adapter are presented.

Importance of Electrostatic Effects for Interpretation of X‐ray Photoemission Spectra of Self‐Assembled Monolayers

AbstractThis paper reviews the relevant work regarding electrostatic effects in X‐ray photoemission from self‐assembled monolayers (SAMs) which are application‐relevant ultrathin molecular films, coupled over a suitable anchoring group to the substrate. Whereas, in most cases, the standard concept of chemical shift is fully sufficient to describe X‐ray photoelectron spectra of these systems, consideration of electrostatic effects is frequently necessary for their proper interpretation. Due to the insulator character of the SAM matrix, decoupled electronically from the substrate, the introduction of a dipolar ´sheet´ at the SAM‐substrate interface or within this matrix creates a potential discontinuity shifting the energy levels above the ´sheet´ with respect to those below it. This shift is reflected then in the matrix‐related spectra, resulting in shifts and splitting of the characteristic photoemission peaks. Several representative examples in this context are provided and discussed in detail. These examples and other relevant literature data underline the importance of electrostatic effects in photoemission and suggest that they should be considered on the equal footing as the chemical shift ones.

Assessing the utility of large language models for phenotype-driven gene prioritization in the diagnosis of rare genetic disease

Phenotype-driven gene prioritization is fundamental to diagnosing rare genetic disorders. While traditional approaches rely on curated knowledge graphs with phenotype-gene relations, recent advancements in large language models (LLMs) promise a streamlined text-to-gene solution. In this study, we evaluated five LLMs, including two generative pre-trained transformers (GPT) series and three Llama2 series, assessing their performance across task completeness, gene prediction accuracy, and adherence to required output structures. We conducted experiments, exploring various combinations of models, prompts, phenotypic input types, and task difficulty levels. Our findings revealed that the best-performed LLM, GPT-4, achieved an average accuracy of 17.0% in identifying diagnosed genes within the top 50 predictions, which still falls behind traditional tools. However, accuracy increased with the model size. Consistent results were observed over time, as shown in the dataset curated after 2023. Advanced techniques such as retrieval-augmented generation (RAG) and few-shot learning did not improve the accuracy. Sophisticated prompts were more likely to enhance task completeness, especially in smaller models. Conversely, complicated prompts tended to decrease output structure compliance rate. LLMs also achieved better-than-random prediction accuracy with free-text input, though performance was slightly lower than with standardized concept input. Bias analysis showed that highly cited genes, such as BRCA1, TP53, and PTEN, are more likely to be predicted. Our study provides valuable insights into integrating LLMs with genomic analysis, contributing to the ongoing discussion on their utilization in clinical workflows.

Environmental Damage Prevention through Digital Transformation on Tourism Industry in Bali, Indonesia

To control environmental damage due to over-booking homestays in tourist villages in Bali, a digital platform was built. In this study, a platform called dewiku was developed to evaluate and integrate all stakeholders that have a shared responsibility for environmental conservation. dewiku was developed using the concept of E-Commerce involving the standard concept of green tourism villages to prevent environmental damage in Bali. dewiku involved four actors: the Government, Developers, Partners, or Business Actors in homestays and green tourist attractions and tourists. The four actors have a major role in preventing environmental damage due to the comprehensive integrated supervision of the dewiku platform. Partners who will register dewiku E-commerce platform must meet the Green Village (GreenV) standards set and supervised by the Bali Tourism Office. GreenV's questionnaire was taken from previous research and shared with the tourism business owners in Bali, which the village government monitored. This platform was tested using the System Usability Scale (SUS), with respondents at least 15 years interested in traveling to Bali. Survey questions were distributed online through social media, Facebook, and WhatsApp, and the questions were shared using the provided link. This study used a quantitative survey approach. The result indicated an average test of 62, meaning the platform was good enough to be applied in the field. The test results showed that the SUS platform test was quite effective and expected to introduce the dewiku platform to the wider community who will travel to Bali.

How to Accurately Detect Renal Replacement Therapy Weaning in Intensive Care: Data Quality and Standardization Considerations for the OMOP Common Data Model.

This study assesses the effectiveness of the Observational Medical Outcomes Partnership common data model (OMOP CDM) in standardising Continuous Renal Replacement Therapy (CRRT) data from intensive care units (ICU) of two French university hospitals. Our objective was to extract and standardise data from various sources, enabling the development of predictive models for CRRT weaning that are agnostic to the data's origin. Data for 1,696 ICU stays from the two data sources were extracted, transformed, and loaded into the OMOP format after semantic alignment of 46 CRRT standard concepts. Although the OMOP CDM demonstrated potential in harmonising CRRT data, we encountered challenges related to data variability and the lack of standard concepts. Despite these challenges, our study supports the promise of the OMOP CDM for ICU data standardization, suggesting that further refinement and adaptation could significantly improve clinical decision making and patient outcomes in critical care settings.

HL7 FHIR in Health Research: A FHIR Specification for Metadata in Clinical, Epidemiological, and Public Health Studies.

This work presents the Fast Healthcare Interoperability Resources (FHIR®) specification of the NFDI4Health Metadata schema based on FHIR Version 4: We created 16 profiles to facilitate the integration of clinical, epidemiological, and public health study data. Despite challenges arising from the extensive MDS as well as missing concepts in semantic standards, it marks a significant advance in applying information technology standards to health research.

Public Responsibility Towards Indonesian Idol's Music Talent: An Adorno Perspective

The music expressed around us, particularly in the realm of competitive music, faces significant challenges in maintaining subjectivity and objectivity to ensure a fair competition process. This study examines reality shows like Indonesian Idol, questioning whether they are pure competitions or avenues for capitalist profit. From Adorno's perspective, this issue is linked to societal impact, highlighting three main problems: standardization, commodification, and massification. Using both quantitative and qualitative methods, this research involved 67 respondents who completed questionnaires to explore the systematic flaws in Indonesian Idol’s competition structure. The study aimed to analyse how these flaws align with Adorno's concepts of standardization, commodification, and massification, and their influence on public perception and critical thinking. The quantitative aspect involved statistical analysis of questionnaire responses, while the qualitative approach included in-depth interviews to gain insights into participants' views on transparency and fairness in the competition. The findings indicate that Indonesian Idol’s competition system is heavily influenced by industry standards that prioritize commercial success over artistic integrity. This results in a homogenized musical output that caters to mass appeal, undermining the authenticity of the competition. Additionally, the commodification of contestants transforms them into marketable products rather than genuine artists, while the massification process dilutes the cultural significance of the musical content presented. The study concludes that for reality shows to serve as responsible public entertainment, they must instil transparency and fairness in their competition processes. Implementing these principles can foster a more critical and discerning audience, ensuring that such shows contribute positively to the cultural landscape rather than merely serving commercial interests

Harmonizing Norwegian registries onto OMOP common data model: Mapping challenges and opportunities for pregnancy and COVID-19 research

ObjectiveNorwegian health registries covering entire population are used for administration, research, and emergency preparedness. We harmonized these data onto the Observational Medical Outcomes Partnership common data model (OMOP CDM) and enrich real-world data in OMOP format with COVID-19 related data. MethodsData from six registries (2018–2021) covering birth registrations, selected primary and secondary care events, vaccinations, and communicable disease notifications were mapped onto the OMOP CDM v5.3. An Extract-Transform-Load (ETL) pipeline was developed on simulated data using data characterization documents and scanning tools. We ran dashboard quality checks, cohort generations, investigated differences between source and mapped data, and refined the ETL accordingly. ResultsWe mapped 1.5 billion rows of data of 5,673,845 individuals. Among these, there were 804,277 pregnancies, 483,585 mothers together with 792,477 children, and 472,948 fathers. We identified 382,516 positive tests for COVID-19 in 380,794 patients. These figures are consistent with results from source data. In addition to 11 million source codes mapped automatically, we mapped 237 non-standard codes to standard concepts and introduced 38 custom concepts to accommodate pregnancy-related terminologies that were not supported by OMOP CDM vocabularies. A total of 3,700/3,705 (99.8%) checks passed. The 5 failed checks could be explained by the nature of the data and only represent a small number of records. Discussion and conclusionNorwegian registry data were successfully harmonized onto OMOP CDM with high level of concordance and provides valuable source for federated COVID-19 related research. Our mapping experience is highly valuable for data partners with Nordic health registries.

Factors Related to The Active Aging Concept and Functional Capacity in The Thai Elderly

Objective: This study aimed to examine factors related to the active aging concept and functional capacity in elderly Thais. Material and Methods: The study population was 253 elderly people aged 60 years and over. The tools used for data collection were a standardized active aging concept questionnaire, which had an index of item objective congruence (IOC) of 0.938. The descriptive statistics used percentages, means, and standard deviation, and inferential statistics were calculated through stepwise multivariate linear regression to investigate the factors that impacted the functional abilities associated with active aging. Results: The results showed that functional capacity had a low to moderately positive correlated significance with mean a correlation with the willingness of the elderly people to follow or practice the active aging concept, the health service system and environmental and lifestyle factors had a moderately positive effect; and behavior had a low positive correlated significance with practice the active aging. The regression coefficients of the health service system factors and environmental and lifestyle factors had a positive relationship to the practice of active aging. Conclusion: In summary, the health service system and environmental and lifestyle factors had a positive relationship with the practice of active aging. Relevant agencies can use this as basic information for planning and promoting the development of increased functional capacity for the elderly.

Need for Data Standardization and Infrastructure of Research Data Management to Promote Using Real-world Data

Real-world data (RWD) have been increasingly used for regulatory decision-making and as a control group for new drug approval applications. RWD is also helpful in understanding information such as risk factors (e.g., pre-existing medical conditions, personal protective equipment, travel, contacts, smoking, and exposure to animals) and vaccination status for the coronavirus disease 2019 (COVID-19). The methodology of utilizing RWD is inconsistent across healthcare institutions. However, there are possible solutions to standardize RWD for clinical data use, which include the use of Clinical Data Interchange Standards Consortium (CDISC) standards, tools, and concepts. This study examines the availability of CDISC and other international standards for the utilization of RWD with concrete examples and presents the potential platform for implementation. We consider the solution currently available to temporarily convert clinical data-warehouse (DWH) data into the Fast Healthcare Interoperability Resources (FHIR) format to comply with the CDISC standard. This approach would allow for converting institution-level standards to national standards as an interim solution until FHIR is supported, mapping national standards to international standards. We believe that the ideal research environment is a data platform that complies with national and international regulations related to RWD applications. Within such a platform, users can share data freely, rather than rely on a specific facility or vendor. Data platform developments are progressing in Japan and globally. In Japan, initiatives to use research data on research data platforms are being conducted. We are experimenting with implementing tools and knowledge shared by CDISC.

Is Prompt Hyperbaric Oxygen Adjunctive Therapy Able to Reduce Mortality and Amputation in Management of Necrotizing Soft-Tissue Infection?

Background: Necrotizing soft-tissue infection (NSTI) is a rare and serious disease with high morbidity and mortality. Standard therapeutic concepts have included urgent surgical intervention, broad-spectrum antibiotic treatment, and intensive care. Hyperbaric oxygen therapy (HBOT) is used as adjuvant therapy in some centers, but its benefits remain controversial. Methods: A retrospective analysis was conducted in which 98 patients with a clinical diagnosis of NSTI were treated with standard treatments plus HBOT. The clinical outcomes were wound healing, performance status, hospital length, complication rate, recurrence rate, morbidity (amputation rate), and mortality. Primary or secondary outcomes were compared between the time interval of HBOT and the clinical outcomes. Results: The average times from diagnosis of NSTI to initial HBO treatment and from initial surgery to initial HBO treatment were both significantly longer in dead patients than in surviving patients (P = 0.031; P = 0.020). These two time intervals were both significantly longer in amputated patients than in preserved patients (P = 0.031; P = 0.037). Conclusions: Using combined treatment with early surgical debridement combined with HBOT, it is possible to reduce hospital stay, intensive care unit stay, number of debridements, improve complete wound healing rate, and lower amputation and mortality rates among patients with NSTI. The early onset of HBOT soon after diagnosis, especially during critical conditions, is proved to be associated with higher survival and preservation rates.

Logical Consequence (Slight Return)

Abstract In this paper I ask what logical consequence is, and give an answer that is somewhat different from the usual ones. It isn’t clear why anyone would need a new approach to logical consequence, so I begin by explaining the work that I need the answer to do and why the standard conceptions aren’t adequate. Then I articulate a replacement view which is.

The Concept of Beauty, its Importance, Sections, and Standards in Islam

The Concept of Beauty, its Importance, Sections, and Standards in Islam

Postoperative management following osteotomies around the knee: a narrative review.

The present narrative review provides a summary of postoperative therapy modalities and their effectiveness following osteotomies around the knee. The topics that are discussed in the scientific discourse include support of cartilage cell regeneration, pain management, drainage insertion, tourniquet use, pharmacological and mechanical thromboembolism prophylaxis, weight-bearing protocols and bone consolidation. There is evidence for the use of pharmacological thromboembolism prophylaxis and weight-bearing protocols. A standardized postoperative treatment concept following osteotomies around the knee cannot be derived due to lack of evidence for the other topics in current literature.

Standardized Innovative Polygon Trend Analysis for Climate Change Assessment (S-IPTA)

Research and applications on trend analysis have recently been on the agenda and are top priorities in many disciplines due to the effects of climate change. After a thorough evaluation of the literature, it is noted that different hydro-meteorological variables, such as precipitation, temperature, etc., are studied and analyzed individually. This research proposes a new innovative polygon trend analysis application (S-IPTA) using the standardization concept to fill this gap in classical trend applications and comprehensively compare the trends of different variables to temporal and spatial patterns. Firstly, using statistical standardization, S-IPTA adjusts the original data sets and makes them dimensionless. Then, the innovative trend analyses are conducted and interpreted on one single graph (S-IPTA). The S-IPTA methodology is applied to monthly precipitation and temperature time series of Konya Basin in Türkiye at ten meteorological stations between 1959 and 2022. For precipitation, the S-IPTA did not exhibit a consistent polygon across all stations within the study area, while the temperature polygon was more regular, indicating that the temperature mean was generally stable with a positive trend. Also, S-IPTA shows the difference between the average value for each month and the newly proposed long-term average value (0). S-IPTA also provides a basis for a better interpretation of climate change and its effects by providing a common denominator for various trend characteristics, such as trend magnitudes and trend transitions in different hydro-meteorological time series.

Character Education in Korean Military

Purpose: This article is intended as a suggestion for the direction that the military character education system should pursue, which is suitable for changing the values of the young generation to the essential values of the military while respecting democratic values. The existing understanding and approaches to the military character education, which has been limited to solving the problems related to interpersonal relationships and military service adaptation within the group he or she belongs, must now be converted into a consistent system that meets the original purpose of military. The new military culture must respect the individuality of its members while integrating individual capabilities into the goals of the military organization. The changes of military culture should begin with changes in the aim and the methods of character education implemented in the military. Method: In that the concept of a soldier's character itself implies intersubjective universality, we would like to examine this article through Weber's ideal type (Idealtypus), which is a social scientific research methodology concepts, a standard concept established based on intrinsic values and universal standards to recognize the diverse and fluid social and cultural phenomena. Taking some into account the Weber’s assertion, the objective validity of all empirical knowledge is based solely on the fact that a given reality is in a certain sense ordered by subjective categories, this study will be conducted by a qualitative approach with literature analysis and materials review. Ideals are subjectivity, but the causality of those Ideals can be objective. Objectivity is the “intersubjective universality,” which refers to whether one's logical process can be valid or not. Objectivity can only be achieved when a value-neutral attitude is maintained, which Weber calls “value freedom (Werfreiheit).” Results: Despite the fact that the mental attitude based on an individual' value system and the externally manifested behavior are not independent of each other, there has been little interest in the relationship between the character of an individual soldier and his will to fight, to the extent that character and mental power are treated separately in military character education. In order to build a soldier's character with mental combat capabilities, the reason and purpose of the military's existence, or the functional characteristics and attributes of the military, must be reflected in military character education. The fact that, while the behavior pursued by a military organization should be purpose-rational, the desirable behavior required of individual soldiers who are members of the military organization is value-rational behavior must be taken into consideration when constructing a character education system. Conclusion: If the purpose of military character education is presented in line with the legitimate and essential values for which the military must exist, military character education will directly and indirectly contribute to improving military efficiency. For a soldier, his or her character is not simply a way of necessary for the adaptation in his or her barracks life and a kind of good interpersonal relationships in it, but also a moral competency that is demonstrated in the battle or the war he or she may carry out. As Weber defined society as a means/end rationality, military organizations also perform their unique functions and use the most efficient and rational means to achieve their specific end. Just as the means/end rationality destroys old traditions, military character education consistent with military identity can most effectively change military organizations.