Sporadic Phenomenon Research Articles

Surface deformation monitoring and forecasting of sinabung volcano using interferometry synthetic aperture radar and forest-based algorithm

The Sinabung volcano on Sumatra Island stands out as one of the most active volcanos, having recorded the highest number of eruptions since it resumed activity in 2010. The eruptive activities have caused significant deformations on the volcano's surface. This research aimed to analyze, cluster, and forecast its deformation patterns based on Sentinel-1 A time series data from 2016 to 2023. The differential interferometry synthetic aperture radar (DInSAR) technique was used to monitor monthly deformations and to create time series data. A forest-based forecast (FBF) model was used to predict the rate of changes in volcano surface inflation from January 2024 to December 2027. The deformation times series patterns were also analyzed and clustered into three regions to reveal areas with similar deformation behaviors. The results indicated that Mount Sinabung's deformation is an overall continuous sporadic phenomenon where random ground inflation and deflation were recorded throughout the area with an average deformation rate ranging from 0.06 to 0.32 cm/month and an overall average of 0.197 cm/month with a standard deviation of 0.96 cm, confirming that the volcano is inflating. The highest single-pixel monthly inflation of 4.62 cm was recorded in 2023, while the highest deflation occurred in 2018 at −4.58 cm. The FBF model predicted a gradual and increasing inflationary pattern at the rate of 0.54 cm/month for 2024–2027, higher than the average of the observed data. The deformation within the lava dome and caldera poses a significant risk and could lead to wall collapses and landslides in the crater dome, potentially triggering explosive eruptions. The outcomes of this research serve as valuable supporting information and offer an early warning of potential volcanic disasters in the future.

Aglutinarea articolului hotărât în carpatismele poloneze de origine română

Lexicalization of Definite Article in Polish Carpathian Vocabulary of Romanian Origin The conditions under which the borrowing and diffusion of Carpathian vocabulary of Romanian origin in the mountain dialects of Lesser Poland and the Sub-Carpathian region, as well as the morphological properties of Romanian nouns, seem to favor the phenomenon of agglutination (integration) of a definite article in loanwords. The study of lexemes (common nouns and toponyms) considered by some linguists to be of Romanian origin has led to the conclusion that the agglutination of the Romanian definite article is a sporadic phenomenon in the case of toponyms present in the Polish part of the Western Carpathians (region of Polish dialects). As for the common nouns, none continue the Romanian articulated form, and the endings that can be confused with the masculine definite article are Polish suffixes of Slavic origin.

From a Partition to a Barrier

Abstract This article examines gender separation at Jewish holy sites in the State of Israel. From a rare and sporadic phenomenon just a few decades ago, gender serparation at sacred sites has become normative. Segregation is in part directed ‘from above’ by the State of Israel's various religious arms, which fund, organize, and oversee the practice. But it also arises ‘from below’ as a result of the activity of individuals and Haredi groups—both Ashkenazi and Mizrahi—leading to the imposition of increasingly stringent modesty demands on Jewish Israeli women. Gender separation is presented as a religious obligation, and state authorities accept this extreme interpretation as if it represented a monolithic, unchanging religious position.

WGS trio sequencing at diagnosis of cancer: adult and paediatric patients show different genomic cancer risks

The genetic risk landscapes of adult and paediatric cancers are quantitatively and qualitatively different. Adult cancer is a common but sporadic phenomenon: fewer than 10% of adult cancer patients carry a cancer risk allele, predominantly in genes involved in DNA maintenance. In contrast, paediatric cancer is a rare disease in which germline cancer risk alleles are observed at a higher frequency and in a broader set of genes, including regulators of signalling and development. Beyond these general observations, much remains unknown about the link between germline genotype and paediatric cancer risk. To address this, we report a systematic whole genome analysis and clinical curation of over 1,000 paediatric cancer patients and their relatives, incorporating the TARGET, PRISM, and PREDICT studies. In an interim analysis, we find that over 18% of unselected childhood cancer patients carry reportable germline cancer risk alleles. We discuss this result and related work expanding gene cancer relationships, examining the diagnostic utility of familial sequencing, and leveraging the trio design to establish whether polygenic risk might also contribute to childhood cancer.

Profiling Human Traffickers

Human trafficking is not a sporadic phenomenon that has consequences for a limited number of people, but a phenomenon with deep social and economic implications, bearing in mind the tendency to benefit from globalization and the use of new technologies. It is spread on every continent and every region of the world with the intention of permanent growth. Although it affects all ages and both sexes, it is dominant about women and girls as victims of human trafficking for sexual exploitation. The forms of exploitation are diverse and all involve the violent exploitation and abuse of human beings and their rights. The causes of this phenomenon are numerous and complex because our everyday life is full of numerous contradictions, conditioned by our existence in a specific global crisis of morality. One of the side effects of this crisis is the ubiquitous alienation of man from man. Therefore, this paper focuses on the importance of profiling human traffickers, their characteristics and modus operandi in the process of recruitment, and the mechanisms they use to control victims. It is one of the ways of reacting to make human trafficking more visible, as part of preventive programs before the belated manifestation. Methods were applied: quantitative and qualitative content analysis, comparative analysis (reaction to human trafficking), and descriptive and analytical statistics. The creative goal is to recognize human trafficking as a crime against humanity that requires an effective response from society.

Cylinders and Assemblage- Sertoli-Leydig Cell Tumour -Ovary

Sertoli-Leydig cell tumour is an exceptionally discerned, ovarian neoplasm composed of sex cord or Sertoli cells admixed with stromal component expounded by Leydig cells. Sertoli-Leydig cell tumour may occur in association with DICER1 syndrome or emerge as a sporadic phenomenon. Sertoli-Leydig cell tumour manifests as well differentiated, moderately differentiated or intermediate grade and poorly differentiated neoplasms. Additionally, categories such as Sertoli-Leydig cell tumour with heterologous elements or retiform variant of Sertoli-Leydig cell tumour may be expounded. Majority of paediatric Sertoli- Leydig cell tumours are moderately differentiated or poorly differentiated, concur with DICER1 syndrome and frequently display heterologous elements or retiform tumour configuration. Histological categorization of neoplasms with enhanced tumour grade appears challenging.

Trojan asteroids and the co-orbital dust ring of Venus

Context. Co-orbital asteroids have been thought to be the possible source of the zodiacal dust ring around the orbit of Venus, but the conclusions about the orbital stability and thus about the existence of Venus Trojans are inconsistent in the literature. Aims. We present a systematic survey of the orbital stability of Venus Trojans that takes the dynamical influences from General Relativity and the Yarkovsky effect into account. Methods. The orbits of thousands of fictitious Venus Trojans were simulated numerically. Using a frequency analysis, we describe their orbital stabilities and the dynamical mechanisms behind them. The influences of General Relativity and of the Yarkovsky effect, which were previously either neglected or oversimplified, were investigated in long-term numerical simulations. Results. The stability maps on the (a0, i0) plane and (a0, e0) plane are depicted, and the most stable Venus Trojans are found to occupy low-inclination horseshoe orbits with low eccentricities. The resonances that carve the fine structures in the stability map are determined. General Relativity decreases the stability of orbits only little, but the Yarkovsky effect may drive nearly all Venus Trojans out of the Trojan region in a relatively short time. Conclusions. The Venus Trojans have a poor orbital stability and cannot survive to the age of the Solar System. The zodiacal dust ring found around the orbit of Venus is more likely a sporadic phenomenon, as the result of a temporary capture into the 1:1 mean motion resonance of dust particles that were probably produced by passing comets or asteroids, but not by Venus Trojans.

A Case of Monoclonal Immunoglobulin Deposition Disease – on Bortezomib regimen, A Novel strategy in Multisystemic Involvement

Background: Monoclonal immunoglobulin deposition disease (MIDD) is a rare and sporadic phenomenon often manifesting in individuals who are in their 5th – 6th decade of life. MIDD along with restrictive cardiomyopathy and Renal AL amyloidosis as in the present case is also an unaccustomed phenomenon. Often, the patient presents with unusual symptoms and is more prone to misdiagnosis. The congo red (-) deposition of the monoclonal light chain can be frequently noted in multiple organs including the heart and kidney. The light chain deposition can be either isolated lambda or gamma chain and they are classified accordingly. While serum electrophoresis at an early presentation may reveal underlying monoclonal gammopathy, the immunofluorescence and histopathological examination of renal biopsy remain the mainstay diagnostic tool. Objective: The case study was done because of its uniqueness in the usage of a novel strategy in the treatment of MIDD. Results: In the current case, a 52-year-old male presented with chest pain and NYHA grade 3 dyspnea for 8 days along with bilateral lower limb pitting oedema since 3 months. In certain prevailing situations, a patient can be misdiagnosed with ischemic heart disease or acute on chronic renal failure. However, detailed history and time-bound investigation will act as a safeguard. Conclusion: When patients have no co-morbidities and no addictions, and the patient’s investigation reveals heavy proteinuria, the rheumatological and haematological etiologies must be ruled out to establish a final diagnosis for timely treatment. As in our case, the rheumatological work-up was negative but we found an M band spike on serum electrophoresis, which expedited our search for underlying plasma-cell dyscrasia.

Islamic factor in the immigration process of the European Union

The article attempts to draw attention to the fact that the future of Western Europe depends to a certain extent on the timely resolution of immigration problems related to Muslims. This article aims to make a contribution to the research of the issue concerning the future of the Western Europe immigration process, which depends to a certain extent on the timely resolution of immigration problems related to Muslims. The point is that immigration flows, especially from the Muslim world, from a sporadic phenomenon have become a constant factor and raised questions about the development and implementation of measures to adapt Muslim immigrants to new working, living and cultural conditions in their new countries, search decisions aimed at reducing the pressure of the demographic factor on the economic development of host countries, cooperation in respect of human rights.

Vaccine-induced immune thrombotic thrombocytopenia: definition, risks with different vaccines, and regulatory responses

After the vaccination campaign initiation in Europe and the UK, reports of rare cases of atypical thrombosis, including sinus vein thrombosis and splanchnic venous thrombosis, began to appear in association with the use of vector vaccines AstraZeneca (ChAdOx1) and Johnson & Johnson/Janssen. The syndrome called VITT (vaccine-induced immune thrombotic thrombocytopenia) manifested as thrombosis simultaneously with a decrease in platelet count, a significant increase in D-dimer levels and a detection of factor 4 platelet (PF4) antibodies. We present a detailed review of the epidemiology, pathogenesis, clinical presentation, diagnostics and treatment of VITT, which is by its nature an immune complication, similar to the processes occurring in heparin-induced thrombocytopenia (HIT). All international and national organizations and regulatory authorities, including experts in the field of thrombosis and hemostasis and the VITT expert council recommend continuing the prompt mass vaccination against COVID-19 as the only method that can reduce the incidence of severe cases, stop the spread of COVID-19 infection and the emergence of new dangerous mutations in the viral genome. Failure to vaccinate poses an incomparably greater risk of fatal thrombotic and inflammatory complications associated with infections, compared with the risks of extremely rare adverse events that can occur after vaccination. It should be noted that information on VITT, described as a sporadic phenomenon of an abnormal immune response to some variants of vaccines against COVID-19, cannot be translated to other vaccines (including registered in the Russian Federation) and even more cannot be a reason for refusal to use them.

PREVALENCE AND DISTRIBUTION OF DIFFERENT NATURAL ENEMIES IN THE HARLEQUIN LADYBIRD HARMONIA AXYRIDIS (COLEOPTERA COCCINELLIDAE)

The harlequin ladybird Harmonia axyridis (Coleoptera: Coccinellidae) is one of the most common invasive alien species in the world, which has a global impact on biodiversity and agriculture, and causes economic loss and harm to humans. This insect can be infected by different natural enemies, but their interactions remain understudied. In the present study, 581 adult Ha. axyridis specimens were collected from 21 localities in Hungary with the help of citizen scientists and examined for natural enemies. The parasitic nematode Parasitylenchus bifurcatus (Nematoda: Allantonematidae) is reported in Hungary on the harlequin ladybird for the first time. The ladybirds were also infected by the ectoparasitic fungus Hesperomyces virescens (Ascomycota: Laboulbeniales) and parasitoid Dinocampus coccinellae (Hymenoptera: Braconidae). The nematode parasite was present in all localities where Hesperomyces-infected ladybirds appeared. The prevalence of recorded natural enemies varied by locality: for P. bifurcatus it ranged from 1% to 8%; for He. virescens from 2% to 36%; and for the parasitoid it was 4%. Besides, a statistically significant positive correlation was shown between the nematode and the fungus co-infection using Spearman’s correlation. A study on the multiparasitism of harlequin ladybirds was not yet performed in Hungary. The study area is located between two distant areas in Europe where co-infections had already been observed, indicating that this is probably not a sporadic phenomenon, but that parasitism of the harlequin ladybird by multiple natural enemies might be prevalent throughout the area.

Evidence of Atlantic bluefin tuna spawning in the Bay of Biscay, north-eastern Atlantic.

The spawning grounds of the Atlantic bluefin tuna (Thunnus thynnus) are traditionally considered to be the Gulf of Mexico (Gulf of Mexico) and the Mediterranean Sea (Mediterranean Sea). However, for the western Atlantic, unequivocal evidence of bluefin spawning outside the Gulf of Mexico has been shown. In this study we present the first records of genetically confirmed bluefin larvae in the southern Bay of Biscay (eastern Atlantic). These findings provide evidence of bluefin spawning activity outside the Mediterranean Sea, in the north-eastern Atlantic. However, our results suggest that the bluefin spawning in the Bay of Biscay is a sporadic phenomenon.

Collecting Pandemic Phenomena: Reflections on Rapid Response Collecting and the Art Museum

Rapid Response Collecting has been a most apt methodology with which to document the COVID-19 pandemic for an increasing number of museums. As the phenomenon unfolded across the globe, museums searched for and head-hunted the truth-revealing objects that could tell the stories and histories of the present to current and future generations. Indeed, the COVID-19 pandemic took Rapid Response Collecting to a higher level. A methodology originally conceived for a sporadic phenomenon happening within a specific context during the early years of the 21st century gained much more traction almost overnight. This paper shall make a case for a better understanding of the potential use and application of Rapid Response Collecting by art museums. It shall look into the defining values of this collections development methodology and how these can be applied and adopted when acquiring works of art. In doing so, it shall seek to understand to what extent the mainstream version of Rapid Response Collecting can be adapted for the needs, purposes and requirements of the art museum.

Spasmodic Dysphonia.

Spasmodic dysphonia (SD) is a rare focal laryngeal dystonia. It is characterized by task-specific voice dysfluency resulting from selective intrinsic laryngeal musculature hyperfunction. Symptoms may be attenuated by a sensory trick. Although SD can be seen at times in generalized dystonia syndromes, it is typically a sporadic phenomenon. Involvement of the laryngeal adductor muscles is more common than abductor muscles. The standard treatment of this disorder is with botulinum toxin injection, usually electromyography-guided, which must be repeated periodically as the toxin wears off. A number of non-reversible surgical procedures have also been described to mitigate the symptoms. Other treatment modalities are under investigation, including implantable electrical stimulation devices and deep brain stimulation.

An Unusual Intracranial Collision Tumor of Anaplastic Ependymoma and Atypical Meningioma

Abstract The close geographic association of two or more synchronous primary brain tumors is an unusual occurrence. There are around 50 case reports of these intracranial collision tumors, mostly consisting of malignant astrocytoma (mainly glioblastoma) and meningioma. We present a rare intracranial collision tumor consisting of anaplastic ependymoma and atypical meningioma. To our knowledge, this is the first reported case of intracranial collision tumor with this combination. The patient is a 33-year-old gentleman who presented 2 years ago with new-onset intermittent headaches with increasing severity and associated blurry vision and vomiting. On imaging, he was found to have a 4.2 × 4.1 × 4.1-cm cystic-solid and heterogeneously enhancing extra-axial mass lesion in the left frontal lobe, with an enhancing dural tail. Histologic examination of the surgically excised lesion showed two geographically distinct areas of an extra-axial atypical meningioma (World Health Organization grade II) and an intra-axial anaplastic ependymoma (World Health Organization grade III). The anaplastic ependymoma component showed increased cellularity, pseudorosettes, microvascular proliferation, necrosis, and increased mitoses. It was diffusely positive for GFAP and had a Ki-67 proliferation index of 40%. The atypical meningioma showed 5 mitoses per 10 high-power fields. It had a membranous EMA immunoreaction and a Ki-67 proliferation index of approximately 20%. Recently, the patient had a recurrence of the anaplastic ependymoma component only. So far, no clear explanation has been found in the literature to understand the mechanisms leading to collision tumors. Since our patient does not appear to have any syndrome, it may represent a sporadic phenomenon; however, the sharing of a common oncogenic insult or any underlying molecular/genetic mechanism leading to synchronous tumorigenesis remains to be elucidated in this case.

New Data about Long-Term Changes of Solar Activity

The double Hale cycle (about 44 years) was found in changes of power-law index for integral distributions of equivalent diameters of large groups of sunspots having sizes of 50–90 Mm. According to the Greenwich catalog data, this cycle is traced in the last 13 cycles of solar activity, nos. 12–24. In addition to this periodic change, a unique sporadic phenomenon was discovered, namely, a sharp jump in the maximum diameters of sunspot groups in the 18th cycle (more precisely, in 1946–1947), which has no analogues in other cycles.

Localized Marked Elongation of the Distal Internal Carotid Artery with or without PHACE Syndrome: Segmental Dolichoectasia of the Distal Internal Carotid Artery.

Segmental intracranial dolichoectasia of the distal ICA is a feature of PHACE syndrome or a sporadic phenomenon. We evaluated the relationship between intracranial dolichoectasia of the distal ICA and PHACE syndrome and illustrated the characteristic radiologic findings of the lesions. Intracranial dolichoectasia of the distal ICA was identified in 20 patients at our institution from 2005 to 2016 through a review of diagnostic cerebral angiography results. All radiologic images were reviewed to determine the vascular morphologic dispositions around the distal ICA, including dysplasia, mural calcification, vessel wall enhancement, lumen narrowing, and aneurysm formation. Medical records were reviewed to determine the symptoms of PHACE syndrome. Subsequently, the correlation between radiologic findings and PHACE syndrome was assessed. In this cohort, which had a strong female predominance (male/female ratio= 2:18), intracranial dolichoectasia had a more ipsilateral vascular morphologic disposition. Mural calcification was detected more frequently in elderly patients, whereas vessel wall enhancement was detected more frequently in younger patients. Follow-up images showed a slow progression of the lesions. However, no significant differences in the vascular morphologic disposition and brain structural changes were observed between patients with (n = 11) and without (n = 9) PHACE syndrome. The striking elongation and tortuosity of the distal ICA generally appeared to be a type of congenital lesion occurring early in embryogenesis as either a sporadic phenomenon or an arterial change associated with PHACE syndrome. Imaging findings revealed various mural abnormalities with a benign clinical course.

The Evolutionary Loss of RNAi Key Determinants in Kinetoplastids as a Multiple Sporadic Phenomenon.

We screened the genomes of a broad panel of kinetoplastid protists for genes encoding proteins associated with the RNA interference (RNAi) system using probes from the Argonaute (AGO1), Dicer1 (DCL1), and Dicer2 (DCL2) genes of Leishmania brasiliensis and Crithidia fasciculata. We identified homologs for all the three of these genes in the genomes of a subset of these organisms. However, several of these organisms lacked evidence for any of these genes, while others lacked only DCL2. The open reading frames encoding these putative proteins were structurally analyzed in silico. The alignments indicated that the genes are homologous with a high degree of confidence, and three-dimensional structural models strongly supported a functional relationship to previously characterized AGO1, DCL1, and DCL2 proteins. Phylogenetic analysis of these putative proteins showed that these genes, when present, evolved in parallel with other nuclear genes, arguing that the RNAi system genes share a common progenitor, likely across all Kinetoplastea. In addition, the genome segments bearing these genes are highly conserved and syntenic, even among those taxa in which they are absent. However, taxa in which these genes are apparently absent represent several widely divergent branches of kinetoplastids, arguing that these genes were independently lost at least six times in the evolutionary history of these organisms. The mechanisms responsible for the apparent coordinate loss of these RNAi system genes independently in several lineages of kinetoplastids, while being maintained in other related lineages, are currently unknown.

Variability features associated with ozone column and surface UV irradiance observed over Svalbard from 2008 to 2014

The present report shortly summarises the conclusions about the ozone column and solar UV irradiance variability that were achieved through the analysis of the data obtained from the narrow-band filter radiometer UV-RAD, operating at Ny-Alesund from 2008 to 2014. The polar summer gives the opportunity to register the solar irradiance 24 h per day during several months that provides comparatively long continuous time series as regards for the short- (diurnal) and medium-term (monthly) variations. To exclude the hypothesis about the artificial nature of the large amplitudes registered in the short-term ozone column variations, which can be due to the measurement or methodological errors, they were related to the corresponding variations in the solar UV radiation. In addition, these oscillations were studied using the methods developed for the analysis of non-linear dynamical systems that revealed a complex chaotic interaction between the ozone column and five other atmospheric factors. This approach leads to the conclusion that the short-term variations can be predicted for 10–20 h if a long history is available. The effect of a sporadic phenomenon, such as the ozone depletion event, occurred over Arctic in the spring of 2011, which can be considered an impulse perturbation of the medium-term ozone variations, on the mid-latitude ozone column and surface solar UV irradiance has been studied by analysing the data collected from six surface stations.

VACTERL association after infertility treatment - case report

VACTERL association includes at least three of the following congenital anomalies: vertebral defects, anal atresia, cardiac defects, tracheo-esophageal fistula, renal and limb abnormalities. The objective of article is to demonstrate the perinatal outcome of VACTERL case in 38-year-old pregnant woman with a history of infertility. Pregnancy has occurred after intracytoplasmic sperm injection and embryoscopy before embryo transfer. The 1st trimester ultrasound demonstrated right forearm anomaly-aplasia of the right radius and thumb. The normal female karyotype (46XX) was obtained. Increasing amniotic fluid index and invisible stomach from 26 weeks confirmed the suspicion of VACTERL association. After reduction of 900 ml of amniotic fluids at 34 +4 weeks of gestation the symptoms of premature separation of placenta occurred. The newborn weight was 2,360 g according to Apgar scale assessment 5/5 at 1 st and 5 th minutes. Multiple reconstructive operations were performed after birth. Among them sigmostomy, gastrostomy, ezofageotraheal fistulae plastic, that were followed by bronchoscopy and fibrogastroscopy. VACTERL association is a sporadic phenomenon, but among ICSI pregnancies fetal structural abnormalities occurrence is slightly higher. Our case demonstrates that the different components included into VACTERL association can be visualized at different gestational age, allowing to suspecting this association later in the pregnancy and often not prior to delivery. The family must has to understand the consequences of complications and their impact on the quality of child life.