Spiral Form Research Articles

Comparison of three methods for generating the coccoid form of Helicobacter pylori and proteomic analysis

BackgroundHelicobacter pylori changes from spiral to coccoid depending on the host state, environmental factors, and surrounding microbial communities. The coccoid form of H. pylori still maintains its complete cellular structure, retains virulence genes, and thus plays a role in pathogenicity. To understand the coccoid form, it is crucial to establish the in vitro generation of the coccoid H. pylori. Although some conditions have been studied for the generation of the coccoid form, few studies have compared these conditions for coccoid generation. Here, we generated coccoid forms via three methods and compared the differences in morphology, viability, culturability, and protein expression.ResultsThe coccoid H. pylori was generated in vitro via three methods: a starvation method, a method using amoxicillin, and a method using the culture supernatant of Streptococcus mitis. The morphology and viability of the cells were examined by fluorescence microscopy after staining with SYTO9 and propidium iodide. The culturability of H. pylori was examined by counting colony-forming units on chocolate agar plates. In the starvation group, no colonies formed after 7 days, but viable coccoids were continuously observed. In the amoxicillin-treated group, the culturability decreased rapidly after 12 h, and showed a viable but non culturable (VBNC) state after the third day. Most cells treated with S. mitis supernatant changed to coccoid forms after 7 days, but colonies were continuously formed, probably due to living spiral forms. We performed proteomics to analyse the differences in protein profiles between the spiral and coccoid forms and protein profiles among the coccoid forms generated by the three methods.ConclusionAmoxicillin treatment changed H. pylori to VBNC cells faster than starvation. Treatment with the S. mitis supernatant prolonged the culturability of H. pylori, suggesting that the S. mitis supernatant may contain substances that support spiral form maintenance. Proteomic analysis revealed that the expression of proteins differed between the spiral form and coccoid form of H. pylori, and this variation was observed among the coccoid forms produced via three different methods. The proteins in the coccoid forms produced by the three methods differed from each other, but common proteins were also observed among them.

Exploring non-thermal plasma technology for microalgae removal

The global population and economic development surge has substantially increased water demand, resulting in heightened sewage and pollutant generation, posing environmental hazards. Addressing this challenge necessitates the implementation of efficient and cost-effective water reclamation methods. Non-thermal plasma technology (NTP) has emerged as a promising solution, garnering attention for its superior efficiency compared to alternatives. While existing studies have predominantly focused on energy efficiency and pollutant removal, limited research has delved into the biological removal aspect, particularly concerning algae. This study utilized a dielectric barrier plasma diffuser to eliminate Spirulina microalgae (Spirulina platensis) from wastewater solutions, demonstrating higher algae removal and superior mass transfer compared to alternative plasma methods. The effect of sample volume, input voltage and power, flow rate, and initial solution concentration on the algae removal was investigated. Investigation of operational parameters revealed the best condition resulting in a 98 % removal rate and 20 g/kWh energy efficiency. The best conditions for the removal of Spirulina microalgae were considered in a sample volume of 50 mL, a voltage of 7.6 kV, a flow rate of 700 mL/min, and an initial solution concentration of 1280 mg/liter. Scanning Electron Microscope (SEM) images illustrated the impact of active species on cell structure, leading to the destruction of spiral form and loss of reproductive ability. The study underscores the potential of NTP for efficient algae removal and identifies key active species involved in the process. The removal of Spirulina microalgae was attributed to a combination of singlet oxygen (1O2), hydroxyl radicals, and ozone.

Hydrogen production from wastewater using interdigitated printed electrode-based Single-Chamber microbial electrolysis cells

In the ever-increasing quest for alternative energy sources, hydrogen emerged as a promising green option, but efficient and economical production and management have been the primary constraints. Converting wastewater into H2 and other forms of energy attracted significant attention in terms of simultaneously and sustainably managing both the wastewater and the energy generation problems. Microbial Electrolysis Cells (MEC) evolved recently as promising options for converting wastewater into H2 and electricity but with serious constraints on scalability. The current research aims to explore design and manufacturing solutions to build structurally strong and electrochemically effective electrodes that can also lead to scalable MEC. Two designs based on the interdigitated and spiral electrode architectures are proposed and evaluated. The added design freedom with additive manufacturing by selective laser melting of specific alloys of choice is effectively utilised in physically prototyping the interdigitated and spiral electrode forms designed with controlled porosity constraints. Microstructural, electrochemical, and cell performance characterisations led to the understanding that the spiral electrode configuration with polypyrrole-coated stainless steel 316L anode is a promising design option for both longitudinal and lateral scale-up of the MEC.

Пьезоэлектрический дисковый актюатор кручения с дискретно-спиральными электродами

A mathematical model of a disk (ring) torsion actuator with curvilinear interdigital electrodes – «villi» of a spiral form, which are characterized by a constant value of the orientation angle of an arbitrary section of the villus to the circumferential direction of the disk, has been developed. Bases of electrode-villi interacting with each other through local areas of piezoelectric layer are connected with periodic alternation to central or peripheral concentric circular base electrodes, to outputs of which control voltages are connected. As a result of numerical modeling of the «twisting bimorph» graphs of the dependence of the twist angle and the blocking torque on the ratio of the inner and outer radii and the values of the control voltage at the outputs of the base electrodes of the annular two-layer actuator with symmetrical (relative to the radial line) directions of the spiral orientations of the electrode-villi and, as a result, the spiral polarization lines of the piezoelectric layers working for tension/compression.

A Conceptual Study on Marma, Nadi & Chakra in Context of Prana

Marma are the vital points of the body where Prana resides & is the site where conglomeration of Mamsa, Sira, Snayu, Asthi & Sandhi occurs. According to Acharya Charak, Marma are the points where extensively pain felt & this is the site of Chetana. Acharya Sushruta said that at Marmasthana Prana resides while according to Vagbhatta, Marma is that place where abnormal pulsation and pain on touch found. Nadi are the energy channels that carry the Prana & transfer Prana from one point to another point. Nadi originates from the Kanda to their respective termination point or orifices of the body. Chakra is the transformer of Prana from where Prana frequency increases & decreases. On the Sushumna nadi the point where Ida & Pingala nadi meets is the location of different Chakra in a spiral form i.e Muladhara chakra, Swadisthana chakra, Manipura chakra etc. Prana is the key connecting point between Marma, Nadi & Chakra as Marma is the Adhisthana of Prana, where the Nadi are the energy channels that carries the Prana & at Chakra Prana is found in concentrated form which circulates Prana in different parts of the body.

Pathohistological Changes in the Gastric Mucosa in Correlation with the Immunohistochemically Detected Spiral and Coccoid Forms of Helicobacter pylori.

The coccoid form of Helicobacter pylori (H. pylori) is resistant to antibiotics. There are only a few studies that have analyzed the frequency of coccoid H. pylori in patients with gastritis. The aim of this work was to examine the correlation between the H. pylori form and the pathohistological characteristics of the stomach in patients with gastritis. This research was cross-sectional and focused on the gastric mucosa samples of 397 patients from one general hospital in Croatia. Two independent pathologists analyzed the samples regarding the pathohistological characteristics and the form of H. pylori. There was a statistically significant difference in the gender of patients with H. pylori gastritis. Only the coccoid form of H. pylori was present in 9.6% of patients. There was a statistically significant difference in the frequency of a certain form of the bacterium depending on its localization in the stomach. The intensity of the bacterium was low in the samples where only the coccoid or spiral form was described. In cases of infection in the antrum, premalignant lesions and the coccoid form of H. pylori were more often present. In the diagnosis of H. pylori infection, the determination of the form of the bacterium via immunohistochemistry should be included to increase the rate of eradication therapy and reduce the incidence of gastric malignancy.

Film cooling performance under plasma aerodynamic actuation and spoiler ribs of an internal cooling channel based on Suzen model

In this paper, a plasma actuator (PA), treated by the Suzen model, is introduced into film cooling, and four rows of rectangular ribs are employed in internal cooling. Combined action and individual action of film cooling and internal cooling are then investigated at four blowing ratios (M = 0.25; 0.5; 0.75; 1.0). Results show that (no PA, no ribs) the coolant is ejected from the film hole in a spiral form under the action of internal crossflow, and its distributions are inclined to crossflow direction. When the plasma actuator is opened (no ribs), the strength and scale of the counter-rotating vortex pairs are weakened, and the motion of coolant is accelerated, the average cooling effectiveness shows an increase of 82.4% (M = 0.25), 98.9% (M = 0.5), 33.4% (M = 0.75) and a decrease of 2.1% (M = 1.0), the spanwise cooling effectiveness is raised by 57.3–143.3% for each streamwise position, the flow coefficient is lowered by 1.8–3.2%. Ribs (no PA) interfere with the coolant flow in the internal channel, reducing the rotation degree and exit momentum of the coolant, and greatly eliminate the uneven distribution of coolant along the spanwise direction, resulting in an enhancement of 50.4–162.8% in the spanwise cooling effectiveness and of 59.2% (M = 0.25) and 79.5% (M = 0.5) in average film cooling effectiveness. The effect of combined action (PA plus ribs) is lower than those effects of individual factors, and wall average film cooling effectiveness with PA and ribs exhibits a 62.4% (M = 0.25) and 49.4% (M = 0.5) higher to PA off a case (no PA, no ribs); however, a local or global heat transfer deterioration appears at M = 0.75 and 1.0.

Antigenicity and immunogenicity of different morphological forms of Borrelia burgdorferi sensu lato spirochetes

Borrelia burgdorferi sensu lato is a species complex of pleomorphic spirochetes, including species that cause Lyme disease (LD) in humans. In addition to classic spiral forms, these bacteria are capable of creating morphological forms referred to as round bodies and aggregates. The subject of discussion is their possible contribution to the persistence of infection or post-infection symptoms in LD. This study investigates the immunological properties of these forms by monitoring reactivity with early (n = 30) and late stage (n = 30) LD patient sera and evaluating the immune response induced by vaccination of mice. In patient sera, we found a quantitative difference in reactivity with individual morphotypes, when aggregates were recognized most intensively, but the difference was statistically significant in only half of the tested strains. In post-vaccination mouse sera, we observed a statistically significant higher reactivity with antigens p83 and p25 (OspC) in mice vaccinated with aggregates compared to mice vaccinated with spiral forms. The importance of the particulate nature of the antigen for the induction of a Th1-directed response has also been demonstrated. In any of morphological forms, the possibility of inducing antibodies cross-reacting with human nuclear and myositis specific/associated autoantigens was not confirmed by vaccination of mice.

An ensemble of ResNet model for classification of Parkinson disease

Parkinson disease (PD) is one of the neurological illnesses incurred. However, there is a no chance to recognize PD. A fine motor symptom has been identified in this study. A group of patients with PD, as well as the healthy group, is used in the research. The authors have developed a technique that can determine whether a patient has PD or not. Using deep learning methods, the same design generalizing neural networks in the brain can be solved. The categorization of patients with PD and non-PD behavior is found from the analysis of spiral and wave forms using CNN model. Various CNN models were used in the experiment by transfer learning and spiral and wave data sketches. With the help of spiral sketching, the system achieved an accuracy of 96.67% using the ResNet50 model. The main objective of this paper is to explore the application of transfer learning, which improved the performance of the model.

Radial phase spirals in the Solar neighbourhood

ABSTRACT The second data release of ESA’s Gaia mission revealed numerous signatures of disequilibrium in the Milky Way’s disc. These signatures are seen in the planar kinematics of stars, which manifest as ridges and ripples in R–vϕ, and in vertical kinematics, where a prominent spiral is seen in the z–vz phase space. In this work, we show an equivalent ΔR–vR phase spiral forms following a perturbation to the disc. We demonstrate the behaviour of the ΔR–vR phase spirals in both a toy model and a high-resolution N-body simulation of a satellite interaction. We then confront these models with the data, where we find partial ΔR–vR phase spirals in the Solar neighbourhood using the most recent data from Gaia DR3. This structure indicates ongoing radial phase mixing in the Galactic disc, suggesting a history of recent perturbations, either through internal or external (e.g. satellite) processes. Future work modelling the z–vz and ΔR–vR phase spirals in tandem may help break degeneracy’s between possible origins of the perturbation.

Determination of the Mathematical Theorems on Ancient Mosaics

The aim of this research is to examine and evaluate the reflection of mathematical knowledge on examples of ancient mosaic art. As a result of the comparison between history of mathematics and art of mosaics, a connection has been made between the well-known theorems and patterns through the nature of the forms. For this purpose, patterns like swastika, meander, spiral and cube forms, as well as the forms that can be produced from the graph related to the lunar area calculation of Hippocrates of Chios have been analyzed. In addition, analyzes, discussions and evaluations on the identification of the forms similar to the semi-regular solids of Archimedes and the hexagons of Pappus of Alexandria have been presented. It is thought that the methods used and the information obtained in this study will contribute to the research of mosaic art and history of mathematics, the documentation and evaluation of archaeological artifacts, the museology practices and conservation studies.

Determination of the form of a spiral spring in a free state

The object of research. This article deals with a spiral spring made of tape material with a rectilinear cross-section.
 Investigated problem. If one end of a metal ruler is pinched, and a certain force is applied to the other end, it will bend under the action of the generated moment. The magnitude of the moment depends on the applied force and the length of the ruler. Therefore, the amount of deflection will increase with the increase of these parameters, and the shape of the ruler may take the spiral form. After the termination of the external load, the ruler will regain its original shape, that is, it will become straight. However, such spiral springs do not exist in practice. For compact sizes, the spring in its free state also has a spiral shape. In this regard, the purpose of the study is to find the elastic axis of a tape spiral spring in a free state, which under the action of a concentrated force takes a given shape.
 The main scientific results. The shape of the spiral spring in the free state is determined, which under the action of the applied force acquires the desired shape, which does not lead to the occurrence of frictional forces between adjacent coils.
 The area of practical use of research results. Spiral springs are widely used. One example is mechanical clock movements and measuring devices, in which the determination of indicators depends on the applied force that "unwinds" or "twists" the spring.
 Innovative technological product. The paper calculates the elastic axis of a spiral spring in a free state according to its given final shape, taking into account the moment that arises as a result of the applied force at the end of the spring. For this, the nonlinear theory of absolutely elastic bending using the methods of differential geometry of curved lines as a function of the own length of the arc of the spring axis is applied.
 The scope of application of the innovative technological product. The results obtained in the study can be used in the manufacture of spiral springs for various purposes, as well as for the accumulation of potential energy in the absence of other sources

Mejilawi to Enhance the Symbolic Thinking Abilities for Children’s Kindergarten

This research aims to improve children's symbolic thinking abilities through the use of mejilawi (teaching method) and describes the application of mejilawi in enhancing children's symbolic thinking abilities. The subjects of this research were Group A students of PAS Baitul Qur'an Gontor Full-day Kindergarten. This research uses a qualitative descriptive classroom action research approach. Data collection methods used in this research include observation and oral tests. Meanwhile, the data analysis method uses a qualitative descriptive approach. The research model used in this research refers to Kemmis and McTaggart's theory, which is applied in a spiral form consisting of planning, implementation, observation and reflection. Research findings show increased children's symbolic thinking abilities after implementing mejilawi. In cycle I, out of 20 children aged 4-5 years at PAS Baitul Qur'an Gontor Fullday Kindergarten, 11 (55%) achieved BSH and BSB grades. In cycle II, there was an increase in the number of children who obtained BSH and BSB scores, reaching 17 (85%). The application of mejilawi as a learning medium to improve children's symbolic thinking skills consists of five stages: (1) the child arranges ten bowls neatly and counts them, (2) the child arranges and places the numbers 1 to 10 under the bowl, (3) the child holds the nuts correctly, (4) children put nuts in their hands as a symbolic representation of the numbers, (5) children are allowed to count the number of nuts again in each bowl. Scientific use of mejilawi can improve children's symbolic thinking abilities.

An ever-present Gaia snail shell triggered by a dark matter wake

ABSTRACT We utilize a novel numerical technique to model star formation in cosmological simulations of galaxy formation – called superstars – to simulate a Milky Way-like galaxy with ≳108 star particles to study the formation and evolution of out-of-equilibrium stellar disc structures in a full cosmological setting. In the plane defined by the coordinate and velocity perpendicular to the mid-plane [vertical phase space, (Z, VZ)], stars in solar-like volumes at late times exhibit clear spirals qualitatively similar in shape and amplitude to the Gaia ‘snail shell’ phase spiral. We show that the phase spiral forms at a lookback time of ∼6 Gyr during the pericentric passage of an ∼1010$\rm {\rm M}_{\odot }$ satellite on a polar orbit. This satellite stimulates the formation of a resonant wake in the dark matter halo while losing mass at a rate of ∼0.5–1 dex per orbit loop. The peak magnitude of the wake-induced gravitational torque at the solar radius is ∼8 times that from the satellite, and triggers the formation of a disc warp that wraps up into a vertical phase spiral over time. As the wake decays, the phase spiral propagates several gigayears to present day and can be described as ‘ever-present’ once stable disc evolution is established. These results suggest an alternative scenario to explain the Gaia phase spiral, which does not rely on a perturbation from bar buckling or a recent direct hit from a satellite.

Optimization configuration of scrubber steel wire coils as porous materials for augmenting the performance of hemispherical distillers

BackgroundThe present study aims to improve the productivity of hemispherical solar distillers to overcome the problem of freshwater shortage facing many countries of the world, especially remote countries, due to population increase and climate changes. To achieve this goal, scrubber steel wire coils were incorporated in the basin of a hemispherical distiller as porous materials and energy store materials. To identify the best configuration of installation and form of scrubber steel wire coils that provides the highest thermal efficiency of hemispherical solar distillers (HSDs), two configurations were considered for installing and forming the scrubber steel wire coils inside the basin; spiral form and cake form. MethodsTo examine their performance experimentally, besides to a traditional HSD (THSD), two new HDSs, one containing spiral-shaped coils of scrubber steel wire (HSD-SSCSSW), and one HDS with cake-shaped coils of scrubber steel wire (HSD-CSCSSW) were constructed and studied under same climate weather conditions. Significant findingsOutcomes showed that the HSD-CSCSSW is the best configuration that provides the highest hemispherical distiller performance. Its distillate accumulation reached 7110 mL/m2, while THSD accumulation totaled 4830 mL/m2. The accumulation productivity of the HSD-CSCSSW is 1.472 times higher than the output of THSD. Outcomes proved that utilizing the scrubber steel wire coils in the shape of a cake is a good choice which augments the thermal and exergy efficiencies by 46.47 and 101.1%.

Design and Simulation of the Spiral Micromixer with Chaotic Advection

In recent years, the microfluidics technique has screwed up rising attention and be in progress a fascinating topic. Species mixing is a compelling part of any microfluidic system that abides by the major challenge. In this research, a relative explication of mixing quality of microchannels of two cross-sections square and circular in spiral form is presented by numerical simulation. To perform the visitation, geometric parameters like axial length of microchannels and hydraulic diameter are taken equal for both cases. Computational Fluid Dynamics codes unriddle the Continuity equation, Navier-Stokes equation, and Convection-Diffusion equation. Explication of fluid flow and mixing have been gone through with an extensive limit of Reynolds numbers 1 to 125. The results explicate that the circular section spiral microchannel affords a higher mixing quality admixed to the square section spiral microchannel. Furthermore, in the circumstance of circular section spiral micromixer, mixing index esteem has attained 92% at Re =125. For both section micromixer, the esteem of mixing index enhancement be contingent on Reynolds numbers. For both cases, pressure downfall has been computed for microchannels of similar lengths. The esteem of pressure downfall in square section spiral mixer is excess than circular section spiral mixer. The simulation outcomes exhibited that the circular section spiral micromixer is an effective design for microfluidic devices like Lab on a chip (LOC).

Proposal for Shape Memory Alloy Positioning Actuator using Electric Parameter Based Controller

This paper proposes the controller design for a shape memory alloy (SMA) positioning actuator system. The system utilizes spiral-formed SMA wire as the driving power source. SMA generates force via temperature-based crystalline phase transitions. The wire is deformed in the spiral form under low temperature and heated by applying direct current, it recovers to the original form and generates the recovering force, which rotates the attached load. This paper proposes using the electric resistance of the SMA, which is related to its crystalline phase status, for designing the controller of the actuator system. The feasibility of the proposed system and controller design are evaluated experimentally with a sample test device, manufactured using a 3D printer, and the device achieves the designed rotation.

Chemical composition and anti-Helicobacter pylori activity of essential oil from fresh fruits of Litsea cubeba (Lour.) Pers

ABSTRACT Main chemical compositions of essential oil (EO) from Litsea cubeba fruit collected in Kon Tum Province of Vietnam were geranial (32.0%), neral (24.3%), citronellal (14.2%), and limonene (10.1%). Twenty-four compounds of the EO were identified and compared with those from EOs previously reported in India, China, and Malaysia. Minimal inhibitory and bactericidal concentrations (MIC and MBC) indicated that the EO induced high levels of growth inhibition and moderate bactericidal activity against seven test Helicobacter pylori strains, including six strains resistant to one to four antibiotics, azithromycin, erythromycin, levofloxacin, and metronidazole. The bacterial biofilm formation was significantly suppressed by the EO at 1/2 and 3/4×MIC. The EO also exerts inhibitory activity against H. pylori-urease and convert a spiral form of H. pylori into a coccoid form. Fruit EO inhibits bacterial growth via both contact and fumigant action.

Religion and the modern education

The purpose of the research is to solve the paradox of religion integration in education, by the new balance between religion, philosophy and science, during the post communism transition. In the field of thinking, the process is the transition from ideology to integral thinking. It is realized through the re-evaluation of the topics of the integration of religion, transitology and integral though, education, inclusiveness, solidarity, new laicity and new secularity. In the philosophical sense, integration is the objective process of being developed. This is understood as a return to identity towards a universal being. In the context of the social being, the process realizes the opening and cooperative development of all mental, spiritual-religious, scientific, creative-artistic, economic, cultural, material and non-material political fields. It includes the individual, the community, and all institutions of social life. The path of integration development is the transitive movement in a spiral form. In Albania, with the fall of communism, freedom of religion was legalized according to the standards of European democracy. The rehabilitation of religious figures that had been condemned and persecuted by the totalitarian regime began. The post-communist transition brought profound changes in the field of faith and religion such as the new dimension in the relationship of society with religion, new and unfamiliar attitudes of believers to religion, new relations between the state and religious institutions, new relations between education and religion in public institutions, opening of religious schools and increasing the influence of religion through the media and religious literature. What is considered tolerance in Europe, in the Albanian case is respect. Albanians are the best model for religious tolerance (respect). There has never been a religious clash in Albania for any reason. Respect for the religious affiliation and religious belief of the other in the Albanian case is modeled as the guiding value of their identity and appears in everyday life as the acceptance of the other. For this reason, they are the best model of respect and acceptance of the other, regardless of religious affiliation. This is an ontological value, built over the centuries and continues to this day. Albanians have not converted, but have adapted to a religious belief for economic and survival reasons. Marriages with different religions and keeping two names (Christian and Muslim) are natural phenomena among Albanians. In Albania, there are in the family and tribe people with Christian and Muslim religions individuals with two names, Christian and Muslim: Kristo and Muhamed. Albanians have lived in peaceful symbiosis with the Slavs in the centuries of the latter’s influx into Albanian lands. They have also lived peacefully with other neighbors, Greeks or Romans. This is even though the neighbors have not always been peaceful with the Albanians.

Precursor skyrmion states near the ordering temperatures of chiral magnets.

In noncentrosymmetric magnets, chiral Dzyaloshinskii-Moriya interactions (DMI) provide a distinctive mechanism for the stabilization of localized skyrmion states in two and three dimensions with a fixed sense of rotation. Near the ordering transition, the skyrmion strings develop attractive skyrmion-skyrmion interactions and ultimately become confined in extended clusters or textures [A. O. Leonov and U. K. Rößler, Nanomaterials, 2023, 13, 891], which is a consequence of the coupling between the magnitude and the angular part of the order parameter. Multi-skyrmionic states built from isolated skyrmions (IS) can form multiple modulated magnetic phases that may underlie the exotic magnetic phenomena of "partial order" or the field-driven "A-phase" observed in MnSi and other cubic helimagnets. Based on the standard phenomenological Dzyaloshinskii model, we obtain numerically exact solutions for skyrmion lattices (SkL), formulate their basic properties, and elucidate physical mechanisms of their formation and stability. Our detailed numerical studies show that the bound skyrmion states arise as hexagonal lattices of ±π-skyrmions (with the magnetization in the center along or opposite to the magnetic field) or square staggered lattices of π/2-skyrmions, which contain defect lines with zero modulus value and thus may form thermodynamically stable states only near the ordering temperature. In the simplest case of a two-dimensional (2D) skyrmionic texture, the structure is homogeneous in the third dimension (3D). The skyrmions preserve an ideal axisymmetric "double twist" core in condensed phases, while continuation into a space-filling texture is frustrated. The evolution of skyrmion lattices in an increasing magnetic field leads to a succession of phase transitions of first or second kind between diverse textures and finally ends due to the formation of isolated skyrmion-filaments with fixed radius and shape embedded in a homogeneously magnetized matrix. In the framework of the phenomenological model including only isotropic interactions (exchange, Zeeman, and DM energy contributions), the considered skyrmion lattices are only metastable states as the competing conical one-dimensional spiral forms the equilibrium state. But due to the weak couplings between skyrmions, secondary effects like anisotropies can stabilize skyrmionic textures as compared to simple helices. Also the topological nature of skyrmion condensates makes the magnetization processes in chiral magnets history-dependent and hysteretic.