Lesion In Splenium Of Corpus Callosum Research Articles

Transient splenial lesion of corpus callosum: A window to many diagnoses

Transient splenial lesions (TSL) are not of frequent occurrence and are usually observed with other diseases. The mechanism of TSL development still unclear despite of various theories put forward. These are secondary lesions and their diagnosis is of importance to associate them with clinical conditions. Magnetic resonance imaging is the modality of diagnosing TSL and 3T MRI was used in this study. The study includes 10 cases of TSL with varied disease etiologies like migraine, trauma, infection, demyelination etc. All the cases had follow-up imaging which showed resolution of the lesions after varied time intervals. An attempt to correlate the various theories with each type of disease is done in this study.

Reversible Cerebral Vasoconstriction Syndrome Combined with Posterior Encephalopathy Syndrome, and Transient Splenial Lesion after Delivery

The postpartum period is generally considered to be increased risk of various cerebral disorders, such as reversible cerebral vasoconstriction syndrome (RCVS), posterior reversible encephalopathy syndrome (PRES), and eclampsia. They manifest as an isolated syndrome or overlapped. Emergent diagnosis and appropriate treatment are mandatory because of the risk of permanent cerebral damage. Here, we report a case presenting with the overlap of RCVS, PRES, and transient splenial lesion of corpus callosum after delivery.

Clinically mild encephalitis/encephalopathy with a reversible splenial lesion of corpus callosum in Chinese children

ObjectiveTo investigate the characteristics and etiology of mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) in Chinese children. MethodsWe collected ten pediatric MERS patients from local hospital and enrolled another nineteen patients by reviewing the available literatures. The information of enrolled patients about clinical features, laboratory data, treatment strategies and prognoses were collected for further analysis. ResultsA total of 29 children, the median age of twenty-nine patients was (4.09±3.64) years old. The male-to-female ratio was 1.42:1.0. The major cause of MERS was viral infection. 18 patients had consciousness disturbance which was the most prominent syndrome. 18 patients had transient seizures and only one needed anticonvulsant treatment for long. 9 patients were observed serum sodium levels <135mEq/L. The cells and protein of cerebral spinal fluid (CSF) were increased in 3 patients. In all patients, brain MRI evaluation revealed typical lesion in splenium of the corpus callosum (SCC). 5 patients had additional lesions involving the periventricular white matter or bilateral centrum semiovale diagnosed. 3 patients were treated with antivirus treatment because of virus infection. 7 patients received corticosteroid. 2 patients received intravenous IVIG. As a result, all patients had fully recovered without neurological residual. ConclusionsThe result of present study suggests that Chinese children with MERS might have favorable prognosis, although there is still no guideline for treatment.

Isolated splenial lesion in the corpus callosum in combination with urinary retention in a case of aseptic meningoencephalitis

Aseptic meningoencephalitis in rare instances can present radiologically as a reversible isolated splenial lesion in corpus callosum (Reversible Splenial Lesion Syndrome or RSLS). Patients rarely develop temporary urinary retention, previously described as the meningitis-retention syndrome. We report a case report of a 28-year-old woman with aseptic meningoencephalitis with an unusual combination of RSLS and urinary retention. A complete resolution of neurological symptoms and urinary retention was noted within two months. In cases of aseptic meningoencephalitis, RSLS and urinary retention are good prognostic factors and are associated with complete recovery.

Transient lesion in the splenium of the corpus callosum and a sudden antiepileptic drugs withdrawal: A case with focal epilepsy in presurgical evaluation

A sudden withdrawal of antiepileptic drugs gives higher rate of epileptic seizures in the settings of video electroencephalography (vEEG), monitoring that is a subject to further registration and analysis. A very rare complication of this method is transient lesion of the splenium of corpus callosum (SCC) detected with brain MRI. We presented a patient with a 5-year history of pharmacoresistant epilepsy admitted to the Institute of Neurology (August, 2008) for vEEG monitoring. Interictal epileptic discharges but none seizure were recorded after the sudden withdrawal of antiepileptic medications, during 5 days of vEEG monitoring Initial brain MRI three days after vEEG monitoring revealed focal lesion in SCC, hyperintense on T2 and FLAIR sequence. A longitudinal radiological follow-up (7 and 49 days after initial acquisition) confirmed transient nature of the lesion without diffusion coefficient changes. SCC lesion, reversible and harmless, may occur after a sudden antiepileptic withdrawal. Its early detection makes further extensive neuroradiological and clinical examinations unnecessary.

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Infection with rotavirus, a common pathogen for gastroenteritis in children, is occasionally associated with central nervous system involvement, manifesting from benign afebrile convulsion to lethal encephalopathy or encephalitis [ [1] Dickey M. Jamison L. Michaud L. Care M. Bernstein D.I. Staat M.A. Rotavirus meningoencephalitis in a previously healthy child and a review of the literature. Pediatr Infect Dis J. 2009; 28: 318-321 Crossref PubMed Scopus (58) Google Scholar ]. We appreciate that Kato et al. [ [2] Kato Z. Orii K.E. Morimoto M. et al. A transient lesion in the corpus callosum during rotavirus infection. Pediatr Neurol. 2009; 41: 467-469 Abstract Full Text Full Text PDF PubMed Scopus (10) Google Scholar ] have presented an additional case of rotavirus infection associated with transient splenial lesion of corpus callosum. Although the case we recently reported and their case exhibited different central nervous system manifestations, both cases share a similar change on the splenium of the corpus callosum during rotavirus infection, and both patients recovered within a few days without major complications [ 2 Kato Z. Orii K.E. Morimoto M. et al. A transient lesion in the corpus callosum during rotavirus infection. Pediatr Neurol. 2009; 41: 467-469 Abstract Full Text Full Text PDF PubMed Scopus (10) Google Scholar , 3 Fukuda S. Kishi K. Yasuda K. Sejima H. Yamaguchi S. Rotavirus-associated encephalopathy with a reversible splenial lesion. Pediatr Neurol. 2009; 40: 131-133 Abstract Full Text Full Text PDF PubMed Scopus (30) Google Scholar ]. A Transient Lesion in the Corpus Callosum During Rotavirus InfectionPediatric NeurologyVol. 41Issue 6PreviewTo the Editor: Full-Text PDF

Transient splenial lesion of corpus callosum associated with antiepileptic drug: conventional and diffusion-weighted magnetic resonance images

Transient focal lesions of splenium of corpus callosum can be seen as a component of many central nervous system diseases, including antiepileptic drug toxicity. The conventional magnetic resonance (MR) findings of the disease are characteristic and include ovoid lesions with high signal intensity at T2-weighted MRI. Limited information exists about the diffusion-weighted MRI characteristics of these lesions vanishing completely after a period of time. We examined the conventional, FLAIR, and diffusion-weighted MR images of a patient complaining of depressive mood and anxiety disorder after 1 year receiving antiepileptic medication.