Squamous Papillomata Research Articles

A case series of laryngeal papilloma management in children

<p class="abstract">Squamous papillomata caused by the human papillomavirus (HPV) are the most common benign neoplasms seen by laryngologists. I hereby presenting a case series of laryngeal papilloma in pediatric age with varied outcome following surgery. Microlaryngoscopy guided excision using cold steel instruments and cautery (if required) was the treatment of choice in our cases. Of the 2 cases one did not recur but the other 2 had recurrence who underwent second surgery with oral antivirals post operatively. Papilloma treatment should be individualized/ tailor made because recurrence rate varies.</p>

Squamous cell carcinoma of the equine external genitalia: a review and assessment of penile amputation and urethrostomy as a surgical treatment

A retrospective analysis was performed on 48 cases of suspected neoplasia involving the equine external genitalia. Forty nine squamous cell carcinomata (SCC) and 23 squamous papillomata (SP) were identified. Two cases of epithelial hyperplasia and one case of habronemiasis were also recognised histopathologically. The glans penis was the most common site of tumour development accounting for 53 per cent of cases of SCC and 61 per cent of SP. The urethral diverticulum, urethral process or urethra was involved in 27.6 per cent (8/29) of cases of SCC. Twelve per cent (5/41) of cases of SCC were confirmed to have metastatic involvement of the local lymph nodes. Papillomata showing pre-malignant changes were identified in five cases. Seventy five per cent (36/48) of the animals presented were ponies. All were geldings, mean age 16.5 years. Penile amputation and urethrostomy, preputial ablation and proximal urethrostomy or local excision were used in the surgical management of these animals; three cases were inoperable and destroyed at presentation. Oedema, haemorrhage and stenosis of the urethrostomy site were encountered as post operative complications. Sixty six per cent (6/9) of animals with SCC of the glans penis (without urethral involvement), which had a known history over the follow up period, treated by penile amputation and urethrostomy survived for longer than 18 months. Similarly, of those with urethral involvement only 28.6 per cent (2/7) survived for a similar follow-up period. SCC not uncommonly affects the external genitalia of aged pony geldings and frequently the glans penis. If the lesion is identified before local metastasis occurs, penile amputation and urethrostomy is indicated and the prognosis is favourable.

Treatment of Recurrent Squamous Papillomata of the Conjunctiva by Carbon Dioxide Laser Vaporization

Complete resection of recurrent conjunctival squamous papillomata frequently may be exceedingly difficult, since such lesions are typically friable and multilobulated. Recurrent lesions often fill the fornicies and spill onto the lid margins. Moreover, since the human papillomavirus (HPV) has been linked to some of these lesions, there remains the further possibility of spread with “cold knife” resection. We discuss the benefits of carbon dioxide laser vaporization therapy for recurrent squamous papillomata of the conjunctiva that have not responded to resection and cryotherapy or topical immunotherapy. The carbon dioxide laser facilitates resection by providing a bloodless field, and reduces the possibility of viral seeding of the conjunctiva by sterilizing the operative site and sealing the lymphatics.

Carcinogenic effects of different nitroso-compounds in Chinese hamsters. I. Dimethylnitrosamine and N-diethylnitrosamine.

Three hundred and twenty Chinese hamsters (Cricetulus griseus) (CH) were treated (s.c.) with 1/5, 1/10 or 1/20 LD50 of dimethylnitrosamine (DMN) or N-diethylnitrosamine (DEN). These substances, in several respects, showed a different organotropy in this species than in both the Syrian golden (SGH) and the European hamster (EH). In CH, DEN produced up to 100% squamous cell papillomata and occasionally also carcinomata of the cheek pouch, tongue, pharynix, oesophagus and forestomach. With DEN a high rate of hepatomata was simultaneously realized. DMN induced a considerable quantity of liver tumours, the highest incidence being demonstrated in the lowest dosage group.

Does cryosurgery have a place in the treatment of papillomata or carcinoma of the larynx?

Cryosurgery may be used as primary treatment for T1 cancer of the larynx in elderly patients with fair or poor medical status and as secondary treatment in postradiation failures of T1 carcinoma, or in multicentric carcinoma in situ. It is of proven value in cases studied to date. Many properly classified patients are being treated by this method with the expectation that most will not require a laryngectomy. Recurrent squamous papillomata of the larynx have responded excellently in many patients with cryosurgery, some necessitating more treatment than others. Fewer laryngoscopies are necessary; in most patients, the disease was eliminated in one to five treatments.

Chiggers Associated with Squamous Papillomata on a Perognathus Mouse

On August 23, 1954 several specimens of Perognathus pernix pcrnix Allen were collected 25 kilometers southwest of Navojoa, Sonora, Mexico by Raymond E. Ryckman, Dean Spencer, and C. P. Christianson. When these animals were inspected for ectoparasites five wart-like structures were seen and removed from the rump region of one mouse. Microscopical inspection of the preserved growths indicated that they were heavily parasitized by mites. These mites were identified as Trombicula polosina and T. painamensis by Deane P. Furman and Douglas Gould. Dr. Furman (in litt.) states, I have seen a similar reaction in wild birds such as the California road-runner and also quail, following chigger attachment; usually numerous chiggers are attached at one particular site and are associated with these growths. This is believed to be the first report of T. potosina from the state of Sonora, Mexico. These growths were diagnosed as squamous papillomata of the skin. They consisted of a polypoid structure covered with benign stratified squamous epithelium which in several places showed papillary projections and elsewhere keratin-filled crypts. The stroma was dense connective tissue infiltrated with lymphocytes.-RAYMOND E. RYCKMAN, Department of Entomology, School of Tropical and Preventive Medicine, and JOHN C. Roos, Department of Pathology, School of Medicine, College of Medical Evangelists, Loma Linda, California.