Frequency-domain Spectroscopy Research Articles

Terahertz Frequency-Domain Spectroscopy with a Method for Suppressing Water Vapor Absorption Peaks for Analysis of Pharmaceutical Hydrate Samples

AbstractMeasurements of terahertz absorption spectra of pharmaceutical hydrate samples are achieved under a normal humidity condition by combining terahertz frequency-domain spectroscopy with a newly proposed method for suppressing absorption peaks caused by water vapor. In this method, only simple mathematical operations such as subtraction, thresholding, interpolation, and smoothing are applied to extinction (or absorbance) data obtained by locating samples under a normal humidity condition. By considering the difference in spectral line width between narrow absorption peaks caused by water vapor and the relatively wide absorption peaks caused by active pharmaceutical ingredients (APIs) in solid forms, the absorption peaks caused by water vapor can be effectively suppressed without affecting the absorption peaks of the APIs in the samples. In the present study, levofloxacin hydrates were used as samples to investigate the performance of the proposed method. Spectra were obtained under both dry and normal humidity conditions. The temperature of the samples was raised from 300 to 363 K to dehydrate them and brought back to 313 K to observe hydration under the normal humidity condition. Spectra obtained under the normal humidity condition were processed with the proposed method. The spectra of the hydrates obtained under the dry condition were slightly different from those obtained under the normal humidity condition and processed by our method. Dehydration during the measurements under the dry condition was suggested. Stable and reliable results are expected by measuring spectra under normal humidity conditions and applying the proposed method to suppress absorption peaks by water vapor.

Cross-wavelength calibrating method for real-time imaging of tissue optical properties using frequency-domain diffuse optical spectroscopy

Frequency-domain diffuse optical spectroscopy (FD-DOS) is a powerful non-invasive technique for assessing tissue optical properties, with applications ranging from basic research to clinical diagnosis. In this study, we introduce and validate a novel approach termed the cross-wavelength calibrating (CWC) method within the framework of TrackDOSI, a real-time FD-DOS imaging system for tissue characterization. The CWC method aims to mitigate the effects of changing optical coupling and motion artifacts encountered during probe scanning, thus enhancing the accuracy and reliability of optical property measurements. Notably, the CWC method also allows for a simpler geometry with fewer sources than traditional self-calibrating (SC) methods, reducing instrumental complexity and cost while maintaining robustness in estimating optical properties. We first validate the CWC method on solid silicone phantoms, demonstrating strong agreement with the gold standard SC method with an error of -10% and 1% for absorption and reduced scattering coefficients, respectively. Furthermore, experiments on phantom and human tissue reveal the CWC approach's ability to suppress motion artifacts and optical coupling variations, thereby improving measurement repeatability, signal fidelity, and artifact correction in dynamic imaging scenarios. Our findings underscore the potential of the CWC method to enhance the clinical utility of DOSI techniques by enabling real-time artifact correction and improving the accuracy of tissue optical property measurements.

Harmonic voltage measurement based on capacitive equipment dielectric equivalent model and responding current

Abstract With the increasing proportion of new energy and the power electronic equipment in the power grid, accurate measurement of harmonic voltage has become increasingly important for power quality monitoring. In order to solve the problem of high-precision measurement of harmonic voltage in the power grid, this manuscript proposes a high-precision harmonic voltage measurement method based on the dielectric equivalent model (DEM) of capacitive equipment and its responding current. Based on DEM, a voltage-current transfer function of the capacitive device is established, and harmonic voltage is reconstructed with the responding current. Considering the dielectric relaxation characteristics of capacitive device other than a pure capacitor model, this manuscript analyzes the fitting performance of different equivalent capacitance models and improves the traditional pure capacitance model to a more suitable DEM for harmonic voltage reconstruction. The DEM parameters of capacitive devices are obtained through the frequency domain spectroscopy (FDS) and intelligent parameter identification algorithms, which improved the measurement accuracy of harmonic voltage and reduced computational complexity. The harmonic voltage testing platform is established to test the simulated high-voltage harmonics and the harmonic voltage of the actual grid voltage. The results show that the proposed harmonic voltage measurement method can meet the high-precision reconstruction of harmonic voltage in the frequency range of 50~2500Hz, and the system testing error with sensors is less than 2%. The testing accuracy is higher than traditional voltage transformers and testing systems based on pure capacitance models.

Broadband terahertz frequency-domain emission spectroscopy of DAST with a widely tunable quasi-monochromatic source and sensitive up-conversion detection

A continuous 4–32 THz emission spectrum of organic crystal DAST is obtained through a widely tunable quasi-monochromatic terahertz source and sensitive up-conversion detection. The spectrum is characterized by a frequency resolution of ∼0.05 THz and a highest signal-to-noise ratio of ∼65 dB. Terahertz signals are detectable at room temperature even in the high absorption regions of DAST, thus most of the absorption peaks of DAST are clearly located. The results verify the findings of previous works well, including density functional theory calculations and other similar experiments. This paper provides a highly sensitive instrument for broadband terahertz spectroscopic characterization.

Phase-based structured interrogation frequency-domain near-infrared spectroscopy

Frequency-domain near-infrared spectroscopy (FD-NIRS) is a noninvasive method for quantitatively measuring optical absorption and scattering in tissue. This study introduces structured interrogation (SI) as an interference-based approach for implementing FD-NIRS in order to enhance optical property estimation in multilayered tissues and sensitivity to deeper layers. We find that, in the presence of realistic noise, SI accurately estimates properties and chromophore concentrations with less than a 5% error. Particularly noteworthy, the phase-only component of SI FD-NIRS can quantify both the optical absorption and reduced scattering in homogeneous tissues and shows a 20% improved sensitivity to absorption changes in deeper tissues compared to conventional methods. We show that this enhanced sensitivity is promising for improving the accuracy of functional brain monitoring in the cortex of an infant with less superficial contamination.

Evaluating the insulation condition of oil‐impregnated paper bushings based on the time constant database

AbstractAssessing the insulation condition of oil‐impregnated paper (OIP) bushings is necessary to guarantee the safe operation of power transformers. Moisture is the main threat to the insulation of OIP bushings. Therefore, accurately estimating their moisture value is crucial to keep power systems running smoothly. However, it has been suggested that the ageing status of OIP bushings should be considered while assessing the moisture. Dielectric frequency‐domain spectroscopy (FDS) has been extensively employed for assessing insulation condition of OIP insulations due to its benefits. A new approach was proposed to assess the insulation condition of OIP bushings using FDS results. Various OIP samples with various moisture levels and degrees of polymerisation (DP) were selected. The extended Debye model (EDM) parameters related to each sample were calculated using their tanδ − f curve. A time constant database (TCD) was created using the obtained time constants of EDM, which includes the dominant time constant and time constant related to the R0 – C0 branch, and their corresponding insulation condition. Then, a method was introduced based on the created TCD to estimate the insulation condition of OIP bushings. The results showed that the average relative error of moisture and DP estimation is 8.33% and 6.32%, respectively.

Evaluating the insulation condition of oil‐impregnated paper bushings based on the time constant database

AbstractAssessing the insulation condition of oil‐impregnated paper (OIP) bushings is necessary to guarantee the safe operation of power transformers. Moisture is the main threat to the insulation of OIP bushings. Therefore, accurately estimating their moisture value is crucial to keep power systems running smoothly. However, it has been suggested that the ageing status of OIP bushings should be considered while assessing the moisture. Dielectric frequency‐domain spectroscopy (FDS) has been extensively employed for assessing insulation condition of OIP insulations due to its benefits. A new approach was proposed to assess the insulation condition of OIP bushings using FDS results. Various OIP samples with various moisture levels and degrees of polymerisation (DP) were selected. The extended Debye model (EDM) parameters related to each sample were calculated using their tanδ − f curve. A time constant database (TCD) was created using the obtained time constants of EDM, which includes the dominant time constant and time constant related to the R0 – C0 branch, and their corresponding insulation condition. Then, a method was introduced based on the created TCD to estimate the insulation condition of OIP bushings. The results showed that the average relative error of moisture and DP estimation is 8.33% and 6.32%, respectively.

Analysis of converter transformer pressboard insulation degradation under surge using mathematical morphology

Nowadays, with the significant expansion of industrial growth, the bulk power requirement can only be satisfied through high-voltage direct current HVDC transmission. The converter transformer is the utmost vital part of the HVDC transmission. Pressboard insulation is most commonly used as inter-disc insulation in converter transformers. During working conditions due to elevated temperature and different operational stresses, insulation material gets deteriorated. It may cause a risk to the life of the converter transformer. The effects of elevated temperatures as well as frequency on pressboard insulation of the converter transformer are examined in this study. The condition evaluation and morphological changes in pressboard insulation at elevated temperatures can evaluate with the help of frequency domain spectroscopy (FDS) and atomic force microscopy (AFM) techniques. The impact of elevated temperatures on insulation material can be analyzed based on surface roughness and dielectric parameters. In MATLAB Simulink environment, a dual winding single-phase converter transformers valve side star winding 60 discs model is constructed for impulse test. Based upon arrival time and velocity of traveling wave, insulation degradation location can be identified by using mathematical morphology. The simulation results demonstrate that the suggested method can notably located degradation across disc winding.

Maximizing the Reliability and Precision of Measures of Prefrontal Cortical Oxygenation Using Frequency-Domain Near-Infrared Spectroscopy.

Frequency-domain near-infrared spectroscopy (FD-NIRS) has been used for non-invasive assessment of cortical oxygenation since the late 1990s. However, there is limited research demonstrating clinical validity and general reproducibility. To address this limitation, recording duration for adequate validity and within- and between-day reproducibility of prefrontal cortical oxygenation was evaluated. To assess validity, a reverse analysis of 10-min-long measurements (n = 52) at different recording durations (1-10-min) was quantified via coefficients of variation and Bland-Altman plots. To assess within- and between-day within-subject reproducibility, participants (n = 15) completed 2-min measurements twice a day (morning/afternoon) for five consecutive days. While 1-min recordings demonstrated sufficient validity for the assessment of oxygen saturation (StO2) and total hemoglobin concentration (THb), recordings ≥4 min revealed greater clinical utility for oxy- (HbO) and deoxyhemoglobin (HHb) concentration. Females had lower StO2, THb, HbO, and HHb values than males, but variability was approximately equal between sexes. Intraclass correlation coefficients ranged from 0.50-0.96. The minimal detectable change for StO2 was 1.15% (95% CI: 0.336-1.96%) and 3.12 µM for THb (95% CI: 0.915-5.33 µM) for females and 2.75% (95%CI: 0.807-4.70%) for StO2 and 5.51 µM (95%CI: 1.62-9.42 µM) for THb in males. Overall, FD-NIRS demonstrated good levels of between-day reliability. These findings support the application of FD-NIRS in field-based settings and indicate a recording duration of 1 min allows for valid measures; however, data recordings of ≥4 min are recommended when feasible.

Microscopic mechanisms analysis of various dielectric response processes in oil‐paper insulation with different insulating states

AbstractVarious dielectric response processes in the oil‐paper insulation are sensitively affected by the insulating states (ageing degrees and moisture contents). However, the existing research is still incomplete in revealing the microscopic mechanisms of various dielectric response processes in oil‐paper insulation with different insulating states. Given this issue, the genetic algorithm is first adopted to extract the Dissado–Hill (D–H) model parameters by simulating the frequency domain spectroscopy (FDS) of oil‐paper insulation. Then, the change laws of the extracted D–H model parameters are adopted to reveal the microscopic mechanisms of various dielectric response processes. Microscopic mechanisms of four dielectric response processes are studied, which are quasi‐dc relaxation, loss peak relaxation, optical frequency relaxation, and DC conductance. Meanwhile, due to the dielectric response processes being dominated by various polar particles (methanol, ethanol, furfural, and water molecule), the contents of various ageing by‐products dissolved in the insulating oil are measured to support the above analysis. In this respect, a dielectric theoretical reference for the FDS technique to research the insulating states of oil‐paper insulation is provided.

A Highly Frequency-Selective 3D-Printed Dielectric Structure for the Terahertz Range

AbstractIn this paper, we present a terahertz transmission frequency-selective quasi surface (FSQS) that exhibits strong absorption lines and a periodic band-pass characteristic. The FSQS structure is created by laterally combining Fabry-Pérot resonators with different thicknesses. The transfer function of the FSQS can serve as a broadband reference for testing the signal integrity of the transmission path for broadband terahertz systems. The transfer function achieves a combination of band-pass characteristics and sharp resonances with a theoretical attenuation of over 80 dB and with quality factors of more than 40,000 for a combination of 36 resonators. A single FSQS made up of four resonators is 3D printed by fused deposition modeling using a low-loss cyclic olefin copolymer (COC) filament. Finally, the 3D-printed FSQS is characterized using both frequency-domain and time-domain terahertz spectroscopy. The results show an attenuation of over 42 dB and a quality factor above 100.

The influence of voxelotor on cerebral blood flow and oxygen extraction in pediatric sickle cell disease

AbstractVoxelotor is an inhibitor of sickle hemoglobin polymerization that is used to treat sickle cell disease. Although voxelotor has been shown to improve anemia, the clinical benefit on the brain remains to be determined. This study quantified the cerebral hemodynamic effects of voxelotor in children with sickle cell anemia (SCA) using noninvasive diffuse optical spectroscopies. Specifically, frequency-domain near-infrared spectroscopy combined with diffuse correlation spectroscopy were used to noninvasively assess regional oxygen extraction fraction (OEF), cerebral blood volume, and an index of cerebral blood flow (CBFi). Estimates of CBFi were first validated against arterial spin–labeled magnetic resonance imaging (ASL-MRI) in 8 children with SCA aged 8 to 18 years. CBFi was significantly positively correlated with ASL-MRI–measured blood flow (R2 = 0.651; P = .015). Next, a single-center, open-label pilot study was completed in 8 children with SCA aged 4 to 17 years on voxelotor, monitored before treatment initiation and at 4, 8, and 12 weeks (NCT05018728). By 4 weeks, both OEF and CBFi significantly decreased, and these decreases persisted to 12 weeks (both P < .05). Decreases in CBFi were significantly correlated with increases in blood hemoglobin (Hb) concentration (P = .025), whereas the correlation between decreases in OEF and increases in Hb trended toward significance (P = .12). Given that previous work has shown that oxygen extraction and blood flow are elevated in pediatric SCA compared with controls, these results suggest that voxelotor may reduce cerebral hemodynamic impairments. This trial was registered at www.ClinicalTrials.gov as #NCT05018728.

Standing Wave Pattern Suppression in the Terahertz Frequency Domain Spectroscopy by Means of Windowed Fourier Filtering

Standing Wave Pattern Suppression in the Terahertz Frequency Domain Spectroscopy by Means of Windowed Fourier Filtering

A comprehensive evaluation method for moisture and aging state of oil-immersed paper bushings based on dielectric modulus and K-nearest neighbor algorithm

The insulation performance of oil-immersed paper bushings is prone to deteriorate, primarily due to moisture intrusion and thermal aging. The frequency domain spectroscopy (FDS) method is commonly employed to assess the insulation condition of the bushing. However, identifying and extracting relaxation polarization information from the low-frequency region of the FDS curve can be challenging, and there is little research about the condition evaluation under the combined effects of aging states and moisture content. To address this issue, this article uses the Taylor formula mathematical model to extract characteristic parameters from the dielectric modulus curve of OIP bushings and uses the KNN algorithm to achieve the evaluation of aging and moisture status. Then, the effectiveness and accuracy of the proposed method are validated on three field OIP bushings. The results demonstrate that the evaluation accuracy of the proposed method exceeds 83%, which has significant advantages compared to other classification algorithms. The innovation of this article lies in extracting new feature parameters and combining them with intelligent classification algorithms to evaluate the moisture and aging state of the bushing.

Condition Assessment of Thermally-Aged Polypropylene Cable Insulation Based on Frequency Domain Spectroscopy

Condition Assessment of Thermally-Aged Polypropylene Cable Insulation Based on Frequency Domain Spectroscopy

Two Models for Predicting Frequency-Domain Spectroscopy of Nonuniformly Damped OIP Bushings Based on FEM and Dielectric Theory

Two Models for Predicting Frequency-Domain Spectroscopy of Nonuniformly Damped OIP Bushings Based on FEM and Dielectric Theory

High resolution terahertz ATR frequency-domain spectroscopy for monitoring spinal cord injury in rats.

Traumatic spinal cord injury (SCI) can lead to permanent neurological impairment, underscoring the urgency of regular therapeutic intervention and monitoring. In this study, we propose a new strategy for monitoring spinal cord injury through serum based on high-resolution THz attenuated total reflection frequency domain spectroscopy (THz-ATR-FDS). We demonstrated serum spectral differences at different time points after experimental SCI in rats. We also studied the relationship between serum lipid concentration and the time of SCI, which revealed the potential of lipid molecules as biomarkers of SCI. In addition, based on the principal component analysis (PCA) and least squares regression (LSR) models, the quantitative relationship between the refractive index spectrum and lipid concentration in serum was automatically analyzed. This work highlights terahertz spectroscopy as a promising tool for label-free, periodic, and efficient monitoring of SCI.

Single-distance and dual-slope frequency-domain near-infrared spectroscopy to assess skeletal muscle hemodynamics.

Non-invasive optical measurements of deep tissue (e.g., muscle) need to take into account confounding contributions from baseline and dynamic optical properties of superficial tissue (adipose tissue). Discriminate superficial and deep tissue hemodynamics using data collected with frequency-domain (FD) near-infrared spectroscopy (NIRS) in a dual-slope (DS) configuration. Experimental data were collected in vivo on the forearm of three human subjects during a 3-min arterial occlusion or 1-min venous occlusion. Theoretical data were generated using diffusion theory for two-layered media with varying values of the reduced scattering coefficient () (range: 0.5 to ) and absorption coefficient () (range: ) of the two layers, and top layer thickness (range: 2 to 8mm). Data were analyzed using diffusion theory for a homogeneous semi-infinite medium. Experimental data in vivo were consistent with simulated data for a two-layered medium with a larger in the top layer, comparable absorption changes in the top and bottom layers during venous occlusion, and smaller absorption changes in the top vs. bottom layers during arterial occlusion. The dataset generated by DS FD-NIRS may allow for discrimination of superficial and deep absorption changes in two-layered media, thus lending itself to individual measurements of hemodynamics in adipose and muscle tissue.

Cumulative brain desaturation: Time to consider brain derived parameters to measure daytime sleepiness in obstructive sleep apnea

Objective/Background: The change in cerebral hemodynamics induced by sleep apneas and hypopneas may contribute to the daytime sleepiness in patients with obstructive sleep apnea (OSA). However, previous studies failed to discovery their relationship. We propose and test a new parameter, the cumulative brain oxygen desaturation, which may contribute to OSA patient's daytime sleepiness. Patients/methods22 patients with severe OSA (apnea-hypopnea index (AHI) at diagnosis [mean ± standard deviation, std.]: 52.1 ± 21.6/h, median: 45.1/h, interquartile range: 34.4–60.2/h) were monitored by polysomnography during routine continuous positive airway pressure titration. The reductions of brain tissue oxygen saturation (StO2) in all respiratory events at baseline sleep were measured by frequency-domain near-infrared spectroscopy (NIRS). The cumulative brain desaturation was calculated as AHI times the mean StO2 desaturation (i.e., AHI×ΔStO2‾). Similarly, cumulative peripheral desaturation was also calculated, i.e., AHI×ΔSpO2‾ where ΔSpO2‾ was the mean reduction of peripheral arterial oxygen saturation (SpO2). The correlations between Epworth sleepiness scale (ESS) and AHI, ΔStO2‾, AHI×ΔStO2‾, and AHI×ΔSpO2‾ were tested, respectively. Linear regression was applied to predict ESS using AHI×ΔStO2‾ and AHI×ΔSpO2‾, with age and BMI as covariates. ResultsESS significantly correlates to the cumulative brain desaturation (Pearson's correlation coefficient: 0.68, p = 0.00056), not the other parameters. Regression analysis only finds significant association between ESS and the cumulative cerebral desaturation (p = 0.00195) but not the cumulative peripheral desaturation (p = 0.71). ConclusionsThe cumulative brain oxygen desaturation, which comprehensively combines total sleep time, the frequency of apnea and hypopnea events, and the severity of cerebral oxygen desaturation, is a new indicator for daytime sleepiness in severe OSA.

Research on Changes in the Phase Shift Angle and Admittance of the Cellulose–Bio-Oil Composite under the Influence of Increasing Moisture during the Long-Term Operation of Power Transformers

In this study, the temperature–frequency dependencies of the pressboard–bio-oil–water nanoparticle composite’s fundamental parameters—phase shift angle and admittance—were examined using the Frequency Domain Spectroscopy method. Measurements were conducted in a frequency range of 10−4 Hz to 5 × 103 Hz at temperatures ranging from 293.15 K to 343.15 K, with a step of 10 K. The temperature stabilization accuracy was less than ±0.05 K. A total of 15 Arrhenius plots were determined for various phase shift angle values, from which 15 values and the average activation energy of relaxation time were determined. Similarly, the values of the activation energy of admittance relaxation time and the activation energy of admittance were determined. It was established that all three average values are identical within the bounds of uncertainty. Based on 45 values, a generalized activation energy was determined, with a value of ΔW ≈ (1.032 ± 0.0196) eV. Using the generalized activation energy value, the phase shift angle curves determined for all temperatures were recalculated to a temperature of 293.15 K. It was found that after conversion, all curves perfectly overlap. A similar operation was carried out for the frequency dependencies of admittance. In this case, too, the recalculated dependencies perfectly match. This means that the shape of the frequency dependencies of the phase shift angle and admittance depends solely on the moisture content in the pressboard–bio-oil–water nanodrop composite. The position of the curves in doubly logarithmic coordinates depends only on temperature and is determined by the generalized activation energy Using the generalized activation energy determined in this study will allow for the development of accurate methods for estimating moisture content in cellulose insulation of power transformers containing bio-oil. This will contribute to the detection of critical moisture content, which is about 5% by weight, and to the elimination of the risk, associated with such a high moisture content, of catastrophic failure of power transformers.