Sexually Transmitted Diseases (STDs) described a condition passed from one person to another through sexual contact. Depending on the specific STDs, infections may also be transmitted through sharing needles and breastfeeding example HIV. The best treatment for STDs will always be prevention. Among the new infections that occur each year, over half occur among young people (15-24 years old) meaning, more at risk for STDs than older adults. STDs create great social problems in the community among which is death toll raising especially the working population (Kimberly, & Gail, 2015). The questionnaire that was given to respondents served as the research instrument. From the result in Table 1, the study revealed that 42% fall within the age limit of 15-24, while 33% fall within age limit of 20-24, and 25% aged above 25. In table 2, 30% of the populations are men, while 70% are female. Majority of the students that filled the forms are females which support vulnerability of females to STDs. Figure 2, shows that young teenagers know about the STDs through friends mostly. 45% of them know dangers about STDs while 55 don’t know which shows that the students’ practices unprotected sex because they do not know the negative effects of STDs. A very good number of the students can identify STDs client. The study concluded that adolescents in Federal Polytechnic, Mubi are mostly aware of sexually transmitted diseases(STDs) but have deficiencies in having correct knowledge about these diseases, their basic symptoms, and modes of transmission. From the chi-square distribution table, we reject the null hypothesis (11.070), and accept the alternative hypothesis(635), hence conclude that most students are somehow ignorance of STDs danger especially Syphilis and gonorrhea in Federal Polytechnic, Mubi. Finally there shall be wider publicity to enrich the campaigns about STDs in Nigeria and world at large.