AbstractUntil the recent discovery of a page of Isaac Newton's observations on John Locke's Paraphrase and Notes on St Paul's Epistle to the Romans, it was not known whether Newton had received or remarked upon Locke's work or, in turn, whether Locke had ever received Newton's comments. Since its discovery, however, it is possible to trace Locke's corrections and speculate on the extent and direction to which Newton may have influenced Locke. This article first establishes the theological relationship between Newton and Locke and, second, argues that Locke's revisions in light of Newton's suggestions reveal an anti-trinitarian spirit to his discussion. A previously unpublished transcription of Newton's manuscript fragment is also included.