Stable Trend Research Articles

Spatial and Temporal Evolution of Regional Energy Efficiency in China and Its Influencing Factors

Finding ways to improve regional energy efficiency is important for the Chinese government to achieve its dual carbon target. This paper aims to explore ways to improve regional energy efficiency by studying the spatial–temporal dynamic evolution of energy efficiency. To scientifically study the evolution trend in regional energy efficiency in China, this study uses convergence analysis, a spatial Gini coefficient decomposition model (no spatial consideration), and a spatial Markov chain model and spatial measurement model (spatial consideration). The results show the following: from 2008 to 2019, the mean value of regional single-factor energy efficiency (RS) showed an obvious trend of continuous increase, while the mean value of regional green total-factor energy efficiency (RT) changed from a trend of continuous decline to a relatively stable trend. The overall Gini coefficient of RS showed a trend of “steady–rising–steady”, and the overall Gini coefficient of RT showed a trend of “steady–small increase–sharp increase–fall”. There was club convergence in the two types of regional energy efficiency, and both of them achieved certain “leapfrog” changes. The factors that had a significant impact on RS include human capital, industrialization, openness, urbanization, financial development, and innovation environment. The significant factors for RT included governance structure, industrialization, openness, policy support, and financial development. The limitation of this paper is that only provincial data were used. In the future, city-level data can be mined and more detailed policy suggestions can be put forward for city-level differences. The research method used in this paper to study regional energy efficiency evolution trends is also applicable to other countries.

Study on the coupling coordination characteristics and influencing factors of ecological environmental civilization and resident public health in China-based on a modified coupling coordination model.

As industrial technologies advance, climate change and environmental pollution increasingly pose threats to human health. This study examines the coupling coordination characteristics between ecological environmental civilization (EEC) and resident public health (RPH) to promote both higher public health standards and enhanced societal sustainability. Utilizing panel data from 31 provinces in China spanning from 2010 to 2022, this paper constructs evaluation indices for EEC and RPH. Initially, the entropy method is employed to determine the development levels of each domain. Subsequently, a modified coupling coordination degree (CCD) model is applied to assess the CCD between EEC and RPH. This research further investigates the spatiotemporal evolution trends of the CCD using methods such as the Dagum Gini coefficient, kernel density estimation (KDE), and Markov chains. Finally, the panel Tobit model is utilized to analyze factors influencing the CCD. Findings reveal that during the study period, both EEC and RPH in China exhibited a stable upward trend, although the overall development level remained relatively low. The CCD showed consistent growth both nationally and across three major regions. Overall inequality in coupling coordination, as measured by Dagum Gini coefficient, has decreased, with the coefficient reducing from 0.0316 in 2010 to 0.0199 in 2022. KDE results indicate a rightward shift in the density curve of the CCD, suggesting a significant reduction in absolute disparities. Panel Tobit regression analysis shows that economic development, urbanization, and education levels significantly and positively influence the CCD on a national scale, with urbanization having the most substantial impact, followed by economic development and education levels.

DIGITALIZING THE PERFORMING ARTS DURING COVID-19 PANDEMIC IN LATVIA: TRANSFORMATIONOR SURVIVAL TACTICS?

The article seeks to answer the question of whether the transformation and acceleration of digital content in performing arts during the COVID-19 pandemic are determined situatively or are a naturally stable trend initiated by the development of ICT. It focuses on the theatre industry in order to understand whether theatre performances in the digital environment and the use of digital elements in performing arts do not create a confrontation with the necessary sense of physical presence.The research data showed that the practices of using digital environment elements and digital technologies in the creation of theatre performances were both 1) a short-term solution, as it allowed staging a play, working with actors remotely, as well as creating products that are available to the audience in conditions of distancing requirements, and 2) gave an acceleration to the spread of digital innovations in the theatre industry in general, which was especially manifested in the works of directors who are open to the search for new experimental forms and the ambition of artistic excellence in theatre art, thus generating a long-term development potential. On the one hand, the sense of presence, including physical presence and simultaneity, is still recognized as the most essential feature of theatre and also a certain measure of quality. On the other hand, it is recognized that the possibilities of digital solutions, including artificial intelligence and other technological resources, may also change and erase the boundaries between the real and digital environments in performing arts as well.

Spatiotemporal controls on organic matter sourcing to minerogenic salt marshes

AbstractSalt marshes are important carbon sinks; however, identification of the drivers of carbon burial rates is challenging because estuaries sit at terrestrial and marine interfaces. Here, we address the questions: what are the sources of organic matter sequestered in minerogenic salt marshes, and how do sources change through time? We characterized down‐core sediment biogeochemistry (C : N, δ13C, δ15N) for the last century in seven Oregon USA high marshes and used a mixing model to elucidate differences in organic matter sources across estuaries and through time. Autochthonous biomass production consistently accounted for only half of overall organic matter accumulation, and the remainder was allochthonous, originating from a combination of estuarine and terrestrial sources. Salt marshes with high sediment loads buried more terrestrial organic matter, whereas those with low loads and substantial subtidal habitat buried more estuarine‐derived organic matter. When assessed through depth/time, stable isotope trends indicated that decomposition is not the primary control. Instead, organic matter became increasingly more terrestrial in recent decades, especially in salt marshes with low fluvial loads. We hypothesize that salt marshes with lower loads took longer to regain lost elevation following coseismic subsidence of the 1700 ce Cascadia earthquake. This result magnifies the role of river floods in sediment and carbon accumulation on the marsh surface. Ultimately, the highest carbon burial rates coincided with highest fractions of terrestrially sourced organic matter, though spatiotemporal complexities obscured any potentially significant trends. While the term “blue” typically excludes terrestrial carbon, minerogenic salt marshes still perform the important ecosystem function of burying organic matter.

Analytical review of the literature on plastic surgery with a research depth of 5 years according to PubMed data

Purpose of the work: to study current areas of research in plastic surgery for 2018–2023. based on determining the frequency and structure of publication topics in the PubMed electronic database (MEDLINE).Material and methods. The literature review was carried out in accordance with the international requirements of PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). The search for literature sources was carried out in the electronic database PubMed (MEDLINE) using combinations of operators OR, AND and keywords: plastic surgery OR aesthetic surgery OR reconstructive surgery OR microsurgery AND plastic surgery OR flap in reconstr surgery. The study period was 5 years, the search was carried out from February 8, 2018 to February 8, 2023.Results. For analysis, we selected 521 articles that fully met the inclusion criteria. Articles on reconstructive surgery predominated – 78%, compared to aesthetic problems – 22%. When evaluating articles according to the anatomical section, it was revealed that 122 articles (23.42%) were devoted to the head and neck section, 109 (20.92%) – to the mammary gland, 104 (19.96%) – to the skin, 40 (7.68%) – to limbs, 33 (6.33%) – to flaps, 26 (4.99%) – to peripheral nerves, 23 (4.41%) – to urogenital pathology, 15 (2.88%) – to lymphatic system, 14 (2.69%) – to body, 10 (1.92%) – to other questions, 8 (1.54%) – to anatomy, 6 (1.15%) – to genetics, 6 (1.15%) – to hair cover, 3 (0.58%) – to microsurgical technique, 2 articles (0.38%) – to stomach. It was noted that urogenital reconstruction remains less popular among plastic surgery articles. The topic of limb replantation is also insufficiently studied.Conclusion. An analysis of publication activity corresponding to the research topic, as well as the inclusion criteria, demonstrated that there is a stable trend towards an increase in the number of publications in the time period 2019–2023, which is due to the relevance and demand for this area of surgical practice.

National trends in the prevalence and recurrence of anaphylaxis across all ages: The role of neighborhood deprivation and comorbidity (2002–2019)

BackgroundUnderstanding the trends of anaphylaxis and risk factors associated with its recurrence is essential for the effective management and prevention of this condition. ObjectiveThis study aimed to analyze the prevalence trends of anaphylaxis and identify risk factors for recurrence, with a focus on the influence of neighborhood deprivation and comorbidities, across all age groups. MethodsWe conducted a retrospective administrative cohort study on anaphylaxis utilizing the National Health Insurance-National Sample Cohort (NHIS-NSC) database in Korea (2002–2019). Anaphylaxis was defined with ICD-10 codes for the diagnosis combined with prescription codes. The Neighborhood Deprivation Index was used to identify the risk of recurrent anaphylaxis. Trends in the annual prevalence and recurrence of anaphylaxis were assessed through joinpoint regression and Cox proportional hazard models. ResultsOut of the 1,137,861 individuals studied, 37,012 (3.25%) cases of anaphylaxis were identified. Among these, 5783 individuals (15.6%) experienced a recurrence, half of them experiencing it within the first year after the initial episode. The highest incidence of anaphylaxis was observed in children and adolescents, followed by middle-aged adults. A rapid increase in anaphylaxis cases was observed from 2002 to 2006 (Annual Percentage Change [APC], 33.2), followed by a more gradual increase until 2013 (APC, 12.8), and a stable trend from 2013 to 2019 (APC, 0.61). Males and adult age groups exhibited an increased risk of recurrence. Living in an area with neighborhood deprivation and the presence of comorbid conditions were associated with increased recurrence risk. ConclusionsThe increasing prevalence of anaphylaxis and its association with certain risk factors calls for targeted intervention. Addressing neighborhood deprivation and comorbid conditions may aid in reducing the recurrence and overall burden of anaphylaxis.

A decade of conservation agriculture in intensive cereal systems: Transitioning to soil resilience and stable yield trends in a climate crisis

Climate change jeopardizes the food security gains achieved in India since the Green Revolution, especially by impacting the productivity of the rice-wheat system in the Indo-Gangetic Plain, a region that serves as the ‘breadbasket’ of South Asia. In this study, we characterized the potential of long-term conservation agriculture (CA) based management practices (i.e., no-tillage, residue retention, and diversified rotations) to stabilize and enhance crop yields in Northwest India. The study consisted of six different production scenarios (Sc) namely Sc I: conventional rice-wheat system; Sc II: partial CA-puddled transplanted rice-zero till wheat-zero till mung bean (TPR-ZTWMb); Sc III: CA-based zero-till direct seeded rice-zero till wheat-zero till mung bean (ZTDSR-ZTWMb); Sc IV: CA-based zero till maize-zero till wheat-zero till mung bean (ZTM-ZTWMb); Sc V: Sc III + subsurface drip irrigation (SSDI); and Sc VI: Sc IV + SSDI. Long-term yield analysis indicated that the CA-based maize-wheat-mung bean system with SSDI (Sc VI) produced approximately 12%, 27% and 35% higher rice equivalent yield (REY), wheat yield and overall system yield, respectively, over to Sc I. Our study examines Wricke's ecovalence index (Wi2) and the sustainability yield index (SYI) to gauge long-term yield stability and sustainability. Consistently higher wheat yields with lower Wi2 and higher SYI were recorded in CA-based scenarios (Sc V: Wi2 = 0.82, SYI = 0.81; Sc VI: Wi2 = 0.85 and SYI = 0.82). CA-based scenarios also demonstrated stable REY over time. The soil physical properties were influenced by CA systems and compared to Sc I, bulk density was −5.89% in Sc V, followed by −3.62% in Sc III and −1.73% in Sc VI. Moreover, CA systems, Sc IV, Sc VI, and Sc V exhibited positive responses by +106%, +99 % and +72%, respectively for water infiltration rates. Overall, soil organic carbon was +83% and +69% with Sc VI and Sc V, respectively than in Sc I. By substantially enhancing soil health and crop productivity, as well as boosting resilience, CA emerges as a promising solution for meeting the increasing food demand in Northwest India and beyond.

Temporal changes in the burden of leukaemia and lymphoma in the Australasia and Oceania regions, 2010–2019: an analysis of the Global Burden of Disease Study 2019

ObjectivesLeukaemias and lymphomas are among the most prevalent and significant cancers in Australasia and Oceania. This study aims to examine the burden of leukaemias/lymphomas and its temporal trend in Australasia...

Reducing antimicrobial use in livestock alone may be not sufficient to reduce antimicrobial resistance among human Campylobacter infections: an ecological study in the Netherlands.

Reducing antimicrobial use (AMU) in livestock may be one of the keys to limit the emergence of antimicrobial resistance (AMR) in bacterial populations, including zoonotic pathogens. This study assessed the temporal association between AMU in livestock and AMR among Campylobacter isolates from human infections in the Netherlands between 2004 - 2020. Moreover, the associations between AMU and AMR in livestock and between AMR in livestock and AMR in human isolates were assessed. AMU and AMR data per antimicrobial class (tetracyclines, macrolides and fluoroquinolones) for Campylobacter jejuni and Campylobacter coli from poultry, cattle, and human patients were retrieved from national surveillance programs. Associations were assessed using logistic regression and the Spearman correlation test. Overall, there was an increasing trend in AMR among human C. jejuni/coli isolates during the study period, which contrasted with a decreasing trend in livestock AMU. In addition, stable trends in AMR in broilers were observed. No significant associations were observed between AMU and AMR in domestically produced broilers. Moderate to strong positive correlations were found between the yearly prevalence of AMR in broiler and human isolates. Reducing AMU in Dutch livestock alone may therefore not be sufficient to tackle the growing problem of AMR in Campylobacter among human cases in the Netherlands. More insight is needed regarding the population genetics and the evolutionary processes involved in resistance and fitness among Campylobacter.

Routine measurement of cardiometabolic disease risk factors in primary care in England before, during, and after the COVID-19 pandemic: A population-based cohort study.

This study estimated to what extent the number of measurements of cardiometabolic risk factors (e.g., blood pressure, cholesterol, glycated haemoglobin) were impacted by the COVID-19 pandemic and whether these have recovered to expected levels. A cohort of individuals aged ≥18 years in England with records in the primary care-COVID-19 General Practice Extraction Service Data for Pandemic Planning and Research (GDPPR) were identified. Their records of 12 risk factor measurements were extracted between November 2018 and March 2024. Number of measurements per 1,000 individuals were calculated by age group, sex, ethnicity, and area deprivation quintile. The observed number of measurements were compared to a composite expectation band, derived as the union of the 95% confidence intervals of 2 estimates: (1) a projected trend based on data prior to the COVID-19 pandemic; and (2) an assumed stable trend from before pandemic. Point estimates were calculated as the mid-point of the expectation band. A cohort of 49,303,410 individuals aged ≥18 years were included. There was sharp drop in all measurements in March 2020 to February 2022, but overall recovered to the expected levels during March 2022 to February 2023 except for blood pressure, which had prolonged recovery. In March 2023 to March 2024, blood pressure measurements were below expectation by 16% (-19 per 1,000) overall, in people aged 18 to 39 (-23%; -18 per 1,000), 60 to 79 (-17%; -27 per 1,000), and ≥80 (-31%; -57 per 1,000). There was suggestion that recovery in blood pressure measurements was socioeconomically patterned. The second most deprived quintile had the highest deviation (-20%; -23 per 1,000) from expectation compared to least deprived quintile (-13%; -15 per 1,000). There was a substantial reduction in routine measurements of cardiometabolic risk factors following the COVID-19 pandemic, with variable recovery. The implications for missed diagnoses, worse prognosis, and health inequality are a concern.

The Effect of Accelerated Storage Temperature Conditions on the Shelf Life of Pasteurized Orange Juice Based on Microbiological, Physicochemical, and Color Attributes

The accelerated life testing (ASLT) method was used to evaluate the effect of increasing the storage temperature from 10 to 40 °C on the aerobic plate count (APC), the pH, and the colorimetric parameters (L*, a*, b*) of pasteurized orange juice during 40 days of storage. For APC growth, a polynomial model was found to fit better, and at the lower temperatures of 10 and 15 °C, the shelf life was longer, as expected. More specifically, 15 and 10 days were needed, respectively, until the rise in the APC population to 1000 cfu/mL. However, for the temperature range of 30–40 °C, only approximately 3 days were needed to reach 1000 cfu/mL APC. Regarding pH, according to an exponential 3P model, a stable trend was apparent at all temperatures until 30 days of storage, followed by a more abrupt decreasing trend at 25 °C. The lightness (L*), redness (a*), and yellowness (b*) of the juice showed a decreasing trend with the temperature increase, and this trend was more profound at higher temperature levels. The multiple regression analysis between the predictors L*, a*, b*, pH, storage temperature, and the APC response showed an increase in APC growth when the colorimetric parameters decreased and the temperature increased.

Mechanism of MiR-145a-3p/Runx2 pathway in dexamethasone impairment of MC3T3-E1 osteogenic capacity in mice.

In this experiment, we screened key miRNAs involved in the dexamethasone-induced decrease in osteogenic capacity of mouse precursor osteoblasts MC3T3-E1 over and investigated their specific regulatory mechanisms. In this experiment, cell counting kit assay was utilized to act on MC3T3-E1 cells at 0, 5μM, 10μM, 15μM concentrations of dexamethasone for 24h, 48h and 72h to observe the changes in cell viability in order to select the appropriate dexamethasone concentration. Apoptosis and reactive oxygen species were detected by flow cytometry. The transcription of osteogenesis-related genes (Runx2, ALP, OCN, OPN, OPG, COL1A1) and protein expression levels (Runx2, ALP, OCN, OPN) were detected by Western Blot and qRT-PCR to validate the changes in cellular osteogenesis. The differentially expressed miRNAs related to MC3T3-E1 osteogenic differentiation after dexamethasone action were screened out. The expression levels of selected target miRNAs were verified in the experimental group and the control group by qRT-PCR. The miRNA inhibitor was transfected to knock down miRNA in dexamethasone-induced MC3T3-E1 injury. Alkaline phosphatase staining and flow cytometry were performed to detect apoptosis and reactive oxygen species changes. transcript and protein expression levels of osteogenesis-related genes in mouse MC3T3-E1 were detected by qRT-PCR and Western blot experiments. By miRNA target gene prediction, luciferase reporter gene experiments, qRT-PCR and Western blot experiments were used to verify whether the selected target miRNAs targeted the target gene. First, it was determined that 10μM dexamethasone solution was effective in inducing a decrease in osteogenic function in mouse MC3T3-E1 by CCK8 experiments, which showed a significant decrease in alkaline phosphatase activity, a decrease in calcium nodules as shown by alizarin red staining, an increase in apoptosis and reactive oxygen species as detected by flow cytometry, as well as a decrease in the expression of osteogenesis-related genes and proteins. Five target miRNAs were identified: miR-706, miR-296-3p, miR-7011-5p, miR-145a-3p, and miR-149-3p. miR-145a-3p, which had the most pronounced and stable expression trend and was the most highly expressed miRNA, was chosen as the target of this experiment by qRT-PCR analysis. -145a-3p, as the subject of this experiment. Knockdown of miR-145a-3p in MC3T3-E1 cells after dexamethasone action significantly improved the expression of their impaired osteogenic indicators. It was shown that after knocking down the target miRNA, alkaline phosphatase staining was significantly increased compared with the dexamethasone-stimulated group and approached the level of the blank control group. Meanwhile, the expression of osteogenic function-related proteins and genes also increased in the dexamethasone-stimulated group after knocking down miR-145a-3p, and approached the level of the blank control group. A direct targeting relationship between miR-145a-3p and Runx2 was indeed confirmed by luciferase reporter gene assays, qRT-PCR and Western blot experiments. The results indicated that dexamethasone impaired the osteogenic differentiation ability of MC3T3-E1 cells by inducing the up-regulation of miR-145a-3p expression. MiR-145a-3p inhibited the osteogenic differentiation ability of MC3T3-E1 cells by targeting and suppressing the expression level of Runx2 protein. Inhibition of miR-145a-3p levels significantly improved the osteogenic differentiation ability of MC3T3-E1 cells.

Trends of genetic contributions on epigenetic clocks and related methylation sites with aging: A population-based adult twin study.

Several crucial acceleration periods exist during aging process. Epigenetic clocks, serving as indicators of aging, are influenced by genetic factors. Investigating how the genetic contributions on these clocks change with age may provide novel insights into the aging process. In this study, based on 1084 adult twins from the Chinese National Twin Registry (CNTR), we established structural equation models (SEMs) to evaluate the trends in genetic influence with aging for epigenetic clocks, which include PC-Horvath, PC-Hannum, PC-PhenoAge, PC-GrimAge, and DunedinPACE. A decline in overall heritability was observed for all five clocks from ages 31 to 70, with a relatively stable trend at first. Subsequently, apart from PC-GrimAge, the other four clocks displayed a more evident drop in heritability: DunedinPACE and PC-PhenoAge experienced a clear decline between 55 and 65 years, while PC-Horvath and PC-Hannum showed a similar decrease between 60 and 70 years. In contrast, the heritability of PC-GrimAge remained stable throughout. An analysis of methylation sites (CpGs) from these clocks identified 41, 26, 4, and 36 CpG sites potentially underlying heritability changes in DunedinPACE, PC-Horvath, PC-Hannum, and PC-PhenoAge, respectively. Data from the CNTR were collected through two surveys in 2013 and 2018. Based on 308 twins with longitudinal data, declines in genetic components were observed at follow-up compared to baseline, with significant decreases in the four PC-clocks. DunedinPACE peaked in 5-year longitudinal genetic contribution changes at age 55-60, while PC-clocks consistently peaked at age 50-55. These findings may offer novel insights into the role of genetic variations in aging.

Evolution of orthodontic services in the Brazilian Unified Health System: a time series analysis (2011–2022)

BackgroundAlthough malocclusion is the third most prevalent oral health condition, orthodontics is not part of the minimum list of mandatory specialties to be offered in the Dental Specialty Centers of the Brazilian public health system, but rather as optional. Since the acknowledgment of this field as a part of the Brazilian Unified Health System (SUS), access to orthodontic procedures has become optional by municipal governments. Therefore, this study analyzed the evolution of orthodontic procedure provision within SUS from 2011 to 2022.MethodologyWe conducted a retrospective observational study of time series analysis trends on the number of orthodontic procedures and municipalities offering them. The presentation of findings followed the recommendations of the Reporting of Studies Conducted using Observational Routinely Collected Data. Secondary data from 2011 to 2022 were collected from the SUS Department of Informatics. Orthodontic procedures were organized by year, region, state, and municipality. The study applied descriptive analyses, and the Prais-Winsten generalized linear regressions for time series analysis.ResultsThe quantity of municipalities offering orthodontic procedures have shown a small increasing during period analyzed (from 128 to 157). Northeast and South macro-regions have increased consistently the municipalities with orthodontic offering. All regions showed stable trends for each procedure, except for the South, which exhibited increasing rates of space maintainer placement (Annual Percentage Change (APC): 72.95; 95% CI: 31.6, 127.3) and maintenance sessions (APC: 15.40; 95% CI: 4.5, 27.5). The study showed decreasing trends for appliance removal in the South (APC: -38.07; 95% CI: -47.1, -27.5) and Northeast (APC: -25.19; 95% CI: -36.5, -11.9) regions.ConclusionFrom 2011 to 2022, there was a small increase in number of municipalities offering orthodontic procedures in the Brazilian public health system, in addition to a stationary trend for almost all types of procedures.

Real Estate Inflation and Housing Finance in India : Mapping the Correlation between Raising Property Prices & Increasing Home Loans among Indian Cities

Focusing specifically on India — a country that has recently faced recessions partially due to housing bubbles, like many other nations around the world — this research explores in depth how development of real estate linked financing sector have fuelled mortgage led asset price inflation across different cities (both metros & Tier II/III) over decades. Drawing upon a variety of market statistics, policy and economic indicators, the research identifies strong relationships between housing loan availability — by way of loosening mortgage regulations — and property price growth. The study shows that metropolitan cities have witnessed growth in housing loans at a CAGR of 10-12% over last decade (2010–2020) resulting into similar annual price appreciation for real estate standing between 010-15%. Tier II and III cities alternatively, exhibited slower but more stable growth trends in property prices of 6-8% driven by government push & infrastructure developments. The research emphasizes how this relationship has been altered by a number of variables, including as urbanization, demographic changes, government housing programs, and regulatory reforms like RERA and GST. The results imply that although housing financing has played a significant part in promoting the expansion of the real estate market, the influence varies greatly depending on local market dynamics, infrastructural development, and the state of the local economy.

Disposable e-cigarettes: Prevalence of use in Germany from 2016 to 2023 and associated user characteristics.

To provide data on prevalence and trends in the use of different types of e-cigarettes (disposable, pod, tank) in Germany (a country with high smoking prevalence of approximately 30%) from 2016 to 2023, and to analyse the characteristics and smoking behaviours of users of these types. A series of nationally representative cross-sectional face-to-face household surveys. General population of Germany, 2016-2023. A total of 92 327 people (aged ≥14 years) of which 1398 reported current use of e-cigarettes. Type of e-cigarette usually used (single choice: disposable, pod, or tank), person characteristics, and smoking/vaping behaviour. E-cigarette use in the population of Germany has increased from 1.6% (95% confidence interval [CI] = 1.1,2.2) in 2016 to 2.2% (95% CI = 1.6,3.0) at the end of 2023. Disposable e-cigarette use has increased in this period from 0.1% (95% CI = 0.0,0.3) to 0.8% (95% CI = 0.4,1.8). Pod type use exhibited the most stable trend, with a steady rise to 0.6% (95% CI = 0.4,0.9) in 2023. Tank e-cigarette use peaked at 1.6% (95% CI = 1.3,1.9) in November 2017, declined to 0.7% (95% CI = 0.6,0.9) in December 2020, and has since remained constant at 0.8% (95% CI = 0.6,1.0). Disposable e-cigarette users were on average 3.5 and 4.1years younger than tank and pod users, respectively. They were more likely than tank users to be female, non-daily users, and dual users of tobacco. In the subgroup of dual users, there were no significant differences with regard to urges to smoke, cigarettes smoked per day, motivation to stop, and attempts to stop smoking between users of disposables and other types. The use of e-cigarettes has increased in Germany from 2016 to 2023, especially that of disposable e-cigarettes, which are now the most commonly used type with a prevalence rate of 0.8%. However, the use of e-cigarettes is still much lower compared with tobacco smoking.

Apparent survival and population turnover in a long-lived generalist raptor: a comparison of estimation methods

Adult survival and turnover rates are often estimated in long-lived species as the primary drivers of population dynamics. Various methods have been used, yet comparison of estimation methods is seldom undertaken. To address this gap, we used colour-ringing across different age groups, as well as GPS-tracking and genetic analysis of shed feathers, to estimate these critical parameters in a population of the medium-sized bird of prey, the Lesser Spotted Eagle. According to the colour-ringing data, the apparent survival during the first year of life (0.21) was more than four times lower than that of birds older than one year (0.88); the GPS-tracking (0.84) and genetic analysis (0.81) yielded similar survival estimates. All used techniques indicated a stable trend in apparent survival rates. However, population turnover rates derived from genetic feather analysis (0.17–0.43) exceeded expectations based on apparent survival estimates, as well as those derived from colour-rings (0.05–0.17) and GPS-tracking (0.05–0.08). Notably, all markers indicated high site fidelity among adult eagles, with breeding dispersal events being infrequent. Our findings underscore the utility of diverse methods for estimating apparent survival, though the ecological characteristics of the species may influence the efficacy of each method. However, estimates of population turnover rates were notably influenced by the choice of method and should be interpreted cautiously before recommending management actions.

Total burden of hepatitis B and C attributed to injecting drug use in 204 countries and territories from 1990 to 2021: Analyses based on the Global Burden of Disease Study 2021

This study assesses the global, regional, and national burden of hepatitis B (HBV) and hepatitis C (HCV) related to injecting drug use (IDU) from 1990 to 2021. Data from the global burden of disease study 2021 were analyzed to quantify deaths, age-standardized mortality rates (ASMR), disability-adjusted life years (DALYs), and age-standardized DALYs rates (ASDR) due to HBV and HCV from IDU across 204 countries. Trends was evaluated using estimated annual percentage change. Analyzing the association between ASDR and SDI using a loess regression model. From 1990 to 2021, the global burden of deaths and DALYs due to HBV and HCV attributed to IDU showed an increasing trend, especially among males, whose mortality rates were significantly higher than females. In 2021, global deaths due to HBV from IDU were 13,050.8, with an ASMR of 0.15 per 100,000 and an ASDR of 5.3, both showing an increasing trend with estimated annual percentage changes (EAPCs) of 1.09 and 0.96, respectively. HCV deaths reached 231,764.4, with an ASMR of 2.68 (EAPC: 0.38) and a relatively stable ASDR trend (EAPC: 0.01). Although raw death rates for HCV have increased, the ASMR and ASDR have remained stable or slightly declined, highlighting different trends across sexes and regions. India had the highest national deaths, while the highest ASDRs were in the Republic of Moldova (HBV) and Mongolia (HCV). South Asia recorded the highest regional deaths for both HBV and HCV. Positive correlations between ASDRs for HBV and HCV with SDI were observed. The burden of HBV and HCV due to IDU has increased from 1990 to 2021, especially among males, with significant regional and national disparities. Targeted drug prohibition interventions and policies are needed.

МАТЕРИАЛЬНО-ТЕХНИЧЕСКОЕ ОБЕСПЕЧЕНИЕ СЕЛЬСКОГО ХОЗЯЙСТВА: СОСТОЯНИЕ, ПРОБЛЕМЫ, НАПРАВЛЕНИЯ СОВЕРШЕНСТВОВАНИЯ

One of the determining conditions for competitive domestic agricultural production in foreign markets is the technical and technological modernization of the industry. However, despite the significance of the problem, over the past two decades, a stable trend of reduction in the number of employees in agricultural organizations in Russia has developed for all types of agricultural machinery. The highest rates of reduction in agricultural machinery were observed until 2010, and in subsequent periods the downward trend has significantly decreased. At the same time, it is not entirely correct to assess the current situation unambiguously, since the reduction in the fleet of machinery and equipment in agricultural organizations is due to certain objective circumstances and conditions: the area of cultivated land and cultivation of specific crops has decreased; the number of animals has decreased; the technical means used have become more energy-intensive and productive, which is especially important in the context of a shortage of personnel in rural areas. In 2018-2022 the production of domestic agricultural machinery in value terms increased by almost 2.5 times, while in physical terms the changes are insignificant. At the same time, domestic mechanical engineering practically does not produce machinery and equipment for pig farming, poultry farming, milk processing, potato harvesters, beet harvesting equipment, equipment for gardening, vegetable growing. As a result of the outstripping rate of disposal of agricultural machinery and equipment over the rate of their production and replenishment, the energy capacity of the industry is declining. The sanctions imposed on the Russian economy have led to increased risks of non-receipt of critical components and spare parts; disruption of stable logistics and distribution chains that have functioned for a long time, their rise in price; revision of contract terms, failure to meet delivery deadlines. Sanctions against the use of foreign high technologies used in precision farming, genetics, selection, enterprise management, etc. have a negative impact on the development of the agro-industrial complex.

Trend analysis of drowning mortality and years of life lost (YLL) in the south of Iran, 2004–2019

Background and Aims: Drowning is defined as a process with consequences ranging from death to survival without continuous injury. This study was conducted to determine the mortality rate and the years of life lost (YLL) due to drowning in Fars Province. Methods: All deaths due to drowning in Fars Province were obtained from the electronic population-based death registration system (EDRS). Crude and age-standardized mortality rate, YLL, and YLL rate data were calculated, and joinpoint regression was used to examine the trend. Results: During the study period (2004–2019), 910 deaths due to drowning occurred in Fars Province. Of these, 80.5% (733 cases) were reported in men and 41.0% (373 cases) were in the age group of 15–29 years. Crude mortality rate had decreasing trends in male and stable trends in female. The total YLL due to drowning during the 16-year study period were 19,583 (0.62 per 1000 people) in men and 4797 (0.15 per 1000 people) in women. According to the joinpoint regression analysis, the 16-year trend of YLL rate due to premature mortality in males was decreasing. The annual percent change (APC) was -6.0% [95% confidence interval (95% CI) -8.4 to -3.5, p < 0.001] and stable trends in female (APC = - 5.4%; 95% CI -11.8 to 1.4, p = 0.108). Conclusion: Although the trend of crude and standardized mortality rates and YLL due to drowning in men decreased during 2004–2019, these trends have been constant in women. Therefore, the need to invest in the implementation and evaluation of drowning prevention interventions cannot be ignored.