Specific Damage Research Articles

The role of the hippocampus in statistical learning and language recovery in persons with post stroke aphasia

Although several studies have aimed for accurate predictions of language recovery in post stroke aphasia, individual language outcomes remain hard to predict. Large-scale prediction models are built using data from patients mainly in the chronic phase after stroke, although it is clinically more relevant to consider data from the acute phase. Previous research has mainly focused on deficits, i.e., behavioral deficits or specific brain damage, rather than compensatory mechanisms, i.e., intact cognitive skills or undamaged brain regions. One such unexplored brain region that might support language (re)learning in aphasia is the hippocampus, a region that has commonly been associated with an individual’s learning potential, including statistical learning. This refers to a set of mechanisms upon which we rely heavily in daily life to learn a range of regularities across cognitive domains. Against this background, thirty-three patients with aphasia (22 males and 11 females, M = 69.76 years, SD = 10.57 years) were followed for 1 year in the acute (1–2 weeks), subacute (3–6 months) and chronic phase (9–12 months) post stroke. We evaluated the unique predictive value of early structural hippocampal measures for short-term and long-term language outcomes (measured by the ANELT). In addition, we investigated whether statistical learning abilities were intact in patients with aphasia using three different tasks: an auditory-linguistic and visual task based on the computation of transitional probabilities and a visuomotor serial reaction time task. Finally, we examined the association of individuals’ statistical learning potential with acute measures of hippocampal gray and white matter. Using Bayesian statistics, we found moderate evidence for the contribution of left hippocampal gray matter in the acute phase to the prediction of long-term language outcomes, over and above information on the lesion and the initial language deficit (measured by the ScreeLing). Non-linguistic statistical learning in patients with aphasia, measured in the subacute phase, was intact at the group level compared to 23 healthy older controls (8 males and 15 females, M = 74.09 years, SD = 6.76 years). Visuomotor statistical learning correlated with acute hippocampal gray and white matter. These findings reveal that particularly left hippocampal gray matter in the acute phase is a potential marker of language recovery after stroke, possibly through its statistical learning ability.

Resquícios de uma doença erradicada: desafios para saúde global

The challenges for global public health in the coming decades directly involve government action and investments. The document lists 13 urgent challenges for the world's population, among them the extremely shaken relationship between the ecosystem, climate and health and the preparation for new epidemics. The WHO also pointed out that new epidemics are inevitable and are directly related to the environmental issue, however, planned preparedness and response actions are behaviors that can prevent specific damage, and avoid higher than expected morbidity and mortality indicators.

A fingerprint of plasma proteome alteration after local tissue damage induced by Bothrops leucurus snake venom in mice

Bothrops spp. is responsible for about 70% of snakebites in Brazil, causing a diverse and complex pathophysiological condition. Bothrops leucurus is the main species of medical relevance found in the Atlantic coast in the Brazilian Northeast region. The pathophysiological effects involved B. leucurus snakebite as well as the organism's reaction in response to this envenoming, it has not been explored yet. Thus, edema was induced in mice paw using 1.2, 2.5, and 5.0 μg of B. leucurus venom, the percentage of edema was measured 30 min after injection and the blood plasma was collected and analyzed by shotgun proteomic strategy. We identified 80 common plasma proteins with differential abundance among the experimental groups and we can understand the early aspects of this snake envenomation, regardless of the suggestive severity of an ophidian accident. The results showed B. leucurus venom triggers a thromboinflammation scenario where family's proteins of the Serpins, Apolipoproteins, Complement factors and Component subunits, Cathepsins, Kinases, Oxidoreductases, Proteases inhibitors, Proteases, Collagens, Growth factors are related to inflammation, complement and coagulation systems, modulators platelets and neutrophils, lipid and retinoid metabolism, oxidative stress and tissue repair. Our findings set precedents for future studies in the area of early diagnosis and/or treatment of snakebites. SignificanceThe physiopathological effects that the snake venoms can cause have been investigated through classical and reductionist tools, which allowed, so far, the identification of action mechanisms of individual components associated with specific tissue damage. The currently incomplete limitations of this knowledge must be expanded through new approaches, such as proteomics, which may represent a big leap in understanding the venom-modulated pathological process. The exploration of the complete protein set that suffer modifications by the simultaneous action of multiple toxins, provides a map of the establishment of physiopathological phenotypes, which favors the identification of multiple toxin targets, that may or may not act in synergy, as well as favoring the discovery of biomarkers and therapeutic targets for manifestations that are not neutralized by the antivenom.

Oxidative stress induces Z-DNA-binding protein 1–dependent activation of microglia via mtDNA released from retinal pigment epithelial cells

Oxidative stress, inflammation, and aberrant activation of microglia in the retina are commonly observed in ocular pathologies. In glaucoma or age-related macular degeneration, the chronic activation of microglia affects retinal ganglion cells and photoreceptors, respectively, contributing to gradual vision loss. However, the molecular mechanisms that cause activation of microglia in the retina are not fully understood. Here we show that exposure of retinal pigment epithelial (RPE) cells to chronic low-level oxidative stress induces mitochondrial DNA (mtDNA)-specific damage, and the subsequent translocation of damaged mtDNA to the cytoplasm results in the binding and activation of intracellular DNA receptor Z-DNA-binding protein 1 (ZBP1). Activation of the mtDNA/ZBP1 pathway triggers the expression of proinflammatory markers in RPE cells. In addition, we show that the enhanced release of extracellular vesicles (EVs) containing fragments of mtDNA derived from the apical site of RPE cells induces a proinflammatory phenotype of microglia via activation of ZBP1 signaling. Collectively, our report establishes oxidatively damaged mtDNA as an important signaling molecule with ZBP1 as its intracellular receptor in the development of an inflammatory response in the retina. We propose that this novel mtDNA-mediated autocrine and paracrine mechanism for triggering and maintaining inflammation in the retina may play an important role in ocular pathologies. Therefore, the molecular mechanisms identified in this report are potentially suitable therapeutic targets to ameliorate development of ocular pathologies.

Anemia in early congenital syphilis

The determination of blood parameters allowed us to establish that anemia develops in a number of infectious diseases, which is called "anemia of inflammation" or anemia of chronic diseases. The article presents a rare clinical case of the development of anemia of the inflammatory response, accompanied by a marked decrease in the content of hemoglobin (less than 110 g/l), hematocrit (less than 30%) and red blood cells (less than 3,0 х 1012/l), in a child with early congenital syphilis with symptoms of: specific rhinitis, papular infiltration, pemphigus, hepatosplenomegaly and damage to the nervous system. As a result of specific treatment with water-soluble benzylpenicillin salt at the rate of 100 U/kg of body weight for 28 days, and transfusion of erythrocyte mass of 15 ml/kg of child weight, there was a parallel regression of clinical manifestations of syphilis with positive dynamics of serological reactions and restoration of the number of red blood cells and the concentration of hemoglobin in the blood.

New discovery of rare insect damage in the Pliocene of India reinforces the biogeographic history of Eurasian ecosystems

Plant–insect interactions in the fossil record are, as yet, sparsely known and understudied. Here, we document evidence of a new type of insect skeletonization on Abroma augustum (L.) L. f. (Malvaceae) leaf remains from the latest Neogene (Pliocene) sediments of Chotanagpur plateau, Jharkhand, eastern India. This unique skeletonization feeding trace attributable to herbivorous insects occurs all over the surfaces of our recovered Pliocene leaf remains. In the skeletonized area, the interveinal tissues are completely removed leaving behind only the tough leaf veins. This type of insect feeding behaviour is documented for the first time on Indian Cenozoic leaf remains. Based on published data, as well as our survey of modern forests adjacent to the fossil locality, we suggest that probable damage inducers of this skeletonization on Abroma Jacq. fossil leaves might be Chrysomelid (Coleopteran) beetles. This finding also reveals that specific insect feeding damage, such as the one presented here, can reveal similarity of environments despite the difference of plant species observed. Such results strengthen the importance of using plant–insect interactions on leaves as a complementary proxy to others revealing paleoenvironmental conditions.

329 Heart failure predictive value of the electric risk score in patients suffering from thalassemia major

Abstract Aims Complications associated with iron accumulation were highly recurrent in thalassemia patients, who underwent frequent blood transfusions, in particular hemosiderotic cardiomyopathy which could lead to heart failure and arrhythmias. Nowadays, the better iron chelation therapy has improved cardiovascular morbidity in these patients; nevertheless, mild impairment should be seek for and eventually treated. The objective of our study was to evaluate the possibility of using early electrocardiographic markers of myocardial damage and predictors of mortality, such as the Electric Risk Score (ERS). Methods and results 73 patients with thalassemia major were enrolled in this study, which were divided into two groups, with 45 years old as cut off. Anamnestic, clinical, electrocardiographic, and echocardiographic data were collected. From ECG, ERS was obtained. over 45 yrs-old group of pts, in addition to a predictable increase in the prevalence of traditional cardiovascular risk factors and drug intake, an alteration of the QRS-T angle (14[30] vs. −4[28], p value: <0.0001) and an increased prevalence of left ventricular hypertrophy (2.88 ± 0.86 vs. 2.40 ± 0.57 p value: <0.05) were found. In patients taking drugs with possible interactions with the ventricular repolarization phase, there is a slight increase in the QT interval, left ventricular hypertrophy and a reduction in Tpeak-Tend (Table 1). Electrocardiographic values in groups of patients with different age groups who are taking therapies that can affect QT. The echocardiogram revealed an increase in the end-diastolic diameter of the right ventricle (26 ± 3 vs. 28 ± 3 mm, P-value: 0.05) in the group of patients over the age of 45, a decrease in the acceleration time of the pulmonary systolic flow (138 ± 25 vs. 125 ± 13 ms, P-value: 0.04) and TAPSE (25 ± 3 vs. 22 ± 4 mm, P-value: 0.002). Conclusions From the data in our study it emerged that an appropriate iron-chelation therapy is able to effectively counteract the hemosiderotic cardiomyopathy of thalassemic patients so as to detect electro- and echocardiographic anomalies only in patients of more advanced age, a result that we think both the consequence, not so much of iron overload, but of an increase in the prevalence of age- and gender-related cardiovascular risk factors. The initial changes in cardiac electromechanics, which can be assessed with the aforementioned methods, we believe, can become a very early sign of specific myocardial damage. 329 Figure 1Electrical risk score parameters.

A generalized computational approach to predict high-frequency acoustic pressure response of cavity structures for structural health monitoring of wind turbine blades

This paper details the development of a generalized computational approach that enables prediction of cavity-internal sound pressure distribution due to flow-generated noise at high frequencies. The outcomes of this research is of particular interest for development of an acoustics-based structural health monitoring system for wind turbine blades. The methodology builds from existing reduced-order aeroacoustic modeling techniques and ray tracing based geometrical acoustics and is demonstrated on the model NREL 5 MW wind turbine blade as a case study. The computational predictions demonstrated that damage could be successfully detected in the first half of the blade cavity near the root and that the change in frequency content may be indicative of the type of damage that has occurred. This study provides a foundation to analyze specific blades and likely damage cases for determining key factors of system design such as number and placement of sensors as well as for hardware selection.

Segmental Abnormalities of White Matter Microstructure in End-Stage Renal Disease Patients: An Automated Fiber Quantification Tractography Study.

Background and Purpose: End-stage renal disease (ESRD) results in extensive white matter abnormalities, but the specific damage segment cannot be identified. This study aimed to determine the segmental abnormalities of white matter microstructure in ESRD and its relationship with cognitive and renal function indicators.Methods: Eighteen ESRD patients and 19 healthy controls (HCs) were prospectively recruited. All participants underwent DTI and clinical assessments. Automatic fiber quantification (AFQ) was applied to generate bundle profiles along 16 main white matter tracts. We compared the DTI parameters between groups. Besides, we used partial correlation and multiple linear regression analyses to explore the associations between white matter integrity and cognitive performance as well as renal function indicators.Results: In the global tract level, compared to HCs, ESRD patients had greater MD, AD, and RD values and lower FA value in several fibers (P < 0.05, FDR correction). In the point-wise level, extensive damage existed in specific locations of different fiber tracts, particularly in the left hemisphere (P < 0.05, FDR correction). Among these tracts, the mean AD values of the left cingulum cingulate correlated negatively with MoCA score. Urea and UA level were independent predictors of the AD value of superior component of the left corticospinal. Besides, urea level was the independent predictors of mean MD value of left anterior thalamic radiation (ATR).Conclusion: White matter fiber tract damage in ESRD patients may be characterized by abnormalities in its specific location, especially in the left hemisphere. Aberrational specific located fibers were related to cognitive impairment and renal dysfunction.

RESEARCH OF INNOVATIVE MECHANISMS CREATION OF MODERN BUILDING MATERIALS FOR IMPROVEMENT OF PRODUCTION PROCESSES

Purpose. To reveal the mechanism of formation of contact zones and purposeful choice of mastic composition and its substantiation on the basis of revealing of regularities of interrelations "mastic composition – waterproofing resource". Methodology. The sequence of changes in the technical condition of roofing materials, which varies from normal without damage to emergency with intermediate satisfactory and unsuitable for normal operation depending on the specific damage and leakage of the roof affects the definition of conventional material resources, means and methods of arrangement and arrangements. roofs, as well as the mechanism and kinetics of loss of serviceability are a key factor in improving the whole set of measures aimed at making technology competitive. Results. Technologies of repair of point and local damages in the form of cracks, breaks, exfoliations which are carried out by cutting and the subsequent gluing of pieces of cloths on the prepared sites with filling, allow to receive short-term results. Elimination of continuous surface damage by applying an additional layer of rolled or mastic material is associated with the inevitable preservation in the lower layers of the causes of premature loss of operational functions of the coating. The results provide an opportunity to perform non-dismantling repair and restoration work using purposefully proposed repair composition with the minimum possible cost of resources and a high degree of mechanization. The developed technology is based on the ability of the used repair composition to impregnate and saturate the adjacent surfaces with ingredients that can eliminate damage of a certain type and return the coating or protective layer of the initial waterproofing potential and strengthen it. Originality. Substantiation of possibilities of use of the residual waterproofing resource of the existing soft roof by its saturation with ingredients of the offered repair composition. Practical value. It is possible to effectively use, restore and enhance the residual waterproofing potential of bitumen-roofing roof by pneumatic spraying repair composition of the developed composition.

Neuropathic pain in the IMI-APPROACH knee osteoarthritis cohort: prevalence and phenotyping

ObjectivesOsteoarthritis (OA) patients with a neuropathic pain (NP) component may represent a specific phenotype. This study compares joint damage, pain and functional disability between knee OA patients with a likely...

Impact of glucocorticoids on the incidence of lupus-related major organ damage: a systematic literature review and meta-regression analysis of longitudinal observational studies

ObjectiveIn systemic lupus erythematosus (SLE), disease activity and glucocorticoid (GC) exposure are known to contribute to irreversible organ damage. We aimed to examine the association between GC exposure and organ...

Numerical Simulation of Dynamic Response and Evaluation of Flexural Damage of RC Columns under Horizontal Impact Load

By using the ABAQUS finite element (FE) model, which has been verified by experiments, the deformation and internal force changes of RC columns during the impact process are investigated, and a parametric analysis is conducted under different impact kinetic energies Ek. According to the development path of the bottom bending moment-column top displacement curve under impact, the member is in a slight damage state when the curve rebounds before reaching the peak and in a moderate or severe damage state when the curve exceeds the peak, in which case the specific damage state of the member needs to be determined by examining whether there is a secondary descending stage in the curve. Accordingly, a qualitative method for evaluating the bending failure of RC column members under impact is obtained. In addition, the damage state of RC columns under impact can also be quantitatively evaluated by the ratio of the equivalent static load Feq and the ultimate static load-bearing capacity Fsu.

A Screening Methodology for the Identification of Critical Units in Major-Hazard Facilities Under Seismic Loading

The complexity of process industry and the consequences that Na-Tech events could produce in terms of damage to equipment, release of dangerous substances (flammable, toxic, or explosive), and environmental consequences have prompted the scientific community to focus on the development of efficient methodologies for Quantitative Seismic Risk Analysis (QsRA) of process plants. Several analytical and numerical methods have been proposed and validated through representative case studies. Nevertheless, the complexity of this matter makes their applicability difficult, especially when a rapid identification of the critical components of a plant is required, which may induce hazardous material release and thus severe consequences for the environment and the community. Accordingly, in this paper, a screening methodology is proposed for rapid identification of the most critical components of a major-hazard plant under seismic loading. It is based on a closed-form assessment of the probability of damage for all components, derived by using analytical representations of the seismic hazard curve and the fragility functions of the equipment involved. For this purpose, fragility curves currently available in the literature or derived by using low-fidelity models could be used for simplicity, whereas the parameters of the seismic hazard curve are estimated based on the regional seismicity. The representative damage states (DS) for each equipment typology are selected based on specific damage states/loss of containment (DS/LOC) matrices, which are used to individuate the most probable LOC events. The risk is then assessed based on the potential consequences of a LOC event, using a classical consequence analysis, typically adopted in risk analysis of hazardous plants. For this purpose, specific probability classes will be used. Finally, by associating the Probability Class Index (PI) with Consequence Index (CI), a Global Risk Index (GRI) is derived, which provides the severity of the scenario. This allows us to build a ranking of the most hazardous components of a process plant by using a proper risk matrix. The applicability of the method is shown through a representative case study.

Contact fatigue of WC-6%wtCo cemented carbides: Influence of corrosion-induced changes on emergence and evolution of damage

The effect of corrosion-induced changes on the contact fatigue response and associated damage in a medium-grained WC-6%wtCo hardmetal grade is investigated. Cyclic contact loading tests are conducted by means of Hertzian indentation techniques. Corrosion damage is introduced in a controlled way by previous immersion of specimens in a stirred acidic medium. Results reveal that corrosion significantly affects the contact fatigue behavior of the material under consideration, in terms of decreasing the effective load bearing capability of the material as well as earlier emergence and evolution of specific damage features, as compared to those discerned under monotonic loading and in a pristine hardmetal respectively. As cycle number increases, damage evolution in the corroded condition is more gradual and diffuse than for the uncorroded one. In general, it is dominated by existence of ill-defined radial cracks together with pronounced carbide grain pull-out which finally evolve into cohesive-like spallation in regions close to the periphery of indentation imprints. These findings are rationalized on the basis of phase assemblage changes linked to corrosion, particularly in terms of lessening of toughening capability and easiness of WC grain pull-out intrinsic to the loose and porous binderless WC skeleton remnant at the surface level, after exposure to the acid medium. Although some removal of carbide grains and discrete cohesive chipping is also observed in the pristine sample for very high number of cycles, such different response, as compared to monotonic loading, is linked to oxidation phenomena of the metallic binder for this reference condition.

Biological Significance and Prognostic Value of Cytogenetics in 160 Patients with Multiple Myeloma: Predictivity of 13 and/or 14 Monosomies

Until recently, MM was defined using strict clinical pathological criteria that required evidence of specific end-organ damage (CRAB) attributable to the underlying clonal plasma cell disorder. In the case of absence of end-organ damage, patients with clonal plasma cell proliferation were diagnosed either with monoclonal gammopathy of undetermined significance (MGUS) or with smoldering multiple myeloma (SMM). Further, on one hand there have been on-going revisions of the diagnostic criteria for MM and SMM, on the other there have also been revisions of the molecular classification of these disorders; namely, staging and risk. These revisions regarding both the diagnostic criteria and the molecular classification of these disorders are very important because recent advances in understanding these disorders have led to significant progress in the treatment of MM and SMM, in our understanding of disease biology, and in prognostic evaluation for cancer patients. The Revised International Staging System (RISS) combines elements of tumor burden (ISS) and disease biology (presence of high-risk cytogenetic abnormalities or elevated lactate dehydrogenase level) to create a unified prognostic index that helps in clinical care, comparing clinical trial data. The RISS will be of importance in the clinic in terms of counseling patients regarding prognosis, as well as in clinical trials to compare outcomes across clinical trials. The initial cytogenetic classification of SMM also has implications for prognosis as patients with t(4;14) translocation, 17p deletion, and 1q amplification have a higher risk of progression from SMM to MM. Although patients with trisomies are considered to have a better prognosis when diagnosed with MM, they have a higher risk of progression from SMM to MM compared to patients with t(11;14). It is possible that trisomic MM manifests earlier with more obvious bone disease, producing in essence a lead-time bias. Thus, the time from SMM to MM is shortened while the time from MM to death appears longer. There are several molecular subtypes of MM, associated with several unique differences in disease presentation and prognosis. For example, trisomic MM appears to respond particularly well to lenalidomide-based therapy, while t(4;14) MM requires bortezomib-based induction and maintenance for good outcome. In terms of clinical presentation, t(4;14) MM appears to have a lower propensity for bone disease at diagnosis, while t(14;16) MM is often associated with high levels of serum free light chains (FLC) and a higher risk of acute renal failure at diagnosis. Disease biology in MM is best reflected based on the molecular subtype of the disease and the presence or absence of specific cytogenetic abnormalities. The abnormalities such as t(4;14), t(14;16), t(14;20), gain(1q), del(1p), and del(17p) influence disease course, response to therapy, and prognosis in MM. In our center we evaluated the cytogenetics data at the onset of the disease, after 1st line therapy, after transplantation and during maintenance therapy to analyze any changes in the cytogenetic panel and additional anomalies and if all this is correlated with the characteristics of the disease, patient, and risk predictor. In particular, we evaluated 160 patients and analyzed the clinical evolution in patients in which monosomies 13 and/or 14 were present, currently not classifiable in prognostic terms. The significance of these monosomies was evaluated based on the various stages of the disease and the type of therapy administered. DisclosuresNo relevant conflicts of interest to declare.

Fabrication routes for advanced first wall design alternatives

In future nuclear fusion reactors, plasma facing components have to sustain specific neutron damage. While the majority of irradiation data provides a relatively clear picture of the displacement damage, the effect of helium transmutation is not yet explored in detail. Nevertheless, available results from simulation experiments indicate that 9%-chromium steels will reach their operating limit as soon as the growing helium bubbles extent a critical size. At that point, the material would most probably fail due to grain boundary embrittlement. In this contribution, we present a strategy for the mitigation of the before-mentioned problem using the following facts. (1) The neutron dose and related transmutation rate decreases quickly inside the first wall of the breeding blankets, that is, only a plasma-near area is extremely loaded. (2) Nanostructured oxide dispersion strengthened (ODS) steels may have an enormous trapping effect on helium, which would suppress the formation of large helium bubbles for a much longer period. (3) Compared to conventional steels, ODS steels also provide improved irradiation tensile ductility and creep strength. Therefore, a design, based on the fabrication of the plasma facing and highly neutron and heat loaded parts of blankets by an ODS steel, while using EUROFER97 for everything else, would extend the operating time and enable a higher heat flux. Consequently, we (i) developed and produced 14%Cr ferritic ODS steel plates and (ii) optimized and demonstrated a scalable industrial production route. (iii) We fabricated a mock-up with five cooling channels and a plated first wall of ODS steel, using the same production processes as for a real component. (iv) Finally, we performed high heat flux tests in the Helium Loop Karlsruhe, applying a few hundred short and a few 2 h long pulses, in which the operating temperature limit for EUROFER97 (i.e. 550 °C) was finally exceeded by 100 K. (v) Thereafter, microstructure and defect analyses did not reveal critical defects or recognizable damage. Only a heat affected zone in the EUROFER/ODS steel interface could be detected. However, a solution to prohibit the formation of such heat affected zones is given. These research contributions demonstrate that the use of ODS steel is not only feasible and affordable but could make a decisive difference in the future design and performance of breeding blankets.

GAP ANAGAP ANALYSIS ON RISK BASED INSPECTION (RBI) IMPLEMENTATION AT PT. XYZLYSIS ON RISK BASED INSPECTION (RBI) IMPLEMENTATION AT PT. XYZ

Risk Based Inspection (RBI) has been implemented mainly in oil and gas industry to manage the risk of aging facilities. The RBI plan has also been introduced for new facilities and become part of the design requirements, making it the right time for PT. XYZ to improve their RBI implementation to support the Facility Risk Integrity Management System. This is a semi-quantitative study on primary data collected through focus group discussion using the RBI evaluation parameters based on API 580, API 581, and field observation and secondary data from previous RBI reports, maintenance program, and inspection program. Finally, an evaluation was conducted to assess whether the RBI management strategy has been integrated to the safety and asset management; inspection, testing, and monitoring; and operation strategies. This gap analysis aims to evaluate the effectiveness of the ongoing RBI implementation at PT. XYZ in general while specifically identify the part of RBI and related Asset Integrity Management already implemented and those that still need further improvement. Results show an overall score of 328 of 470, showing a good implementation of RBI. The largest gaps identified are RBI on specific equipment (score=3.0), documented RBI management policy and strategy (score=3.8), risk target and risk acceptable level (score=4.0), and specific damage mechanism components (score=5.3).

ПОРАЖЕНИЕ СЕРДЕЧНО-СОСУДИСТОЙ СИСТЕМЫ ПРИ COVID-19 У ДЕТЕЙ

Coronavirus infection poses a particular danger in relation to decompensation of existing chronic diseases and specific damage to the cardiovascular system (CVS) both during an acute infection and during convalescence. Objective of the study: to summarize current knowledge about the potential involvement of CVS in the development and progression of acute COVID-19 infection and multisystem inflammatory syndrome (MIS) in children and to form an sense of the predictive value, diagnostic tactics and treatment of cardiac anomalies during the coronavirus pandemic. A search was performed in MEDLINE, PubMed, e-library using the search terms «cardiovascular disease in COVID-19/MIS in children», «congenital heart disease/pulmonary hypertension/prolonged QT interval and COVID-19 in children» to identify articles published from April 1, 2020 to May 1, 2021. A literature review indicates that cardiac disorders associated with the new coronavirus infection in children, in the vast majority of cases, developed during MIS, which manifests itself in the form of febrile fever, external signs of Kawasaki disease, hyperinflammatory state and multi-organ damage with an emphasis on CVS. Cardiovascular symptoms occur in the vast majority of children with MIS, and in more than half of the patients – by the type of myocardial dysfunction and/or shock, somewhat less often – in the form of ECG changes, pericardial effusion, сoronary artery ectasia. Against the background of treatment with steroids, intravenous human immunoglobulin (IVIG) and biologic drugs in combination with inotropic support in almost all children, the morphofunctional characteristics of CVS are restored to normal or subnormal levels in a few days. The need for extracorporeal membrane oxygenation and lethal cases are rare. The possibility of developing myocarditis (including fatal), pulmonary hypertension and cardiac arrhythmias associated with COVID-19 in pediatric patients with discussion of possible pathophysiological mechanisms was also described. Long-term observation of this category of persons is necessary due to the uncertain prognosis and the risk of progression of cardiac manifestations. An early comprehensive diagnosis of cardiac disorders and monitoring of the identified changes in children with MIS and acute coronavirus infection are needed.

Multi-objective optimization for joint actuator and sensor placement for guided waves based structural health monitoring using fibre Bragg grating sensors

Structural Health Monitoring (SHM) systems have a potential to reduce lifecycle costs of structures. As a result, there is a lot of active research in the area for SHM of civil and mechanical structures. Guided waves (GW) based SHM techniques allow monitoring of large plate-like structures with a few sensors and have been identified as the most promising of techniques for SHM. Fibre Bragg grating (FBG) sensors due to their low weight, and ability to be multiplexed have been long thought to be ideal sensors for SHM. The recent development of the edge filtering approach has increased their sensitivity to GW sensing and made them ideal sensors. Unfortunately the FBG sensors are passive sensors and show directional sensitivity. These operational constraints make extension of the earlier developed GW based SHM techniques for FBG sensors difficult. Recently the authors developed a technique for damage detection specifically designed for a network with FBG sensors. This paper builds on the past work by the authors and develops a methodology for a design of an actuator–sensor (AS) network for improving the damage assessment capability of the previously proposed method. The paper develops a multi objective optimization technique for the joint optimization of actuator and sensor placement for a network with FBG sensors. The joint optimization of the actuators and sensors is necessary due to the passive nature of the FBG sensors and also incorporates the directional nature of the FBG sensors. The paper develops an integer encoded NSGA-II for the optimization of the AS network. The objectives for the optimization are derived from the specific damage detection technique tailored for the use of FBG sensors. The objective are: coverage with at least 2 AS pairs, coverage with at least 1 edge reflected path and the cost of the deployed network. The results indicate that the encoding of the objectives of the optimization is valid and indeed the damage detection capabilities of the AS network are as predicted analytically. The paper for the first time develops a joint optimization of network for FBG sensors. It is also the first attempt at a truly multi-objective optimization of the AS network and promises to have applications on real structures.