Spectrum Of Uveitis Research Articles

Spectrum of uveitis in India

We look at the spectrum of uveitis in India before the year 2010 and after the year 2010, the changing patterns in uveitis over time, the probable factors for the changing patterns and newer uveitis entities in India.

Erratum to: Changes in patterns of uveitis at a tertiary referral center in Northern Italy: analysis of 990 consecutive cases.

Purpose The role of uveitis, an uncommon ocular disease, is often neglected in research and treatment of autoimmune conditions. The study described the spectrum of uveitis at a referral center in North Italy, and compared that to a previously published series of patients.

Changes in patterns of uveitis at a tertiary referral center in Northern Italy: analysis of 990 consecutive cases

PurposeThe role of uveitis, an uncommon ocular disease, is often neglected in research and treatment of autoimmune conditions. The study described the spectrum of uveitis at a referral center in North Italy, and compared that to a previously published series of patients.MethodsWe reviewed all patients with uveitis diagnosed from 2013 to 2015 at the Immunology Eye Unit, Arcispedale S. M. Nuova-IRCCS, Reggio Emilia, Italy. We examined patient characteristics, disease spectrum, and etiologies.ResultsIn total, 990 cases of uveitis were identified, who were mostly female (59%) with a median age at presentation of 44 years (interquartile range = 29–57). Anterior uveitis was most frequent (53.5%), followed by panuveitis (22.8%), posterior (16.2%), and intermediate uveitis (5.5%). Anterior herpetic uveitis (15.6%), Fuchs uveitis (9.7%), and HLA-B27 positive anterior uveitis (7.7%) were the most common specific diagnoses. Compared with the previous series, we observed an increased incidence of uveitis, and a different pattern of diagnoses. Rates of herpetic, HLA-B27 positive uveitis, and presumed ocular tuberculosis were higher, but Fuchs uveitis was less frequent.ConclusionsThe pattern of uveitis appears to be changing, very likely due to population-level increases in infectious diseases, to the availability of new diagnostic tests and to the interdisciplinary approach used in patient diagnosis.

The Spectrum of Uveitis in Southern Vietnam

ABSTRACTPurpose: To describe the pattern of uveitis among Vietnamese at two eye hospitals in Southern Vietnam.Methods: We retrospectively reviewed the charts of 212 consecutive uveitis cases that presented to two eye hospitals in Ho Chi Minh City, Vietnam, from July 2011 to February 2015. The patients were identified from a database maintained by the hospitals. Patients with keratitis, episcleritis, orbital inflammation, post-surgical endophthalmitis, traumatic iritis, and corneal graft rejection were excluded. Data collected included demographic, clinical, and laboratory findings.Results: Uveitis was seen most commonly in the 21–60-year-old age group. Gender distribution was not significantly different among the various age groups. Anterior uveitis was the most common (46%), followed by posterior uveitis (22%), panuveitis (18%), and intermediate uveitis (14%). Infectious etiologies were observed in 27%. Idiopathic uveitis (36%) was the most common non-infectious uveitis, followed by Vogt–Koyanagi–Harada disease (14%) and Behçet disease (7%). Tuberculous uveitis was the most common infectious etiology (9%), followed by toxocariasis (6%) and herpetic uveitis (6%), and cytomegalovirus anterior uveitis (4%).Conclusions: In southern Vietnam, infectious uveitis, such as tuberculosis, toxocariasis, and herpetic infection, are common but toxoplasmosis is rare. Idiopathic uveitis, Vogt–Koyanagi–Harada disease, and Behçet disease are the most common non-infectious uveitis, with a notable absence of birdshot retinochoroidopathy.

Land of the Long White Cloud: The Spectrum of Uveitis at a Tertiary Referral Center in New Zealand

ABSTRACTPurpose: To investigate the patterns of uveitis at a tertiary referral center in New Zealand.Methods: Retrospective data were collected for 1260 patients presenting to uveitis clinics in Auckland, New Zealand, between January 2008 and April 2014. Demographics, disease characteristics, and uveitis subtype were analyzed for all patients.Results: Among 1148 patients, 70.3% had anterior uveitis. The most common diagnosis causing anterior uveitis was HLA B27-associated disease. Toxoplasmosis was the most common cause of posterior uveitis, and sarcoidosis featured prominently in cases of panuveitis. Infectious etiologies represented 19.6% of all cases. Ethnic variations were noted, such as an increased prevalence of panuveitis in Pacific Islanders, TB-related uveitis in Indian patients, and Posner-Schlossman uveitis in East Asians. Patients over the age of 60 showed an increased prevalence of herpetic anterior uveitis and drug-induced uveitis.Conclusions: New Zealand has a multicultural population with a wide spectrum of ocular inflammation that varies with ethnicity and age.

Uveitis in a tertiary ophthalmology centre in Thailand

Purpose:To determine the aetiology and clinical characteristics of patients with uveitis in a tertiary ophthalmology centre in northern Thailand.Methods:Standard ophthalmological examination and laboratory screening blood tests were performed in 200...

Birdshot chorioretinopathy: Long-term manifestations and visual prognosis

Purpose To ascertain the clinical features and long-term visual prognosis of birdshot chorioretinopathy (BCR), and to identify patients at risk of visual loss. Design Retrospective noncomparative case series. Participants Fifty-five consecutive patients with HLA-A29–positive BCR who were identified in ophthalmology departments of the University Medical Center of Utrecht and The Eye Hospital Rotterdam, of whom 37 were observed for at least 5 years. Intervention A review of the medical and photographic and/or angiographic records of 55 patients with HLA-A29–positive BCR. Main outcome measures Numerous variables were compared, including age and gender distribution, onset and course of BCR, ocular manifestations, therapeutic strategies and their outcomes, complications, systemic diseases, visual acuity (VA), and features associated with poor visual outcome. Results Loss of VA was gradual; the number of affected eyes with VA less than 20/200 increased from 9 of 108 (8%) at onset to 22 of 73 (30%) at 5 years and 19 of 49 (39%) at 10 years of follow-up. The cause of compromised VA was predominantly macular edema and macular atrophy (42 of 55 [76% of cases]). We found strong associations between the VA at onset and visual outcome after 5 and 10 years ( P = 0.005 and P = 0.006, respectively). Mean VA at the 5-year follow-up was significantly lower if macular leakage was observed on angiography ( P<0.001). No differences in annual loss of VA were observed between patients treated by standard therapeutic modalities and untreated patients. Conclusion The visual prognosis of BCR in a spectrum of uveitis is poor, and the recommended therapeutic regimens have had no effect on long-term visual prognosis. New treatment strategies are needed for this blinding disorder.