Spleen Deficiency Type Research Articles

Study on the metabolism of Xiao-Jian-Zhong-Tang in rats with chronic atrophic gastritis coupled with bioinformatics.

Xiao-Jian-Zhong-Tang (XJZT) has the effect of warming the middle and tonifying the deficiency, easing the urgency and relieving pain according to the theory of traditional Chinese medicine (TCM), and is able to treat spleen deficiency type chronic atrophic gastritis (CAG). Metabolites of TCM in cecum contents are common metabolites of intestinal bacteria and hosts, which can reflect the metabolic status in disease states. The present work was performed to study the effect of XJZT against CAG coupled with the cecal metabolites analysis and bioinformatics. A total of nine prototypical components and 144 metabolites were firstly identified in the cecum metabolites of XJZT using ultra-high performance liquid chromatography added to the quadrupole-time of flight mass spectrometry (UHPLC-Q-TOF/MS), which underwent the metabolism of oxidation, reduction, methylation, and glucuronic acid reaction Furthermore, different prototypical compounds might metabolize into identical metabolites in the presence of intestinal flora. Bioinformatics was further used to correlate these metabolites with the disease and intestinal flora. Components and targets were screened by Cytoscape, and molecular docking of key targets and core components showed good binding ability. This study provided important information for exploring the mechanism of TCM formulae.

Nursing of patient with cancer-related insomnia of heart and spleen deficiency type treated with holographic meridian scraping therapy

Nursing of patient with cancer-related insomnia of heart and spleen deficiency type treated with holographic meridian scraping therapy

Effects of Buzhong Yiqi Decoction (Middle Qi Tonifying Decoction) in the Treatment of Chronic Cervicitis of Spleen Deficiency Type

Objective: To observe the effects of modified Buzhong Yiqi Decoction (Middle Qi Tonifying Decoction) in the treatment of chronic cervicitis of spleen deficiency type. Methods: From May 2021 to December 2022, 80 patients from our hospital (The First People’s Hospital of Huangzhong District) were randomly divided into two groups (40 cases/group). Patients in the control group were treated with Western medicine, whereas patients in the observation group were treated with Buzhong Yiqi Decoction (Middle Qi Tonifying Decoction) on the basis of Western medicine. The effects (curative effect, traditional Chinese medicine [TCM] symptom scores, and incidence of adverse reactions) were compared between both groups. Results: Before treatment, the differences in TCM symptom scores and incidence of adverse reactions between the two groups were not statistically significant (P > 0.05). Compared with the control group, the observation group had significantly lower TCM symptom scores after treatment and higher curative effect (P < 0.05). Conclusion: For patients with chronic cervicitis of spleen deficiency type, Buzhong Yiqi Decoction (Middle Qi Tonifying Decoction) is effective. Significant improvement in symptoms is evident with the use of Buzhong Yiqi Decoction, and it has little side effects. Given its outstanding therapeutic advantages, its application should be advocated in clinical practice.

Treatment of acne of liver depression and spleen deficiency type

Acne is a long-term inflammatory skin disease, which occurs in hair follicles and sebaceous glands. Also known as "acne", "acne" and "acne". Clinically, it is often treated on the basis of wind heat in the lung meridian, damp heat in the intestines and stomach, phlegm dampness and stasis. With the rapid development of society, people's living environment and way are also changing, and the cause of acne is more complex. Through clinical observation and following my tutor's outpatient study, it was found that the cause of acne in most patients was closely related to liver and spleen. By consulting the relevant literature, we can dialectically treat acne from the direction of soothing the liver and strengthening the spleen, which provides a new idea for the clinical treatment of acne.

Retracted: Insulin Aspart Combined with Exercise Therapy in Spleen Deficiency Type Gestational Diabetes Mellitus: The Effect on Disease Control and Pregnancy Outcomes.

[This retracts the article DOI: 10.1155/2022/3084522.].

Insulin Aspart Combined with Exercise Therapy in Spleen Deficiency Type Gestational Diabetes Mellitus: The Effect on Disease Control and Pregnancy Outcomes.

Objective To investigate the effect of insulin aspart combined with exercise therapy on the disease control and pregnancy outcomes of spleen deficiency type gestational diabetes mellitus patients. Methods In this prospective study, a total of 102 patients with spleen deficiency type gestational diabetes mellitus admitted to our hospital from January 2019 to December 2019 were selected and assigned at a ratio of 1 : 1 via the random number table method to receive insulin aspart (control group) or insulin aspart plus exercise therapy (observation group). Outcome measures include blood sugar, clinical efficacy, adverse pregnancy outcomes, and complications. Results Insulin aspart plus exercise therapy was associated with significantly lower blood glucose and glycosylated hemoglobin levels versus insulin aspart alone (P < 0.05). Insulin aspart plus exercise therapy resulted in significantly higher total efficacy (96.08%) versus insulin aspart (74.51%) (P < 0.05). Patients receiving insulin aspart plus exercise therapy showed a significantly lower incidence of adverse pregnancy outcomes (3.92%) versus those given insulin aspart alone (37.25%) (P < 0.05). Insulin aspart plus exercise therapy resulted in a lower incidence of complications (5.88%) versus insulin aspart (41.17%) (P < 0.05). Conclusion Exercise therapy plus insulin aspart might offer a viable treatment alternative for patients with spleen deficiency-type gestational diabetes mellitus given its promising effects in disease control and pregnancy outcomes, with good efficacy and safety profiles.

Effect of Ruanjian Xiaoying Granules on Hashimoto Rats with Depression of Liver and Deficiency of Spleen and Effect on Intestinal Microflora.

In order to investigate the effect of Ruanjian Xiaoying Granule, experiments were conducted on the intestinal flora of rats with liver depression and spleen deficiency. 48 SPF grade rats are used as the object, and 12 rats are randomly selected as the normal control group. The Hashimoto rat model of liver depression and spleen deficiency type by drug intervention is constructed by the remaining rats. They are randomly divided into three groups: the model group, the traditional Chinese medicine group, and the Jinshuibao group. The normal group and model group are given 2 ml of distilled water twice a day, and the traditional Chinese medicine group is given the Ruanjian Xiaoying granule group (12.96 g/kg/day) twice a day. The Jinshuibao capsule is dissolved in water and given orally at a dose of 0.45 g/kg/day twice a day. After 12 weeks of intervention, the effect is evaluated, and the levels of serum TGAb, TPOAb, and bacterial diversity are compared. Experimental results show that Ruanjian Xiaoying granules can promote the regulation of flora levels in Hashimoto rats with liver depression and spleen deficiency.

Expression of chitinase-3-like protein 1 in different TCM syndromes and its correlation with liver fibrosis.

We aimed to explore the expression of chitinase-3-like protein 1 (CHI3L1) in different traditional Chinese medicine (TCM) syndromes and its correlation with liver fibrosis. A total of 95 patients with hepatitis B e antigen (HBeAg)-positive chronic hepatitis B who were diagnosed by pathological examination of liver biopsy specimens were selected as study subjects. According to different TCM syndrome types, 47 cases were divided into damp-heat moderate resistance type, and 48 cases were liver depression and spleen-deficiency type. Serum samples of the 2 groups were collected, then the levels of CHI3L1 were detected by enzyme-linked immunosorbent assay (ELISA). Hyaluronic acid (HA), laminin (LN), fibronectin (FN), collagen type IV (CIV), and N-terminal procollagen III propeptide (PIIINP) were measured by chemiluminescence. The levels of CHI3L1 was studied to explore the correlations between the 2 types of TCM syndromes and liver fibrosis. The serum CHI3L1 level of the 2 groups increased with increasing fibrosis stage and peaked at the S4 stage. The serum CHI3L1 levels of liver depression and spleen deficiency type patients in the S0-S1, S2-S3, and S4 stages were higher than those of patients with damp-heat moderate resistance type, and the difference was significant (P<0.01). The levels of HA, LN, FN, CIV, and PIIINP in the 2 groups increased with the increase of fibrosis stage and reached the highest level at the S4 stage. Compared to patients with damp-heat syndrome, the levels of HA, LN, FN, CIV, and PIIINP in patients with liver depression and spleen deficiency syndrome were lower, and the difference was statistically significant (P<0.05). There were positive correlations between CHI3L1 and HA, LN, FN, CIV, and PIIINP (all <0.05). The expression level of CHI3L1 in HBeAg-positive chronic hepatitis B patients was higher than expected. The levels of CHI3L1, HA, LN, FN, CIV, and PIIINP in liver depression and spleen deficiency type patients were lower than those in damp-heat moderate resistance type patients. These findings indicated that CHI3L1 is correlated with HA, LN, FN, CIV, PIIINP liver fibrosis indexes, and the syndrome of stagnation of spleen deficiency has a better correlation.

Acupoint massage on meridians in the treatment of insomnia of heart and spleen deficiency type after stroke

Acupoint massage on meridians in the treatment of insomnia of heart and spleen deficiency type after stroke

Study on Effect of Shugan Jianpi Recipe on Spleen Stomach Disease of Liver Depression and Spleen Deficiency Type

Study on Effect of Shugan Jianpi Recipe on Spleen Stomach Disease of Liver Depression and Spleen Deficiency Type

Efficacy and safety of oral traditional Chinese patent medicine in treatment of liver stagnation and spleen deficiency of depression: A protocol for systematic review.

Background:Depression is a kind of chronic and recurrent mental disorder, the main clinical characteristics of the patients are marked and persistent depression. At the same time, it is often accompanied by chronic physical disease, cognitive impairment, and functional damage, which is one of the common diseases that seriously threaten human health. At present, 3 kinds of oral Chinese patent medicine have clinical comparability in the treatment of depression of liver stagnation and spleen deficiency, but there is no evidence for clinical efficacy and safety. Therefore, this study aims to integrate the clinical related syndromes of direct and indirect comparison by using systematic evaluation and network meta-analysis (NMA). According to the data, the different Chinese patent medicines with the same evidence body for the treatment of the disease are collected, analyzed, and sequenced in a quantitative and comprehensive way, and then the advantages and disadvantages of the efficacy and safety between different Chinese patent medicines are screened out to get the best choice scheme, thus providing reference value and evidence-based theoretical evidence for the clinical optimization of drug selection.Methods:Comprehensive retrieval of China National Knowledge Infrastructure, Chinese scientific journal database (VIP), China biological feature database (CBM) and WANFANG Data Chinese electronic database and the Cochrane Library, PubMed, Web of Science, and EMBASE foreign database. Search and publish the clinical randomized controlled trials of these 3 Chinese patent medicines combined with fluoxetine compared with fluoxetine. The retrieval time is from the establishment of the database to October 31, 2019. The 2 first authors will screen the literatures that meet the inclusion criteria, extract the data independently according to the predesigned rules, and evaluate the literature quality and bias risk of the included research according to the Cochrane 5.1 manual standard. R and Aggregate Data Drug Information System software were used for data consolidation and NMA to evaluate the ranking probability of all interventions.Results:This result will show that the best oral Chinese patent medicine to assist the treatment of liver stagnation and spleen deficiency depression provides reliable evidence.Conclusion:This study will provide systematic evidence-based medicine evidence for TCM assisted treatment of depression of liver stagnation and spleen deficiency type, and help clinicians, patients with depression and decision-makers to make more effective, safer, and economic optimal treatment plan in the decision-making process.PROSPERO registration number:CRD42019115695.

Research of Jiawei-Xiaoyao powder on the Ghrelin, VIP for the non-erosive reflux disease with stagnation of liver Qi and spleen deficiency type

Objective To investigate the effect of Jiawei-Xiaoyao powder on the levels of somatotropin and vasoaetive intestinal peptide (VIP) in patients with non-erosive reflux disease (NERD). Methods Seventy patients with liver-stagnation and spleen-deficiency NERD who met the inclusion criteria were divided into two groups according to the random number table, 35 in each group. The treatment group was orally administered with Jiawei-Xiaoyao powder, and the control group was given oral omeprazole enteric-coated tablets and domperidone. Both groups were treated for 8 weeks. Plasma somatotropin and VIP levels were measured by ELISA. Results After treatment, plasma somatotropin levels (210.96 ± 16.85 pg/ml vs. 195.75 ± 12.62 pg/ml, t=4.274) in the treatment group were significantly higher than that in the control group (P<0.01), and plasma VIP level (16.12 ± 1.41 pg/ml vs. 18.57 ± 2.68 pg/ml, t=4.786) in the treatment group was significantly lower than that in the control group (P<0.01). Conclusions The Jiawei-Xiaoyao powder could reduce plasma VIP level in NERD patients, increase plasma somatotropin levels of NERD. Key words: Jia Wei Xiao Yao San; Non-erosive reflux disease; Syndrome of stagnation of liver qi and spleen deficiency; Somatotropin; Vasoactive intestinal peptide

健脾除湿汤对脾虚型慢性湿疹小鼠血清IL-4、IFN-γ的干预作用研究

健脾除湿汤对脾虚型慢性湿疹小鼠血清IL-4、IFN-γ的干预作用研究

Effect of acupuncture and moxibustion on severe obesity complicated with hyperlipidemia in different genders

To explore the effect of acupuncture and moxibustion on severe obesity complicated with hyperlipidemia in different genders and their comprehensive effect, lipid indexes, and obesity indexes. A total of 264 patients of severe obesity complicated with hyperlipidemia were assigned into a male group (106 cases) and a female group (158 cases)．According to their clinical symptoms and patterns, acupuncture and moxibustion differentiation therapies were applied for stomach and intestine heat type, spleen deficiency and dampness resistance type, phlegm-dampness internal resistance type, liver depression and spleen deficiency type, spleen and kidney yang deficiency type and yin deficiency and blood stasis type．The obesity indexes were weight (W), obesity degree (A), body mass index (BMI) and body fat percentage (F); the blood lipid indexes were total cholesterol (TC)，triglyceride (TG)，low density lipoprotein (LDL-C) and high density lipoprotein (HDL-C). The comprehensive effect, obesity and blood lipid indexes were observed．. The total effective rate of the male group was 91.5% (97/106), and the total effective rate of the female group was 85.4% (135/158) , without statistical significance (R>0.05). After treatment, the obesity indexes of W, A, BMI and F and the blood lipid levels of TC, TG, LDL-C decreased, the levels of HDL-C increased compared with those before treatment in the two groups (P<0.05, P<0.01). The different values before and after treatment of the above all indexes in the male group were higher than those in the female group (all P<0.05). Acupuncture and moxibustion can both improve the obesity and blood lipid indexes for the patients with obesity complicated with hyperlipidemia. The effect is better for male than for female. The methods can prevent and treat hyperlipidemia.

Clinical curative effect of ShuganJianpi acupuncture manipulation combined with magnetic stimulation in Yintang acupoint in the treatment of depression with liver-qi stagnation and spleen deficiency type

Objective To evaluate the clinical efficacy of different combinations with Shugan Jianpi acupuncture and Yintang acupoint magnetic stimulation in the treatment of depression with liver depression and spleen deficiency type. Methods 160 patients with depression treated in hospital from December 2013 to June 2017 were divided into 4 groups according to the random number table, with 40 cases in each group.Group A received basic drug therapy, Shugan Jianpi acupuncture combined with Yintang acupoint magnetic stimulation, group B received basic drug therapy combined with Yintang acupoint magnetic stimulation, group C received basic drug therapy combined with Shugan Jianpi acupuncture treatment, group D was treated with basic medicine only for 4 weeks.Hamilton Depression Scale (HAMD) was used to assess the short-term and long-term efficacy for 4 groups before treatment, after 2 weeks of treatment, after 4 weeks and 2 months after treatment and the safety of these 4 types of therapy was evaluated with the side effects scale(TESS). 2 months after the treatment, the quality of life universal scale (SF-36) was evaluated for patients in 4 groups. Results After 2 weeks, 4 weeks and 2 months of treatment, HAMD scores in the 4 groups were significantly lower than those before treatment (P 0.05). The scores of each dimension of SF-36 in group A were significantly higher than those of group B, C and D (P 0.05). Conclusion The results suggest that there is a synergistic effect in combination of the ShuganJianpi acupuncture combined with Yintang acupoint magnetic stimulation in the treatment of depression of liver qi stagnation and spleen deficiency type, and it can effectively reduce the degree and improve their quality of life in patients with depression. Key words: Acupuncture; Acupoint magnetic stimulation; Depression; Yintang acupoint; Quality of life; Curative effect

Metabonomics research of functional dysplasia of hepatic stagnation and spleen deficiency type

Metabonomics research of functional dysplasia of hepatic stagnation and spleen deficiency type

Protocol of Miao medical LIU's infant tuina genre "Tui Wu Jing" in western Hunan province for prevention of asthma recurrence

The Miao medical LIU's (LIU Kaiyun) infant tuina genre in western Hunan Province is one of the most famous infant tuina genres in China. Based on physiological and pathological characteristics of infants, generation-inhibition theory of five-elements and Miao medical's promotion-inhibition theory of five-meridians, the tuina protocol of "Tui Wu Jing" was flexibly adjusted; according to different constitution types, including lung-deficiency type, spleen-deficiency type, kidney-deficiency type, qi-deficiency type, yin-deficiency type, yang-deficiency type, phlegm-wet type, phlegm-heat type, different protocols were adopted to prevent or reduce the asthma recurrence and reach the aim of regulating constitution and disease prevention.

Correspondence analysis between traditional Chinese medicine (TCM) syndrome differentiation and histopathology in colorectal cancer

IntroductionDefining Traditional Chinese medicine (TCM) syndrome is considered the key therapeutical principle of TCM. The present study was to explore the correlation between TCM syndrome differentiation and histopathology in colorectal cancer (CRC). MethodsA total of 180 patients were differentiated into 5 TCM syndrome types, including accumulated damp-heat type (ADH), deficiency of both qi and blood type (DBQB), deficiency of liver and kidney yin type (DLKY), deficiency of spleen and kidney yang type (DSKY) and qi stagnation due to spleen deficiency type (QSSD). They were also differentiated into pathologic types, including adenocarcinoma, mucous carcinoma, signet ring cell carcinoma and anaplastic carcinoma. Moreover, the expression of protein 53 (P53), cluster of differentiation 44 (CD44), non-metastasis 23 (nm23), proliferating cell nuclear antigen (PCNA) and B-cell lymphoma-2 (Bcl-2) was detected by immunohistochemistry in 61 patients. Finally, the correspondence analysis between TCM syndrome differentiation and histopathology or pathological molecular markers was conducted. ResultsChi-square test of independence showed that TCM syndrome types correlated with pathological types (χ2=33.456, P=0.001), while not with molecular markers (χ2=7.344, P=0.834). Correspondence analysis showed that the distances between adenocarcinoma and QSSD or DLKY were the shortest among the distances of adenocarcinoma with other TCM syndrome types. Moreover, distances between mucinous carcinoma and ADH, signet ring cell carcinoma and ADH, anaplastic carcinoma and DBQB were the shortest among all the types. ConclusionTCM syndrome differentiation is strongly correlated with histopathology of colorectal cancer. TCM syndrome differentiation may be used as a supplement in the diagnosis of CRC.

Investigation of independent college students’insomnia status and the syndrome type of traditional Chinese Medicine

Objective To explore college students’ sleep and insomnia syndrome type of traditional Chinese medicine.Methods A questionnaire survey was conducted among 1 325 college students of independent colleges using the Pittsburgh sleep quality index and the standardization of TCM syndrome introduced by guiding principles of clinical research on treatment of insomnia with new drugs of traditional Chinese (2002).The results underwent analysis.Results Of 1 325 college students in independent college,209 people had poor sleep quality,in which liver fire retarding type accounted for 129 people,hyperactivity of fire due to yin deficiency type accounted for 67 people,followed by the heart and spleen deficiency type two(3 people),phlegm heat disturbance type(4 people),Qi deficiency type (2 people),other type (4 people).Conclusions College students in sub-health state with insomnia showed two common types:liver depression transforming into fire,hyperactivity of fire due to yin deficiency type.We should give effective intervention based on dialectical theory of the Chinese medicine. Key words: Independent college students; Sleep disorders; Chinese medicine syndrome type