With the installed capacity of the renewable energy power generation is growing at a high speed, a large number of the renewable energy is connected to the grid, the energy problem has been solved to a large extent, but the ensuing problems can not be ignored, the first is the consumption of the renewable energy, which is followed by the stability problem of the power system, and a multi-regional integrated energy system (MRIES) is constructed to solve the problem. In view of the wind power uncertainty, the absorption treatment is carried out by the equipment layer and the optimization layer respectively. A hybrid energy storage system (HESS) is introduced in the equipment layer to suppress the influence of the wind power uncertainty on the system stability. A combination of the convolutional filtering algorithm, the Improved Complete Ensemble Empirical Mode Decomposition with Adaptive Noise algorithm and the fuzzy control algorithm is introduced in the optimization layer to develop the charging and discharging strategy of the HESS. With the strategy, the impact of the electric power fluctuations on the power system during the optimization process can be reduced largely. Then, on the basis of fully considering the energy coupling in different equipments, a collaborative optimization model of the MRIES is constructed. And the integrated demand response model considering the time-of-use electric price is introduced in the load side. Finally, the improved Beluga optimization(IBWO) algorithm is developed to optimize the model. The optimization results show that the IBWO algorithm plays a good optimization effect both in the participation of energy supply equipments and the economy, plays a collaborative optimization role in the MRIES and ensures the stability of the whole power system.