You have accessJournal of UrologyInfections/Inflammation/Cystic Disease of the Genitourinary Tract: Interstitial Cystitis II1 Apr 2017MP29-11 OVERACTIVE BLADDER AND CO-OCCURRING INTERSTITIAL CYSTITIS/BLADDER PAIN SYNDROME: THE ROLE OF CENTRAL SENSITIZATION IN CLINICAL PRESENTATION. Lindsey McKernan, Joshua Cohn, Stephen Bruehl, Roger Dmochowski, and W. Stuart Reynolds Lindsey McKernanLindsey McKernan More articles by this author , Joshua CohnJoshua Cohn More articles by this author , Stephen BruehlStephen Bruehl More articles by this author , Roger DmochowskiRoger Dmochowski More articles by this author , and W. Stuart ReynoldsW. Stuart Reynolds More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.02.923AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Many clinical characteristics overlap between Overactive Bladder (OAB) and Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) suggesting possible common pathophysiologic mechanisms. Central sensitization, which is an induced state of spinal hypersensitivity and well-recognized mechanism of centrally amplified pain perception, may be such a mechanism. Psychosocial and pain characteristics are important aspects of central sensitization disorders, but are often overlooked in women with OAB. Our aim was to examine whether these characteristics differ among OAB patients with a self-reported history of IC/BPS, OAB alone, and controls. METHODS We enrolled 39 adult women initiating third-line OAB therapy and 25 healthy controls to complete clinical and psychosocial assessment. We identified a subset of women with OAB who self-identified as having a history of IC/BPS (n=13). Using Fischers exact test and linear regression, we then compared differences in bladder symptoms, psychosocial functioning, and pain sensitivity across these three groups (OAB = 26, OAB & IC/BPS = 13, and control = 25). RESULTS Women with OAB with or without IC/BPS reported significantly greater urinary symptoms and psychosocial and pain burden than controls (Tables 1 and 2). The subset of women with IC/BPS demonstrated significantly increased symptom severity, higher rates of co-morbid somatic conditions, emotional distress, and poorer quality of life when compared to other groups. This group also reported a greater degree of widespread pain and symptoms attributable to central sensitization than those with OAB alone. CONCLUSIONS In this group of women undergoing third-line therapy for OAB, a personal history of IC/BPS was associated with worsened psychosocial, bladder, and pain function compared to those with OAB or controls. However, women with OAB alone also demonstrated similar characteristics, supporting the hypothesis that central sensitization may play a role in both conditions. © 2017FiguresReferencesRelatedDetails Volume 197Issue 4SApril 2017Page: e384 Advertisement Copyright & Permissions© 2017MetricsAuthor Information Lindsey McKernan More articles by this author Joshua Cohn More articles by this author Stephen Bruehl More articles by this author Roger Dmochowski More articles by this author W. Stuart Reynolds More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...