Collector Speed Research Articles

Fabrication and characterization of multi-layered coaxial agar-based electrospun biocomposite mat, novel replacement for transdermal patches

In the performed study, a novel fabrication of agar-based nanofibers was electrospun in an asymmetric bilayer dressing for biomedical transdermal patches. The optimal parameters for the fabrication of agar-based nanofibers after optimization were a feed rate of 10 μL/min, a 7 cm collector-to-nozzle distance, a 15 kV applied voltage, and a 700-rpm rotating collector speed. Coaxial nanofibers, as a second asymmetric layer, were produced using polyvinyl alcohol (PVA) with cephalexin hydrate, an antibacterial drug, as the core and agar-PCL as the sheath. The morphology of the developed uniaxial and coaxial nanofibrous layers was analysed using a scanning electron microscope and transmission electron microscopy, respectively. For the formation of bilayer asymmetric structures, the agar-PCL uniaxial layer was fabricated over the layer of coaxial PVA and agar-PCL layers for sustained drug release. The agar-based nanofibrous mats exhibited tensile strength of 7 MPa with 40 % elongation failure, 8-fold increased swelling, enhanced wettability (60° contact angle), and a moisture transmission rate of 2174 g/m2/day. The developed coaxial bilayer mats exhibited antimicrobial activity, hemocompatibility, and cytocompatibility. Overall, this novel agar nanofibrous dressing offers promising potential for advanced biomedical applications, particularly as transdermal patches for efficient drug delivery systems.

Synthesis, Optical Performance Characterization, and Durability of Electrospun PTFE-PEO Materials for Space Applications.

Passive heat management is crucial in space, especially for extended missions involving protection from sunlight. Thermal coatings with desirable optical properties can drastically reduce the power consumed by active cooling systems, thereby reserving more resources for other critical systems onboard. Specifically, materials with wavelength-dependent reflectance and emittance are desirable for managing incident sunlight and self-cooling by thermal emission. This study demonstrates the use of polymer nanofibers, specifically poly(tetrafluoroethylene) (PTFE), for passive temperature control in space applications. This study describes the electrospinning fabrication process to create nanofibers and how process parameters can be varied to control the fiber geometry. We combine poly(tetrafluoroethylene) (PTFE) and poly(ethylene oxide) (PEO) polymers to fabricate highly reflective thermal control materials by electrospinning. To understand the role of material and fiber geometry, we measure spectral reflectance, absorptance, and transmittance using spectrophotometers interfaced with integrating spheres. We control the materials' fiber geometry and solar reflectance by modifying the solution properties, flow rate, rotating collector speed, and fabrication time. With 220-1560 μm thick electrospun nanofiber materials, we demonstrate an average solar reflectance of 94.73-99.75%, with values approaching 99.9% for thicker samples, which is among the highest for space applications. Meanwhile, a thermal emittance of 81.4% was observed at 300 K for a 3360 μm thick sample. The durability of these samples was also tested under ultraviolet light and atomic oxygen. Compared to the state-of-the-art materials, the electrospun PTFE-PEO fibers present a new paradigm for passive thermal management in space applications.

Design and Fabrication of Fibrous Spindle‐Like Constructs Using a Melt Electrohydrodynamic Writing Process

AbstractAdvanced manufacturing of 3D‐structured materials enables the production of biomimetic muscle tissues. While models of muscle tissue exist, current approaches possess a limited ability to capture essential elements of the muscle tissue microarchitecture. Therefore, this paper aims to engineer the intrinsically complex muscle spindle‐like ellipsoid geometry using a polymer melt‐based electrohydrodynamic (EHD) printing system. EHD systems have conventionally reported fiber deposition in a layerwise fashion. However, without mitigation, the observed fiber sagging and residual charge phenomena for the melt electrowriting (MEW) process limit the ability to produce layered fibrous 3D constructs with in‐plane fiber alignment. However, in this work, fiber sagging and residual charge phenomena are leveraged as part of the design intent to deposit nonoverlapping suspended fibers between two stationary walls toward spindle‐like construct fabrication. Specifically, herein the structural and mechanical properties of the MEW‐enabled spindle‐like constructs are analyzed as a function of the process and design parameters that govern control over fiber sagging and residual charge. The results indicate that the collector speed and wall‐to‐wall distance are the key parameters for tuning the spindle morphology. Moreover, cycle number and fiber diameter are identified as effective parameters for tuning the spindle mechanical properties.

Monitoring of multiple fabrication parameters of electrospun polymer fibers using mueller matrix analysis

Electrospun polymer fiber mats feature versatile applications in tissue engineering, drug delivery, water treatment and chemical processes. The orientation of fibers within these mats is a crucial factor that significantly influences their properties and performance. However, the analysis of fiber samples using scanning electron microscopy (SEM) has limitations such as time consumption, fixed assembly, and restricted field of vision. Therefore, a fast and reliable method for qualitative measurements of fiber orientation is required. Mueller matrix polarimetry, a well-established method for measuring orientation of chemical and biological species, was employed in this case. We investigated the effect of four important parameters of the electrospinning process, namely collector speed, applied voltage, needle-to-collector distance, and solution concentration, on fiber orientation using Mueller matrix polarimetry thus extending the range of parameters analyzed. Measurements were performed using two extreme values and a central optimized value for each fabrication parameter. Changes in matrix values were observed for each fabrication parameter, and their correlation with fiber orientation was analyzed based on the Lu-Chipman decomposition. The results were compared with SEM images, which served as the ground truth, and showed overall good agreement. In the future, the analysis of electrospun polymer fibers can be done by using Mueller matrix polarimetry as alternative to current technology and fabrication parameters, including solution concentration for the first time in this context and the production can quickly be adjusted based on the outcome of the measurements.

Effect of Collector Rotational Speed on the Morphology and Structure of Solution Blow Spun Polylactic Acid (PLA).

Apart from structure and composition, morphology plays a significant role in influencing the performance of materials in terms of both bulk and surface behavior. In this work, polylactic acid (PLA) constituted by submicrometric fibers is prepared. Using a modified electrospinning (ES) device to carry out solution blow spinning (SBS), the fibrillar morphology is modified, with the aim to induce variations in the properties of the material. The modification of the ES device consists of the incorporation of a source of pressurized gas (air) and a 3D-printed nozzle of our own design. For this work, the morphology of the PLA submicrometric fibers is modified by varying the rotational speed of the collector in order to understand its influence on different properties and, consequently, on the performance of the material. The rotational speed of a cylindrical collector (250, 500, 1000 and 2000 rpm) is considered as variable for changing the morphology. Morphological study of the materials was performed using scanning electron microscopy and image analysis carried out with ImageJ 1.54f software. Besides a morphology study, structural characterization by Fourier transformed infrared spectroscopy using attenuated total reflectance of prepared materials is carried out. Finally, the morphology and structure of produced PLA fibrous mats were correlated with the analysis of mechanical properties, wettability behavior and adhesion of DH5-α E. coli bacteria. It is of interest to highlight how small morphological and chemical structure variations can lead to important changes in materials' performance. These changes include, for example, those above 30% in some mechanical parameters and clear variations in bacterial adhesion capacity.

Fabricating ultra-thin nanofiber structures towards the advanced MEA of fuel cells: investigation of the degree of alignment, diameter, bead generation, and precision with Taguchi designs.

Modified nanofibers with a more aligned and very thin structure are a potential approach owing to their promising properties and enhanced fuel cell performance compared to conventional randomly oriented nanofibers. The strategy to fabricate randomly oriented nanofibers has been widely explored. However, the key factors of oriented fibres, such as the degree of alignment, diameter, bead generation, and precision, have not been investigated in detail. In this work, four specific profiles of nanofibres related to the parameters of the electrospinning system were analysed in more detail for the first time: collector speed, distance, voltage, and nozzle movement. The concentration was set at a constant value of 10% (w/w) of polyvinyl alcohol (PVA), which is suitable for the potential application of fabricating membrane electrode assemblies (MEAs) for fuel cells. The results indicated that the applied electrical voltage is the most important factor among all the features. Taguchi methods implemented in this work revealed the correlation factors for each specific parameter.

Conductive and auxetic composite membranes based on graphene nanoplatelets and polybutylene succinate produced via electrospinning

AbstractThis work presents a method to produce conductive and auxetic composite membranes from a biobased and biodegradable matrix: polybutylene succinate (PBS). The conductivity was improved by the addition of graphene nanoplatelets (GNP) and the samples were produced via solution electrospinning. The membrane properties were shown to increase with increasing GNP concentration and the rotational speed of the collector. In particular, a membrane having 0.2% w/v GNP and fabricated at the highest collector speed (9.96 m/s) showed the highest electrical conductivity (1.56 × 10−4 S/m) while having a negative Poisson's ratio (NPR) of −1.5 in tension. To complete the analysis, mechanical characterizations showed that the presence of GNP led to a substantial increase in Young's modulus (234%) and tensile strength (190%) compared to the neat PBS membrane produced under the same conditions. Differential scanning calorimetry (DSC) revealed a slight crystallinity increase since GNP are acting as heterogeneous nucleating agents, while thermogravimetric analysis (TGA) showed an improved thermal stability for the GNP/PBS membranes. This unique combination of auxetic and conductive properties can be useful for a wide range of innovative applications such as electronic devices, smart textiles, biomaterials, and biomedical devices.Highlights Electrospinning was successful to produce polybutylene succinate (PBS) nanofibers. A careful control of the processing conditions led to auxetic fiber mats. Electrically conductive mats were produced by adding graphene nanoplatelets (GNP) to PBS. The PBS mechanical properties were highly improved (200%) with low GNP content (0.2%).

Effects of Six Processing Parameters on the Size of PCL Fibers Prepared by Melt Electrospinning Writing.

Melt electrospinning writing is a new and promising method for fabricating micro/nanofibers, which has shown great prospects in the biomedical fields such as 3D printing of porous scaffolds. The diameter of the melt electrospinning writing fiber can determine the resolution of the microstructure; thus, the controllability of the fiber diameter is of great significance to the whole fabrication process. In this paper, an orthogonal design experiment (six factors, three levels) was used to explore the impacts of six melt electrospinning parameters (melt temperature, collector speed, tip-to-collector distance, melt flow rate, voltage, and needle gauge) on the fiber diameter. In this experiment, the diameter of fibers obtained with the designed experimental parameters and conditions varied from 10.30 μm to 20.02 μm. The range analysis of orthogonal test results showed that the melt flow rate was the most important factor influencing the diameter of melt electrospinning writing fiber, while the voltage was the least influential factor. The variance analysis of orthogonal test results showed that melt temperature, collector velocity, tip-to-collector distance and melt flow rate had a significant influence on the diameter of melt electrospinning writing fiber. On the basis of the first-order regression equation, the fiber diameter of poly-ε-caprolactone can be accurately controlled, thus improving the engineering applications of poly-ε-caprolactone.

A Decade of Melt Electrowriting.

Over the past decade, melt electrowriting (MEW) has established the fundamental understanding of processing (and printer) requirements. Iterative work on parametric development and dissemination of this recent additive manufacturing technology has been performed across many systems and polymers (mainly poly-(ε-caprolactone)), showing similarities and trends. However, the software and hardware ecosystems of MEW are not mature. Further, due to its multi-parametric nature, MEW can be challenging for laboratories to master. This review intends to provide a unique perspective on the dynamic relationship between MEW processing parameters. Such parameters can be divided into 1) those that affect the polymer flow rate to or 2) from the nozzle, and 3) environmental conditions. The most influential parameters for high-quality printing are applied voltage, applied pressure, collector speed, polymer temperature, nozzle diameter, and the conditions that lead to charge buildup (e.g., relative humidity). Other factors such as ambient temperature, nozzle size, and protrusion, collector temperature and conductivity, and collector distance can all affect the process. Success for MEW printing means fibers fall onto the collector according to their pre-programmed path with predicted fiber diameter. Here, the authors elucidate how the dynamic relationship between these parameters can converge into ideal printing conditions to produce scaffolds.

Fabrication of Janus Composite Membranes with a Gradient Pore Structure Based on Melt Electrowriting and Solution Electrospinning for Directional Water Transport

As a functional textile, the directional water transport textile has been widely used in daily life due to the ability of excellent moisture absorption and quick drying. However, it is still a great challenge to construct a textile that ensures water to transport rapidly from the skin to the outer environment (positive direction) and prevents the skin from being rewetted effectively in the reverse direction. Herein, this study aims to improve the ability of the hydrophobic layer in moisture management using melt electrowriting (MEW) to fabricate gradient pore structures precisely. The pore sizes in different layers can be tailored by altering the collector speed, and thus, the configuration of the pore structure dominates the process of water transportation. The unique multilayered structure achieves the directional water transport effects by improving the permeability with large pores and hindering the transport with small pores in the reverse direction. Meanwhile, we use solution electrospinning (SE) technology to fabricate the hydrophilic layer. The constructed composite membranes exhibit excellent performance with a one-way transport index R up to 1281% and a desired overall moisture management capacity (OMMC) of 0.87. This research outlines an approach to fabricating Janus membranes to enhance its directional water transport performance, facilitating the MEW technique to be applied on the more expanded field for directional water transport textiles.

Synthesis of PVDF-SiO2 nanofiber membrane using electrospinning multi-jet vertical on conveyor collector as a lithium-ion battery separator

Research on synthesis of PVDF-SiO2 nanofiber membrane by electrospinning multi-jet vertical method on conveyor collector as a lithium-ion battery separator was systematically investigated. Various voltages of 15 kV, 16 kV, and 17 kV and types of PVDF such as Aldrich, Solvay, and both mixtures were used for nanofiber membrane synthesis. The nanofiber membrane was synthesized for 4 hours with a distance between the tip of the needle, and the collector was 10 cm, with a flow rate of 2.6 mL/hour and a collector speed of 37 rpm. Furthermore, the results were tested for the physicochemical properties of the nanofiber. Solution B (PVDF Solvay) treated with 17kV has the largest porosity percentage value of membrane, which was 84.659%. The optimum shrinkage ratio test was from solution A (PVDF Aldrich) with 15 kV, 16 kV, and 17 kV voltages. The smallest average diameter nanofiber was obtained from solution B (PVDF Solvay) with a voltage of 15kV. The FTIR spectrum was not affected by voltages variations. In addition, the nanofiber membrane was assembled in the battery using Aldrich, Solvay, and mixed PVDF types. The battery was then tested for the electrochemical properties of the lithium-ion battery. Solution B (Solvay) has the optimum charge-discharge results showing a specific charge of 107.472 mAh/g and a specific discharge of 77.990 mAh/g.

The Effect of Electrospinning Parameters on Morphological and Mechanical Properties of PAN-based Nanofibers Membrane

The electrospun nanofibers membranes (ENMs) have gained great attention due to their superior performance. However, the low mechanical strength of ENMs, such as the rigidity and low strength, limits their applications in many aspects which need adequate strength, such as water filtration. This work investigates the impact of electrospinning parameters on the properties of ENMs fabricated from polyacrylonitrile (PAN) solved in N, N-Dimethylformamide (DMF). The studied electrospinning parameters were polymer concentration, solution flow rate, collector rotating speed, and the distance between the needle and collector. The fabricated ENMs were characterized using scanning electron microscopy (SEM) to understand the surface morphology and estimate the average fiber sizes. The membrane porosity percentage was measured using the dry-wet weight method. Also, a dynamic mechanical analyzer was used to determine the mechanical strength properties (tensile strength and Young's modulus) (DMA). The obtained results revealed that the polymer concentration and flow rate mainly affect the porosity and fiber size in ENMs. Increasing the polymer concentration improves the strength and flexibility, while the flow rate did not show a clear effect on the mechanical strength of ENMs. Both fibers collecting speed and spinning distance did not clearly impact the membrane morphology. ENMs flexibility significantly increased with increasing the collector speed and decreasing the spinning distance. Strong and flexible ENMs with small fibers can be fabricated using 10% PAN/DMF at a flow rate of 1 mL/h, collector speed of 140 rpm, and spinning distance of 13 cm.

Fabrication of 3D oriented carbon nanofiber by two-nuzzle electrospinning as a cell scaffold.

One of the important issues in tissue engineering has been the development of 3D scaffolds, which guide cells to grow functional tissues and allow the diffusion of nutrients, metabolites, and soluble factors. Factors governing scaffold design include considerations of pore size and morphology, mechanical properties versus porosity, surface properties, and appropriate biodegradability. Three-dimensional structures with low density, high surface area and porosity can be utilized effectively in the tissue engineering. Recently two-nozzle electrospinning was used for fabricate polymeric and ceramic bulky layers with specific formulation. Fabrication of 3D carbon nanofiber with this method was investigated in this assay with FESEM, TGA-DTA, FTIR and XRD. Polyacrylonitrile was used as precursor. The collector speed was changed (15, 30, 60, 150, 300 and 450rpm) to result in oriented 3D carbon nanofiber after stepwise thermal process under neutral gas atmosphere. The effect of the mechanical force applied by the collector rotation not only can arranged carbon fiber mat but also can change the crystallinity of the carbon structure. The viability and growth capability of cells on nanofibers towards the lowest cytotoxicity of them proved by MTT test. The growth characteristic of neural and mouse bone marrow mesenchymal stem cells cultured in the webs showed the good adhesion with the blown web relative to a normal electrospun mat. The electrospun nanofibers mat had good tensile properties and high porosity and provides a favorable environment for neural cell attachment and proliferation comparable to other scaffolds. The cell viability and cell growth capability in prepared nanofibers were assessed.

Self-powered solar desalination using solar still enhanced by external solar collector and phase change material

• Performance of Solar still (SS) with solar collector (SC) and phase change material (PCM) was studied. • External SC and PCM increased the productivity by about 340%. • Increasing hot water flow from SC increased SS productivity. • The daily productivity on typical May-month/Jordan reached almost 10 L/m 2 . • The studied PCMs provided almost similar effect on productivity. The performance of a self-powered double-glass cover solar still with phase change material (PCM) connected to solar collector was studied. Black painted stainless-steel tubes filled with the required amount of PCM were placed at the bottom of the basin covering its surface area. Three modes of experiments were carried out al with cooling the glass cover: first, the solar still alone (SS), second: the solar still being connected to an external solar collector (SSC) and third: the solar still contains PCM and being connected to an external collector (SSCP). The effect of PCM type (sodium thiosulfate pentahydrate (STP), sodium acetate trihydrate (SAT) and paraffin wax (PWAX)) and its amount on the unit performance were investigated. The effect of hot water flow rate from the solar collector, solar radiation, ambient temperature and wind speed on the unit’s performance were also investigated. The novelty of the work lies in combining the above techniques and parameters to improve the still productivity under set of controllable operating conditions. The experimental work was conducted in the months of May, June and July of 2019 in northern Jordan. During May, the daily productivity of the SS and the SSC modes were found to be 2.1 and 9.7 L/m 2 . During July, the productivity was lower by 20% than that of May. The addition of PCM increased the productivity of the SSC system by about 50%. The type of PCM tested has no significant effect on the unit productivity. The addition of the external solar collector to the SS system unit increased the productivity by about 340%. The overall enhancement in productivity of SSCP reached almost 400% compared to that of SS unit.

Electrospinning Synthesis of Na0.5Bi0.5TiO3 Nanofibers for Dielectric Capacitors in Energy Storage Application.

Dielectric composites based on ferroelectric ceramics nanofibers are attracting increasing attention in capacitor application. In this work, the sol–gel method and electrospinning technology are utilized to prepare one-dimensional Na0.5Bi0.5TiO3 (NBT) nanofibers, and the influence of electrospinning process parameters such as spinning voltage, liquid supply rate, and collector speed on the morphology and structure of nanofibers are systematically explored. The final optimized parameters include the applied voltage of 20 kV, the solution flow rate of 1 mL/h, and the collector’s rotation speed of 1500 rpm. The optimized NBT nanofibers are introduced into the PVDF polymer matrix for energy storage application. Owing to the enhanced interfacial polarization between PVDF matrix and NBT nanofibers with a high aspect ratio, the NBT–PVDF nanocomposites achieve a high discharge energy density of 14.59 J cm−3 and an energy efficiency of 53.69% at 490 kV mm−1, which are higher than those of pure PVDF, i.e., 10.26 J cm−3 and 48.17% at 420 kV mm−1, respectively. The results demonstrate that the strategy of synthesizing NBT nanofibers using the electrospinning method is of great potential for high-performance dielectric capacitor application.

Prediction of the fiber diameter of melt electrospinning writing by kriging model

AbstractMelt electrospinning writing (MEW) has proven its potential to direct‐write complex and multiscaled architectures and structures, which are widely used in the biomedical fields such as 3D printing of porous scaffolds. For the resolution of the microstructure is characterized by the diameter of the melt electrospun fiber, uniform spinning fiber with predictable diameter is of great significance for precise fabrication of the microstructure. In this paper, the Kriging model was introduced to explore the scaling laws of the fiber diameter to several processing parameters (including temperature, tip‐to‐collector distance, flow rate, and collector speed). The Latin hypercube sampling was adopted for experiment design. The prediction results of the Kriging model were cross‐validated with the response surface model to compare the prediction accuracy of the two methods. The root‐mean‐square error, maximum absolute error, and mean absolute percentage error of the Kriging model (0.49%, 0.73%, and 3.52%, respectively) are all lower than the response surface model (0.81%, 1.25%, and 4.74%, respectively), indicating that the prediction accuracy of the Kriging model is superior to the response surface model. The present paper provides a new idea for the modeling of the complex nonlinear system of MEW. Moreover, the implementation of the Kriging model minimizes the number of experimental trials required from 31 to 27, resulting in the reduction of the fabrication time and materials wastage.

Comprehensive Characterization of PVDF Nanofibers at Macro- and Nanolevel.

This study is focused on the characterization and investigation of polyvinylidene fluoride (PVDF) nanofibers from the point of view of macro- and nanometer level. The fibers were produced using electrostatic spinning process in air. Two types of fibers were produced since the collector speed (300 rpm and 2000 rpm) differed as the only one processing parameter. Differences in fiber’s properties were studied by scanning electron microscopy (SEM) with cross-sections observation utilizing focused ion beam (FIB). The phase composition was determined by Fourier-transform infrared spectroscopy (FTIR) and Raman spectroscopy. The crystallinity was determined by differential scanning calorimetry (DSC), and chemical analysis of fiber’s surfaces and bonding states were studied using X-ray photoelectron spectroscopy (XPS). Other methods, such as atomic force microscopy (AFM) and piezoelectric force microscopy (PFM), were employed to describe morphology and piezoelectric response of single fiber, respectively. Moreover, the wetting behavior (hydrophobicity or hydrophilicity) was also studied. It was found that collector speed significantly affects fibers alignment and wettability (directionally ordered fibers produced at 2000 rpm almost super-hydrophobic in comparison with disordered fibers spun at 300 rpm with hydrophilic behavior) as properties at macrolevel. However, it was confirmed that these differences at the macrolevel are closely connected and originate from nanolevel attributes. The study of single individual fibers revealed some protrusions on the fiber’s surface, and fibers spun at 300 rpm had a core-shell design, while fibers spun at 2000 rpm were hollow.

The Influence of Humidity-Control Addition on Electrospinning System for Nanofiber Formation

This research was conducted to determine the effect of humidity control system and collector rotational speed on electrospinning during PVA nanofiber fabrication. The humidity control system is controlled by Arduino Uno and the actuator is an air pump, and modifications are made to the air pump by adding silica gel as a more optimal humidity reducing agent. A 12 V DC-motor and L293D driver are used to control the direction and speed of rotation of the collector. The collector speed control uses the principle of Pulse Width Modulation (PWM). The humidity control system that has been made has an accuracy rate of more than 88%, and the lowest relative humidity achieved is 30%. The collector control system that has been made has an accuracy rate of more than 95%, and the lowest rotational speed is 125 RPM. Carbon nanofiber was successfully fabricated with an average diameter distribution of 43.4 nm and 79.2 nm at 30% and 40% humidity, respectively.

Design and Automation of a vertical electrospinning system for manufacturing nanofibers

The objective of this research consists of the design, construction and automation of the electrospinning mechatronic system to obtain nanofibers. As a first stage, the structure of the electrospinning mechatronic system and the distribution, injection and manifold system were designed and built. In the second stage, the open-loop control system was outlined and implemented. It is made up of: control, isolation stage, and the plant. In the first element, the LabView interface and ATMega2560 microcontroller were used to manipulate the variables of the injection speed and distribution of the solution, the speed of the nanofiber collector and the height between the capillary tube and the collector, the magnitude of the temperature and humidity from the environment, also, the graphic interface was developed, the second element consists of isolating the control and power stage in addition to amplifying the command signals and enabling the correction elements, the third element receiving the signals from the power stage to perform the action and produce a change in the controlled variables in the process. With this prototype, it is intended to obtain nanofibers from different polymer solutions for use in the area of catalysis and biomaterials.

Enhancing critical features of poly(amino acid) based meshes

AbstractThe following manuscript presents a comprehensive investigation regarding the influence of electrospinning parameters on fiber quality and mechanical properties of nanofibrous poly(amino acid) meshes. At first, we examine parameters including: solvent options, polymer concentrations, collector speed and distance, voltage, needle sizes and flow rates to prepare fibrous scaffolds based on polysuccinimide. The main objective was to attempt and decrease the fiber diameter as much as possible while not reducing the fiber quality. After that mechanical properties of the meshes were investigated, we demonstrate two possible methods to reinforce them: mechanically induced alignment of the fibers and multilayer compression. Characterization methods include a solubility study, viscosity and conductivity measurements, ATR‐FTIR spectroscopy, scanning electron microscopy, and mechanical uniaxial test. Fiber size was successfully reduced from 615 to 280 nm without any quality aberrations. Mechanical performance not only improved almost three‐fold, but was also enhanced in two directions due to the multilayer composition. With these optimizations, the PSI mesh now possess favorable features for biomedical application according to the relevant literature.