This paper extends the research on the self-consistent effective-one-body theory of a real spinless two-body system based on the post-Minkowskian approximation (Science China, 65, 100411, (2022)) to the case of a binary system for the spinning black holes. An effective rotating metric and an improved Hamiltonian for the spinning black hole binaries were constructed. The decoupled equation for the null tetrad component of the gravitational perturbed Weyl tensor $\psi^B_{4}$ in the effective rotating spacetime is found with the help of the gauge transform characteristics of the Weyl tensors. The decoupled equation is then separated between radial and angular variables in the slowly rotating background spacetime, and a formal solution of $\psi^B_{4}$ is obtained. On this basis, the formal expressions of the radiation reaction force and the waveform for the ``plus'' and ``cross'' modes of the gravitational wave are presented. These results, obtained in the same effective spacetime, constitute a self-consistent effective-one-body theory for the spinning black hole binaries based on the post-Minkowskian approximation.