Spectrum Of Disorders In Children Research Articles

Magnetic resonance imaging of disorders with white matter changes in children and adolescents: a pictorial essay.

White matter changes are seen in a spectrum of disorders in children and adolescents. Understanding their distribution and appearance helps to reach diagnoses in daily radiologic practice. This pictorial essay will outline the magnetic resonance imaging (MRI) appearances of diseases with white matter changes including demyelinating diseases, dysmyelinating disorders/leukodystrophies, infections, autoimmune diseases, vascular causes, mitochondrial disorders and neurocutaneous syndromes, along with a brief overview of clinical aspects of the diseases such as typical age of presentation, etiology, symptoms and signs and treatment options. This article highlights important features in common white matter diseases in children and adolescents.

Interstitial bleomycin sclerotherapy in children with vascular malformations: Our initial experience in Hong Kong

AbstractBackgroundVascular malformations represent a wide spectrum of disorders in children. Recently, interstitial bleomycin sclerotherapy has been shown to be a safe and effective treatment for selected cases of vascular malformation in children and adults.AimTo evaluate the short‐term outcome and safety of interstitial bleomycin sclerotherapy in children with vascular malformations.MethodsThis is a retrospective study in which patients under 18 years old with vascular malformation undergoing bleomycin sclerotherapy between August 2019 and January 2022 in Hong Kong were included. Relevant demographics of the included patients were collected. Short‐term outcomes including clinical response, immediate and early complications were evaluated.ResultsFour patients who aged from 4 to 8 years old were identified, three with lymphatic malformation and one with arteriovenous malformation. A total of eight sessions of interstitial bleomycin sclerotherapy were performed. Three of them reported clinical response with either reduction in lesion size or reduction in discomfort or disfigurement. No immediate complication was reported. However, one of them experienced post‐operative hyperpigmentation with scratch marks.ConclusionThe experience in the use of interstitial bleomycin sclerotherapy in children with vascular malformations is still limited in our locality. Further study with larger cohorts and longer follow‐up is required to further establish its efficacy and safety profile in paediatric patients.

Spectrum of Rheumatological Disorders in Children from a Tertiary Care Hospital in Bhubaneswar, Odisha

Spectrum of Rheumatological Disorders in Children from a Tertiary Care Hospital in Bhubaneswar, Odisha

MUSCLE DISORDERS IN CHILDHOOD. ED. 2. Victor Dubowitz. Philadelphia, W. B. Saunders, 1995. $95.00, 540 pp.

This is the second edition of a single-author text designed to cover the spectrum of muscle disorders in children. The book is divided into fifteen chapters. In the first chapter, the many diagnostic approaches to and the classification of neuromuscular disorders are well reviewed. The longest and strongest chapter is, appropriately, that on the muscular dystrophies, which encompasses 100 pages. Other chapters deal with the congenital myopathies; the metabolic myopathies (there are three separate chapters devoted to glycogenoses; lipid and mitochondrial disorders; and ion-channel disorders, including periodic paralysis, myasthenia gravis, malignant hyperthermia, …

Inheritance Patterns in Tourette Syndrome

The spectrum of tic disorders in children is neither so uncommon nor transient that pediatricians can disregard or take lightly a parent's or teacher's observations about a child's involuntary motor movements or vocal utterances. Rather, such information warrants a more detailed history about the child and family, especially as it pertains to other members who have tics or obsessive-compulsive disorders, particularly when they are chronic. The combination of an uncontrollable chronic motor tic disorder with vocal tics that are manifested by echolalia, coprolalia, or echokinesis suggests Tourette syndrome. This is by far the most serious of the chronic tic disorders, with a prevalence of 1 in 2000.