Spindle Cell Carcinoma Of Kidney Research Articles

High-grade mucinous tubular and spindle cell carcinoma of the kidney in a patient on hemodialysis: a case report and literature review

BackgroundEnd-stage renal disease is a risk factor for renal cell carcinoma. However, mucinous tubular and spindle cell carcinoma of the kidney is rare. We report a patient on hemodialysis who had high-grade mucinous tubular and spindle cell carcinoma of the kidney.Case presentationA 62-year-old Japanese woman had end-stage renal disease and had been on hemodialysis for the previous 4 years. However, periodic imaging examinations to detect kidney cancer had not been conducted. The patient visited our department of urology complaining of general fatigue and dyspnea. Computed tomography with enhancement revealed a solid renal mass with a diameter of 66 mm. It had invaded the right psoas muscle and had multiple lymph node metastases. In addition, the patient had massive ascites and right-sided predominant pleural effusion. We drained the pleural effusion, but she died 11 days after admission. An autopsy was performed. Pathological examination revealed high-grade mucinous tubular and spindle cell carcinoma of the right kidney; multiple organ metastases to the bilateral lungs, liver, gall bladder, uterus, ovary, and inferior vena cava; cancerous pleuritis; and cancerous peritonitis. Our case indicates that high-grade mucinous tubular and spindle cell carcinoma emerging in end-stage kidney causes a detrimental clinical course.ConclusionHigh-grade mucinous tubular and spindle cell carcinoma of the kidney had a severe clinical course. We recommend periodic screening of patients with end-stage renal disease, using computed tomography or ultrasound.

Mucinous Tubular and Spindle Cell Carcinoma of Kidney: A Case Report of a Rare Tumor

The objective of this research is to enhance the understanding and recognition of Mucinous Tubular and Spindle Cell Carcinoma of the Kidney (MTSCC-K), a rare renal tumor occurring in less than 1% of all renal tumors. The focus is on improving clinical diagnosis, understanding the tumor's characteristics, and exploring the prognosis and implications for patients. The method used in this research is a case study. The results of this research indicate that Clinical Presentation: MTSCC-K predominantly occurs in women and often presents with flank pain, similar to other renal tumors. However, it may lack other typical symptoms such as significant weight loss or urinary problems. Imaging Characteristics: CT scans may reveal solid masses with patchy calcification, often protruding outside the renal contour. These specific imaging features can aid in the differential diagnosis of MTSCC-K Histopathological Features: MTSCC-K is characterized by small, elongated cords or tubules arranged densely, with interspersed myxoid stroma. The presence of slender tubular spindle cell-like structures is a distinctive feature Prognosis: Patients with MTSCC-K, especially when diagnosed early and treated with radical nephrectomy, have a comparatively good prognosis compared to other renal cell carcinomas. The lack of identified metastases in the presented case also supports a positive prognosis. Implications of this research include: Increased awareness among doctors and radiologists about the unique clinical and imaging features of MTSCC-K can lead to faster and more accurate diagnoses.

A rare case of Mucinous, tubular and spindle cell carcinoma of kidney and Histomorphological study of renal cell tumours

A rare case of Mucinous, tubular and spindle cell carcinoma of kidney and Histomorphological study of renal cell tumours - IJPO- Print ISSN No: - 2394-6784 Online ISSN No:- 2394-6792 Article DOI No:- 10.18231/j.ijpo.2020.033, Indian Journal of Pathology and Oncology-Indian J Pathol Oncol

Mucinous tubular and spindle cell carcinoma of kidney: A case report of a mucin and stroma poor tumour causing diagnostic difficulty

Mucinous tubular and spindle cell carcinoma (MTSCC) is a rare and unusual variant of renal cell carcinoma (RCC). We report an unusual tumour in an 81-year-old male with an incidental finding of a tumour in the lower pole of the left kidney. The core biopsy showed a renal cell carcinoma with mostly tubular morphology and an immunophenotype indistinguishable from papillary renal cell carcinoma. The partial nephrectomy showed a tumour comprising predominantly tubular structures with focal abortive papillae, psammomatous calcifications and scattered small aggregates of foam cells. Only focal areas showed myxoid change and spindle cells, but this made the diagnosis of a mucinous tubular and spindle cell carcinoma more straightforward. This case highlights the importance of recognising a mucin/stroma poor variant of MTSCC of the kidney and how the entity can cause diagnostic confusion with papillary renal cell carcinoma as there is morphologic and immunophenotypic overlap, particularly on core biopsy.

Renal mucinous tubular and spindle cell carcinoma: a report of 8 cases and review of the literature

BackgroundMucinous tubular and spindle cell carcinoma of kidney (MTSCC-K) is a rare variant of renal tumor. The current data show most of MTSCCs are of low malignant potential and rare cases metastatic to lymph nodes have been reported; however, the recorded computed tomography (CT) and follow up data are limited.Material and methodIn the present study, we retrospectively analyzed CT and clinicopathological data of eight patients with renal MTSCC-K.ResultsA total of eight cases, including six females and two males, were included in this analysis with a mean age of 48.4 (range 25 to 81) years. Mean tumor size was 4.2 (range 2.5 to 10.0) cm. Preoperative CT demonstrated that all tumors were slightly enhanced on both corticomedullary and nephrographic phase, which was different from many other renal cell carcinomas. Three of them were treated with open radical nephrectomy, three with laparoscopic radical nephrectomy and the other two with laparoscopic partial nephrectomy. No postoperative therapy was applied. Patients were followed up for 15 to 64 months and there was no evidence of recurrence and metastasis.ConclusionsThe MTSCC-K has special clinicopathological characteristics, low degree of malignancy and relative good prognosis. The diagnosis mainly depends on the histopathological examination and CT may help to differentiate with papillary renal cell carcinoma. Surgical treatment is recommended and additional therapies are not necessary.Virtual slidesThe virtual slides for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/8435581771088249.

Mucinous tubular and spindle cell carcinoma of the kidney

Mucinous tubular and spindle cell carcinoma of the kidney (MTSCC) is a recently recognized renal tumour. First described in 1998 and previously classified in the category “renal cell carcinoma, unclassified” it was included as a separate entity in the World Health Organization (WHO) classification of renal neoplasm in 2004 (1-3). We report a mucinous tubular and spindle cell carcinoma of kidney which occurred in a 60 year old man.

Mucinous tubular and spindle cell carcinoma of kidney: A clinicopathologic study of six cases

Mucinous tubular and spindle carcinoma (MTSCC) of kidney is a rare, low-grade polymorphic tumor. Recent studies have described a wide morphology spectrum of this tumor. To report the clinico-pathologic features of six cases of MTSCC of kidney. Six cases of MTSCC of kidney were studied and literature was reviewed. Immunohistochemistry was done by Envision method. The age of the patients ranged from 44 to 84 years (mean 58.5 years). Four patients were males and two were females. The tumor was located in the left kidney in four cases and in the right kidney in two cases. The tumor size ranged from 4.5 to 15 cm (mean 6.4 cm). All tumors exhibited an admixture of tubules, spindle cells, and mucinous stroma in variable proportions. Tubules were predominant in five cases and spindle cells in one case. Psammomatous calcifications, papillations, and necrosis were seen in two cases. Collections of foamy histiocytes were noted in four cases. Cytoplasmic vacuoles and osseous metaplasia were seen in one case each. All cases were Fuhrman's nuclear grade II. Five cases were of stage pT1, and one was pT3. All cases stained positive for alcian blue at pH 2.5. Immunohistochemical stain CK7 was positive in all cases and CD10 was positive in 1/1 case. All patients were alive and well at follow-up of 12-59 months (mean 33.5 months). No metastases were detected. We report six cases of MTSCC of kidney, a rare distinct variant of RCC, with a favorable prognosis. A male predominance was seen in our cases. MTSCC shares histologic and immunohistochemical overlap with papillary renal cell carcinoma (PRCC) and cytogenetic analysis should be performed in difficult cases to avoid a misdiagnosis.

Mucinous tubular and spindle cell carcinoma of kidney: a clinicopathological study

To investigate the clinicopathological features, histogenesis and prognosis of mucinous tubular and spindle cell carcinoma (MTSCC). Five MTSCCs were studied with histochemical, immunohistochemical staining, electron microscopy, and review of the related literatures. Four cases of MTSCC were females and one was male. Three patients presented with flank discomfort and two were incidentally found with health examination. In gross examination, the tumors were circumscribed. The cut surface was solid, gray-white, yellow or red. Necrosis was present in one case of high-grade MTSCC. Microscopically, low-grade MTSCC was mainly consisted of tubular, spindle cell and mucinous stroma with relatively bland morphology, and mitoses were rare. While in the high-grade area of one case, the cells were spindle or polymorphic with severe atypia and high mitotic activity, without mucinous stroma and tubular structure. Mucin was positive for Alcian blue. The neoplastic cells were positive for vimentin (5/5), CKpan (5/5), CK7 (5/5), CK19 (5/5), 34betaE12 (1/5), EMA (5/5), E-cadherin (3/5), CD10 (1/5), P504S (5/5), and CAM5.2 (5/5). The Ki-67 index was low (< or = 5%) in the low-grade component, while it was high (15%) in the high-grade component. Ultrastructural study showed short microvilli along glandular lumens. The nuclear membrane was focally invaginated. Four cases were followed up for 3 to 52 months, and recurrence and metastasis were not found. MTSCC occurs predominantly in females and it is a rare kidney neoplasm. Most of MTSCCs are low-grade and the prognosis is relatively good. However, the patients of high-grade MTSCC should be closely followed up.

Mucinous tubular and spindle cell carcinoma of kidney and problems in diagnosis

Mucinous tubular and spindle cell carcinomas (MTSCC's) are recently described rare type of renal cell carcinoma (RCC). MTSCC's are characterized by small, elongated tubules lined by cuboidal cells and/or cords of spindled cells separated by pale mucinous stroma. They have morphological similarities to papillary RCC (papRCC). We evaluated the importance of the immunohistochemical features in the differential diagnosis of MTSCC and papRCC. We re-evaluated 9 cases of MTSCC diagnosed between 2004 and 2010 and compared 10 cases of papRCC. All tumors were stained with alpha-methylacyl-CoA racemase (AMACR), cytokeratin 7 (CK7), CK19, renal cell carcinoma marker (RCC Ma), CD10 and kidney specific cadherin (KspCad). A total of 6/9 cases were considered classical. Two of 9 MTSCC's were classified as "mucin-poor". Foamy macrophages were identified in 4 cases. The immunoreactivity in MTSCC was AMACR 100%, CK7 100%, CK19 100%, RCC Ma 50%, CD10 11%, and KspCad 38% while the values for papRCC were AMACR 100%, CK7 90%, CK19 100%, RCC Ma 100%, CD10 80%, and KspCad 0%. MTSCCs may include little mucin and show a marked predominance of either of its principal morphological components. They may mimic other forms of RCC. Pathologists should be aware of the histological spectrum of MTSCCs to ensure an accurate diagnosis. Careful attention to the presence of a spindle cell population may be helpful in the differential diagnosis in tumors with predominant compact tubular growth. Immunohistochemical stains for papRCC are also expressed in MTSCC, but strong CD10 expression may not favor MTSCC.

Mucinous tubular and spindle cell carcinoma of kidney without sarcomatoid change showing metastases to liver and retroperitoneal lymph node

Mucinous tubular and spindle cell carcinoma (MTSCC) is an uncommon, newly recognized tumor that in its classic histological form shows tightly packed, elongated tubules with transition into spindle cell areas and pale mucinous stroma. The current data suggest that the great majority of MTSCCs have a favorable prognosis; however, the follow-up data are limited and the full biologic potential of this tumor remains to be established. There are a few examples of MTSCCs metastatic to lymph nodes and rare cases with sarcomatoid differentiation associated with distant metastases. We report on a case of MTSCC of kidney with concurrent nodal and liver metastases. The metastatic nodules were well circumscribed and showed morphological and immunophenotypic features similar to those of the primary tumor. Extensive sampling revealed no evidence of sarcomatoid morphology. To our knowledge, this is the first case of MTSCC without sarcomatoid differentiation showing parenchymal metastasis.

Mucinous Tubular and Spindle Cell Carcinoma of Kidney

Mucinous Tubular and Spindle Cell Carcinoma of Kidney

Mucinous tubular and spindle cell carcinoma of kidney: A rare case report and review of the literature

Low grade mucinous tubular and spindle cell carcinoma of kidney was newly established as a distinct renal cell carcinoma in the World Health Organization (WHO) classification of 2004. Until now, less than 60 cases have been reported and the largest series represented approximately 15 patients with this type of tumor. Herein, we report a case of mucinous tubular and spindle cell carcinoma in a 63-year-old male presented with right flank pain which was diagnosed after nephrectomy. Pathologists should consider this diagnosis and its spectrum of histopathologic features in mind to ensure an accurate diagnosis.

Mucinous tubular and spindle cell carcinoma of kidney is probably a variant of papillary renal cell carcinoma with spindle cell features

Mucinous tubular and spindle cell carcinoma is a rare and newly described type of renal cell carcinoma (RCC) with a relatively indolent behavior. However, its histogenetic origin or line of differentiation remains unclear. Twelve cases of mucinous tubular and spindle cell carcinoma were identified and retrieved from the files of 3 institutions. Detailed morphological features, as well as their immunohistochemical profile established with markers of proximal renal tubules (RCC marker antigen, CD15, and alpha-methylacyl-CoA racemase) and of distal renal tubules (kidney-specific cadherin and cytokeratin 7), were studied. The age range of the patients was 35 to 73 years with a median of 56 years. The male to female ratio was 1:3. All of the patients were alive with follow-up between 4 and 38 months. All the tumors were confined to the kidney with a mean tumor size of 6.9 cm (range, 1.8-17 cm). The tumors were composed of variable proportions of tubular and spindle cell areas with focal to prominent mucinous or myxoid stroma. Foamy macrophages were seen in 10 cases and were prominent in 4 cases. A focal compressed tubulopapillary growth pattern was seen in 10 cases. The tumor cells were uniformly cuboidal with ovoid to round nuclei and inconspicuous nucleoli (Furhman nuclear grade 3 in 6 cases). Focal necrosis was seen in 3 cases. Immunostains showed that tumors were positive for RCC marker antigen (11/12), alpha-methylacyl-CoA racemase (11/12), CD15 (8/12), CD10 (2/12), kidney-specific cadherin (1/12), and cytokeratin 7 (11/12). Its morphological features as well as a strong preferential expression of proximal tubule markers suggest that this tumor is a type of RCC with proximal tubular differentiation, which appears closely related to or represents a morphological variant of papillary RCC.

Mucinous tubular and spindle cell carcinoma of kidney

例1男,27岁.因体检发现右肾占位性病变6 d于2005年11月入院.辅助检查:CT示右肾中上极背侧见一类圆形低密度影,向肾外突出,大小5.2 cm×5.7 cm×5.0 cm,边缘清楚,光滑.诊断:右肾中上极占位,良性病变可能性大.MRI扫描表现:右肾体积弱增大,上极见一类圆形弱短T1等T2异常信号,边界清楚,大小约5.5 cm×5.5 cm×5.0 cm,肾盂明显受压.MRI诊断:右肾上极占位性病变,良性可能性大:(1)囊性肿块并出血可能,(2)实性肿块待排.术前临床诊断肾脏囊肿、肾脏良性占位。