Overall schedule optimization, considering time, cost, and resource constraints is a difficult task due to the inherent complexity of projects, the difficulties associated with modeling all aspects combined, and the inability of traditional optimization tools to solve this large-size problem. In this paper, a practical approach is presented for the modeling and optimization of overall construction schedules. To simplify modeling, a spreadsheet-based model is developed to be easily usable by practitioners. The spreadsheet model integrates critical-path network scheduling with time-cost trade-off analysis, resource allocation, resource leveling, and cash flow management. The model uses the total project cost as the objective function to be minimized. To facilitate this large-size optimization, a nontraditional optimization technique, genetic algorithms, is used to locate the globally optimal solution, considering all aspects simultaneously. Details of the proposed model are described, and a hypothetical cas...