Abstract Background Ligaments injury and anterior knee pain is the most common problem in the knee joint. In practice, there are various interventions for the treatment of patellofemoral pain syndrome (PFPS). Kinesio taping is one of them, but little literature is available on the immediate effects of treating this problem. Methodology From June to September 2017, a randomized control study was conducted at the Army Sports Complex GHQ Rawalpindi to determine the effectiveness of Kinesio Taping (KT) in patellofemoral pain syndrome in athletes. Data were collected from 48 athletes who fully met the inclusion criteria and were randomly divided into 2 groups. The data collection tool was Numerical Pain Rating Scale (NPRS), Kujala PFPS Score, and self-structured Questionnaire. The data was analyzed on SPSS 21. Results The overall mean age was 22.7±3.0. The immediate effects showed improved NPRS in both groups; in the control group the NPRS pre 1st visit mean was 5.36±1.2 and post 1st visit mean was 4.68±1.3 with the difference of 0.68±0.1 having p value p<0.001. In the treatment group the NPRS pre 1st visit mean was 5.90±1.2 and post 1st visit mean was 5.00±1.0 with the difference of 0.90±0.1 having p value p<0.001. Conclusion This study shows immediate effects of Kinesio-Taping, however there was not any significant difference between both groups but the treatment group performed well after the sessions.