Event Abstract Back to Event Prefrontal Involvement in Switching Between Speed and Accuracy: An fMRI Study Cristiano Crescentini1, Anthony R. McIntosh2, 3, Donald T. Stuss2, 3 and Antonino Vallesi1, 2* 1 SISSA, Italy 2 Rotman Research Institute at Baycrest, Canada 3 University of Toronto, Canada Strategically switching between rapid and accurate decision-making requires a top-down regulation of the response criteria. However, the brain mechanisms important to smoothly change the speed-accuracy strategy trial-by-trial remain mostly unclear. This issue was addressed here by testing 12 right-handed volunteers (6 females, age: 19-39 years) using fMRI. On each trial, participants had to stress speed or accuracy in performing a color discrimination task on a target stimulus according to the instructions given by an initial cue. As the behavioral data showed, participants were capable of trading speed for accuracy and vice versa. Standard GLM whole-brain analyses on cue-related activations revealed a significant recruitment of left middle frontal gyrus (Talairach coordinates = x: -32, y: 32, z: 26) and right cerebellum (32, -42, -30) when switching from speed to accuracy (vs. from accuracy to speed). Analysis of target-related activations suggested that the anterior cingulate cortex (-4, 24, 15) was more recruited during speeded (vs. accuracy) trials, especially when those were preceded by another speeded trial. The present results extend previous findings on the role of left lateral prefrontal cortex in initial task-setting and anterior cingulate in subsequent energization of the relevant processes to the control of speed-accuracy trade-off. Conference: The 20th Annual Rotman Research Institute Conference, The frontal lobes, Toronto, Canada, 22 Mar - 26 Mar, 2010. Presentation Type: Poster Presentation Topic: Cognitive Neuroscience Citation: Crescentini C, McIntosh AR, Stuss DT and Vallesi A (2010). Prefrontal Involvement in Switching Between Speed and Accuracy: An fMRI Study. Conference Abstract: The 20th Annual Rotman Research Institute Conference, The frontal lobes. doi: 10.3389/conf.fnins.2010.14.00118 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 30 Jun 2010; Published Online: 30 Jun 2010. * Correspondence: Antonino Vallesi, Rotman Research Institute at Baycrest, Toronto, Canada, antoniovallesi@yahoo.it Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Cristiano Crescentini Anthony R McIntosh Donald T Stuss Antonino Vallesi Google Cristiano Crescentini Anthony R McIntosh Donald T Stuss Antonino Vallesi Google Scholar Cristiano Crescentini Anthony R McIntosh Donald T Stuss Antonino Vallesi PubMed Cristiano Crescentini Anthony R McIntosh Donald T Stuss Antonino Vallesi Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.