This study investigated the effects of spraying air pressure and outlet air temperature on the physicochemical and functional properties of skimmed milk powder. Experimental design methodology showed that higher outlet air temperatures improved dry matter content, gelation ability, and flowability, but strengthened colour, moisture sensitivity, and favoured protein denaturation. Spraying air pressure primarily influenced particle size, affecting powder rheological properties and colour. This study highlights the importance of controlling drying parameters to optimize powder properties. The use of a genetic evolutionary algorithm in the optimization process allowed the simultaneous improvement of several functionalities of skimmed milk powder. The findings of this study can contribute to the development of enhanced powders with tailored properties for specific industrial applications.