While optimizing wind energy harvesting has always been the principal goal of wind turbine control, extensive research has been conducted on the use of advanced control methodologies aiming to maximize the turbine’s power generation while also achieving secondary performance objectives, such as fatigue load minimization. Some recent studies have investigated the application of a classical control methodology known as exact output regulation for improved wind turbine control. This control method is designed to achieve the rejection of known input disturbances, while also ensuring the system output tracks a desired reference signal. These studies all assumed wind preview information from LIDAR measurements was available to support the controller design.In this paper we investigate the use of exact output regulation for turbine control, using wind speed estimates obtained from rotor speed measurements. Simulated performance comparisons conducted over a wide range of mean wind speeds show that the exact output regulation methodology using wind speed estimates derived from rotor measurements can deliver similar reductions in fatigue loads to those obtainable with LIDAR measurements, without compromising power generation.